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Protein

ATP-dependent permease PDR11

Gene

PDR11

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transporter involved in the uptake of sterol.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi782 – 7898ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

  • cellular response to drug Source: GO_Central
  • sterol import Source: GO_Central
  • sterol transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31289-MONOMER.

Protein family/group databases

TCDBi3.A.1.205.8. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent permease PDR11
Gene namesi
Name:PDR11
Ordered Locus Names:YIL013C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IX

Organism-specific databases

EuPathDBiFungiDB:YIL013C.
SGDiS000001275. PDR11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 388387CytoplasmicSequence analysisAdd
BLAST
Transmembranei389 – 40921HelicalSequence analysisAdd
BLAST
Topological domaini410 – 4189ExtracellularSequence analysis
Transmembranei419 – 43921HelicalSequence analysisAdd
BLAST
Topological domaini440 – 47132CytoplasmicSequence analysisAdd
BLAST
Transmembranei472 – 49221HelicalSequence analysisAdd
BLAST
Topological domaini493 – 4942ExtracellularSequence analysis
Transmembranei495 – 51521HelicalSequence analysisAdd
BLAST
Topological domaini516 – 5249CytoplasmicSequence analysis
Transmembranei525 – 54521HelicalSequence analysisAdd
BLAST
Topological domaini546 – 63691ExtracellularSequence analysisAdd
BLAST
Transmembranei637 – 65721HelicalSequence analysisAdd
BLAST
Topological domaini658 – 1090433CytoplasmicSequence analysisAdd
BLAST
Transmembranei1091 – 111121HelicalSequence analysisAdd
BLAST
Topological domaini1112 – 11176ExtracellularSequence analysis
Transmembranei1118 – 113821HelicalSequence analysisAdd
BLAST
Topological domaini1139 – 117537CytoplasmicSequence analysisAdd
BLAST
Transmembranei1176 – 119621HelicalSequence analysisAdd
BLAST
Topological domaini1197 – 12048ExtracellularSequence analysis
Transmembranei1205 – 122521HelicalSequence analysisAdd
BLAST
Topological domaini1226 – 12305CytoplasmicSequence analysis
Transmembranei1231 – 125121HelicalSequence analysisAdd
BLAST
Topological domaini1252 – 1355104ExtracellularSequence analysisAdd
BLAST
Transmembranei1356 – 137621HelicalSequence analysisAdd
BLAST
Topological domaini1377 – 141135CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: GO_Central
  • membrane Source: SGD
  • plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 14111410ATP-dependent permease PDR11PRO_0000093444Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi595 – 5951N-linked (GlcNAc...)Sequence analysis
Glycosylationi1289 – 12891N-linked (GlcNAc...)Sequence analysis
Glycosylationi1324 – 13241N-linked (GlcNAc...)Sequence analysis
Glycosylationi1346 – 13461N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

BioGridi34978. 32 interactions.
DIPiDIP-8310N.
IntActiP40550. 3 interactions.
MINTiMINT-407564.

Structurei

3D structure databases

ProteinModelPortaliP40550.
SMRiP40550. Positions 41-259, 722-1004.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 273243ABC transporter 1PROSITE-ProRule annotationAdd
BLAST
Domaini751 – 979229ABC transporter 2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi708 – 7136Poly-Ser
Compositional biasi1046 – 10494Poly-Leu

Sequence similaritiesi

Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00550000075308.
HOGENOMiHOG000162078.
InParanoidiP40550.
OMAiCHESIIP.
OrthoDBiEOG092C1HKF.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR013525. ABC_2_trans.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
IPR010929. PDR_CDR_ABC.
[Graphical view]
PfamiPF01061. ABC2_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
PF06422. PDR_CDR. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P40550-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLSKYFNPI PDASVTFDGA TVQLEESLGA VQNDEESASE FKNVGHLEIS
60 70 80 90 100
DITFRANEGE VVLVLGNPTS ALFKGLFHGH KHLKYSPEGS IRFKDNEYKQ
110 120 130 140 150
FASKCPHQII YNNEQDIHFP YLTVEQTIDF ALSCKFHIPK QERIEMRDEL
160 170 180 190 200
LKEFGLSHVK KTYVGNDYVR GVSGGERKRI SIIETFIANG SVYLWDNSTK
210 220 230 240 250
GLDSATALEF LSITQKMAKA TRSVNFVKIS QASDKIVSKF DKILMLGDSF
260 270 280 290 300
QVFYGTMEEC LTHFHDTLQI KKNPNDCIIE YLTSILNFKF KETSNSIVGL
310 320 330 340 350
DTPSVVSEEN QALNINNETD LHTLWIQSPY YKHWKAITSK TVQECTRKDV
360 370 380 390 400
NPDDISPIFS IPLKTQLKTC TVRAFERIIG DRNYLISQFV SVVVQSLVIG
410 420 430 440 450
SLFYNIPLTT IGSFSRGSLT FFSILFFTFL SLADMPASFQ RQPVVRKHVQ
460 470 480 490 500
LHFYYNWVET LATNFFDCCS KFILVVIFTI ILYFLAHLQY NAARFFIFLL
510 520 530 540 550
FLSVYNFCMV SLFALTALIA PTLSMANLLA GILLLAIAMY ASYVIYMKDM
560 570 580 590 600
HPWFIWIAYL NPAMFAMEAI LSNELFNLKL DCHESIIPRG EYYDNISFSH
610 620 630 640 650
KACAWQGATL GNDYVRGRDY LKSGLKYTYH HVWRNFGIII GFLCFFLFCS
660 670 680 690 700
LLAAEYITPL FTRENLLRWN NYLKRYCPFL NSQKKNNKSA ITNNDGVCTP
710 720 730 740 750
KTPIANFSTS SSSVPSVSHQ YDTDYNIKHP DETVNNHTKE SVAMETQKHV
760 770 780 790 800
ISWKNINYTI GDKKLINDAS GYISSGLTAL MGESGAGKTT LLNVLSQRTE
810 820 830 840 850
SGVVTGELLI DGQPLTNIDA FRRSIGFVQQ QDVHLELLTV RESLEISCVL
860 870 880 890 900
RGDGDRDYLG VVSNLLRLPS EKLVADLSPT QRKLLSIGVE LVTKPSLLLF
910 920 930 940 950
LDEPTSGLDA EAALTIVQFL KKLSMQGQAI LCTIHQPSKS VISYFDNIYL
960 970 980 990 1000
LKRGGECVYF GSLPNACDYF VAHDRRLTFD REMDNPADFV IDVVGSGSTN
1010 1020 1030 1040 1050
IPMDDAEKPT SSKIDEPVSY HKQSDSINWA ELWQSSPEKV RVADDLLLLE
1060 1070 1080 1090 1100
EEARKSGVDF TTSVWSPPSY MEQIKLITKR QYICTKRDMT YVFAKYALNA
1110 1120 1130 1140 1150
GAGLFIGFSF WRTKHNINGL QDAIFLCFMM LCVSSPLINQ VQDKALQSKE
1160 1170 1180 1190 1200
VYIAREARSN TYHWTVLLIA QTIVELPLAI SSSTLFFLCC YFCCGFETSA
1210 1220 1230 1240 1250
RVAGVFYLNY ILFSMYYLSF GLWLLYSAPD LQTAAVFVAF LYSFTASFCG
1260 1270 1280 1290 1300
VMQPYSLFPR FWTFMYRVSP YTYFIETFVS LLLHDREVNC STSEMVPSQP
1310 1320 1330 1340 1350
VMGQTCGQFM KPFIDEFGGK LHINNTYTVC AYCMYTVGDD FLAQENMSYH
1360 1370 1380 1390 1400
HRWRNFGFEW VFVCFNIAAM FVGFYLTYIK KIWPSVIDGI KKCIPSMRRS
1410
KTSHNPNEQS V
Length:1,411
Mass (Da):160,538
Last modified:January 23, 2007 - v3
Checksum:i83D040F42BB04526
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38113 Genomic DNA. Translation: CAA86236.1.
Z46881 Genomic DNA. Translation: CAA86980.1.
BK006942 Genomic DNA. Translation: DAA08533.1.
PIRiS48442.
RefSeqiNP_012252.1. NM_001179363.1.

Genome annotation databases

EnsemblFungiiYIL013C; YIL013C; YIL013C.
GeneIDi854802.
KEGGisce:YIL013C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38113 Genomic DNA. Translation: CAA86236.1.
Z46881 Genomic DNA. Translation: CAA86980.1.
BK006942 Genomic DNA. Translation: DAA08533.1.
PIRiS48442.
RefSeqiNP_012252.1. NM_001179363.1.

3D structure databases

ProteinModelPortaliP40550.
SMRiP40550. Positions 41-259, 722-1004.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34978. 32 interactions.
DIPiDIP-8310N.
IntActiP40550. 3 interactions.
MINTiMINT-407564.

Protein family/group databases

TCDBi3.A.1.205.8. the atp-binding cassette (abc) superfamily.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYIL013C; YIL013C; YIL013C.
GeneIDi854802.
KEGGisce:YIL013C.

Organism-specific databases

EuPathDBiFungiDB:YIL013C.
SGDiS000001275. PDR11.

Phylogenomic databases

GeneTreeiENSGT00550000075308.
HOGENOMiHOG000162078.
InParanoidiP40550.
OMAiCHESIIP.
OrthoDBiEOG092C1HKF.

Enzyme and pathway databases

BioCyciYEAST:G3O-31289-MONOMER.

Miscellaneous databases

PROiP40550.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR013525. ABC_2_trans.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
IPR010929. PDR_CDR_ABC.
[Graphical view]
PfamiPF01061. ABC2_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
PF06422. PDR_CDR. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPDR11_YEAST
AccessioniPrimary (citable) accession number: P40550
Secondary accession number(s): D6VVR7, Q03092
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 145 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.