ATP-dependent permease PDR11 - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

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P40550 (PDR11_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 105. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
ATP-dependent permease PDR11

Gene names

Name:	PDR11
Ordered Locus Names:	YIL013C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	1411 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function

Transporter involved in the uptake of sterol. Ref.4

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily. [View classification]

Contains 2 ABC transporter domains.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane
Domain	Repeat Transmembrane Transmembrane helix
Ligand	ATP-binding Nucleotide-binding
PTM	Glycoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	sterol transport Inferred from mutant phenotype Ref.4. Source: SGD
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity, coupled to transmembrane movement of substances Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

Removed Ref.3

Chain

2 – 1411

1410

ATP-dependent permease PDR11

PRO_0000093444

Regions

Topological domain

2 – 388

387

Cytoplasmic Potential

Transmembrane

389 – 409

Helical; Potential

Topological domain

410 – 418

Extracellular Potential

Transmembrane

419 – 439

Helical; Potential

Topological domain

440 – 471

Cytoplasmic Potential

Transmembrane

472 – 492

Helical; Potential

Topological domain

493 – 494

Extracellular Potential

Transmembrane

495 – 515

Helical; Potential

Topological domain

516 – 524

Cytoplasmic Potential

Transmembrane

525 – 545

Helical; Potential

Topological domain

546 – 636

Extracellular Potential

Transmembrane

637 – 657

Helical; Potential

Topological domain

658 – 1090

433

Cytoplasmic Potential

Transmembrane

1091 – 1111

Helical; Potential

Topological domain

1112 – 1117

Extracellular Potential

Transmembrane

1118 – 1138

Helical; Potential

Topological domain

1139 – 1175

Cytoplasmic Potential

Transmembrane

1176 – 1196

Helical; Potential

Topological domain

1197 – 1204

Extracellular Potential

Transmembrane

1205 – 1225

Helical; Potential

Topological domain

1226 – 1230

Cytoplasmic Potential

Transmembrane

1231 – 1251

Helical; Potential

Topological domain

1252 – 1355

104

Extracellular Potential

Transmembrane

1356 – 1376

Helical; Potential

Topological domain

1377 – 1411

Cytoplasmic Potential

Domain

31 – 273

243

ABC transporter 1

Domain

751 – 979

229

ABC transporter 2

Nucleotide binding

782 – 789

ATP Potential

Compositional bias

708 – 713

Poly-Ser

Compositional bias

1046 – 1049

Poly-Leu

Amino acid modifications

Glycosylation

595

N-linked (GlcNAc...) Potential

Glycosylation

1289

N-linked (GlcNAc...) Potential

Glycosylation

1324

N-linked (GlcNAc...) Potential

Glycosylation

1346

N-linked (GlcNAc...) Potential

Sequences

Sequence

Length

Mass (Da)

Tools

P40550 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 83D040F42BB04526
Show »

FASTA

1,411

160,538

        10         20         30         40         50         60 
MSLSKYFNPI PDASVTFDGA TVQLEESLGA VQNDEESASE FKNVGHLEIS DITFRANEGE 

        70         80         90        100        110        120 
VVLVLGNPTS ALFKGLFHGH KHLKYSPEGS IRFKDNEYKQ FASKCPHQII YNNEQDIHFP 

       130        140        150        160        170        180 
YLTVEQTIDF ALSCKFHIPK QERIEMRDEL LKEFGLSHVK KTYVGNDYVR GVSGGERKRI 

       190        200        210        220        230        240 
SIIETFIANG SVYLWDNSTK GLDSATALEF LSITQKMAKA TRSVNFVKIS QASDKIVSKF 

       250        260        270        280        290        300 
DKILMLGDSF QVFYGTMEEC LTHFHDTLQI KKNPNDCIIE YLTSILNFKF KETSNSIVGL 

       310        320        330        340        350        360 
DTPSVVSEEN QALNINNETD LHTLWIQSPY YKHWKAITSK TVQECTRKDV NPDDISPIFS 

       370        380        390        400        410        420 
IPLKTQLKTC TVRAFERIIG DRNYLISQFV SVVVQSLVIG SLFYNIPLTT IGSFSRGSLT 

       430        440        450        460        470        480 
FFSILFFTFL SLADMPASFQ RQPVVRKHVQ LHFYYNWVET LATNFFDCCS KFILVVIFTI 

       490        500        510        520        530        540 
ILYFLAHLQY NAARFFIFLL FLSVYNFCMV SLFALTALIA PTLSMANLLA GILLLAIAMY 

       550        560        570        580        590        600 
ASYVIYMKDM HPWFIWIAYL NPAMFAMEAI LSNELFNLKL DCHESIIPRG EYYDNISFSH 

       610        620        630        640        650        660 
KACAWQGATL GNDYVRGRDY LKSGLKYTYH HVWRNFGIII GFLCFFLFCS LLAAEYITPL 

       670        680        690        700        710        720 
FTRENLLRWN NYLKRYCPFL NSQKKNNKSA ITNNDGVCTP KTPIANFSTS SSSVPSVSHQ 

       730        740        750        760        770        780 
YDTDYNIKHP DETVNNHTKE SVAMETQKHV ISWKNINYTI GDKKLINDAS GYISSGLTAL 

       790        800        810        820        830        840 
MGESGAGKTT LLNVLSQRTE SGVVTGELLI DGQPLTNIDA FRRSIGFVQQ QDVHLELLTV 

       850        860        870        880        890        900 
RESLEISCVL RGDGDRDYLG VVSNLLRLPS EKLVADLSPT QRKLLSIGVE LVTKPSLLLF 

       910        920        930        940        950        960 
LDEPTSGLDA EAALTIVQFL KKLSMQGQAI LCTIHQPSKS VISYFDNIYL LKRGGECVYF 

       970        980        990       1000       1010       1020 
GSLPNACDYF VAHDRRLTFD REMDNPADFV IDVVGSGSTN IPMDDAEKPT SSKIDEPVSY 

      1030       1040       1050       1060       1070       1080 
HKQSDSINWA ELWQSSPEKV RVADDLLLLE EEARKSGVDF TTSVWSPPSY MEQIKLITKR 

      1090       1100       1110       1120       1130       1140 
QYICTKRDMT YVFAKYALNA GAGLFIGFSF WRTKHNINGL QDAIFLCFMM LCVSSPLINQ 

      1150       1160       1170       1180       1190       1200 
VQDKALQSKE VYIAREARSN TYHWTVLLIA QTIVELPLAI SSSTLFFLCC YFCCGFETSA 

      1210       1220       1230       1240       1250       1260 
RVAGVFYLNY ILFSMYYLSF GLWLLYSAPD LQTAAVFVAF LYSFTASFCG VMQPYSLFPR 

      1270       1280       1290       1300       1310       1320 
FWTFMYRVSP YTYFIETFVS LLLHDREVNC STSEMVPSQP VMGQTCGQFM KPFIDEFGGK 

      1330       1340       1350       1360       1370       1380 
LHINNTYTVC AYCMYTVGDD FLAQENMSYH HRWRNFGFEW VFVCFNIAAM FVGFYLTYIK 

      1390       1400       1410 
KIWPSVIDGI KKCIPSMRRS KTSHNPNEQS V

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome IX." Churcher C.M., Bowman S., Badcock K., Bankier A.T., Brown D., Chillingworth T., Connor R., Devlin K., Gentles S., Hamlin N., Harris D.E., Horsnell T., Hunt S., Jagels K., Jones M., Lye G., Moule S., Odell C. Barrell B.G. Nature 387:84-87(1997) [PubMed: 9169870] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Identification and characterization of SNQ2, a new multidrug ATP binding cassette transporter of the yeast plasma membrane." Decottignies A., Lambert L., Catty P., Degand H., Epping E.A., Moye-Rowley W.S., Balzi E., Goffeau A. J. Biol. Chem. 270:18150-18157(1995) [PubMed: 7629127] [Abstract] Cited for: IDENTIFICATION, PROTEIN SEQUENCE OF 2-11.
[4]	"Transcriptional profiling identifies two members of the ATP-binding cassette transporter superfamily required for sterol uptake in yeast." Wilcox L.J., Balderes D.A., Wharton B., Tinkelenberg A.H., Rao G., Sturley S.L. J. Biol. Chem. 277:32466-32472(2002) [PubMed: 12077145] [Abstract] Cited for: FUNCTION.
[5]	"A global topology map of the Saccharomyces cerevisiae membrane proteome." Kim H., Melen K., Oesterberg M., von Heijne G. Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed: 16847258] [Abstract] Cited for: TOPOLOGY [LARGE SCALE ANALYSIS]. Strain: ATCC 208353 / W303-1A.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z38113 Genomic DNA. Translation: CAA86236.1. Z46881 Genomic DNA. Translation: CAA86980.1. BK006942 Genomic DNA. Translation: DAA08533.1.
PIR	S48442.
RefSeq	NP_012252.1. NM_001179363.1.
3D structure databases
ProteinModelPortal	P40550.
SMR	P40550. Positions 170-262, 749-967.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-8310N.
IntAct	P40550. 2 interactions.
MINT	MINT-407564.
STRING	P40550.
Protein family/group databases
TCDB	3.A.1.205.8. ATP-binding cassette (ABC) superfamily.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YIL013C; YIL013C; YIL013C.
GeneID	854802.
KEGG	sce:YIL013C.
NMPDR	fig\|4932.3.peg.1789.
Organism-specific databases
SGD	S000001275. PDR11.
Phylogenomic databases
eggNOG	KOG0065.
GeneTree	EFGT00050000001203.
HOGENOM	HBG323792.
Gene expression databases
ArrayExpress	P40550.
Genevestigator	P40550.
GermOnline	YIL013C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR013525. ABC_2_trans. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR003593. ATPase_AAA+_core. IPR010929. PDR_CDR_ABC. [Graphical view]
Pfam	PF01061. ABC2_membrane. 2 hits. PF00005. ABC_tran. 2 hits. PF06422. PDR_CDR. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
PROSITE	PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	977616.

Entry information

Entry name

PDR11_YEAST

Accession

Primary (citable) accession number: P40550
Secondary accession number(s): D6VVR7, Q03092

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	January 23, 2007
Last modified:	December 14, 2011
This is version 105 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome IX

Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents