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Protein

ATP-dependent permease PDR11

Gene

PDR11

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transporter involved in the uptake of sterol.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi782 – 789ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATPase activity, coupled to transmembrane movement of substances Source: SGD
  • ATP binding Source: UniProtKB-KW

GO - Biological processi

  • sterol transport Source: SGD

Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31289-MONOMER

Protein family/group databases

TCDBi3.A.1.205.8 the atp-binding cassette (abc) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent permease PDR11
Gene namesi
Name:PDR11
Ordered Locus Names:YIL013C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IX

Organism-specific databases

EuPathDBiFungiDB:YIL013C
SGDiS000001275 PDR11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 388CytoplasmicSequence analysisAdd BLAST387
Transmembranei389 – 409HelicalSequence analysisAdd BLAST21
Topological domaini410 – 418ExtracellularSequence analysis9
Transmembranei419 – 439HelicalSequence analysisAdd BLAST21
Topological domaini440 – 471CytoplasmicSequence analysisAdd BLAST32
Transmembranei472 – 492HelicalSequence analysisAdd BLAST21
Topological domaini493 – 494ExtracellularSequence analysis2
Transmembranei495 – 515HelicalSequence analysisAdd BLAST21
Topological domaini516 – 524CytoplasmicSequence analysis9
Transmembranei525 – 545HelicalSequence analysisAdd BLAST21
Topological domaini546 – 636ExtracellularSequence analysisAdd BLAST91
Transmembranei637 – 657HelicalSequence analysisAdd BLAST21
Topological domaini658 – 1090CytoplasmicSequence analysisAdd BLAST433
Transmembranei1091 – 1111HelicalSequence analysisAdd BLAST21
Topological domaini1112 – 1117ExtracellularSequence analysis6
Transmembranei1118 – 1138HelicalSequence analysisAdd BLAST21
Topological domaini1139 – 1175CytoplasmicSequence analysisAdd BLAST37
Transmembranei1176 – 1196HelicalSequence analysisAdd BLAST21
Topological domaini1197 – 1204ExtracellularSequence analysis8
Transmembranei1205 – 1225HelicalSequence analysisAdd BLAST21
Topological domaini1226 – 1230CytoplasmicSequence analysis5
Transmembranei1231 – 1251HelicalSequence analysisAdd BLAST21
Topological domaini1252 – 1355ExtracellularSequence analysisAdd BLAST104
Transmembranei1356 – 1376HelicalSequence analysisAdd BLAST21
Topological domaini1377 – 1411CytoplasmicSequence analysisAdd BLAST35

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000934442 – 1411ATP-dependent permease PDR11Add BLAST1410

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi595N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1289N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1324N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1346N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP40550
PRIDEiP40550

PTM databases

CarbonylDBiP40550

Interactioni

Protein-protein interaction databases

BioGridi34978, 88 interactors
DIPiDIP-8310N
IntActiP40550, 3 interactors
MINTiP40550
STRINGi4932.YIL013C

Structurei

3D structure databases

ProteinModelPortaliP40550
SMRiP40550
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 273ABC transporter 1PROSITE-ProRule annotationAdd BLAST243
Domaini751 – 979ABC transporter 2PROSITE-ProRule annotationAdd BLAST229

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi708 – 713Poly-Ser6
Compositional biasi1046 – 1049Poly-Leu4

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00550000075308
HOGENOMiHOG000162078
InParanoidiP40550
OrthoDBiEOG092C1HKF

Family and domain databases

CDDicd03233 ABCG_PDR_domain1, 1 hit
cd03232 ABCG_PDR_domain2, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR013525 ABC_2_trans
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR034001 ABCG_PDR_1
IPR034003 ABCG_PDR_2
IPR027417 P-loop_NTPase
IPR010929 PDR_CDR_ABC
PfamiView protein in Pfam
PF01061 ABC2_membrane, 2 hits
PF00005 ABC_tran, 2 hits
PF06422 PDR_CDR, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P40550-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLSKYFNPI PDASVTFDGA TVQLEESLGA VQNDEESASE FKNVGHLEIS
60 70 80 90 100
DITFRANEGE VVLVLGNPTS ALFKGLFHGH KHLKYSPEGS IRFKDNEYKQ
110 120 130 140 150
FASKCPHQII YNNEQDIHFP YLTVEQTIDF ALSCKFHIPK QERIEMRDEL
160 170 180 190 200
LKEFGLSHVK KTYVGNDYVR GVSGGERKRI SIIETFIANG SVYLWDNSTK
210 220 230 240 250
GLDSATALEF LSITQKMAKA TRSVNFVKIS QASDKIVSKF DKILMLGDSF
260 270 280 290 300
QVFYGTMEEC LTHFHDTLQI KKNPNDCIIE YLTSILNFKF KETSNSIVGL
310 320 330 340 350
DTPSVVSEEN QALNINNETD LHTLWIQSPY YKHWKAITSK TVQECTRKDV
360 370 380 390 400
NPDDISPIFS IPLKTQLKTC TVRAFERIIG DRNYLISQFV SVVVQSLVIG
410 420 430 440 450
SLFYNIPLTT IGSFSRGSLT FFSILFFTFL SLADMPASFQ RQPVVRKHVQ
460 470 480 490 500
LHFYYNWVET LATNFFDCCS KFILVVIFTI ILYFLAHLQY NAARFFIFLL
510 520 530 540 550
FLSVYNFCMV SLFALTALIA PTLSMANLLA GILLLAIAMY ASYVIYMKDM
560 570 580 590 600
HPWFIWIAYL NPAMFAMEAI LSNELFNLKL DCHESIIPRG EYYDNISFSH
610 620 630 640 650
KACAWQGATL GNDYVRGRDY LKSGLKYTYH HVWRNFGIII GFLCFFLFCS
660 670 680 690 700
LLAAEYITPL FTRENLLRWN NYLKRYCPFL NSQKKNNKSA ITNNDGVCTP
710 720 730 740 750
KTPIANFSTS SSSVPSVSHQ YDTDYNIKHP DETVNNHTKE SVAMETQKHV
760 770 780 790 800
ISWKNINYTI GDKKLINDAS GYISSGLTAL MGESGAGKTT LLNVLSQRTE
810 820 830 840 850
SGVVTGELLI DGQPLTNIDA FRRSIGFVQQ QDVHLELLTV RESLEISCVL
860 870 880 890 900
RGDGDRDYLG VVSNLLRLPS EKLVADLSPT QRKLLSIGVE LVTKPSLLLF
910 920 930 940 950
LDEPTSGLDA EAALTIVQFL KKLSMQGQAI LCTIHQPSKS VISYFDNIYL
960 970 980 990 1000
LKRGGECVYF GSLPNACDYF VAHDRRLTFD REMDNPADFV IDVVGSGSTN
1010 1020 1030 1040 1050
IPMDDAEKPT SSKIDEPVSY HKQSDSINWA ELWQSSPEKV RVADDLLLLE
1060 1070 1080 1090 1100
EEARKSGVDF TTSVWSPPSY MEQIKLITKR QYICTKRDMT YVFAKYALNA
1110 1120 1130 1140 1150
GAGLFIGFSF WRTKHNINGL QDAIFLCFMM LCVSSPLINQ VQDKALQSKE
1160 1170 1180 1190 1200
VYIAREARSN TYHWTVLLIA QTIVELPLAI SSSTLFFLCC YFCCGFETSA
1210 1220 1230 1240 1250
RVAGVFYLNY ILFSMYYLSF GLWLLYSAPD LQTAAVFVAF LYSFTASFCG
1260 1270 1280 1290 1300
VMQPYSLFPR FWTFMYRVSP YTYFIETFVS LLLHDREVNC STSEMVPSQP
1310 1320 1330 1340 1350
VMGQTCGQFM KPFIDEFGGK LHINNTYTVC AYCMYTVGDD FLAQENMSYH
1360 1370 1380 1390 1400
HRWRNFGFEW VFVCFNIAAM FVGFYLTYIK KIWPSVIDGI KKCIPSMRRS
1410
KTSHNPNEQS V
Length:1,411
Mass (Da):160,538
Last modified:January 23, 2007 - v3
Checksum:i83D040F42BB04526
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38113 Genomic DNA Translation: CAA86236.1
Z46881 Genomic DNA Translation: CAA86980.1
BK006942 Genomic DNA Translation: DAA08533.1
PIRiS48442
RefSeqiNP_012252.1, NM_001179363.1

Genome annotation databases

EnsemblFungiiYIL013C; YIL013C; YIL013C
GeneIDi854802
KEGGisce:YIL013C

Similar proteinsi

Entry informationi

Entry nameiPDR11_YEAST
AccessioniPrimary (citable) accession number: P40550
Secondary accession number(s): D6VVR7, Q03092
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 162 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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