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P40549

- MNT3_YEAST

UniProt

P40549 - MNT3_YEAST

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Protein

Alpha-1,3-mannosyltransferase MNT3

Gene

MNT3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans.

Pathwayi

GO - Molecular functioni

  1. alpha-1,3-mannosyltransferase activity Source: SGD

GO - Biological processi

  1. mannosylation Source: GOC
  2. protein O-linked glycosylation Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciYEAST:G3O-31290-MONOMER.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT71. Glycosyltransferase Family 71.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1,3-mannosyltransferase MNT3 (EC:2.4.1.-)
Gene namesi
Name:MNT3
Ordered Locus Names:YIL014W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IX

Organism-specific databases

CYGDiYIL014w.
SGDiS000001276. MNT3.

Subcellular locationi

GO - Cellular componenti

  1. Golgi apparatus Source: SGD
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 630630Alpha-1,3-mannosyltransferase MNT3PRO_0000080560Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi34 – 341N-linked (GlcNAc...)Sequence Analysis
Glycosylationi168 – 1681N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP40549.
PaxDbiP40549.

Expressioni

Gene expression databases

GenevestigatoriP40549.

Interactioni

Protein-protein interaction databases

BioGridi34977. 12 interactions.
DIPiDIP-4122N.
IntActiP40549. 1 interaction.
MINTiMINT-548877.
STRINGi4932.YIL014W.

Structurei

3D structure databases

ProteinModelPortaliP40549.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1414CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini32 – 630599LumenalSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei15 – 3117Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the MNN1/MNT family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG127370.
GeneTreeiENSGT00390000003622.
HOGENOMiHOG000113621.
InParanoidiP40549.
KOiK10969.
OMAiWVNGGLK.
OrthoDBiEOG7QRR3H.

Family and domain databases

InterProiIPR022751. Alpha_mannosyltransferase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF11051. Mannosyl_trans3. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 2 hits.

Sequencei

Sequence statusi: Complete.

P40549-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLKSLKSRRL ILKRLVTLLL SLFFSYLIFS ASRNVTSSNK LNNHASERTA
60 70 80 90 100
VESSAFNWIE KRQHQVRSEN LMNRLSAYFL PFLSRSSHKE RVLLRQLGNN
110 120 130 140 150
EIAKSDKCRY IFEVLYKIDP DWDNAQTAKF YNVDGVDNTL ASLLGERLRS
160 170 180 190 200
YDYCFLSGQL DPTAIFANST VNPHDLQNRM FPFLKKINEE SKTVMWPIIT
210 220 230 240 250
DMTTGEAVPA PEVDMESSNF NGNFWSNWNR LSKGRGFVLT IAEKDVPLFL
260 270 280 290 300
KQLKVMEFSK NELPFQIVST GNELSAESIA KISETAKETE QRVYLVDCST
310 320 330 340 350
VLDTNFANTY ISFFQNKWVA TLFNTFEEYI LLDADVVPFV GSDYFFDSPS
360 370 380 390 400
YRESGILLFK DRVMENEQTF QYCIEMLNEV EPSAQERRFI GSRLVFDSSL
410 420 430 440 450
PFSSETSEEA SVYYNFFKKL RLHHVDSGLV VVNKLEKLNG LLMSFMLNLD
460 470 480 490 500
GKLQRCVYGD KEIFWLGQLY AGQDYSINPV DGSIIGPVNE EPENDDGHKS
510 520 530 540 550
GMYYICSTQI AHSDSKNRLL WVNGGLKTCK ISNSAEDDFG REPEYFKSRY
560 570 580 590 600
GDISKLKRIY DASLNVEGLI VPDVSVHPWM QIKECSNYMY CAYATGDGHT
610 620 630
NSELDEGRLI TFTEKELRYI NDISRTWNAN
Length:630
Mass (Da):72,410
Last modified:February 1, 1995 - v1
Checksum:i6B087DD003D8CD91
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z46881 Genomic DNA. Translation: CAA86979.1.
AY558107 Genomic DNA. Translation: AAS56433.1.
BK006942 Genomic DNA. Translation: DAA08532.1.
PIRiS49969.
RefSeqiNP_012251.3. NM_001179364.3.

Genome annotation databases

EnsemblFungiiYIL014W; YIL014W; YIL014W.
GeneIDi854801.
KEGGisce:YIL014W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z46881 Genomic DNA. Translation: CAA86979.1 .
AY558107 Genomic DNA. Translation: AAS56433.1 .
BK006942 Genomic DNA. Translation: DAA08532.1 .
PIRi S49969.
RefSeqi NP_012251.3. NM_001179364.3.

3D structure databases

ProteinModelPortali P40549.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 34977. 12 interactions.
DIPi DIP-4122N.
IntActi P40549. 1 interaction.
MINTi MINT-548877.
STRINGi 4932.YIL014W.

Protein family/group databases

CAZyi GT71. Glycosyltransferase Family 71.

Proteomic databases

MaxQBi P40549.
PaxDbi P40549.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YIL014W ; YIL014W ; YIL014W .
GeneIDi 854801.
KEGGi sce:YIL014W.

Organism-specific databases

CYGDi YIL014w.
SGDi S000001276. MNT3.

Phylogenomic databases

eggNOGi NOG127370.
GeneTreei ENSGT00390000003622.
HOGENOMi HOG000113621.
InParanoidi P40549.
KOi K10969.
OMAi WVNGGLK.
OrthoDBi EOG7QRR3H.

Enzyme and pathway databases

UniPathwayi UPA00378 .
BioCyci YEAST:G3O-31290-MONOMER.

Miscellaneous databases

NextBioi 977613.

Gene expression databases

Genevestigatori P40549.

Family and domain databases

InterProi IPR022751. Alpha_mannosyltransferase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view ]
Pfami PF11051. Mannosyl_trans3. 1 hit.
[Graphical view ]
SUPFAMi SSF53448. SSF53448. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. "Mnt2p and Mnt3p of Saccharomyces cerevisiae are members of the Mnn1p family of alpha-1,3-mannosyltransferases responsible for adding the terminal mannose residues of O-linked oligosaccharides."
    Romero P.A., Lussier M., Veronneau S., Sdicu A.-M., Herscovics A., Bussey H.
    Glycobiology 9:1045-1051(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMNT3_YEAST
AccessioniPrimary (citable) accession number: P40549
Secondary accession number(s): D6VVR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 29, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2310 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

External Data

Dasty 3