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Protein

HSP70 co-chaperone SNL1

Gene

SNL1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Stimulator of ATPase activity of molecular chaperones of the HSP70 family (principally of the SSA class). Stimulation is important for HSP70-substrate complex dissociation after folding of newly synthesized or refolded proteins. SNL1 is probably involved in nuclear pore biogenesis and in particular the folding or refolding of misfolded NUP116, GLE2 and NIC96.2 Publications

Miscellaneous

Present with 3346 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • chaperone binding Source: InterPro
  • ribosome binding Source: SGD

GO - Biological processi

  • nuclear pore organization Source: SGD
  • protein folding Source: SGD

Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

BioCyciYEAST:G3O-31292-MONOMER

Protein family/group databases

TCDBi1.I.1.1.1 the eukaryotic nuclear pore complex (e-npc) family

Names & Taxonomyi

Protein namesi
Recommended name:
HSP70 co-chaperone SNL1
Alternative name(s):
Suppressor of NUP116-C lethal
Gene namesi
Name:SNL1
Ordered Locus Names:YIL016W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IX

Organism-specific databases

EuPathDBiFungiDB:YIL016W
SGDiS000001278 SNL1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12Perinuclear spaceAdd BLAST12
Transmembranei13 – 35Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST23
Topological domaini36 – 159CytoplasmicAdd BLAST124

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi112E → A: Strongly reduces interaction with HSP70 family members. 1 Publication1
Mutagenesisi141R → A: Strongly reduces interaction with HSP70 family members. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000888811 – 159HSP70 co-chaperone SNL1Add BLAST159

Proteomic databases

MaxQBiP40548
PaxDbiP40548
PRIDEiP40548

Interactioni

Subunit structurei

Interacts with the HSP70 family members SSA1, SSA4, and SSB1. These interactions are strongly reduced by ADP and ATP.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi34972172 interactors.
DIPiDIP-5636N
IntActiP40548 42 interactors.
MINTiP40548
STRINGi4932.YIL016W

Structurei

3D structure databases

ProteinModelPortaliP40548
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini73 – 159BAGPROSITE-ProRule annotationAdd BLAST87

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi42 – 63Lys-richAdd BLAST22

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000000972
InParanoidiP40548
KOiK14017
OMAiCNEMLLK
OrthoDBiEOG092C5LHV

Family and domain databases

Gene3Di1.20.58.1201 hit
InterProiView protein in InterPro
IPR036533 BAG_dom_sf
IPR003103 BAG_domain
PfamiView protein in Pfam
PF02179 BAG, 1 hit
SMARTiView protein in SMART
SM00264 BAG, 1 hit
SUPFAMiSSF63491 SSF63491, 1 hit
PROSITEiView protein in PROSITE
PS51035 BAG, 1 hit

Sequencei

Sequence statusi: Complete.

P40548-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHNAMEHWK SKLSKTSTST YVLLAVIAVV FLVTIRRPNG SKGKSSKKRA
60 70 80 90 100
SKKNKKGKNQ FEKAPVPLTL EEQIDNVSLR YGNELEGRSK DLINRFDVED
110 120 130 140 150
EKDIYERNYC NEMLLKLLIE LDSIDLINVD ESLRRPLKEK RKGVIKEIQA

MLKSLDSLK
Length:159
Mass (Da):18,306
Last modified:February 1, 1995 - v1
Checksum:i05524B473D3E888E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46881 Genomic DNA Translation: CAA86976.1
AY558552 Genomic DNA Translation: AAS56878.1
BK006942 Genomic DNA Translation: DAA08529.1
PIRiS49966
RefSeqiNP_012248.1, NM_001179366.1

Genome annotation databases

EnsemblFungiiYIL016W; YIL016W; YIL016W
GeneIDi854796
KEGGisce:YIL016W

Similar proteinsi

Entry informationi

Entry nameiSNL1_YEAST
AccessioniPrimary (citable) accession number: P40548
Secondary accession number(s): D6VVR3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: February 28, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome