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P40548

- SNL1_YEAST

UniProt

P40548 - SNL1_YEAST

Protein

HSP70 co-chaperone SNL1

Gene

SNL1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Stimulator of ATPase activity of molecular chaperones of the HSP70 family (principally of the SSA class). Stimulation is important for HSP70-substrate complex dissociation after folding of newly synthesized or refolded proteins. SNL1 is probably involved in nuclear pore biogenesis and in particular the folding or refolding of misfolded NUP116, GLE2 and NIC96.2 Publications

    GO - Molecular functioni

    1. ribosome binding Source: SGD

    GO - Biological processi

    1. nuclear pore organization Source: SGD
    2. protein folding Source: SGD

    Keywords - Molecular functioni

    Chaperone

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31292-MONOMER.

    Protein family/group databases

    TCDBi1.I.1.1.1. the nuclear pore complex (npc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    HSP70 co-chaperone SNL1
    Alternative name(s):
    Suppressor of NUP116-C lethal
    Gene namesi
    Name:SNL1
    Ordered Locus Names:YIL016W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome IX

    Organism-specific databases

    CYGDiYIL016w.
    SGDiS000001278. SNL1.

    Subcellular locationi

    Endoplasmic reticulum membrane 1 Publication; Single-pass type II membrane protein 1 Publication. Nucleus membrane 1 Publication; Single-pass type II membrane protein 1 Publication

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: SGD
    2. integral component of membrane Source: UniProtKB-KW
    3. membrane Source: SGD
    4. nuclear envelope Source: SGD
    5. nuclear membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi112 – 1121E → A: Strongly reduces interaction with HSP70 family members. 1 Publication
    Mutagenesisi141 – 1411R → A: Strongly reduces interaction with HSP70 family members. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 159159HSP70 co-chaperone SNL1PRO_0000088881Add
    BLAST

    Proteomic databases

    MaxQBiP40548.
    PaxDbiP40548.

    Expressioni

    Gene expression databases

    GenevestigatoriP40548.

    Interactioni

    Subunit structurei

    Interacts with the HSP70 family members SSA1, SSA4, and SSB1. These interactions are strongly reduced by ADP and ATP.1 Publication

    Protein-protein interaction databases

    BioGridi34972. 108 interactions.
    DIPiDIP-5636N.
    IntActiP40548. 41 interactions.
    MINTiMINT-552100.
    STRINGi4932.YIL016W.

    Structurei

    3D structure databases

    ProteinModelPortaliP40548.
    SMRiP40548. Positions 73-159.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1212Perinuclear spaceAdd
    BLAST
    Topological domaini36 – 159124CytoplasmicAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei13 – 3523Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini73 – 15987BAGPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi42 – 6322Lys-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 BAG domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG77307.
    HOGENOMiHOG000000972.
    KOiK14017.
    OMAiCNEMLLK.
    OrthoDBiEOG78M0F4.

    Family and domain databases

    Gene3Di1.20.58.120. 1 hit.
    InterProiIPR003103. BAG_domain.
    [Graphical view]
    PfamiPF02179. BAG. 1 hit.
    [Graphical view]
    SMARTiSM00264. BAG. 1 hit.
    [Graphical view]
    PROSITEiPS51035. BAG. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P40548-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSHNAMEHWK SKLSKTSTST YVLLAVIAVV FLVTIRRPNG SKGKSSKKRA    50
    SKKNKKGKNQ FEKAPVPLTL EEQIDNVSLR YGNELEGRSK DLINRFDVED 100
    EKDIYERNYC NEMLLKLLIE LDSIDLINVD ESLRRPLKEK RKGVIKEIQA 150
    MLKSLDSLK 159
    Length:159
    Mass (Da):18,306
    Last modified:February 1, 1995 - v1
    Checksum:i05524B473D3E888E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46881 Genomic DNA. Translation: CAA86976.1.
    AY558552 Genomic DNA. Translation: AAS56878.1.
    BK006942 Genomic DNA. Translation: DAA08529.1.
    PIRiS49966.
    RefSeqiNP_012248.1. NM_001179366.1.

    Genome annotation databases

    EnsemblFungiiYIL016W; YIL016W; YIL016W.
    GeneIDi854796.
    KEGGisce:YIL016W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46881 Genomic DNA. Translation: CAA86976.1 .
    AY558552 Genomic DNA. Translation: AAS56878.1 .
    BK006942 Genomic DNA. Translation: DAA08529.1 .
    PIRi S49966.
    RefSeqi NP_012248.1. NM_001179366.1.

    3D structure databases

    ProteinModelPortali P40548.
    SMRi P40548. Positions 73-159.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 34972. 108 interactions.
    DIPi DIP-5636N.
    IntActi P40548. 41 interactions.
    MINTi MINT-552100.
    STRINGi 4932.YIL016W.

    Protein family/group databases

    TCDBi 1.I.1.1.1. the nuclear pore complex (npc) family.

    Proteomic databases

    MaxQBi P40548.
    PaxDbi P40548.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YIL016W ; YIL016W ; YIL016W .
    GeneIDi 854796.
    KEGGi sce:YIL016W.

    Organism-specific databases

    CYGDi YIL016w.
    SGDi S000001278. SNL1.

    Phylogenomic databases

    eggNOGi NOG77307.
    HOGENOMi HOG000000972.
    KOi K14017.
    OMAi CNEMLLK.
    OrthoDBi EOG78M0F4.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31292-MONOMER.

    Miscellaneous databases

    NextBioi 977600.

    Gene expression databases

    Genevestigatori P40548.

    Family and domain databases

    Gene3Di 1.20.58.120. 1 hit.
    InterProi IPR003103. BAG_domain.
    [Graphical view ]
    Pfami PF02179. BAG. 1 hit.
    [Graphical view ]
    SMARTi SM00264. BAG. 1 hit.
    [Graphical view ]
    PROSITEi PS51035. BAG. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. "The integral membrane protein snl1p is genetically linked to yeast nuclear pore complex function."
      Ho A.K., Raczniak G.A., Ives E.B., Wente S.R.
      Mol. Biol. Cell 9:355-373(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, NUCLEAR PORE ASSEMBLY.
    5. "Prediction of novel Bag-1 homologs based on structure/function analysis identifies Snl1p as an Hsp70 co-chaperone in Saccharomyces cerevisiae."
      Sondermann H., Ho A.K., Listenberger L.L., Siegers K., Moarefi I., Wente S.R., Hartl F.-U., Young J.C.
      J. Biol. Chem. 277:33220-33227(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH SSA1; SSA4 AND SSB1, HSP70 CO-CHAPERONE ACTIVITY, MUTAGENESIS OF GLU-112 AND ARG-141.
    6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSNL1_YEAST
    AccessioniPrimary (citable) accession number: P40548
    Secondary accession number(s): D6VVR3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 3346 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome IX
      Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

    External Data

    Dasty 3