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Protein

HSP70 co-chaperone SNL1

Gene

SNL1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Stimulator of ATPase activity of molecular chaperones of the HSP70 family (principally of the SSA class). Stimulation is important for HSP70-substrate complex dissociation after folding of newly synthesized or refolded proteins. SNL1 is probably involved in nuclear pore biogenesis and in particular the folding or refolding of misfolded NUP116, GLE2 and NIC96.2 Publications

GO - Molecular functioni

  1. ribosome binding Source: SGD

GO - Biological processi

  1. nuclear pore organization Source: SGD
  2. protein folding Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Enzyme and pathway databases

BioCyciYEAST:G3O-31292-MONOMER.

Protein family/group databases

TCDBi1.I.1.1.1. the nuclear pore complex (npc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
HSP70 co-chaperone SNL1
Alternative name(s):
Suppressor of NUP116-C lethal
Gene namesi
Name:SNL1
Ordered Locus Names:YIL016W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome IX

Organism-specific databases

CYGDiYIL016w.
EuPathDBiFungiDB:YIL016W.
SGDiS000001278. SNL1.

Subcellular locationi

  1. Endoplasmic reticulum membrane 1 Publication; Single-pass type II membrane protein 1 Publication
  2. Nucleus membrane 1 Publication; Single-pass type II membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1212Perinuclear spaceAdd
BLAST
Transmembranei13 – 3523Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini36 – 159124CytoplasmicAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: SGD
  2. integral component of membrane Source: UniProtKB-KW
  3. membrane Source: SGD
  4. nuclear envelope Source: SGD
  5. nuclear membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi112 – 1121E → A: Strongly reduces interaction with HSP70 family members. 1 Publication
Mutagenesisi141 – 1411R → A: Strongly reduces interaction with HSP70 family members. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 159159HSP70 co-chaperone SNL1PRO_0000088881Add
BLAST

Proteomic databases

MaxQBiP40548.
PaxDbiP40548.

Expressioni

Gene expression databases

GenevestigatoriP40548.

Interactioni

Subunit structurei

Interacts with the HSP70 family members SSA1, SSA4, and SSB1. These interactions are strongly reduced by ADP and ATP.1 Publication

Protein-protein interaction databases

BioGridi34972. 109 interactions.
DIPiDIP-5636N.
IntActiP40548. 41 interactions.
MINTiMINT-552100.
STRINGi4932.YIL016W.

Structurei

3D structure databases

ProteinModelPortaliP40548.
SMRiP40548. Positions 73-159.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini73 – 15987BAGPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi42 – 6322Lys-richAdd
BLAST

Sequence similaritiesi

Contains 1 BAG domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG77307.
HOGENOMiHOG000000972.
InParanoidiP40548.
KOiK14017.
OMAiCNEMLLK.
OrthoDBiEOG78M0F4.

Family and domain databases

Gene3Di1.20.58.120. 1 hit.
InterProiIPR003103. BAG_domain.
[Graphical view]
PfamiPF02179. BAG. 1 hit.
[Graphical view]
SMARTiSM00264. BAG. 1 hit.
[Graphical view]
PROSITEiPS51035. BAG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40548-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHNAMEHWK SKLSKTSTST YVLLAVIAVV FLVTIRRPNG SKGKSSKKRA
60 70 80 90 100
SKKNKKGKNQ FEKAPVPLTL EEQIDNVSLR YGNELEGRSK DLINRFDVED
110 120 130 140 150
EKDIYERNYC NEMLLKLLIE LDSIDLINVD ESLRRPLKEK RKGVIKEIQA

MLKSLDSLK
Length:159
Mass (Da):18,306
Last modified:February 1, 1995 - v1
Checksum:i05524B473D3E888E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46881 Genomic DNA. Translation: CAA86976.1.
AY558552 Genomic DNA. Translation: AAS56878.1.
BK006942 Genomic DNA. Translation: DAA08529.1.
PIRiS49966.
RefSeqiNP_012248.1. NM_001179366.1.

Genome annotation databases

EnsemblFungiiYIL016W; YIL016W; YIL016W.
GeneIDi854796.
KEGGisce:YIL016W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46881 Genomic DNA. Translation: CAA86976.1.
AY558552 Genomic DNA. Translation: AAS56878.1.
BK006942 Genomic DNA. Translation: DAA08529.1.
PIRiS49966.
RefSeqiNP_012248.1. NM_001179366.1.

3D structure databases

ProteinModelPortaliP40548.
SMRiP40548. Positions 73-159.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34972. 109 interactions.
DIPiDIP-5636N.
IntActiP40548. 41 interactions.
MINTiMINT-552100.
STRINGi4932.YIL016W.

Protein family/group databases

TCDBi1.I.1.1.1. the nuclear pore complex (npc) family.

Proteomic databases

MaxQBiP40548.
PaxDbiP40548.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYIL016W; YIL016W; YIL016W.
GeneIDi854796.
KEGGisce:YIL016W.

Organism-specific databases

CYGDiYIL016w.
EuPathDBiFungiDB:YIL016W.
SGDiS000001278. SNL1.

Phylogenomic databases

eggNOGiNOG77307.
HOGENOMiHOG000000972.
InParanoidiP40548.
KOiK14017.
OMAiCNEMLLK.
OrthoDBiEOG78M0F4.

Enzyme and pathway databases

BioCyciYEAST:G3O-31292-MONOMER.

Miscellaneous databases

NextBioi977600.
PROiP40548.

Gene expression databases

GenevestigatoriP40548.

Family and domain databases

Gene3Di1.20.58.120. 1 hit.
InterProiIPR003103. BAG_domain.
[Graphical view]
PfamiPF02179. BAG. 1 hit.
[Graphical view]
SMARTiSM00264. BAG. 1 hit.
[Graphical view]
PROSITEiPS51035. BAG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. "The integral membrane protein snl1p is genetically linked to yeast nuclear pore complex function."
    Ho A.K., Raczniak G.A., Ives E.B., Wente S.R.
    Mol. Biol. Cell 9:355-373(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, NUCLEAR PORE ASSEMBLY.
  5. "Prediction of novel Bag-1 homologs based on structure/function analysis identifies Snl1p as an Hsp70 co-chaperone in Saccharomyces cerevisiae."
    Sondermann H., Ho A.K., Listenberger L.L., Siegers K., Moarefi I., Wente S.R., Hartl F.-U., Young J.C.
    J. Biol. Chem. 277:33220-33227(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH SSA1; SSA4 AND SSB1, HSP70 CO-CHAPERONE ACTIVITY, MUTAGENESIS OF GLU-112 AND ARG-141.
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSNL1_YEAST
AccessioniPrimary (citable) accession number: P40548
Secondary accession number(s): D6VVR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 29, 2015
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 3346 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.