P40546 (FAF1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein FAF1

Alternative name(s):
Forty S assembly factor

Gene names

Name:	FAF1
Ordered Locus Names:	YIL019W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	346 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for pre-rRNA processing and 40S ribosomal subunit assembly. Seems to act in the processing of 35S rRNA at the A0, A1, and A2 cleavage sites. Ref.4
Subunit structure	Interacts with KRR1. Ref.4
Subcellular location	Nucleus › nucleolus Ref.4.

Ontologies

Keywords
Biological process	Ribosome biogenesis
Cellular component	Nucleus
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Inferred from mutant phenotype Ref.4. Source: SGD
Cellular component	cytoplasm Inferred from direct assay. Source: SGD nucleolus Inferred from direct assay Ref.4. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 346	346	Protein FAF1		PRO_0000087172

Sequences

	Sequence		Length	Mass (Da)
	P40546 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: 7DE47A11F3952575	FASTA	346	38,889
	10 20 30 40 50 60 MTLDDDDYIK QMELQRKAFE SQFGSLESMG FEDKTKNIRT EVDTRDSSGD EIDNSDHGSD 70 80 90 100 110 120 FKDGTIESSN SSDEDSGNET AEENNQDSKP KTQPKVIRFN GPSDVYVPPS KKTQKLLRSG 130 140 150 160 170 180 KTLTQINKKL ESTEAKEEKE DETLEAENLQ NDLELQQFLR ESHLLSAFNN GGSGSTNSGV 190 200 210 220 230 240 SLTLQSMGGG NDDGIVYQDD QVIGKARSRT LEMRLNRLSR VNGHQDKINK LEKVPMHIRR 250 260 270 280 290 300 GMIDKHVKRI KKYEQEAAEG GIVLSKVKKG QFRKIESTYK KDIERRIGGS IKARDKEKAT 310 320 330 340 KRERGLKISS VGRSTRNGLI VSKRDIARIS GGERSGKFNG KKKSRR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome IX." Churcher C.M., Bowman S., Badcock K., Bankier A.T., Brown D., Chillingworth T., Connor R., Devlin K., Gentles S., Hamlin N., Harris D.E., Horsnell T., Hunt S., Jagels K., Jones M., Lye G., Moule S., Odell C. , Pearson D., Rajandream M.A., Rice P., Rowley N., Skelton J., Smith V., Walsh S.V., Whitehead S., Barrell B.G. Nature 387:84-87(1997) [PubMed: 9169870] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	"Functional and physical interactions of Faf1p, a Saccharomyces cerevisiae nucleolar protein." Karkusiewicz I., Rempola B., Gromadka R., Grynberg M., Rytka J. Biochem. Biophys. Res. Commun. 319:349-357(2004) [PubMed: 15178413] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH KRR1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z46881 Genomic DNA. Translation: CAA86973.1. AY558089 Genomic DNA. Translation: AAS56415.1. BK006942 Genomic DNA. Translation: DAA08526.1.
PIR	S49963.
RefSeq	NP_012245.1. NM_001179369.1.
3D structure databases
ProteinModelPortal	P40546.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-4404N.
IntAct	P40546. 45 interactions.
MINT	MINT-369020.
STRING	P40546.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YIL019W; YIL019W; YIL019W.
GeneID	854793.
KEGG	sce:YIL019W.
NMPDR	fig|4932.3.peg.1782.
Organism-specific databases
CYGD	YIL019w.
SGD	S000001281. FAF1.
Phylogenomic databases
eggNOG	fuNOG09195.
GeneTree	EFGT00050000002919.
HOGENOM	HBG396938.
OMA	FEAQFGS.
OrthoDB	EOG476P8K.
Gene expression databases
ArrayExpress	P40546.
Genevestigator	P40546.
GermOnline	YIL019W. Saccharomyces cerevisiae.
Family and domain databases
ProtoNet	Search...
Other
NextBio	977591.

Entry information

Entry name

FAF1_YEAST

Accession

Primary (citable) accession number: P40546
Secondary accession number(s): D6VVR0, Q6Q5G5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	December 14, 2011
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program