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P40544

- YKE4_YEAST

UniProt

P40544 - YKE4_YEAST

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Protein

Zinc transporter YKE4

Gene

YKE4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Zinc transporter whose role depends on the zinc status of the cells. It helps to balance zinc levels between the cytosol and the secretory pathway. It transports zinc into the secretory pathway in a zinc-adequate environment and in a high zinc medium. In high zinc medium, transport of zinc into the secretory pathway is a way to eliminate zinc from the cytosol. Under low cytosolic zinc conditions, it removes zinc from the secretory pathway and acts as zinc importer that helps to alleviate ER stress.1 Publication

GO - Molecular functioni

  1. zinc ion transmembrane transporter activity Source: SGD

GO - Biological processi

  1. zinc ion transmembrane transport Source: GOC
  2. zinc ion transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-31298-MONOMER.
ReactomeiREACT_205823. Zinc influx into cells by the SLC39 gene family.

Protein family/group databases

TCDBi2.A.5.4.4. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter YKE4
Gene namesi
Name:YKE4
Ordered Locus Names:YIL023C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IX

Organism-specific databases

CYGDiYIL023c.
SGDiS000001285. YKE4.

Subcellular locationi

Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication

GO - Cellular componenti

  1. endoplasmic reticulum Source: SGD
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346Zinc transporter YKE4PRO_0000213698Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence Analysis
Glycosylationi274 – 2741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi285 – 2851N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP40544.

Expressioni

Gene expression databases

GenevestigatoriP40544.

Interactioni

Protein-protein interaction databases

BioGridi34965. 27 interactions.
DIPiDIP-5638N.
MINTiMINT-480644.
STRINGi4932.YIL023C.

Structurei

3D structure databases

ProteinModelPortaliP40544.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 22ExtracellularSequence Analysis
Topological domaini24 – 6946CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini91 – 999ExtracellularSequence Analysis
Topological domaini121 – 1266CytoplasmicSequence Analysis
Topological domaini148 – 20255ExtracellularSequence AnalysisAdd
BLAST
Topological domaini224 – 25229CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini274 – 29017ExtracellularSequence AnalysisAdd
BLAST
Topological domaini312 – 32211CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini344 – 3463ExtracellularSequence Analysis

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei3 – 2321HelicalSequence AnalysisAdd
BLAST
Transmembranei70 – 9021HelicalSequence AnalysisAdd
BLAST
Transmembranei100 – 12021HelicalSequence AnalysisAdd
BLAST
Transmembranei127 – 14721HelicalSequence AnalysisAdd
BLAST
Transmembranei203 – 22321HelicalSequence AnalysisAdd
BLAST
Transmembranei253 – 27321HelicalSequence AnalysisAdd
BLAST
Transmembranei291 – 31121HelicalSequence AnalysisAdd
BLAST
Transmembranei323 – 34321HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0428.
GeneTreeiENSGT00760000119115.
HOGENOMiHOG000185308.
InParanoidiP40544.
KOiK14713.
OMAiHEANHES.
OrthoDBiEOG7NKKWC.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40544-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKASHICSYL LSIAPLVVSH GVHHNRDHGH EANHESKQSF LILKQESIFY
60 70 80 90 100
SLVCFLQNHL FVLGPRYNAI VAILIIQLMP CLFVLFVPGL RKNDRASLTL
110 120 130 140 150
SLLVSFSLGT LLGDILLHVI PESLSGVTDV TMVGGAIFLG FISFLTLDKT
160 170 180 190 200
MRILSGTSND DGSIHSHSHS HTPQQTAEKK AGFNMSAYLN VISGIAHHIT
210 220 230 240 250
DGIALATSFY SSTQVGIMTS IAVTFHEIPH ELGDFAILLS SGFTFPQAIR
260 270 280 290 300
AQAVTAFGAV VGTSIGCWMN EIGNNSHKAT SSSANASELM LPFTAGGLIY
310 320 330 340
IATTSVVPQI LHSSAPDSKL REFKKWALQL VFIFVGFAVM ALMDEH
Length:346
Mass (Da):37,418
Last modified:February 1, 1995 - v1
Checksum:i645960E194778006
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z46881 Genomic DNA. Translation: CAA86969.1.
BK006942 Genomic DNA. Translation: DAA08522.1.
PIRiS49959.
RefSeqiNP_012241.1. NM_001179373.1.

Genome annotation databases

EnsemblFungiiYIL023C; YIL023C; YIL023C.
GeneIDi854789.
KEGGisce:YIL023C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z46881 Genomic DNA. Translation: CAA86969.1 .
BK006942 Genomic DNA. Translation: DAA08522.1 .
PIRi S49959.
RefSeqi NP_012241.1. NM_001179373.1.

3D structure databases

ProteinModelPortali P40544.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 34965. 27 interactions.
DIPi DIP-5638N.
MINTi MINT-480644.
STRINGi 4932.YIL023C.

Protein family/group databases

TCDBi 2.A.5.4.4. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

Proteomic databases

PaxDbi P40544.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YIL023C ; YIL023C ; YIL023C .
GeneIDi 854789.
KEGGi sce:YIL023C.

Organism-specific databases

CYGDi YIL023c.
SGDi S000001285. YKE4.

Phylogenomic databases

eggNOGi COG0428.
GeneTreei ENSGT00760000119115.
HOGENOMi HOG000185308.
InParanoidi P40544.
KOi K14713.
OMAi HEANHES.
OrthoDBi EOG7NKKWC.

Enzyme and pathway databases

BioCyci YEAST:G3O-31298-MONOMER.
Reactomei REACT_205823. Zinc influx into cells by the SLC39 gene family.

Miscellaneous databases

NextBioi 977579.

Gene expression databases

Genevestigatori P40544.

Family and domain databases

InterProi IPR003689. ZIP.
[Graphical view ]
Pfami PF02535. Zip. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "YKE4 (YIL023C) encodes a bidirectional zinc transporter in the endoplasmic reticulum of Saccharomyces cerevisiae."
    Kumanovics A., Poruk K.E., Osborn K.A., Ward D.M., Kaplan J.
    J. Biol. Chem. 281:22566-22574(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  4. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.

Entry informationi

Entry nameiYKE4_YEAST
AccessioniPrimary (citable) accession number: P40544
Secondary accession number(s): D6VVQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 29, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

External Data

Dasty 3