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Protein

Zinc transporter YKE4

Gene

YKE4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Zinc transporter whose role depends on the zinc status of the cells. It helps to balance zinc levels between the cytosol and the secretory pathway. It transports zinc into the secretory pathway in a zinc-adequate environment and in a high zinc medium. In high zinc medium, transport of zinc into the secretory pathway is a way to eliminate zinc from the cytosol. Under low cytosolic zinc conditions, it removes zinc from the secretory pathway and acts as zinc importer that helps to alleviate ER stress.1 Publication

GO - Molecular functioni

  • zinc ion transmembrane transporter activity Source: SGD

GO - Biological processi

  • cellular zinc ion homeostasis Source: GO_Central
  • zinc II ion transport Source: SGD

Keywordsi

Biological processIon transport, Transport, Zinc transport
LigandZinc

Enzyme and pathway databases

BioCyciYEAST:G3O-31298-MONOMER.
ReactomeiR-SCE-442380. Zinc influx into cells by the SLC39 gene family.

Protein family/group databases

TCDBi2.A.5.4.4. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter YKE4
Gene namesi
Name:YKE4
Ordered Locus Names:YIL023C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IX

Organism-specific databases

EuPathDBiFungiDB:YIL023C.
SGDiS000001285. YKE4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 2ExtracellularSequence analysis2
Transmembranei3 – 23HelicalSequence analysisAdd BLAST21
Topological domaini24 – 69CytoplasmicSequence analysisAdd BLAST46
Transmembranei70 – 90HelicalSequence analysisAdd BLAST21
Topological domaini91 – 99ExtracellularSequence analysis9
Transmembranei100 – 120HelicalSequence analysisAdd BLAST21
Topological domaini121 – 126CytoplasmicSequence analysis6
Transmembranei127 – 147HelicalSequence analysisAdd BLAST21
Topological domaini148 – 202ExtracellularSequence analysisAdd BLAST55
Transmembranei203 – 223HelicalSequence analysisAdd BLAST21
Topological domaini224 – 252CytoplasmicSequence analysisAdd BLAST29
Transmembranei253 – 273HelicalSequence analysisAdd BLAST21
Topological domaini274 – 290ExtracellularSequence analysisAdd BLAST17
Transmembranei291 – 311HelicalSequence analysisAdd BLAST21
Topological domaini312 – 322CytoplasmicSequence analysisAdd BLAST11
Transmembranei323 – 343HelicalSequence analysisAdd BLAST21
Topological domaini344 – 346ExtracellularSequence analysis3

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002136981 – 346Zinc transporter YKE4Add BLAST346

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi184N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi274N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi285N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

BioGridi34965. 51 interactors.
DIPiDIP-5638N.
MINTiMINT-480644.
STRINGi4932.YIL023C.

Structurei

3D structure databases

ProteinModelPortaliP40544.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000119115.
HOGENOMiHOG000185308.
InParanoidiP40544.
KOiK14713.
OMAiVLAHEVP.
OrthoDBiEOG092C3MQW.

Family and domain databases

InterProiView protein in InterPro
IPR003689. ZIP.
PfamiView protein in Pfam
PF02535. Zip. 1 hit.

Sequencei

Sequence statusi: Complete.

P40544-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKASHICSYL LSIAPLVVSH GVHHNRDHGH EANHESKQSF LILKQESIFY
60 70 80 90 100
SLVCFLQNHL FVLGPRYNAI VAILIIQLMP CLFVLFVPGL RKNDRASLTL
110 120 130 140 150
SLLVSFSLGT LLGDILLHVI PESLSGVTDV TMVGGAIFLG FISFLTLDKT
160 170 180 190 200
MRILSGTSND DGSIHSHSHS HTPQQTAEKK AGFNMSAYLN VISGIAHHIT
210 220 230 240 250
DGIALATSFY SSTQVGIMTS IAVTFHEIPH ELGDFAILLS SGFTFPQAIR
260 270 280 290 300
AQAVTAFGAV VGTSIGCWMN EIGNNSHKAT SSSANASELM LPFTAGGLIY
310 320 330 340
IATTSVVPQI LHSSAPDSKL REFKKWALQL VFIFVGFAVM ALMDEH
Length:346
Mass (Da):37,418
Last modified:February 1, 1995 - v1
Checksum:i645960E194778006
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46881 Genomic DNA. Translation: CAA86969.1.
BK006942 Genomic DNA. Translation: DAA08522.1.
PIRiS49959.
RefSeqiNP_012241.1. NM_001179373.1.

Genome annotation databases

EnsemblFungiiYIL023C; YIL023C; YIL023C.
GeneIDi854789.
KEGGisce:YIL023C.

Similar proteinsi

Entry informationi

Entry nameiYKE4_YEAST
AccessioniPrimary (citable) accession number: P40544
Secondary accession number(s): D6VVQ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 25, 2017
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names