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P40544

- YKE4_YEAST

UniProt

P40544 - YKE4_YEAST

Protein

Zinc transporter YKE4

Gene

YKE4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Zinc transporter whose role depends on the zinc status of the cells. It helps to balance zinc levels between the cytosol and the secretory pathway. It transports zinc into the secretory pathway in a zinc-adequate environment and in a high zinc medium. In high zinc medium, transport of zinc into the secretory pathway is a way to eliminate zinc from the cytosol. Under low cytosolic zinc conditions, it removes zinc from the secretory pathway and acts as zinc importer that helps to alleviate ER stress.1 Publication

    GO - Molecular functioni

    1. zinc ion transmembrane transporter activity Source: SGD

    GO - Biological processi

    1. zinc ion transmembrane transport Source: GOC
    2. zinc ion transport Source: SGD

    Keywords - Biological processi

    Ion transport, Transport, Zinc transport

    Keywords - Ligandi

    Zinc

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31298-MONOMER.
    ReactomeiREACT_205823. Zinc influx into cells by the SLC39 gene family.

    Protein family/group databases

    TCDBi2.A.5.4.4. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc transporter YKE4
    Gene namesi
    Name:YKE4
    Ordered Locus Names:YIL023C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome IX

    Organism-specific databases

    CYGDiYIL023c.
    SGDiS000001285. YKE4.

    Subcellular locationi

    Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. endoplasmic reticulum Source: SGD
    2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 346346Zinc transporter YKE4PRO_0000213698Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi274 – 2741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi285 – 2851N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP40544.

    Expressioni

    Gene expression databases

    GenevestigatoriP40544.

    Interactioni

    Protein-protein interaction databases

    BioGridi34965. 26 interactions.
    DIPiDIP-5638N.
    MINTiMINT-480644.
    STRINGi4932.YIL023C.

    Structurei

    3D structure databases

    ProteinModelPortaliP40544.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 22ExtracellularSequence Analysis
    Topological domaini24 – 6946CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini91 – 999ExtracellularSequence Analysis
    Topological domaini121 – 1266CytoplasmicSequence Analysis
    Topological domaini148 – 20255ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini224 – 25229CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini274 – 29017ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini312 – 32211CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini344 – 3463ExtracellularSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei3 – 2321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei70 – 9021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei100 – 12021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei127 – 14721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei203 – 22321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei253 – 27321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei291 – 31121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei323 – 34321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0428.
    GeneTreeiENSGT00750000117326.
    HOGENOMiHOG000185308.
    KOiK14713.
    OMAiHEANHES.
    OrthoDBiEOG7NKKWC.

    Family and domain databases

    InterProiIPR003689. ZIP.
    [Graphical view]
    PfamiPF02535. Zip. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P40544-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKASHICSYL LSIAPLVVSH GVHHNRDHGH EANHESKQSF LILKQESIFY    50
    SLVCFLQNHL FVLGPRYNAI VAILIIQLMP CLFVLFVPGL RKNDRASLTL 100
    SLLVSFSLGT LLGDILLHVI PESLSGVTDV TMVGGAIFLG FISFLTLDKT 150
    MRILSGTSND DGSIHSHSHS HTPQQTAEKK AGFNMSAYLN VISGIAHHIT 200
    DGIALATSFY SSTQVGIMTS IAVTFHEIPH ELGDFAILLS SGFTFPQAIR 250
    AQAVTAFGAV VGTSIGCWMN EIGNNSHKAT SSSANASELM LPFTAGGLIY 300
    IATTSVVPQI LHSSAPDSKL REFKKWALQL VFIFVGFAVM ALMDEH 346
    Length:346
    Mass (Da):37,418
    Last modified:February 1, 1995 - v1
    Checksum:i645960E194778006
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46881 Genomic DNA. Translation: CAA86969.1.
    BK006942 Genomic DNA. Translation: DAA08522.1.
    PIRiS49959.
    RefSeqiNP_012241.1. NM_001179373.1.

    Genome annotation databases

    EnsemblFungiiYIL023C; YIL023C; YIL023C.
    GeneIDi854789.
    KEGGisce:YIL023C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46881 Genomic DNA. Translation: CAA86969.1 .
    BK006942 Genomic DNA. Translation: DAA08522.1 .
    PIRi S49959.
    RefSeqi NP_012241.1. NM_001179373.1.

    3D structure databases

    ProteinModelPortali P40544.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 34965. 26 interactions.
    DIPi DIP-5638N.
    MINTi MINT-480644.
    STRINGi 4932.YIL023C.

    Protein family/group databases

    TCDBi 2.A.5.4.4. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

    Proteomic databases

    PaxDbi P40544.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YIL023C ; YIL023C ; YIL023C .
    GeneIDi 854789.
    KEGGi sce:YIL023C.

    Organism-specific databases

    CYGDi YIL023c.
    SGDi S000001285. YKE4.

    Phylogenomic databases

    eggNOGi COG0428.
    GeneTreei ENSGT00750000117326.
    HOGENOMi HOG000185308.
    KOi K14713.
    OMAi HEANHES.
    OrthoDBi EOG7NKKWC.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31298-MONOMER.
    Reactomei REACT_205823. Zinc influx into cells by the SLC39 gene family.

    Miscellaneous databases

    NextBioi 977579.

    Gene expression databases

    Genevestigatori P40544.

    Family and domain databases

    InterProi IPR003689. ZIP.
    [Graphical view ]
    Pfami PF02535. Zip. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "YKE4 (YIL023C) encodes a bidirectional zinc transporter in the endoplasmic reticulum of Saccharomyces cerevisiae."
      Kumanovics A., Poruk K.E., Osborn K.A., Ward D.M., Kaplan J.
      J. Biol. Chem. 281:22566-22574(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    4. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.

    Entry informationi

    Entry nameiYKE4_YEAST
    AccessioniPrimary (citable) accession number: P40544
    Secondary accession number(s): D6VVQ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome IX
      Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

    External Data

    Dasty 3