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Protein

Ubiquitin-like-specific protease 2

Gene

ULP2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Insertion mutation in SMT4 confers temperature and benomyl sensitivity; high copy suppressor of a temperature sensitive mutation in MIF2.

Catalytic activityi

Hydrolysis of the alpha-linked peptide bond in the sequence Gly-Gly-|-Ala-Thr-Tyr at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptide, Smt3, leading to the mature form of the protein. A second reaction involves the cleavage of an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein.

GO - Molecular functioni

  • cysteine-type peptidase activity Source: SGD
  • SUMO-specific protease activity Source: SGD

GO - Biological processi

  • chromosome condensation Source: SGD
  • mitotic spindle assembly checkpoint Source: SGD
  • plasmid maintenance Source: SGD
  • protein desumoylation Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Enzyme and pathway databases

BioCyciYEAST:G3O-31304-MONOMER.
BRENDAi3.4.22.B67. 984.

Protein family/group databases

MEROPSiC48.005.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-like-specific protease 2 (EC:3.4.22.68)
Gene namesi
Name:ULP2
Synonyms:SMT4
Ordered Locus Names:YIL031W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IX

Organism-specific databases

EuPathDBiFungiDB:YIL031W.
SGDiS000001293. ULP2.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001017321 – 1034Ubiquitin-like-specific protease 2Add BLAST1034

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei788PhosphoserineCombined sources1
Modified residuei903PhosphoserineCombined sources1
Modified residuei983PhosphoserineCombined sources1
Modified residuei984PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP40537.
PRIDEiP40537.

PTM databases

iPTMnetiP40537.

Interactioni

Protein-protein interaction databases

BioGridi34958. 269 interactors.
DIPiDIP-5489N.
IntActiP40537. 9 interactors.
MINTiMINT-492387.

Structurei

3D structure databases

ProteinModelPortaliP40537.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C48 family.Curated

Phylogenomic databases

GeneTreeiENSGT00530000063531.
HOGENOMiHOG000154774.
InParanoidiP40537.
KOiK08596.
OMAiSSTHDIM.
OrthoDBiEOG092C1210.

Family and domain databases

InterProiIPR003653. Peptidase_C48_C.
[Graphical view]
PfamiPF02902. Peptidase_C48. 1 hit.
[Graphical view]
PROSITEiPS50600. ULP_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40537-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSARKRKFNS LKPLDTLNSS RASSPRSSAS LPPKRYNTFR KDPKIVDHLN
60 70 80 90 100
NASTKDFLPV LSMNSESKRQ IELSDNDVDN NDEGEGVNSG CSDQDFEPLQ
110 120 130 140 150
SSPLKRHSSL KSTSNGLLFQ MSNNLGNGSP EPAVASTSPN GSIISTKLNL
160 170 180 190 200
NGQFSCVDSK TLRIYRHKAP CIMTFVSDHN HPKFSLYFQQ SVIYNSQVNL
210 220 230 240 250
LDDVELIILD KKNSFMAIIL KDLKKVKMIL DVNNSSININ TNILIWSTAS
260 270 280 290 300
SASNKKIKSI KRFLLMSYSS SIKVEILDHK EQILERLKHL IHPISSSSPS
310 320 330 340 350
LNMERAINST KNAFDSLRLK KTKLSTNDDE SPQIHTHFLS NKPHGLQSLT
360 370 380 390 400
KRTRIASLGK KEHSISVPKS NISPSDFYNT NGTETLQSHA VSQLRRSNRF
410 420 430 440 450
KDVSDPANSN SNSEFDDATT EFETPELFKP SLCYKFNDGS SYTITNQDFK
460 470 480 490 500
CLFNKDWVND SILDFFTKFY IESSIEKSII KREQVHLMSS FFYTKLISNP
510 520 530 540 550
ADYYSNVKKW VNNTDLFSKK YVVIPINISY HWFSCIITNL DAILDFHQNK
560 570 580 590 600
DKNDAINSDE ISINNPLVNI LTFDSLRQTH SREIDPIKEF LISYALDKYS
610 620 630 640 650
IQLDKTQIKM KTCPVPQQPN MSDCGVHVIL NIRKFFENPV ETIDVWKNSK
660 670 680 690 700
IKSKHFTAKM INKYFDKNER NSARKNLRHT LKLLQLNYIS YLKKENLYEE
710 720 730 740 750
VMQMEEKKST NINNNENYDD DDEEIQIIEN IDQSSKDNNA QLTSEPPCSR
760 770 780 790 800
SSSISTTERE PTELHNSVVR QPTGEIITDN EDPVRAASPE TASVSPPIRH
810 820 830 840 850
NILKSSSPFI SESANETEQE EFTSPYFGRP SLKTRAKQFE GVSSPIKNDQ
860 870 880 890 900
ALSSTHDIMM PSPKPKRIYP SKKIPQLSSH VQSLSTDSME RQSSPNNTNI
910 920 930 940 950
VISDTEQDSR LGVNSESKNT SGIVNRDDSD VNLIGSSLPN VAEKNHDNTQ
960 970 980 990 1000
ESNGNNDSLG KILQNVDKEL NEKLVDIDDV AFSSPTRGIP RTSATSKGSN
1010 1020 1030
AQLLSNYGDE NNQSQDSVWD EGRDNPILLE DEDP
Length:1,034
Mass (Da):116,883
Last modified:February 1, 1995 - v1
Checksum:i782789B3B1DC37F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46861 Genomic DNA. Translation: CAA86920.1.
U27832 Genomic DNA. Translation: AAA69556.1.
BK006942 Genomic DNA. Translation: DAA08516.1.
PIRiS49947.
RefSeqiNP_012233.1. NM_001179381.1.

Genome annotation databases

EnsemblFungiiYIL031W; YIL031W; YIL031W.
GeneIDi854780.
KEGGisce:YIL031W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46861 Genomic DNA. Translation: CAA86920.1.
U27832 Genomic DNA. Translation: AAA69556.1.
BK006942 Genomic DNA. Translation: DAA08516.1.
PIRiS49947.
RefSeqiNP_012233.1. NM_001179381.1.

3D structure databases

ProteinModelPortaliP40537.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34958. 269 interactors.
DIPiDIP-5489N.
IntActiP40537. 9 interactors.
MINTiMINT-492387.

Protein family/group databases

MEROPSiC48.005.

PTM databases

iPTMnetiP40537.

Proteomic databases

MaxQBiP40537.
PRIDEiP40537.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYIL031W; YIL031W; YIL031W.
GeneIDi854780.
KEGGisce:YIL031W.

Organism-specific databases

EuPathDBiFungiDB:YIL031W.
SGDiS000001293. ULP2.

Phylogenomic databases

GeneTreeiENSGT00530000063531.
HOGENOMiHOG000154774.
InParanoidiP40537.
KOiK08596.
OMAiSSTHDIM.
OrthoDBiEOG092C1210.

Enzyme and pathway databases

BioCyciYEAST:G3O-31304-MONOMER.
BRENDAi3.4.22.B67. 984.

Miscellaneous databases

PROiP40537.

Family and domain databases

InterProiIPR003653. Peptidase_C48_C.
[Graphical view]
PfamiPF02902. Peptidase_C48. 1 hit.
[Graphical view]
PROSITEiPS50600. ULP_PROTEASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiULP2_YEAST
AccessioniPrimary (citable) accession number: P40537
Secondary accession number(s): D6VVQ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 450 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.