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P40535

- ACA2_YEAST

UniProt

P40535 - ACA2_YEAST

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Protein

ATF/CREB activator 2

Gene

CST6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcriptional activator of promoters containing ATF/CREB sites. Can independently stimulate transcription through ATF/CREB sites. Important for a variety of biological functions including growth on non-optimal carbon sources.

GO - Molecular functioni

  1. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: SGD
  2. sequence-specific DNA binding Source: SGD

GO - Biological processi

  1. cellular response to carbon dioxide Source: SGD
  2. cellular response to oleic acid Source: SGD
  3. DNA metabolic process Source: SGD
  4. positive regulation of transcription from RNA polymerase II promoter Source: SGD
  5. positive regulation of transcription from RNA polymerase II promoter by oleic acid Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31308-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ATF/CREB activator 2
Alternative name(s):
Chromosome stability protein CST6
Gene namesi
Name:CST6
Synonyms:ACA2
Ordered Locus Names:YIL036W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IX

Organism-specific databases

CYGDiYIL036w.
SGDiS000001298. CST6.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: SGD
  2. nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 587587ATF/CREB activator 2PRO_0000076530Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei171 – 1711Phosphoserine1 Publication
Modified residuei179 – 1791Phosphoserine1 Publication
Modified residuei399 – 3991Phosphoserine1 Publication
Modified residuei557 – 5571Phosphoserine3 Publications
Modified residuei559 – 5591Phosphothreonine4 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP40535.
PaxDbiP40535.
PeptideAtlasiP40535.

Expressioni

Gene expression databases

GenevestigatoriP40535.

Interactioni

Protein-protein interaction databases

BioGridi34954. 57 interactions.
IntActiP40535. 1 interaction.
MINTiMINT-2788526.
STRINGi4932.YIL036W.

Structurei

3D structure databases

ProteinModelPortaliP40535.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini425 – 48864bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni427 – 44721Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni453 – 46715Leucine-zipperPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the bZIP family.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG275055.
GeneTreeiENSGT00530000066653.
InParanoidiP40535.
OMAiRETNARP.
OrthoDBiEOG77M91C.

Family and domain databases

InterProiIPR004827. bZIP.
[Graphical view]
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40535-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFTGQEYHSV DSNSNKQKDN NKRGIDDTSK ILNNKIPHSV SDTSAAATTT
60 70 80 90 100
STMNNSALSR SLDPTDINYS TNMAGVVDQI HDYTTSNRNS LTPQYSIAAG
110 120 130 140 150
NVNSHDRVVK PSANSNYQQA AYLRQQQQQD QRQQSPSMKT EEESQLYGDI
160 170 180 190 200
LMNSGVVQDM HQNLATHTNL SQLSSTRKSA PNDSTTAPTN ASNIANTASV
210 220 230 240 250
NKQMYFMNMN MNNNPHALND PSILETLSPF FQPFGVDVAH LPMTNPPIFQ
260 270 280 290 300
SSLPGCDEPI RRRRISISNG QISQLGEDIE TLENLHNTQP PPMPNFHNYN
310 320 330 340 350
GLSQTRNVSN KPVFNQAVPV SSIPQYNAKK VINPTKDSAL GDQSVIYSKS
360 370 380 390 400
QQRNFVNAPS KNTPAESISD LEGMTTFAPT TGGENRGKSA LRESHSNPSF
410 420 430 440 450
TPKSQGSHLN LAANTQGNPI PGTTAWKRAR LLERNRIAAS KCRQRKKVAQ
460 470 480 490 500
LQLQKEFNEI KDENRILLKK LNYYEKLISK FKKFSKIHLR EHEKLNKDSD
510 520 530 540 550
NNVNGTNSSN KNESMTVDSL KIIEELLMID SDVTEVDKDT GKIIAIKHEP
560 570 580
YSQRFGSDTD DDDIDLKPVE GGKDPDNQSL PNSEKIK
Length:587
Mass (Da):65,264
Last modified:February 1, 1995 - v1
Checksum:i1B98DC38BC8CAE94
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z46861 Genomic DNA. Translation: CAA86915.1.
BK006942 Genomic DNA. Translation: DAA08512.1.
PIRiS49942.
RefSeqiNP_012228.1. NM_001179386.1.

Genome annotation databases

EnsemblFungiiYIL036W; YIL036W; YIL036W.
GeneIDi854775.
KEGGisce:YIL036W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z46861 Genomic DNA. Translation: CAA86915.1 .
BK006942 Genomic DNA. Translation: DAA08512.1 .
PIRi S49942.
RefSeqi NP_012228.1. NM_001179386.1.

3D structure databases

ProteinModelPortali P40535.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 34954. 57 interactions.
IntActi P40535. 1 interaction.
MINTi MINT-2788526.
STRINGi 4932.YIL036W.

Proteomic databases

MaxQBi P40535.
PaxDbi P40535.
PeptideAtlasi P40535.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YIL036W ; YIL036W ; YIL036W .
GeneIDi 854775.
KEGGi sce:YIL036W.

Organism-specific databases

CYGDi YIL036w.
SGDi S000001298. CST6.

Phylogenomic databases

eggNOGi NOG275055.
GeneTreei ENSGT00530000066653.
InParanoidi P40535.
OMAi RETNARP.
OrthoDBi EOG77M91C.

Enzyme and pathway databases

BioCyci YEAST:G3O-31308-MONOMER.

Miscellaneous databases

NextBioi 977547.

Gene expression databases

Genevestigatori P40535.

Family and domain databases

InterProi IPR004827. bZIP.
[Graphical view ]
Pfami PF00170. bZIP_1. 1 hit.
[Graphical view ]
SMARTi SM00338. BRLZ. 1 hit.
[Graphical view ]
PROSITEi PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "New yeast genes important for chromosome integrity and segregation identified by dosage effects on genome stability."
    Ouspenski I.I., Elledge S.J., Brinkley B.R.
    Nucleic Acids Res. 27:3001-3008(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  4. "Aca1 and Aca2, ATF/CREB activators in Saccharomyces cerevisiae, are important for carbon source utilization but not the response to stress."
    Garcia-Gimeno M.A., Struhl K.
    Mol. Cell. Biol. 20:4340-4349(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-557 AND THR-559, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  7. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
    Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
    Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-399 AND THR-559, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-171; SER-557 AND THR-559, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-179; SER-557 AND THR-559, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiACA2_YEAST
AccessioniPrimary (citable) accession number: P40535
Secondary accession number(s): D6VVP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 29, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1240 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

External Data

Dasty 3