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Protein

ATF/CREB activator 2

Gene

CST6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional activator of promoters containing ATF/CREB sites. Can independently stimulate transcription through ATF/CREB sites. Important for a variety of biological functions including growth on non-optimal carbon sources.

Miscellaneous

Present with 1240 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cellular response to carbon dioxide Source: SGD
  • cellular response to oleic acid Source: SGD
  • positive regulation of transcription from RNA polymerase II promoter Source: SGD
  • positive regulation of transcription from RNA polymerase II promoter by oleic acid Source: SGD
  • regulation of transcription from RNA polymerase II promoter in response to stress Source: SGD

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-31308-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ATF/CREB activator 2
Alternative name(s):
Chromosome stability protein CST6
Gene namesi
Name:CST6
Synonyms:ACA2
Ordered Locus Names:YIL036W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IX

Organism-specific databases

EuPathDBiFungiDB:YIL036W.
SGDiS000001298. CST6.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000765301 – 587ATF/CREB activator 2Add BLAST587

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei171PhosphoserineCombined sources1
Modified residuei179PhosphoserineCombined sources1
Modified residuei399PhosphoserineCombined sources1
Modified residuei557PhosphoserineCombined sources1
Modified residuei559PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP40535.
PRIDEiP40535.

PTM databases

iPTMnetiP40535.

Interactioni

Protein-protein interaction databases

BioGridi34954. 174 interactors.
IntActiP40535. 2 interactors.
MINTiMINT-2788526.
STRINGi4932.YIL036W.

Structurei

3D structure databases

ProteinModelPortaliP40535.
SMRiP40535.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini425 – 488bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni427 – 447Basic motifPROSITE-ProRule annotationAdd BLAST21
Regioni453 – 467Leucine-zipperPROSITE-ProRule annotationAdd BLAST15

Sequence similaritiesi

Belongs to the bZIP family.Curated

Phylogenomic databases

GeneTreeiENSGT00530000066653.
InParanoidiP40535.
OrthoDBiEOG092C5V17.

Family and domain databases

InterProiView protein in InterPro
IPR004827. bZIP.
PfamiView protein in Pfam
PF00170. bZIP_1. 1 hit.
SMARTiView protein in SMART
SM00338. BRLZ. 1 hit.
PROSITEiView protein in PROSITE
PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.

Sequencei

Sequence statusi: Complete.

P40535-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFTGQEYHSV DSNSNKQKDN NKRGIDDTSK ILNNKIPHSV SDTSAAATTT
60 70 80 90 100
STMNNSALSR SLDPTDINYS TNMAGVVDQI HDYTTSNRNS LTPQYSIAAG
110 120 130 140 150
NVNSHDRVVK PSANSNYQQA AYLRQQQQQD QRQQSPSMKT EEESQLYGDI
160 170 180 190 200
LMNSGVVQDM HQNLATHTNL SQLSSTRKSA PNDSTTAPTN ASNIANTASV
210 220 230 240 250
NKQMYFMNMN MNNNPHALND PSILETLSPF FQPFGVDVAH LPMTNPPIFQ
260 270 280 290 300
SSLPGCDEPI RRRRISISNG QISQLGEDIE TLENLHNTQP PPMPNFHNYN
310 320 330 340 350
GLSQTRNVSN KPVFNQAVPV SSIPQYNAKK VINPTKDSAL GDQSVIYSKS
360 370 380 390 400
QQRNFVNAPS KNTPAESISD LEGMTTFAPT TGGENRGKSA LRESHSNPSF
410 420 430 440 450
TPKSQGSHLN LAANTQGNPI PGTTAWKRAR LLERNRIAAS KCRQRKKVAQ
460 470 480 490 500
LQLQKEFNEI KDENRILLKK LNYYEKLISK FKKFSKIHLR EHEKLNKDSD
510 520 530 540 550
NNVNGTNSSN KNESMTVDSL KIIEELLMID SDVTEVDKDT GKIIAIKHEP
560 570 580
YSQRFGSDTD DDDIDLKPVE GGKDPDNQSL PNSEKIK
Length:587
Mass (Da):65,264
Last modified:February 1, 1995 - v1
Checksum:i1B98DC38BC8CAE94
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46861 Genomic DNA. Translation: CAA86915.1.
BK006942 Genomic DNA. Translation: DAA08512.1.
PIRiS49942.
RefSeqiNP_012228.1. NM_001179386.1.

Genome annotation databases

EnsemblFungiiYIL036W; YIL036W; YIL036W.
GeneIDi854775.
KEGGisce:YIL036W.

Similar proteinsi

Entry informationi

Entry nameiACA2_YEAST
AccessioniPrimary (citable) accession number: P40535
Secondary accession number(s): D6VVP6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 22, 2017
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names