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P40535

- ACA2_YEAST

UniProt

P40535 - ACA2_YEAST

Protein

ATF/CREB activator 2

Gene

CST6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Transcriptional activator of promoters containing ATF/CREB sites. Can independently stimulate transcription through ATF/CREB sites. Important for a variety of biological functions including growth on non-optimal carbon sources.

    GO - Molecular functioni

    1. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: SGD
    2. sequence-specific DNA binding Source: SGD

    GO - Biological processi

    1. cellular response to carbon dioxide Source: SGD
    2. cellular response to oleic acid Source: SGD
    3. DNA metabolic process Source: SGD
    4. positive regulation of transcription from RNA polymerase II promoter Source: SGD
    5. positive regulation of transcription from RNA polymerase II promoter by oleic acid Source: SGD

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31308-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATF/CREB activator 2
    Alternative name(s):
    Chromosome stability protein CST6
    Gene namesi
    Name:CST6
    Synonyms:ACA2
    Ordered Locus Names:YIL036W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome IX

    Organism-specific databases

    CYGDiYIL036w.
    SGDiS000001298. CST6.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: SGD
    2. nucleus Source: SGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 587587ATF/CREB activator 2PRO_0000076530Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei171 – 1711Phosphoserine1 Publication
    Modified residuei179 – 1791Phosphoserine1 Publication
    Modified residuei399 – 3991Phosphoserine1 Publication
    Modified residuei557 – 5571Phosphoserine3 Publications
    Modified residuei559 – 5591Phosphothreonine4 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP40535.
    PaxDbiP40535.
    PeptideAtlasiP40535.

    Expressioni

    Gene expression databases

    GenevestigatoriP40535.

    Interactioni

    Protein-protein interaction databases

    BioGridi34954. 56 interactions.
    IntActiP40535. 1 interaction.
    MINTiMINT-2788526.
    STRINGi4932.YIL036W.

    Structurei

    3D structure databases

    ProteinModelPortaliP40535.
    SMRiP40535. Positions 425-477.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini425 – 48864bZIPPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni427 – 44721Basic motifPROSITE-ProRule annotationAdd
    BLAST
    Regioni453 – 46715Leucine-zipperPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the bZIP family.Curated
    Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG275055.
    GeneTreeiENSGT00530000066653.
    OMAiRETNARP.
    OrthoDBiEOG77M91C.

    Family and domain databases

    InterProiIPR004827. bZIP.
    [Graphical view]
    PfamiPF00170. bZIP_1. 1 hit.
    [Graphical view]
    SMARTiSM00338. BRLZ. 1 hit.
    [Graphical view]
    PROSITEiPS50217. BZIP. 1 hit.
    PS00036. BZIP_BASIC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P40535-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFTGQEYHSV DSNSNKQKDN NKRGIDDTSK ILNNKIPHSV SDTSAAATTT    50
    STMNNSALSR SLDPTDINYS TNMAGVVDQI HDYTTSNRNS LTPQYSIAAG 100
    NVNSHDRVVK PSANSNYQQA AYLRQQQQQD QRQQSPSMKT EEESQLYGDI 150
    LMNSGVVQDM HQNLATHTNL SQLSSTRKSA PNDSTTAPTN ASNIANTASV 200
    NKQMYFMNMN MNNNPHALND PSILETLSPF FQPFGVDVAH LPMTNPPIFQ 250
    SSLPGCDEPI RRRRISISNG QISQLGEDIE TLENLHNTQP PPMPNFHNYN 300
    GLSQTRNVSN KPVFNQAVPV SSIPQYNAKK VINPTKDSAL GDQSVIYSKS 350
    QQRNFVNAPS KNTPAESISD LEGMTTFAPT TGGENRGKSA LRESHSNPSF 400
    TPKSQGSHLN LAANTQGNPI PGTTAWKRAR LLERNRIAAS KCRQRKKVAQ 450
    LQLQKEFNEI KDENRILLKK LNYYEKLISK FKKFSKIHLR EHEKLNKDSD 500
    NNVNGTNSSN KNESMTVDSL KIIEELLMID SDVTEVDKDT GKIIAIKHEP 550
    YSQRFGSDTD DDDIDLKPVE GGKDPDNQSL PNSEKIK 587
    Length:587
    Mass (Da):65,264
    Last modified:February 1, 1995 - v1
    Checksum:i1B98DC38BC8CAE94
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46861 Genomic DNA. Translation: CAA86915.1.
    BK006942 Genomic DNA. Translation: DAA08512.1.
    PIRiS49942.
    RefSeqiNP_012228.1. NM_001179386.1.

    Genome annotation databases

    EnsemblFungiiYIL036W; YIL036W; YIL036W.
    GeneIDi854775.
    KEGGisce:YIL036W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46861 Genomic DNA. Translation: CAA86915.1 .
    BK006942 Genomic DNA. Translation: DAA08512.1 .
    PIRi S49942.
    RefSeqi NP_012228.1. NM_001179386.1.

    3D structure databases

    ProteinModelPortali P40535.
    SMRi P40535. Positions 425-477.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 34954. 56 interactions.
    IntActi P40535. 1 interaction.
    MINTi MINT-2788526.
    STRINGi 4932.YIL036W.

    Proteomic databases

    MaxQBi P40535.
    PaxDbi P40535.
    PeptideAtlasi P40535.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YIL036W ; YIL036W ; YIL036W .
    GeneIDi 854775.
    KEGGi sce:YIL036W.

    Organism-specific databases

    CYGDi YIL036w.
    SGDi S000001298. CST6.

    Phylogenomic databases

    eggNOGi NOG275055.
    GeneTreei ENSGT00530000066653.
    OMAi RETNARP.
    OrthoDBi EOG77M91C.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31308-MONOMER.

    Miscellaneous databases

    NextBioi 977547.

    Gene expression databases

    Genevestigatori P40535.

    Family and domain databases

    InterProi IPR004827. bZIP.
    [Graphical view ]
    Pfami PF00170. bZIP_1. 1 hit.
    [Graphical view ]
    SMARTi SM00338. BRLZ. 1 hit.
    [Graphical view ]
    PROSITEi PS50217. BZIP. 1 hit.
    PS00036. BZIP_BASIC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "New yeast genes important for chromosome integrity and segregation identified by dosage effects on genome stability."
      Ouspenski I.I., Elledge S.J., Brinkley B.R.
      Nucleic Acids Res. 27:3001-3008(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    4. "Aca1 and Aca2, ATF/CREB activators in Saccharomyces cerevisiae, are important for carbon source utilization but not the response to stress."
      Garcia-Gimeno M.A., Struhl K.
      Mol. Cell. Biol. 20:4340-4349(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    6. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
      Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
      J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-557 AND THR-559, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: ADR376.
    7. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
      Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
      Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-399 AND THR-559, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-171; SER-557 AND THR-559, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-179; SER-557 AND THR-559, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiACA2_YEAST
    AccessioniPrimary (citable) accession number: P40535
    Secondary accession number(s): D6VVP6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 1240 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome IX
      Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

    External Data

    Dasty 3