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Protein

ATF/CREB activator 2

Gene

CST6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional activator of promoters containing ATF/CREB sites. Can independently stimulate transcription through ATF/CREB sites. Important for a variety of biological functions including growth on non-optimal carbon sources.

GO - Molecular functioni

GO - Biological processi

  • cellular response to carbon dioxide Source: SGD
  • cellular response to oleic acid Source: SGD
  • positive regulation of transcription from RNA polymerase II promoter Source: SGD
  • positive regulation of transcription from RNA polymerase II promoter by oleic acid Source: SGD
  • regulation of transcription from RNA polymerase II promoter in response to stress Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31308-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ATF/CREB activator 2
Alternative name(s):
Chromosome stability protein CST6
Gene namesi
Name:CST6
Synonyms:ACA2
Ordered Locus Names:YIL036W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IX

Organism-specific databases

EuPathDBiFungiDB:YIL036W.
SGDiS000001298. CST6.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: SGD
  • nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000765301 – 587ATF/CREB activator 2Add BLAST587

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei171PhosphoserineCombined sources1
Modified residuei179PhosphoserineCombined sources1
Modified residuei399PhosphoserineCombined sources1
Modified residuei557PhosphoserineCombined sources1
Modified residuei559PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP40535.
PRIDEiP40535.

PTM databases

iPTMnetiP40535.

Interactioni

Protein-protein interaction databases

BioGridi34954. 61 interactors.
IntActiP40535. 2 interactors.
MINTiMINT-2788526.

Structurei

3D structure databases

ProteinModelPortaliP40535.
SMRiP40535.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini425 – 488bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni427 – 447Basic motifPROSITE-ProRule annotationAdd BLAST21
Regioni453 – 467Leucine-zipperPROSITE-ProRule annotationAdd BLAST15

Sequence similaritiesi

Belongs to the bZIP family.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00530000066653.
InParanoidiP40535.
OrthoDBiEOG092C5V17.

Family and domain databases

InterProiIPR004827. bZIP.
[Graphical view]
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40535-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFTGQEYHSV DSNSNKQKDN NKRGIDDTSK ILNNKIPHSV SDTSAAATTT
60 70 80 90 100
STMNNSALSR SLDPTDINYS TNMAGVVDQI HDYTTSNRNS LTPQYSIAAG
110 120 130 140 150
NVNSHDRVVK PSANSNYQQA AYLRQQQQQD QRQQSPSMKT EEESQLYGDI
160 170 180 190 200
LMNSGVVQDM HQNLATHTNL SQLSSTRKSA PNDSTTAPTN ASNIANTASV
210 220 230 240 250
NKQMYFMNMN MNNNPHALND PSILETLSPF FQPFGVDVAH LPMTNPPIFQ
260 270 280 290 300
SSLPGCDEPI RRRRISISNG QISQLGEDIE TLENLHNTQP PPMPNFHNYN
310 320 330 340 350
GLSQTRNVSN KPVFNQAVPV SSIPQYNAKK VINPTKDSAL GDQSVIYSKS
360 370 380 390 400
QQRNFVNAPS KNTPAESISD LEGMTTFAPT TGGENRGKSA LRESHSNPSF
410 420 430 440 450
TPKSQGSHLN LAANTQGNPI PGTTAWKRAR LLERNRIAAS KCRQRKKVAQ
460 470 480 490 500
LQLQKEFNEI KDENRILLKK LNYYEKLISK FKKFSKIHLR EHEKLNKDSD
510 520 530 540 550
NNVNGTNSSN KNESMTVDSL KIIEELLMID SDVTEVDKDT GKIIAIKHEP
560 570 580
YSQRFGSDTD DDDIDLKPVE GGKDPDNQSL PNSEKIK
Length:587
Mass (Da):65,264
Last modified:February 1, 1995 - v1
Checksum:i1B98DC38BC8CAE94
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46861 Genomic DNA. Translation: CAA86915.1.
BK006942 Genomic DNA. Translation: DAA08512.1.
PIRiS49942.
RefSeqiNP_012228.1. NM_001179386.1.

Genome annotation databases

EnsemblFungiiYIL036W; YIL036W; YIL036W.
GeneIDi854775.
KEGGisce:YIL036W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46861 Genomic DNA. Translation: CAA86915.1.
BK006942 Genomic DNA. Translation: DAA08512.1.
PIRiS49942.
RefSeqiNP_012228.1. NM_001179386.1.

3D structure databases

ProteinModelPortaliP40535.
SMRiP40535.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34954. 61 interactors.
IntActiP40535. 2 interactors.
MINTiMINT-2788526.

PTM databases

iPTMnetiP40535.

Proteomic databases

MaxQBiP40535.
PRIDEiP40535.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYIL036W; YIL036W; YIL036W.
GeneIDi854775.
KEGGisce:YIL036W.

Organism-specific databases

EuPathDBiFungiDB:YIL036W.
SGDiS000001298. CST6.

Phylogenomic databases

GeneTreeiENSGT00530000066653.
InParanoidiP40535.
OrthoDBiEOG092C5V17.

Enzyme and pathway databases

BioCyciYEAST:G3O-31308-MONOMER.

Miscellaneous databases

PROiP40535.

Family and domain databases

InterProiIPR004827. bZIP.
[Graphical view]
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACA2_YEAST
AccessioniPrimary (citable) accession number: P40535
Secondary accession number(s): D6VVP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1240 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.