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P40535 (ACA2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ATF/CREB activator 2
Alternative name(s):
Chromosome stability protein CST6
Gene names
Name:CST6
Synonyms:ACA2
Ordered Locus Names:YIL036W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length587 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcriptional activator of promoters containing ATF/CREB sites. Can independently stimulate transcription through ATF/CREB sites. Important for a variety of biological functions including growth on non-optimal carbon sources.

Subcellular location

Nucleus.

Miscellaneous

Present with 1240 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the bZIP family.

Contains 1 bZIP (basic-leucine zipper) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 587587ATF/CREB activator 2
PRO_0000076530

Regions

Domain425 – 48864bZIP
Region427 – 44721Basic motif By similarity
Region453 – 46715Leucine-zipper By similarity

Amino acid modifications

Modified residue1711Phosphoserine Ref.8
Modified residue1791Phosphoserine Ref.9
Modified residue3991Phosphoserine Ref.7
Modified residue5571Phosphoserine Ref.6 Ref.8 Ref.9
Modified residue5591Phosphothreonine Ref.6 Ref.7 Ref.8 Ref.9

Sequences

Sequence LengthMass (Da)Tools
P40535 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 1B98DC38BC8CAE94

FASTA58765,264
        10         20         30         40         50         60 
MFTGQEYHSV DSNSNKQKDN NKRGIDDTSK ILNNKIPHSV SDTSAAATTT STMNNSALSR 

        70         80         90        100        110        120 
SLDPTDINYS TNMAGVVDQI HDYTTSNRNS LTPQYSIAAG NVNSHDRVVK PSANSNYQQA 

       130        140        150        160        170        180 
AYLRQQQQQD QRQQSPSMKT EEESQLYGDI LMNSGVVQDM HQNLATHTNL SQLSSTRKSA 

       190        200        210        220        230        240 
PNDSTTAPTN ASNIANTASV NKQMYFMNMN MNNNPHALND PSILETLSPF FQPFGVDVAH 

       250        260        270        280        290        300 
LPMTNPPIFQ SSLPGCDEPI RRRRISISNG QISQLGEDIE TLENLHNTQP PPMPNFHNYN 

       310        320        330        340        350        360 
GLSQTRNVSN KPVFNQAVPV SSIPQYNAKK VINPTKDSAL GDQSVIYSKS QQRNFVNAPS 

       370        380        390        400        410        420 
KNTPAESISD LEGMTTFAPT TGGENRGKSA LRESHSNPSF TPKSQGSHLN LAANTQGNPI 

       430        440        450        460        470        480 
PGTTAWKRAR LLERNRIAAS KCRQRKKVAQ LQLQKEFNEI KDENRILLKK LNYYEKLISK 

       490        500        510        520        530        540 
FKKFSKIHLR EHEKLNKDSD NNVNGTNSSN KNESMTVDSL KIIEELLMID SDVTEVDKDT 

       550        560        570        580 
GKIIAIKHEP YSQRFGSDTD DDDIDLKPVE GGKDPDNQSL PNSEKIK 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome IX."
Churcher C.M., Bowman S., Badcock K., Bankier A.T., Brown D., Chillingworth T., Connor R., Devlin K., Gentles S., Hamlin N., Harris D.E., Horsnell T., Hunt S., Jagels K., Jones M., Lye G., Moule S., Odell C. expand/collapse author list , Pearson D., Rajandream M.A., Rice P., Rowley N., Skelton J., Smith V., Walsh S.V., Whitehead S., Barrell B.G.
Nature 387:84-87(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"New yeast genes important for chromosome integrity and segregation identified by dosage effects on genome stability."
Ouspenski I.I., Elledge S.J., Brinkley B.R.
Nucleic Acids Res. 27:3001-3008(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[4]"Aca1 and Aca2, ATF/CREB activators in Saccharomyces cerevisiae, are important for carbon source utilization but not the response to stress."
Garcia-Gimeno M.A., Struhl K.
Mol. Cell. Biol. 20:4340-4349(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[5]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]"Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-557 AND THR-559, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Strain: ADR376.
[7]"Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-399 AND THR-559, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-171; SER-557 AND THR-559, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]"Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-179; SER-557 AND THR-559, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z46861 Genomic DNA. Translation: CAA86915.1.
BK006942 Genomic DNA. Translation: DAA08512.1.
PIRS49942.
RefSeqNP_012228.1. NM_001179386.1.

3D structure databases

ProteinModelPortalP40535.
SMRP40535. Positions 425-477.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid34954. 56 interactions.
IntActP40535. 1 interaction.
MINTMINT-2788526.
STRING4932.YIL036W.

Proteomic databases

MaxQBP40535.
PaxDbP40535.
PeptideAtlasP40535.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYIL036W; YIL036W; YIL036W.
GeneID854775.
KEGGsce:YIL036W.

Organism-specific databases

CYGDYIL036w.
SGDS000001298. CST6.

Phylogenomic databases

eggNOGNOG275055.
GeneTreeENSGT00530000066653.
OMARETNARP.
OrthoDBEOG77M91C.

Enzyme and pathway databases

BioCycYEAST:G3O-31308-MONOMER.

Gene expression databases

GenevestigatorP40535.

Family and domain databases

InterProIPR004827. bZIP.
[Graphical view]
PfamPF00170. bZIP_1. 1 hit.
[Graphical view]
SMARTSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio977547.

Entry information

Entry nameACA2_YEAST
AccessionPrimary (citable) accession number: P40535
Secondary accession number(s): D6VVP6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 11, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome IX

Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families