ATF/CREB activator 2 - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

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P40535 (ACA2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 103. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
ATF/CREB activator 2

Alternative name(s):
Chromosome stability protein CST6

Gene names

Name:	CST6
Synonyms:	ACA2
Ordered Locus Names:	YIL036W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›

Protein attributes

Sequence length	587 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Transcriptional activator of promoters containing ATF/CREB sites. Can independently stimulate transcription through ATF/CREB sites. Important for a variety of biological functions including growth on non-optimal carbon sources.
Subcellular location	Nucleus.
Miscellaneous	Present with 1240 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the bZIP family. Contains 1 bZIP (basic-leucine zipper) domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding
Molecular function	Repressor
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA metabolic process Inferred from mutant phenotype Ref.3. Source: SGD cellular response to carbon dioxide Inferred from mutant phenotype PubMed 22253597. Source: SGD cellular response to oleic acid Inferred from mutant phenotype PubMed 20395639. Source: SGD positive regulation of transcription from RNA polymerase II promoter by oleic acid Inferred from mutant phenotype PubMed 20395639. Source: SGD
Cellular_component	nucleus Inferred by curator Ref.4. Source: SGD
Molecular_function	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Inferred from direct assay Ref.4. Source: SGD sequence-specific DNA binding Inferred from direct assay Ref.4 PubMed 19111667. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 587

587

ATF/CREB activator 2

PRO_0000076530

Regions

Domain

425 – 488

bZIP

Region

427 – 447

Basic motif By similarity

Region

453 – 467

Leucine-zipper By similarity

Amino acid modifications

Modified residue

Phosphoserine Ref.9

Modified residue

171

Phosphoserine Ref.9

Modified residue

266

Phosphoserine Ref.9

Modified residue

394

Phosphoserine Ref.8

Modified residue

396

Phosphoserine Ref.7 Ref.8 Ref.9

Modified residue

399

Phosphoserine Ref.7

Modified residue

404

Phosphoserine Ref.9

Modified residue

407

Phosphoserine Ref.9

Modified residue

557

Phosphoserine Ref.6 Ref.7 Ref.8 Ref.9

Modified residue

559

Phosphothreonine Ref.6 Ref.7 Ref.8 Ref.9

Sequences

Sequence

Length

Mass (Da)

Tools

P40535 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 1B98DC38BC8CAE94
Show »

FASTA

587

65,264

        10         20         30         40         50         60 
MFTGQEYHSV DSNSNKQKDN NKRGIDDTSK ILNNKIPHSV SDTSAAATTT STMNNSALSR 

        70         80         90        100        110        120 
SLDPTDINYS TNMAGVVDQI HDYTTSNRNS LTPQYSIAAG NVNSHDRVVK PSANSNYQQA 

       130        140        150        160        170        180 
AYLRQQQQQD QRQQSPSMKT EEESQLYGDI LMNSGVVQDM HQNLATHTNL SQLSSTRKSA 

       190        200        210        220        230        240 
PNDSTTAPTN ASNIANTASV NKQMYFMNMN MNNNPHALND PSILETLSPF FQPFGVDVAH 

       250        260        270        280        290        300 
LPMTNPPIFQ SSLPGCDEPI RRRRISISNG QISQLGEDIE TLENLHNTQP PPMPNFHNYN 

       310        320        330        340        350        360 
GLSQTRNVSN KPVFNQAVPV SSIPQYNAKK VINPTKDSAL GDQSVIYSKS QQRNFVNAPS 

       370        380        390        400        410        420 
KNTPAESISD LEGMTTFAPT TGGENRGKSA LRESHSNPSF TPKSQGSHLN LAANTQGNPI 

       430        440        450        460        470        480 
PGTTAWKRAR LLERNRIAAS KCRQRKKVAQ LQLQKEFNEI KDENRILLKK LNYYEKLISK 

       490        500        510        520        530        540 
FKKFSKIHLR EHEKLNKDSD NNVNGTNSSN KNESMTVDSL KIIEELLMID SDVTEVDKDT 

       550        560        570        580 
GKIIAIKHEP YSQRFGSDTD DDDIDLKPVE GGKDPDNQSL PNSEKIK

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome IX." Churcher C.M., Bowman S., Badcock K., Bankier A.T., Brown D., Chillingworth T., Connor R., Devlin K., Gentles S., Hamlin N., Harris D.E., Horsnell T., Hunt S., Jagels K., Jones M., Lye G., Moule S., Odell C. Barrell B.G. Nature 387:84-87(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"New yeast genes important for chromosome integrity and segregation identified by dosage effects on genome stability." Ouspenski I.I., Elledge S.J., Brinkley B.R. Nucleic Acids Res. 27:3001-3008(1999) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[4]	"Aca1 and Aca2, ATF/CREB activators in Saccharomyces cerevisiae, are important for carbon source utilization but not the response to stress." Garcia-Gimeno M.A., Struhl K. Mol. Cell. Biol. 20:4340-4349(2000) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION.
[5]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]	"Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae." Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P. J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-557 AND THR-559, MASS SPECTROMETRY. Strain: ADR376.
[7]	"Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry." Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F. Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-396; SER-399; SER-557 AND THR-559, MASS SPECTROMETRY.
[8]	"Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases." Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H. Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-394; SER-396; SER-557 AND THR-559, MASS SPECTROMETRY.
[9]	"A multidimensional chromatography technology for in-depth phosphoproteome analysis." Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H. Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-90; SER-171; SER-266; SER-396; SER-404; SER-407; SER-557 AND THR-559, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z46861 Genomic DNA. Translation: CAA86915.1. BK006942 Genomic DNA. Translation: DAA08512.1.
PIR	S49942.
RefSeq	NP_012228.1. NM_001179386.1.
3D structure databases
ProteinModelPortal	P40535.
SMR	P40535. Positions 425-477.
ModBase	Search...
Protein-protein interaction databases
IntAct	P40535. 1 interaction.
MINT	MINT-2788526.
STRING	4932.YIL036W.
Proteomic databases
PaxDb	P40535.
PeptideAtlas	P40535.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YIL036W; YIL036W; YIL036W.
GeneID	854775.
KEGG	sce:YIL036W.
Organism-specific databases
CYGD	YIL036w.
SGD	S000001298. CST6.
Phylogenomic databases
eggNOG	NOG275055.
GeneTree	ENSGT00530000066653.
OrthoDB	EOG4CC79X.
Gene expression databases
Genevestigator	P40535.
GermOnline	YIL036W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR004827. bZIP. [Graphical view]
Pfam	PF00170. bZIP_1. 1 hit. [Graphical view]
SMART	SM00338. BRLZ. 1 hit. [Graphical view]
PROSITE	PS50217. BZIP. 1 hit. PS00036. BZIP_BASIC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	977547.

Entry information

Entry name

ACA2_YEAST

Accession

Primary (citable) accession number: P40535
Secondary accession number(s): D6VVP6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	May 1, 2013
This is version 103 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome IX

Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents