P40534 (PRM2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pheromone-regulated membrane protein 3

Gene names

Name:	PRM2
Ordered Locus Names:	YIL037C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	656 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Induction	By pheromone. Ref.3

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	karyogamy involved in conjugation with cellular fusion Inferred from mutant phenotype PubMed 17101777. Source: SGD
Cellular_component	integral to membrane Inferred from sequence model PubMed 12192589. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 656	656	Pheromone-regulated membrane protein 3		PRO_0000202994
Regions
	Transmembrane	16 – 36	21	Helical; Potential
	Transmembrane	320 – 340	21	Helical; Potential
	Transmembrane	422 – 442	21	Helical; Potential
	Transmembrane	634 – 654	21	Helical; Potential
Amino acid modifications
	Modified residue	474	1	Phosphothreonine Ref.4

Sequences

	Sequence		Length	Mass (Da)
	P40534 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: 63787C6982065607	FASTA	656	75,021
	10 20 30 40 50 60 MNNVHIIKPL SLPQRFFSCI FHPLLLIFFT SVILTIWGSF SVIDITMAKM SHAQVKRNDT 70 80 90 100 110 120 VSTFASISTA TATATTTATT TATMTAVTTQ HAIYSANSYS LNKTFIDNTI DQYFESKLRS 130 140 150 160 170 180 IESTVGTDMQ EKFKSYTDDI LDNKQKLIND QISLETELIK EVLEVNNTIF NELLTKSQLI 190 200 210 220 230 240 NDTWNEISED AMTIDKDSIS QMASNLLLNY SMFDSIFGNY SRKLKSLQNF NGTITDFSTQ 250 260 270 280 290 300 LDTSSTLSLN FLRNSTDWLQ LKRNFTANLQ NEISILSGGS TEVTSSTSII KRSLKTNSEE 310 320 330 340 350 360 NSVLSAVKNH VFRKCKRMTI IFTVMYFAFV ILLMAIERIL FQLENQQVNL VMSQINGLTG 370 380 390 400 410 420 QTNFTKYNKV LKSLITTLNL STLYPIPYQL TKLINQKIFK REPEKIDDKK VKKSKLFYCN 430 440 450 460 470 480 WWIISNGAHL WLFGFLMLLI HWQIVTRLTN FEVPSLPTFH KRAGPSLYKR EVWTDGNITT 490 500 510 520 530 540 TIEGFINDSV SLLCENFQME VNEKFITANL SLQTDPNLKV QSTDILNLWV NDTNTQFEKY 550 560 570 580 590 600 LNESSQNWQG IDLQVEPLLG SDSINEFLGQ YFLPTYEVTN TNSSFALDIQ KYGIINRGIN 610 620 630 640 650 ITNASVAALS SLSKRQIKDK EQKQTYFLHT VYKWGLLAVC LTILFHHMLI FIILKL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome IX." Churcher C.M., Bowman S., Badcock K., Bankier A.T., Brown D., Chillingworth T., Connor R., Devlin K., Gentles S., Hamlin N., Harris D.E., Horsnell T., Hunt S., Jagels K., Jones M., Lye G., Moule S., Odell C. , Pearson D., Rajandream M.A., Rice P., Rowley N., Skelton J., Smith V., Walsh S.V., Whitehead S., Barrell B.G. Nature 387:84-87(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Prm1p, a pheromone-regulated multispanning membrane protein, facilitates plasma membrane fusion during yeast mating." Heiman M.G., Walter P. J. Cell Biol. 151:719-730(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NOMENCLATURE, INDUCTION.
[4]	"A multidimensional chromatography technology for in-depth phosphoproteome analysis." Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H. Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-474, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z46861 Genomic DNA. Translation: CAA86914.1. BK006942 Genomic DNA. Translation: DAA08511.1.
PIR	S49941.
RefSeq	NP_012227.3. NM_001179387.3.
3D structure databases
ProteinModelPortal	P40534.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-6544N.
IntAct	P40534. 1 interaction.
MINT	MINT-698729.
STRING	4932.YIL037C.
Proteomic databases
PaxDb	P40534.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YIL037C; YIL037C; YIL037C.
GeneID	854774.
KEGG	sce:YIL029C. sce:YIL037C.
Organism-specific databases
CYGD	YIL037c.
SGD	S000001299. PRM2.
Phylogenomic databases
eggNOG	NOG299052.
OMA	HAIYSAN.
OrthoDB	EOG4SN4ZN.
Gene expression databases
Genevestigator	P40534.
GermOnline	YIL037C. Saccharomyces cerevisiae.
Family and domain databases
ProtoNet	Search...
Other
NextBio	977544.

Entry information

Entry name

PRM2_YEAST

Accession

Primary (citable) accession number: P40534
Secondary accession number(s): D6VVP5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	April 3, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program