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Protein

Protein TED1

Gene

TED1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Acts together with EMP24 and ERV25 in cargo exit from the endoplasmic reticulum.1 Publication

GO - Molecular functioni

GO - Biological processi

  • ER to Golgi vesicle-mediated transport Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-31311-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein TED1
Alternative name(s):
Trafficking of EMP24/ERV25-dependent cargo disrupted protein 1
Gene namesi
Name:TED1
Ordered Locus Names:YIL039W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome IX

Organism-specific databases

CYGDiYIL039w.
EuPathDBiFungiDB:YIL039W.
SGDiS000001301. TED1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 88CytoplasmicSequence Analysis
Transmembranei9 – 2921HelicalSequence AnalysisAdd
BLAST
Topological domaini30 – 451422LumenalSequence AnalysisAdd
BLAST
Transmembranei452 – 47221HelicalSequence AnalysisAdd
BLAST
Topological domaini473 – 4731CytoplasmicSequence Analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 473473Protein TED1PRO_0000202993Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi38 – 381N-linked (GlcNAc...)Sequence Analysis
Glycosylationi147 – 1471N-linked (GlcNAc...)Sequence Analysis
Glycosylationi229 – 2291N-linked (GlcNAc...)Sequence Analysis
Glycosylationi266 – 2661N-linked (GlcNAc...)Sequence Analysis
Glycosylationi307 – 3071N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP40533.
PaxDbiP40533.
PeptideAtlasiP40533.

Interactioni

Protein-protein interaction databases

BioGridi34951. 76 interactions.
DIPiDIP-4575N.
IntActiP40533. 2 interactions.
MINTiMINT-503750.

Structurei

3D structure databases

ProteinModelPortaliP40533.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG302374.
HOGENOMiHOG000093805.
InParanoidiP40533.
OMAiGDPQING.
OrthoDBiEOG74TX7M.

Family and domain databases

Gene3Di3.60.21.10. 2 hits.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 3 hits.

Sequencei

Sequence statusi: Complete.

P40533-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRCAVKKFA YFATFLTIVA NIYIYTYPSF HPEQCSWNCS NKNAPLQKDL
60 70 80 90 100
TFVDKVKNYF SDVREQWHGS HASAGNDEDI HILAFGDPQI KGIWPKTPYV
110 120 130 140 150
SRLDTYGNDY YLGHIYDMMQ QRLKPQVVTV MGDLFSSQWI GDSEFHNRTK
160 170 180 190 200
RYISRIFKRD PTSIENIKQQ NLDEKGQYKA NWPEWGDRFN EILDNVKENE
210 220 230 240 250
ADNQELSFGF GYENIHSWNP DLEDFLIINI TGNHDVGYSG DATYQHMTRF
260 270 280 290 300
HDLFGKDNYW IEYETNTTHP WRIVVLNDLL LEGPALQPEF VEATWIFLNQ
310 320 330 340 350
LNERKFNGST VLLTHVPFYK REGLCVDGPD TRYYPDAHAP ESYKSGLLRS
360 370 380 390 400
QNHLSESVSN QVLNMIFENG KPGIILTGHD HEGCETVYNK KSTSTWEATK
410 420 430 440 450
NIESDVFVKE ITVKSMMGEF NGNTGLVTGH FNTDSMTWEW TFSLCPFAIQ
460 470
HVWWFAKVSL LVTIFTWSSL LFV
Length:473
Mass (Da):54,928
Last modified:February 1, 1995 - v1
Checksum:i3D8AF321C9BAFDE8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46861 Genomic DNA. Translation: CAA86912.1.
BK006942 Genomic DNA. Translation: DAA08509.1.
PIRiS49939.
RefSeqiNP_012225.1. NM_001179389.1.

Genome annotation databases

EnsemblFungiiYIL039W; YIL039W; YIL039W.
GeneIDi854772.
KEGGisce:YIL039W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46861 Genomic DNA. Translation: CAA86912.1.
BK006942 Genomic DNA. Translation: DAA08509.1.
PIRiS49939.
RefSeqiNP_012225.1. NM_001179389.1.

3D structure databases

ProteinModelPortaliP40533.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34951. 76 interactions.
DIPiDIP-4575N.
IntActiP40533. 2 interactions.
MINTiMINT-503750.

Proteomic databases

MaxQBiP40533.
PaxDbiP40533.
PeptideAtlasiP40533.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYIL039W; YIL039W; YIL039W.
GeneIDi854772.
KEGGisce:YIL039W.

Organism-specific databases

CYGDiYIL039w.
EuPathDBiFungiDB:YIL039W.
SGDiS000001301. TED1.

Phylogenomic databases

eggNOGiNOG302374.
HOGENOMiHOG000093805.
InParanoidiP40533.
OMAiGDPQING.
OrthoDBiEOG74TX7M.

Enzyme and pathway databases

BioCyciYEAST:G3O-31311-MONOMER.

Miscellaneous databases

NextBioi977538.
PROiP40533.

Family and domain databases

Gene3Di3.60.21.10. 2 hits.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 3 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "Identification of yeast proteins necessary for cell-surface function of a potassium channel."
    Haass F.A., Jonikas M., Walter P., Weissman J.S., Jan Y.-N., Jan L.Y., Schuldiner M.
    Proc. Natl. Acad. Sci. U.S.A. 104:18079-18084(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  6. "Global analysis of the glycoproteome in Saccharomyces cerevisiae reveals new roles for protein glycosylation in eukaryotes."
    Kung L.A., Tao S.-C., Qian J., Smith M.G., Snyder M., Zhu H.
    Mol. Syst. Biol. 5:308-308(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTED1_YEAST
AccessioniPrimary (citable) accession number: P40533
Secondary accession number(s): D6VVP3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: July 22, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1070 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.