P40533 (TED1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein TED1

Alternative name(s):
Trafficking of EMP24/ERV25-dependent cargo disrupted protein 1

Gene names

Name:	TED1
Ordered Locus Names:	YIL039W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	473 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Acts together with EMP24 and ERV25 in cargo exit from the endoplasmic reticulum. Ref.5
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein Potential Ref.3 Ref.5.
Post-translational modification	N-glycosylated.
Miscellaneous	Present with 1070 molecules/cell in log phase SD medium.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ER to Golgi vesicle-mediated transport Inferred from mutant phenotype Ref.5. Source: SGD
Cellular_component	endoplasmic reticulum Inferred from direct assay Ref.3. Source: SGD endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	hydrolase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 473	473	Protein TED1		PRO_0000202993
Regions
	Topological domain	1 – 8	8	Cytoplasmic Potential
	Transmembrane	9 – 29	21	Helical; Potential
	Topological domain	30 – 451	422	Lumenal Potential
	Transmembrane	452 – 472	21	Helical; Potential
	Topological domain	473	1	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	38	1	N-linked (GlcNAc...) Potential
	Glycosylation	147	1	N-linked (GlcNAc...) Potential
	Glycosylation	229	1	N-linked (GlcNAc...) Potential
	Glycosylation	266	1	N-linked (GlcNAc...) Potential
	Glycosylation	307	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	P40533 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: 3D8AF321C9BAFDE8	FASTA	473	54,928
	10 20 30 40 50 60 MLRCAVKKFA YFATFLTIVA NIYIYTYPSF HPEQCSWNCS NKNAPLQKDL TFVDKVKNYF 70 80 90 100 110 120 SDVREQWHGS HASAGNDEDI HILAFGDPQI KGIWPKTPYV SRLDTYGNDY YLGHIYDMMQ 130 140 150 160 170 180 QRLKPQVVTV MGDLFSSQWI GDSEFHNRTK RYISRIFKRD PTSIENIKQQ NLDEKGQYKA 190 200 210 220 230 240 NWPEWGDRFN EILDNVKENE ADNQELSFGF GYENIHSWNP DLEDFLIINI TGNHDVGYSG 250 260 270 280 290 300 DATYQHMTRF HDLFGKDNYW IEYETNTTHP WRIVVLNDLL LEGPALQPEF VEATWIFLNQ 310 320 330 340 350 360 LNERKFNGST VLLTHVPFYK REGLCVDGPD TRYYPDAHAP ESYKSGLLRS QNHLSESVSN 370 380 390 400 410 420 QVLNMIFENG KPGIILTGHD HEGCETVYNK KSTSTWEATK NIESDVFVKE ITVKSMMGEF 430 440 450 460 470 NGNTGLVTGH FNTDSMTWEW TFSLCPFAIQ HVWWFAKVSL LVTIFTWSSL LFV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome IX." Churcher C.M., Bowman S., Badcock K., Bankier A.T., Brown D., Chillingworth T., Connor R., Devlin K., Gentles S., Hamlin N., Harris D.E., Horsnell T., Hunt S., Jagels K., Jones M., Lye G., Moule S., Odell C. , Pearson D., Rajandream M.A., Rice P., Rowley N., Skelton J., Smith V., Walsh S.V., Whitehead S., Barrell B.G. Nature 387:84-87(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[4]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]	"Identification of yeast proteins necessary for cell-surface function of a potassium channel." Haass F.A., Jonikas M., Walter P., Weissman J.S., Jan Y.-N., Jan L.Y., Schuldiner M. Proc. Natl. Acad. Sci. U.S.A. 104:18079-18084(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
[6]	"Global analysis of the glycoproteome in Saccharomyces cerevisiae reveals new roles for protein glycosylation in eukaryotes." Kung L.A., Tao S.-C., Qian J., Smith M.G., Snyder M., Zhu H. Mol. Syst. Biol. 5:308-308(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z46861 Genomic DNA. Translation: CAA86912.1. BK006942 Genomic DNA. Translation: DAA08509.1.
PIR	S49939.
RefSeq	NP_012225.1. NM_001179389.1.
3D structure databases
ProteinModelPortal	P40533.
SMR	P40533. Positions 79-138.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-4575N.
IntAct	P40533. 2 interactions.
MINT	MINT-503750.
STRING	4932.YIL039W.
Proteomic databases
PaxDb	P40533.
PeptideAtlas	P40533.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YIL039W; YIL039W; YIL039W.
GeneID	854772.
KEGG	sce:YIL039W.
Organism-specific databases
CYGD	YIL039w.
SGD	S000001301. TED1.
Phylogenomic databases
eggNOG	NOG302374.
HOGENOM	HOG000093805.
OMA	DYYLGHI.
OrthoDB	EOG4ZPJ40.
Gene expression databases
Genevestigator	P40533.
GermOnline	YIL039W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR004843. Metallo_PEstase_dom. [Graphical view]
Pfam	PF00149. Metallophos. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	977538.

Entry information

Entry name

TED1_YEAST

Accession

Primary (citable) accession number: P40533
Secondary accession number(s): D6VVP3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	April 3, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program