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Protein

Protein GVP36

Gene

GVP36

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. endocytosis Source: SGD
  2. establishment or maintenance of actin cytoskeleton polarity Source: SGD
  3. vacuole organization Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-31313-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein GVP36
Alternative name(s):
36 kDa Golgi vesicle protein
Gene namesi
Name:GVP36
Ordered Locus Names:YIL041W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome IX

Organism-specific databases

CYGDiYIL041w.
EuPathDBiFungiDB:YIL041W.
SGDiS000001303. GVP36.

Subcellular locationi

  1. Golgi apparatus membrane 1 Publication; Peripheral membrane protein 1 Publication

GO - Cellular componenti

  1. integral component of Golgi membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 326325Protein GVP36PRO_0000083881Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication
Modified residuei2 – 21Phosphoserine1 Publication
Cross-linki305 – 305Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki313 – 313Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei319 – 3191Phosphoserine3 Publications

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP40531.
PaxDbiP40531.
PeptideAtlasiP40531.

2D gel databases

UCD-2DPAGEP40531.

Expressioni

Gene expression databases

GenevestigatoriP40531.

Interactioni

Protein-protein interaction databases

BioGridi34949. 67 interactions.
IntActiP40531. 4 interactions.
MINTiMINT-2494160.
STRINGi4932.YIL041W.

Structurei

3D structure databases

ProteinModelPortaliP40531.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG73175.
GeneTreeiENSGT00730000114835.
HOGENOMiHOG000164027.
InParanoidiP40531.
OMAiVGVMKNV.
OrthoDBiEOG7034T7.

Family and domain databases

Gene3Di1.20.1270.60. 1 hit.
InterProiIPR027267. AH/BAR-dom.
IPR018859. BAR_dom-cont.
[Graphical view]
PfamiPF10455. BAR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P40531-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFNAFASSL SKKLQEISTS VSEKTQELPS LAQSTQRMVQ ERLGQVTDIS
60 70 80 90 100
QLPREYTELE DKVDTIKLIY NHFLGVTAIY ENGSYDYPKY INESVNEFSR
110 120 130 140 150
SVASKLTELT HATSASEAQN ILVAPGPIKE PKTLNYALSK VALNSSECLN
160 170 180 190 200
KMFPTEEQPL ASALLQFSDV QAKIAQARIQ QDTLIQTKFN KNLRERLSFE
210 220 230 240 250
IGKADKCRKD VHSMRLRYDV ARTNLANNKK PEKEASLRVQ METLEDQFAQ
260 270 280 290 300
VTEDATVCLQ EVISHANFSE DLKELAKAQA EYFETSAGLM KEFLSNSFAE
310 320
EPEAKPEVAE EEKPQTAISM NDEDDA
Length:326
Mass (Da):36,670
Last modified:February 1, 1995 - v1
Checksum:iA692CE1C7A62F351
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46861 Genomic DNA. Translation: CAA86910.1.
BK006942 Genomic DNA. Translation: DAA08507.1.
PIRiS49937.
RefSeqiNP_012223.3. NM_001179391.3.

Genome annotation databases

EnsemblFungiiYIL041W; YIL041W; YIL041W.
GeneIDi854770.
KEGGisce:YIL041W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46861 Genomic DNA. Translation: CAA86910.1.
BK006942 Genomic DNA. Translation: DAA08507.1.
PIRiS49937.
RefSeqiNP_012223.3. NM_001179391.3.

3D structure databases

ProteinModelPortaliP40531.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34949. 67 interactions.
IntActiP40531. 4 interactions.
MINTiMINT-2494160.
STRINGi4932.YIL041W.

2D gel databases

UCD-2DPAGEP40531.

Proteomic databases

MaxQBiP40531.
PaxDbiP40531.
PeptideAtlasiP40531.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYIL041W; YIL041W; YIL041W.
GeneIDi854770.
KEGGisce:YIL041W.

Organism-specific databases

CYGDiYIL041w.
EuPathDBiFungiDB:YIL041W.
SGDiS000001303. GVP36.

Phylogenomic databases

eggNOGiNOG73175.
GeneTreeiENSGT00730000114835.
HOGENOMiHOG000164027.
InParanoidiP40531.
OMAiVGVMKNV.
OrthoDBiEOG7034T7.

Enzyme and pathway databases

BioCyciYEAST:G3O-31313-MONOMER.

Miscellaneous databases

NextBioi977532.
PROiP40531.

Gene expression databases

GenevestigatoriP40531.

Family and domain databases

Gene3Di1.20.1270.60. 1 hit.
InterProiIPR027267. AH/BAR-dom.
IPR018859. BAR_dom-cont.
[Graphical view]
PfamiPF10455. BAR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Bienvenut W.V., Peters C.
    Submitted (JUN-2005) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 25-37; 90-100 AND 141-151, IDENTIFICATION BY MASS SPECTROMETRY.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-305 AND LYS-313.
    Strain: SUB592.
  6. "Immunoisolaton of the yeast Golgi subcompartments and characterization of a novel membrane protein, Svp26, discovered in the Sed5-containing compartments."
    Inadome H., Noda Y., Adachi H., Yoda K.
    Mol. Cell. Biol. 25:7696-7710(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  7. "Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway."
    Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J., Mann M., Jensen O.N.
    Mol. Cell. Proteomics 4:310-327(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    Strain: YAL6B.
  8. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-319, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  9. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-319, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-319, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Sites of ubiquitin attachment in Saccharomyces cerevisiae."
    Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.
    Proteomics 12:236-240(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGVP36_YEAST
AccessioniPrimary (citable) accession number: P40531
Secondary accession number(s): D6VVP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 29, 2015
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 7721 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.