Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P40528 (SYG1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein SYG1
Gene names
Name:SYG1
Ordered Locus Names:YIL047C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length902 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May function in G-protein coupled signal transduction. Ref.1

Subcellular location

Cell membrane; Multi-pass membrane protein Ref.1.

Miscellaneous

Present with 1160 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the SYG1 (TC 2.A.94) family. [View classification]

Contains 1 EXS domain.

Contains 1 SPX domain.

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

itself1EBI-18696,EBI-18696
FTH1P383101EBI-18696,EBI-20959

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 902902Protein SYG1
PRO_0000072382

Regions

Topological domain1 – 404404Cytoplasmic Potential
Transmembrane405 – 42521Helical; Potential
Topological domain426 – 43510Extracellular Potential
Transmembrane436 – 45621Helical; Potential
Topological domain457 – 49741Cytoplasmic Potential
Transmembrane498 – 51821Helical; Potential
Topological domain519 – 5224Extracellular Potential
Transmembrane523 – 54321Helical; Potential
Topological domain544 – 55411Cytoplasmic Potential
Transmembrane555 – 57521Helical; Potential
Topological domain5761Extracellular Potential
Transmembrane577 – 59923Helical; Potential
Topological domain600 – 732133Cytoplasmic Potential
Transmembrane733 – 75321Helical; Potential
Topological domain754 – 7618Extracellular Potential
Transmembrane762 – 78221Helical; Potential
Topological domain783 – 902120Cytoplasmic Potential
Domain1 – 303303SPX
Domain606 – 815210EXS

Amino acid modifications

Modified residue1721Phosphoserine Ref.7
Modified residue1791Phosphoserine Ref.7
Modified residue8591Phosphoserine Ref.6 Ref.8
Modified residue8601Phosphoserine Ref.6 Ref.8

Sequences

Sequence LengthMass (Da)Tools
P40528 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: F8D87D1DDB3AED64

FASTA902104,218
        10         20         30         40         50         60 
MKFADHLTES AIPEWRDKYI DYKVGKKKLR RYKEKLDAEE EQSSSYRSWM PSVSVYQTAF 

        70         80         90        100        110        120 
QQREPGKSRS DGDYRSGPAF KKDYSALQRE FVADFIEDWL ISFQLSKCNE FYLWLLKECD 

       130        140        150        160        170        180 
KKFEVLQSQL HYYSLQKNYE RDNLNRSSSN VDMSTSLYAA GLAGRSDSRV NSIDSDSRSV 

       190        200        210        220        230        240 
MYGSMPCTKE AKKPRLSLLA YCQKVLKDNR LLPSWPKRGF SLLQDLRQDA SSRGRETFAF 

       250        260        270        280        290        300 
GASFLETMTT TQARNLLSNA IIEYYLYLQL VKSFRDINVT GFRKMVKKFD KTCHTRELTT 

       310        320        330        340        350        360 
FMSYARTHYT LFKHADANVQ LVAQKMQQIT SSQPTPTSEL SSAQRDKEPI TWLETQITEW 

       370        380        390        400        410        420 
FTTALTNSPK DRKHNTHKLK KLTIQYSISE QMVHRNNRSI VQMLVVGLGI GVSMTLITYT 

       430        440        450        460        470        480 
LYLGISSEET SFTHKILFPL WGGWYMVLLI AFLFLVNCFI WHRTGINYRF IMLGEIQSKN 

       490        500        510        520        530        540 
GTQFFNNDFA TSKIPLKLYF LTFFIVPCAV CSMLSFALEK LTPLGFLYIG IVSFLFLCPS 

       550        560        570        580        590        600 
GLIPYWDKVV HTRKWLVVTL IRLMMSGFFP VEFGDFFLGD IICSLTYSIA DIAMFFCVYS 

       610        620        630        640        650        660 
HTPNNLCGSS HSRAMGVLSC LPSYWRFMQC LRRFADSGDW FPHLLNAAKY TLGIAYNATL 

       670        680        690        700        710        720 
CAYRLSDRSE QRRTPFIVCA TLNSILTSAW DLVMDWSFAH NTTSYNWLLR DDLYLAGKKN 

       730        740        750        760        770        780 
WENGSYSFSR KLVYYFAMIW DILIRFEWIV YAIAPQTIQQ SAVTSFILAL LEVLRRFVWI 

       790        800        810        820        830        840 
IFRVENEHVA NVHLFRVTGD APLPYPIAQV GDDSMDSSDL GSKAFSSLND IPITPSHDNN 

       850        860        870        880        890        900 
PHSFAEPMPA YRGTFRRRSS VFENISRSIP WAHATDFQRP TVNTVDDRSP ETDSESEVES 


IM 

« Hide

References

« Hide 'large scale' references
[1]"Truncated forms of a novel yeast protein suppress the lethality of a G protein alpha subunit deficiency by interacting with the beta subunit."
Spain B.H., Koo D., Ramakrishnan M., Dzudzor B., Colicelli J.
J. Biol. Chem. 270:25435-25444(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH STE4.
Strain: SP1.
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome IX."
Churcher C.M., Bowman S., Badcock K., Bankier A.T., Brown D., Chillingworth T., Connor R., Devlin K., Gentles S., Hamlin N., Harris D.E., Horsnell T., Hunt S., Jagels K., Jones M., Lye G., Moule S., Odell C. expand/collapse author list , Pearson D., Rajandream M.A., Rice P., Rowley N., Skelton J., Smith V., Walsh S.V., Whitehead S., Barrell B.G.
Nature 387:84-87(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
[6]"Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-859 AND SER-860, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Strain: ADR376.
[7]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-172 AND SER-179, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]"Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-859 AND SER-860, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U14726 Genomic DNA. Translation: AAA91621.1.
Z46861 Genomic DNA. Translation: CAA86904.1.
BK006942 Genomic DNA. Translation: DAA08500.1.
PIRS49931.
RefSeqNP_012217.3. NM_001179397.3.

3D structure databases

ProteinModelPortalP40528.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid34943. 39 interactions.
DIPDIP-2383N.
IntActP40528. 2 interactions.
MINTMINT-599154.
STRING4932.YIL047C.

Proteomic databases

PaxDbP40528.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYIL047C; YIL047C; YIL047C.
GeneID854764.
KEGGsce:YIL047C.

Organism-specific databases

CYGDYIL047c.
SGDS000001309. SYG1.

Phylogenomic databases

eggNOGCOG5408.
GeneTreeENSGT00500000044895.
HOGENOMHOG000141697.
OMAINYRFIM.
OrthoDBEOG75F4P9.

Enzyme and pathway databases

BioCycYEAST:G3O-31318-MONOMER.

Gene expression databases

GenevestigatorP40528.

Family and domain databases

InterProIPR004342. EXS_C.
IPR004331. SPX_N.
[Graphical view]
PfamPF03124. EXS. 1 hit.
PF03105. SPX. 1 hit.
[Graphical view]
PROSITEPS51380. EXS. 1 hit.
PS51382. SPX. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio977514.
PROP40528.

Entry information

Entry nameSYG1_YEAST
AccessionPrimary (citable) accession number: P40528
Secondary accession number(s): D6VVN4, P40964
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: March 19, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome IX

Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families