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P40528

- SYG1_YEAST

UniProt

P40528 - SYG1_YEAST

Protein

Protein SYG1

Gene

SYG1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    May function in G-protein coupled signal transduction.1 Publication

    GO - Biological processi

    1. signal transduction Source: SGD

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31318-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein SYG1
    Gene namesi
    Name:SYG1
    Ordered Locus Names:YIL047C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome IX

    Organism-specific databases

    CYGDiYIL047c.
    SGDiS000001309. SYG1.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: SGD

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 902902Protein SYG1PRO_0000072382Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei172 – 1721Phosphoserine1 Publication
    Modified residuei179 – 1791Phosphoserine1 Publication
    Modified residuei859 – 8591Phosphoserine2 Publications
    Modified residuei860 – 8601Phosphoserine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP40528.
    PaxDbiP40528.

    Expressioni

    Gene expression databases

    GenevestigatoriP40528.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself1EBI-18696,EBI-18696
    FTH1P383101EBI-18696,EBI-20959

    Protein-protein interaction databases

    BioGridi34943. 39 interactions.
    DIPiDIP-2383N.
    IntActiP40528. 2 interactions.
    MINTiMINT-599154.
    STRINGi4932.YIL047C.

    Structurei

    3D structure databases

    ProteinModelPortaliP40528.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 404404CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini426 – 43510ExtracellularSequence Analysis
    Topological domaini457 – 49741CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini519 – 5224ExtracellularSequence Analysis
    Topological domaini544 – 55411CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini576 – 5761ExtracellularSequence Analysis
    Topological domaini600 – 732133CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini754 – 7618ExtracellularSequence Analysis
    Topological domaini783 – 902120CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei405 – 42521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei436 – 45621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei498 – 51821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei523 – 54321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei555 – 57521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei577 – 59923HelicalSequence AnalysisAdd
    BLAST
    Transmembranei733 – 75321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei762 – 78221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 303303SPXPROSITE-ProRule annotationAdd
    BLAST
    Domaini606 – 815210EXSPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 EXS domain.PROSITE-ProRule annotation
    Contains 1 SPX domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5408.
    GeneTreeiENSGT00500000044895.
    HOGENOMiHOG000141697.
    OMAiINYRFIM.
    OrthoDBiEOG75F4P9.

    Family and domain databases

    InterProiIPR004342. EXS_C.
    IPR004331. SPX_N.
    [Graphical view]
    PfamiPF03124. EXS. 1 hit.
    PF03105. SPX. 1 hit.
    [Graphical view]
    PROSITEiPS51380. EXS. 1 hit.
    PS51382. SPX. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P40528-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKFADHLTES AIPEWRDKYI DYKVGKKKLR RYKEKLDAEE EQSSSYRSWM    50
    PSVSVYQTAF QQREPGKSRS DGDYRSGPAF KKDYSALQRE FVADFIEDWL 100
    ISFQLSKCNE FYLWLLKECD KKFEVLQSQL HYYSLQKNYE RDNLNRSSSN 150
    VDMSTSLYAA GLAGRSDSRV NSIDSDSRSV MYGSMPCTKE AKKPRLSLLA 200
    YCQKVLKDNR LLPSWPKRGF SLLQDLRQDA SSRGRETFAF GASFLETMTT 250
    TQARNLLSNA IIEYYLYLQL VKSFRDINVT GFRKMVKKFD KTCHTRELTT 300
    FMSYARTHYT LFKHADANVQ LVAQKMQQIT SSQPTPTSEL SSAQRDKEPI 350
    TWLETQITEW FTTALTNSPK DRKHNTHKLK KLTIQYSISE QMVHRNNRSI 400
    VQMLVVGLGI GVSMTLITYT LYLGISSEET SFTHKILFPL WGGWYMVLLI 450
    AFLFLVNCFI WHRTGINYRF IMLGEIQSKN GTQFFNNDFA TSKIPLKLYF 500
    LTFFIVPCAV CSMLSFALEK LTPLGFLYIG IVSFLFLCPS GLIPYWDKVV 550
    HTRKWLVVTL IRLMMSGFFP VEFGDFFLGD IICSLTYSIA DIAMFFCVYS 600
    HTPNNLCGSS HSRAMGVLSC LPSYWRFMQC LRRFADSGDW FPHLLNAAKY 650
    TLGIAYNATL CAYRLSDRSE QRRTPFIVCA TLNSILTSAW DLVMDWSFAH 700
    NTTSYNWLLR DDLYLAGKKN WENGSYSFSR KLVYYFAMIW DILIRFEWIV 750
    YAIAPQTIQQ SAVTSFILAL LEVLRRFVWI IFRVENEHVA NVHLFRVTGD 800
    APLPYPIAQV GDDSMDSSDL GSKAFSSLND IPITPSHDNN PHSFAEPMPA 850
    YRGTFRRRSS VFENISRSIP WAHATDFQRP TVNTVDDRSP ETDSESEVES 900
    IM 902
    Length:902
    Mass (Da):104,218
    Last modified:February 1, 1995 - v1
    Checksum:iF8D87D1DDB3AED64
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U14726 Genomic DNA. Translation: AAA91621.1.
    Z46861 Genomic DNA. Translation: CAA86904.1.
    BK006942 Genomic DNA. Translation: DAA08500.1.
    PIRiS49931.
    RefSeqiNP_012217.3. NM_001179397.3.

    Genome annotation databases

    EnsemblFungiiYIL047C; YIL047C; YIL047C.
    GeneIDi854764.
    KEGGisce:YIL047C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U14726 Genomic DNA. Translation: AAA91621.1 .
    Z46861 Genomic DNA. Translation: CAA86904.1 .
    BK006942 Genomic DNA. Translation: DAA08500.1 .
    PIRi S49931.
    RefSeqi NP_012217.3. NM_001179397.3.

    3D structure databases

    ProteinModelPortali P40528.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 34943. 39 interactions.
    DIPi DIP-2383N.
    IntActi P40528. 2 interactions.
    MINTi MINT-599154.
    STRINGi 4932.YIL047C.

    Proteomic databases

    MaxQBi P40528.
    PaxDbi P40528.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YIL047C ; YIL047C ; YIL047C .
    GeneIDi 854764.
    KEGGi sce:YIL047C.

    Organism-specific databases

    CYGDi YIL047c.
    SGDi S000001309. SYG1.

    Phylogenomic databases

    eggNOGi COG5408.
    GeneTreei ENSGT00500000044895.
    HOGENOMi HOG000141697.
    OMAi INYRFIM.
    OrthoDBi EOG75F4P9.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31318-MONOMER.

    Miscellaneous databases

    NextBioi 977514.
    PROi P40528.

    Gene expression databases

    Genevestigatori P40528.

    Family and domain databases

    InterProi IPR004342. EXS_C.
    IPR004331. SPX_N.
    [Graphical view ]
    Pfami PF03124. EXS. 1 hit.
    PF03105. SPX. 1 hit.
    [Graphical view ]
    PROSITEi PS51380. EXS. 1 hit.
    PS51382. SPX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Truncated forms of a novel yeast protein suppress the lethality of a G protein alpha subunit deficiency by interacting with the beta subunit."
      Spain B.H., Koo D., Ramakrishnan M., Dzudzor B., Colicelli J.
      J. Biol. Chem. 270:25435-25444(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH STE4.
      Strain: SP1.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    5. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.
    6. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
      Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
      J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-859 AND SER-860, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: ADR376.
    7. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-172 AND SER-179, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-859 AND SER-860, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSYG1_YEAST
    AccessioniPrimary (citable) accession number: P40528
    Secondary accession number(s): D6VVN4, P40964
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 1160 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome IX
      Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

    External Data

    Dasty 3