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Protein

Protein SYG1

Gene

SYG1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May function in G-protein coupled signal transduction.1 Publication

GO - Biological processi

  • signal transduction Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-31318-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SYG1
Gene namesi
Name:SYG1
Ordered Locus Names:YIL047C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome IX

Organism-specific databases

CYGDiYIL047c.
EuPathDBiFungiDB:YIL047C.
SGDiS000001309. SYG1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 404404CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei405 – 42521HelicalSequence AnalysisAdd
BLAST
Topological domaini426 – 43510ExtracellularSequence Analysis
Transmembranei436 – 45621HelicalSequence AnalysisAdd
BLAST
Topological domaini457 – 49741CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei498 – 51821HelicalSequence AnalysisAdd
BLAST
Topological domaini519 – 5224ExtracellularSequence Analysis
Transmembranei523 – 54321HelicalSequence AnalysisAdd
BLAST
Topological domaini544 – 55411CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei555 – 57521HelicalSequence AnalysisAdd
BLAST
Topological domaini576 – 5761ExtracellularSequence Analysis
Transmembranei577 – 59923HelicalSequence AnalysisAdd
BLAST
Topological domaini600 – 732133CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei733 – 75321HelicalSequence AnalysisAdd
BLAST
Topological domaini754 – 7618ExtracellularSequence Analysis
Transmembranei762 – 78221HelicalSequence AnalysisAdd
BLAST
Topological domaini783 – 902120CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 902902Protein SYG1PRO_0000072382Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei172 – 1721Phosphoserine1 Publication
Modified residuei179 – 1791Phosphoserine1 Publication
Modified residuei859 – 8591Phosphoserine2 Publications
Modified residuei860 – 8601Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP40528.
PaxDbiP40528.

Expressioni

Gene expression databases

GenevestigatoriP40528.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself1EBI-18696,EBI-18696
FTH1P383101EBI-18696,EBI-20959

Protein-protein interaction databases

BioGridi34943. 39 interactions.
DIPiDIP-2383N.
IntActiP40528. 2 interactions.
MINTiMINT-599154.
STRINGi4932.YIL047C.

Structurei

3D structure databases

ProteinModelPortaliP40528.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 303303SPXPROSITE-ProRule annotationAdd
BLAST
Domaini606 – 815210EXSPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 EXS domain.PROSITE-ProRule annotation
Contains 1 SPX domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5408.
GeneTreeiENSGT00500000044895.
HOGENOMiHOG000141697.
InParanoidiP40528.
OMAiINYRFIM.
OrthoDBiEOG75F4P9.

Family and domain databases

InterProiIPR004342. EXS_C.
IPR004331. SPX_N.
[Graphical view]
PfamiPF03124. EXS. 1 hit.
PF03105. SPX. 1 hit.
[Graphical view]
PROSITEiPS51380. EXS. 1 hit.
PS51382. SPX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40528-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFADHLTES AIPEWRDKYI DYKVGKKKLR RYKEKLDAEE EQSSSYRSWM
60 70 80 90 100
PSVSVYQTAF QQREPGKSRS DGDYRSGPAF KKDYSALQRE FVADFIEDWL
110 120 130 140 150
ISFQLSKCNE FYLWLLKECD KKFEVLQSQL HYYSLQKNYE RDNLNRSSSN
160 170 180 190 200
VDMSTSLYAA GLAGRSDSRV NSIDSDSRSV MYGSMPCTKE AKKPRLSLLA
210 220 230 240 250
YCQKVLKDNR LLPSWPKRGF SLLQDLRQDA SSRGRETFAF GASFLETMTT
260 270 280 290 300
TQARNLLSNA IIEYYLYLQL VKSFRDINVT GFRKMVKKFD KTCHTRELTT
310 320 330 340 350
FMSYARTHYT LFKHADANVQ LVAQKMQQIT SSQPTPTSEL SSAQRDKEPI
360 370 380 390 400
TWLETQITEW FTTALTNSPK DRKHNTHKLK KLTIQYSISE QMVHRNNRSI
410 420 430 440 450
VQMLVVGLGI GVSMTLITYT LYLGISSEET SFTHKILFPL WGGWYMVLLI
460 470 480 490 500
AFLFLVNCFI WHRTGINYRF IMLGEIQSKN GTQFFNNDFA TSKIPLKLYF
510 520 530 540 550
LTFFIVPCAV CSMLSFALEK LTPLGFLYIG IVSFLFLCPS GLIPYWDKVV
560 570 580 590 600
HTRKWLVVTL IRLMMSGFFP VEFGDFFLGD IICSLTYSIA DIAMFFCVYS
610 620 630 640 650
HTPNNLCGSS HSRAMGVLSC LPSYWRFMQC LRRFADSGDW FPHLLNAAKY
660 670 680 690 700
TLGIAYNATL CAYRLSDRSE QRRTPFIVCA TLNSILTSAW DLVMDWSFAH
710 720 730 740 750
NTTSYNWLLR DDLYLAGKKN WENGSYSFSR KLVYYFAMIW DILIRFEWIV
760 770 780 790 800
YAIAPQTIQQ SAVTSFILAL LEVLRRFVWI IFRVENEHVA NVHLFRVTGD
810 820 830 840 850
APLPYPIAQV GDDSMDSSDL GSKAFSSLND IPITPSHDNN PHSFAEPMPA
860 870 880 890 900
YRGTFRRRSS VFENISRSIP WAHATDFQRP TVNTVDDRSP ETDSESEVES

IM
Length:902
Mass (Da):104,218
Last modified:February 1, 1995 - v1
Checksum:iF8D87D1DDB3AED64
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14726 Genomic DNA. Translation: AAA91621.1.
Z46861 Genomic DNA. Translation: CAA86904.1.
BK006942 Genomic DNA. Translation: DAA08500.1.
PIRiS49931.
RefSeqiNP_012217.3. NM_001179397.3.

Genome annotation databases

EnsemblFungiiYIL047C; YIL047C; YIL047C.
GeneIDi854764.
KEGGisce:YIL047C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14726 Genomic DNA. Translation: AAA91621.1.
Z46861 Genomic DNA. Translation: CAA86904.1.
BK006942 Genomic DNA. Translation: DAA08500.1.
PIRiS49931.
RefSeqiNP_012217.3. NM_001179397.3.

3D structure databases

ProteinModelPortaliP40528.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34943. 39 interactions.
DIPiDIP-2383N.
IntActiP40528. 2 interactions.
MINTiMINT-599154.
STRINGi4932.YIL047C.

Proteomic databases

MaxQBiP40528.
PaxDbiP40528.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYIL047C; YIL047C; YIL047C.
GeneIDi854764.
KEGGisce:YIL047C.

Organism-specific databases

CYGDiYIL047c.
EuPathDBiFungiDB:YIL047C.
SGDiS000001309. SYG1.

Phylogenomic databases

eggNOGiCOG5408.
GeneTreeiENSGT00500000044895.
HOGENOMiHOG000141697.
InParanoidiP40528.
OMAiINYRFIM.
OrthoDBiEOG75F4P9.

Enzyme and pathway databases

BioCyciYEAST:G3O-31318-MONOMER.

Miscellaneous databases

NextBioi977514.
PROiP40528.

Gene expression databases

GenevestigatoriP40528.

Family and domain databases

InterProiIPR004342. EXS_C.
IPR004331. SPX_N.
[Graphical view]
PfamiPF03124. EXS. 1 hit.
PF03105. SPX. 1 hit.
[Graphical view]
PROSITEiPS51380. EXS. 1 hit.
PS51382. SPX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Truncated forms of a novel yeast protein suppress the lethality of a G protein alpha subunit deficiency by interacting with the beta subunit."
    Spain B.H., Koo D., Ramakrishnan M., Dzudzor B., Colicelli J.
    J. Biol. Chem. 270:25435-25444(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH STE4.
    Strain: SP1.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.
  6. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-859 AND SER-860, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  7. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-172 AND SER-179, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-859 AND SER-860, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSYG1_YEAST
AccessioniPrimary (citable) accession number: P40528
Secondary accession number(s): D6VVN4, P40964
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 29, 2015
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1160 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.