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P40528

- SYG1_YEAST

UniProt

P40528 - SYG1_YEAST

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Protein

Protein SYG1

Gene
SYG1, YIL047C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May function in G-protein coupled signal transduction.1 Publication

GO - Biological processi

  1. signal transduction Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-31318-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SYG1
Gene namesi
Name:SYG1
Ordered Locus Names:YIL047C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IX

Organism-specific databases

CYGDiYIL047c.
SGDiS000001309. SYG1.

Subcellular locationi

Cell membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 404404Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei405 – 42521Helical; Reviewed predictionAdd
BLAST
Topological domaini426 – 43510Extracellular Reviewed prediction
Transmembranei436 – 45621Helical; Reviewed predictionAdd
BLAST
Topological domaini457 – 49741Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei498 – 51821Helical; Reviewed predictionAdd
BLAST
Topological domaini519 – 5224Extracellular Reviewed prediction
Transmembranei523 – 54321Helical; Reviewed predictionAdd
BLAST
Topological domaini544 – 55411Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei555 – 57521Helical; Reviewed predictionAdd
BLAST
Topological domaini576 – 5761Extracellular Reviewed prediction
Transmembranei577 – 59923Helical; Reviewed predictionAdd
BLAST
Topological domaini600 – 732133Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei733 – 75321Helical; Reviewed predictionAdd
BLAST
Topological domaini754 – 7618Extracellular Reviewed prediction
Transmembranei762 – 78221Helical; Reviewed predictionAdd
BLAST
Topological domaini783 – 902120Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 902902Protein SYG1PRO_0000072382Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei172 – 1721Phosphoserine1 Publication
Modified residuei179 – 1791Phosphoserine1 Publication
Modified residuei859 – 8591Phosphoserine2 Publications
Modified residuei860 – 8601Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP40528.
PaxDbiP40528.

Expressioni

Gene expression databases

GenevestigatoriP40528.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself1EBI-18696,EBI-18696
FTH1P383101EBI-18696,EBI-20959

Protein-protein interaction databases

BioGridi34943. 39 interactions.
DIPiDIP-2383N.
IntActiP40528. 2 interactions.
MINTiMINT-599154.
STRINGi4932.YIL047C.

Structurei

3D structure databases

ProteinModelPortaliP40528.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 303303SPXAdd
BLAST
Domaini606 – 815210EXSAdd
BLAST

Sequence similaritiesi

Contains 1 EXS domain.
Contains 1 SPX domain.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5408.
GeneTreeiENSGT00500000044895.
HOGENOMiHOG000141697.
OMAiINYRFIM.
OrthoDBiEOG75F4P9.

Family and domain databases

InterProiIPR004342. EXS_C.
IPR004331. SPX_N.
[Graphical view]
PfamiPF03124. EXS. 1 hit.
PF03105. SPX. 1 hit.
[Graphical view]
PROSITEiPS51380. EXS. 1 hit.
PS51382. SPX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40528-1 [UniParc]FASTAAdd to Basket

« Hide

MKFADHLTES AIPEWRDKYI DYKVGKKKLR RYKEKLDAEE EQSSSYRSWM    50
PSVSVYQTAF QQREPGKSRS DGDYRSGPAF KKDYSALQRE FVADFIEDWL 100
ISFQLSKCNE FYLWLLKECD KKFEVLQSQL HYYSLQKNYE RDNLNRSSSN 150
VDMSTSLYAA GLAGRSDSRV NSIDSDSRSV MYGSMPCTKE AKKPRLSLLA 200
YCQKVLKDNR LLPSWPKRGF SLLQDLRQDA SSRGRETFAF GASFLETMTT 250
TQARNLLSNA IIEYYLYLQL VKSFRDINVT GFRKMVKKFD KTCHTRELTT 300
FMSYARTHYT LFKHADANVQ LVAQKMQQIT SSQPTPTSEL SSAQRDKEPI 350
TWLETQITEW FTTALTNSPK DRKHNTHKLK KLTIQYSISE QMVHRNNRSI 400
VQMLVVGLGI GVSMTLITYT LYLGISSEET SFTHKILFPL WGGWYMVLLI 450
AFLFLVNCFI WHRTGINYRF IMLGEIQSKN GTQFFNNDFA TSKIPLKLYF 500
LTFFIVPCAV CSMLSFALEK LTPLGFLYIG IVSFLFLCPS GLIPYWDKVV 550
HTRKWLVVTL IRLMMSGFFP VEFGDFFLGD IICSLTYSIA DIAMFFCVYS 600
HTPNNLCGSS HSRAMGVLSC LPSYWRFMQC LRRFADSGDW FPHLLNAAKY 650
TLGIAYNATL CAYRLSDRSE QRRTPFIVCA TLNSILTSAW DLVMDWSFAH 700
NTTSYNWLLR DDLYLAGKKN WENGSYSFSR KLVYYFAMIW DILIRFEWIV 750
YAIAPQTIQQ SAVTSFILAL LEVLRRFVWI IFRVENEHVA NVHLFRVTGD 800
APLPYPIAQV GDDSMDSSDL GSKAFSSLND IPITPSHDNN PHSFAEPMPA 850
YRGTFRRRSS VFENISRSIP WAHATDFQRP TVNTVDDRSP ETDSESEVES 900
IM 902
Length:902
Mass (Da):104,218
Last modified:February 1, 1995 - v1
Checksum:iF8D87D1DDB3AED64
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U14726 Genomic DNA. Translation: AAA91621.1.
Z46861 Genomic DNA. Translation: CAA86904.1.
BK006942 Genomic DNA. Translation: DAA08500.1.
PIRiS49931.
RefSeqiNP_012217.3. NM_001179397.3.

Genome annotation databases

EnsemblFungiiYIL047C; YIL047C; YIL047C.
GeneIDi854764.
KEGGisce:YIL047C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U14726 Genomic DNA. Translation: AAA91621.1 .
Z46861 Genomic DNA. Translation: CAA86904.1 .
BK006942 Genomic DNA. Translation: DAA08500.1 .
PIRi S49931.
RefSeqi NP_012217.3. NM_001179397.3.

3D structure databases

ProteinModelPortali P40528.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 34943. 39 interactions.
DIPi DIP-2383N.
IntActi P40528. 2 interactions.
MINTi MINT-599154.
STRINGi 4932.YIL047C.

Proteomic databases

MaxQBi P40528.
PaxDbi P40528.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YIL047C ; YIL047C ; YIL047C .
GeneIDi 854764.
KEGGi sce:YIL047C.

Organism-specific databases

CYGDi YIL047c.
SGDi S000001309. SYG1.

Phylogenomic databases

eggNOGi COG5408.
GeneTreei ENSGT00500000044895.
HOGENOMi HOG000141697.
OMAi INYRFIM.
OrthoDBi EOG75F4P9.

Enzyme and pathway databases

BioCyci YEAST:G3O-31318-MONOMER.

Miscellaneous databases

NextBioi 977514.
PROi P40528.

Gene expression databases

Genevestigatori P40528.

Family and domain databases

InterProi IPR004342. EXS_C.
IPR004331. SPX_N.
[Graphical view ]
Pfami PF03124. EXS. 1 hit.
PF03105. SPX. 1 hit.
[Graphical view ]
PROSITEi PS51380. EXS. 1 hit.
PS51382. SPX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Truncated forms of a novel yeast protein suppress the lethality of a G protein alpha subunit deficiency by interacting with the beta subunit."
    Spain B.H., Koo D., Ramakrishnan M., Dzudzor B., Colicelli J.
    J. Biol. Chem. 270:25435-25444(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH STE4.
    Strain: SP1.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.
  6. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-859 AND SER-860, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  7. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-172 AND SER-179, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-859 AND SER-860, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSYG1_YEAST
AccessioniPrimary (citable) accession number: P40528
Secondary accession number(s): D6VVN4, P40964
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 14, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1160 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

External Data

Dasty 3

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