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Protein

60S ribosomal protein L34-B

Gene

RPL34B

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.1 Publication

Miscellaneous

Present with 21000 molecules/cell in log phase SD medium.1 Publication
There are 2 genes for eL34 in yeast.Curated

GO - Molecular functioni

GO - Biological processi

  • cytoplasmic translation Source: SGD
  • ribosome biogenesis Source: GO_Central
  • translation Source: GO_Central

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-31323-MONOMER.
ReactomeiR-SCE-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-SCE-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-SCE-72689. Formation of a pool of free 40S subunits.
R-SCE-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-SCE-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-SCE-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L34-B1 Publication
Alternative name(s):
Large ribosomal subunit protein eL34-B1 Publication
Gene namesi
Name:RPL34B1 Publication
Ordered Locus Names:YIL052C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IX

Organism-specific databases

EuPathDBiFungiDB:YIL052C.
SGDiS000001314. RPL34B.

Subcellular locationi

GO - Cellular componenti

  • cytosolic large ribosomal subunit Source: SGD

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001318461 – 12160S ribosomal protein L34-BAdd BLAST121

Proteomic databases

MaxQBiP40525.
PRIDEiP40525.

Interactioni

Subunit structurei

Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).1 Publication1 Publication

Protein-protein interaction databases

BioGridi34938. 97 interactors.
DIPiDIP-5499N.
IntActiP40525. 6 interactors.
MINTiMINT-8285621.
STRINGi4932.YIL052C.

Structurei

3D structure databases

ProteinModelPortaliP40525.
SMRiP40525.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000008294.
HOGENOMiHOG000216922.
InParanoidiP40525.
KOiK02915.
OMAiRCGDCVK.
OrthoDBiEOG092C5L2Y.

Family and domain databases

InterProiView protein in InterPro
IPR008195. Ribosomal_L34Ae.
IPR018065. Ribosomal_L34e_CS.
PANTHERiPTHR10759. PTHR10759. 1 hit.
PfamiView protein in Pfam
PF01199. Ribosomal_L34e. 1 hit.
PRINTSiPR01250. RIBOSOMALL34.
PROSITEiView protein in PROSITE
PS01145. RIBOSOMAL_L34E. 1 hit.

Sequencei

Sequence statusi: Complete.

P40525-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQRVTFRRR NPYNTRSNKI KVVKTPGGIL RAQHVKKLAT RPKCGDCGSA
60 70 80 90 100
LQGISTLRPR QYATVSKTHK TVSRAYGGSR CANCVKERIV RAFLIEEQKI
110 120
VKKVVKEQTE AAKKSEKKSK K
Length:121
Mass (Da):13,641
Last modified:February 1, 1995 - v1
Checksum:i6B0AD076CD85ACF4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38060 Genomic DNA. Translation: CAA86170.1.
BK006942 Genomic DNA. Translation: DAA08495.1.
PIRiS48427.
RefSeqiNP_012212.1. NM_001179402.1.

Genome annotation databases

EnsemblFungiiYIL052C; YIL052C; YIL052C.
GeneIDi854759.
KEGGisce:YIL052C.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiRL34B_YEAST
AccessioniPrimary (citable) accession number: P40525
Secondary accession number(s): D6VVM9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: July 5, 2017
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names