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Protein

Actin-related protein 2/3 complex subunit 5

Gene

ARC15

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.By similarity

Miscellaneous

Present with 3060 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • actin filament binding Source: GO_Central
  • mRNA binding Source: SGD
  • structural molecule activity Source: SGD

GO - Biological processi

  • actin cortical patch assembly Source: SGD
  • Arp2/3 complex-mediated actin nucleation Source: GO_Central
  • mitochondrion inheritance Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-31330-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunit 5
Alternative name(s):
Arp2/3 complex 16 kDa subunit
Short name:
p16-ARC
Gene namesi
Name:ARC15
Ordered Locus Names:YIL062C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IX

Organism-specific databases

EuPathDBiFungiDB:YIL062C
SGDiS000001324 ARC15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001240591 – 154Actin-related protein 2/3 complex subunit 5Add BLAST154

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei142PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP40518
PaxDbiP40518
PRIDEiP40518
TopDownProteomicsiP40518

PTM databases

iPTMnetiP40518

Interactioni

Subunit structurei

Component of the Arp2/3 complex composed of ARP2, ARP3, ARC40/p41-ARC, ARC35/p34-ARC, ARC18/p21-ARC, ARC19/p20-ARC and ARC16/p16-ARC.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi34930, 423 interactors
DIPiDIP-2101N
IntActiP40518, 18 interactors
MINTiP40518
STRINGi4932.YIL062C

Structurei

3D structure databases

ProteinModelPortaliP40518
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ARPC5 family.Curated

Phylogenomic databases

HOGENOMiHOG000197215
InParanoidiP40518
KOiK05754
OMAiKYIYKGM
OrthoDBiEOG092C4ZPD

Family and domain databases

Gene3Di1.25.40.190, 1 hit
InterProiView protein in InterPro
IPR006789 ARPC5
IPR036743 ARPC5_sf
PANTHERiPTHR12644 PTHR12644, 1 hit
PfamiView protein in Pfam
PF04699 P16-Arc, 1 hit
PIRSFiPIRSF039096 p16-ARC, 1 hit
SUPFAMiSSF69103 SSF69103, 1 hit

Sequencei

Sequence statusi: Complete.

P40518-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEADWRRIDI DAFDPESGRL TAADLVPPYE TTVTLQELQP RMNQLRSLAT
60 70 80 90 100
SGDSLGAVQL LTTDPPYSAD APTKEQYFKS VLEALTQVRQ ADIGNVIKNL
110 120 130 140 150
SDSQRDVLVK YLYKGMSVPQ GQKQGGVLLA WLERITQVSG VTPIVHYISD

RRTV
Length:154
Mass (Da):17,134
Last modified:February 1, 1995 - v1
Checksum:i10E4DAF0F0801B02
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38060 Genomic DNA Translation: CAA86161.1
AY557850 Genomic DNA Translation: AAS56176.1
BK006942 Genomic DNA Translation: DAA08488.1
PIRiS48417
RefSeqiNP_012202.1, NM_001179412.1

Genome annotation databases

EnsemblFungiiYIL062C; YIL062C; YIL062C
GeneIDi854748
KEGGisce:YIL062C

Similar proteinsi

Entry informationi

Entry nameiARPC5_YEAST
AccessioniPrimary (citable) accession number: P40518
Secondary accession number(s): D6VVM2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: March 28, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health