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Protein

Actin-related protein 2/3 complex subunit 5

Gene

ARC15

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.By similarity

GO - Molecular functioni

  • mRNA binding Source: SGD
  • structural molecule activity Source: SGD

GO - Biological processi

  • actin cortical patch assembly Source: SGD
  • Arp2/3 complex-mediated actin nucleation Source: InterPro
  • mitochondrion inheritance Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-31330-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunit 5
Alternative name(s):
Arp2/3 complex 16 kDa subunit
Short name:
p16-ARC
Gene namesi
Name:ARC15
Ordered Locus Names:YIL062C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IX

Organism-specific databases

EuPathDBiFungiDB:YIL062C.
SGDiS000001324. ARC15.

Subcellular locationi

GO - Cellular componenti

  • actin cortical patch Source: UniProtKB-SubCell
  • Arp2/3 protein complex Source: SGD
  • extrinsic component of mitochondrial outer membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 154154Actin-related protein 2/3 complex subunit 5PRO_0000124059Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei142 – 1421PhosphothreonineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP40518.
TopDownProteomicsiP40518.

PTM databases

iPTMnetiP40518.

Interactioni

Subunit structurei

Component of the Arp2/3 complex composed of ARP2, ARP3, ARC40/p41-ARC, ARC35/p34-ARC, ARC18/p21-ARC, ARC19/p20-ARC and ARC16/p16-ARC.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ARC19P332043EBI-2750,EBI-2757

Protein-protein interaction databases

BioGridi34930. 117 interactions.
DIPiDIP-2101N.
IntActiP40518. 15 interactions.
MINTiMINT-507713.

Structurei

3D structure databases

ProteinModelPortaliP40518.
SMRiP40518. Positions 26-154.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ARPC5 family.Curated

Phylogenomic databases

HOGENOMiHOG000197215.
InParanoidiP40518.
KOiK05754.
OMAiADWRRID.
OrthoDBiEOG7WX0MV.

Family and domain databases

Gene3Di1.25.40.190. 1 hit.
InterProiIPR006789. ARPC5.
[Graphical view]
PANTHERiPTHR12644. PTHR12644. 1 hit.
PfamiPF04699. P16-Arc. 1 hit.
[Graphical view]
PIRSFiPIRSF039096. p16-ARC. 1 hit.
SUPFAMiSSF69103. SSF69103. 1 hit.

Sequencei

Sequence statusi: Complete.

P40518-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEADWRRIDI DAFDPESGRL TAADLVPPYE TTVTLQELQP RMNQLRSLAT
60 70 80 90 100
SGDSLGAVQL LTTDPPYSAD APTKEQYFKS VLEALTQVRQ ADIGNVIKNL
110 120 130 140 150
SDSQRDVLVK YLYKGMSVPQ GQKQGGVLLA WLERITQVSG VTPIVHYISD

RRTV
Length:154
Mass (Da):17,134
Last modified:February 1, 1995 - v1
Checksum:i10E4DAF0F0801B02
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38060 Genomic DNA. Translation: CAA86161.1.
AY557850 Genomic DNA. Translation: AAS56176.1.
BK006942 Genomic DNA. Translation: DAA08488.1.
PIRiS48417.
RefSeqiNP_012202.1. NM_001179412.1.

Genome annotation databases

EnsemblFungiiYIL062C; YIL062C; YIL062C.
GeneIDi854748.
KEGGisce:YIL062C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38060 Genomic DNA. Translation: CAA86161.1.
AY557850 Genomic DNA. Translation: AAS56176.1.
BK006942 Genomic DNA. Translation: DAA08488.1.
PIRiS48417.
RefSeqiNP_012202.1. NM_001179412.1.

3D structure databases

ProteinModelPortaliP40518.
SMRiP40518. Positions 26-154.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34930. 117 interactions.
DIPiDIP-2101N.
IntActiP40518. 15 interactions.
MINTiMINT-507713.

PTM databases

iPTMnetiP40518.

Proteomic databases

MaxQBiP40518.
TopDownProteomicsiP40518.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYIL062C; YIL062C; YIL062C.
GeneIDi854748.
KEGGisce:YIL062C.

Organism-specific databases

EuPathDBiFungiDB:YIL062C.
SGDiS000001324. ARC15.

Phylogenomic databases

HOGENOMiHOG000197215.
InParanoidiP40518.
KOiK05754.
OMAiADWRRID.
OrthoDBiEOG7WX0MV.

Enzyme and pathway databases

BioCyciYEAST:G3O-31330-MONOMER.

Miscellaneous databases

PROiP40518.

Family and domain databases

Gene3Di1.25.40.190. 1 hit.
InterProiIPR006789. ARPC5.
[Graphical view]
PANTHERiPTHR12644. PTHR12644. 1 hit.
PfamiPF04699. P16-Arc. 1 hit.
[Graphical view]
PIRSFiPIRSF039096. p16-ARC. 1 hit.
SUPFAMiSSF69103. SSF69103. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. "The complex containing actin-related proteins Arp2 and Arp3 is required for the motility and integrity of yeast actin patches."
    Winter D., Podtelejnikov A.V., Mann M., Li R.
    Curr. Biol. 7:519-529(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE ARP2/3 COMPLEX.
  5. Erratum
    Winter D., Podtelejnikov A.V., Mann M., Li R.
    Curr. Biol. 7:R593-R593(1997)
  6. "Arp2/3 complex and actin dynamics are required for actin-based mitochondrial motility in yeast."
    Boldogh I.R., Yang H.C., Nowakowski W.D., Karmon S.L., Hays L.G., Yates J.R. III, Pon L.A.
    Proc. Natl. Acad. Sci. U.S.A. 98:3162-3167(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  8. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-142, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiARPC5_YEAST
AccessioniPrimary (citable) accession number: P40518
Secondary accession number(s): D6VVM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: July 6, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 3060 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.