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P40505 (SDS3_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcriptional regulatory protein SDS3
Alternative name(s):
Suppressor of defective silencing protein 3
Gene names
Name:SDS3
Ordered Locus Names:YIL084C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length327 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. SDS3 is required for the HDAC activity of the complex and for the RPD3-SIN3 association. Ref.1 Ref.5 Ref.6 Ref.7

Subunit structure

Component of the RPD3C(L) complex composed of at least ASH1, CTI6, DEP1, PHO23, RPD3, RXT2, RXT3, SAP30, SDS3, SIN3, UME1 and UME6. Ref.5 Ref.6 Ref.8 Ref.11 Ref.12

Subcellular location

Nucleus Ref.9.

Miscellaneous

Present with 105 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the SDS3 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 327327Transcriptional regulatory protein SDS3
PRO_0000097654

Regions

Coiled coil61 – 13575 Potential

Amino acid modifications

Modified residue1661Phosphoserine Ref.13
Modified residue2111Phosphoserine Ref.13

Sequences

Sequence LengthMass (Da)Tools
P40505 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 4A6186E68BFE0CC7

FASTA32737,625
        10         20         30         40         50         60 
MAIQKVSNKD LSRKDKRRFN IESKVNKIYQ NFYSERDNQY KDRLTALQTD LTSLHQGDNG 

        70         80         90        100        110        120 
QYARQVRDLE EERDLELVRL RLFEEYRVSR SGIEFQEDIE KAKAEHEKLI KLCKERLYSS 

       130        140        150        160        170        180 
IEQKIKKLQE ERLLMDVANV HSYAMNYSRP QYQKNTRSHT VSGWDSSSNE YGRDTANESA 

       190        200        210        220        230        240 
TDTGAGNDRR TLRRRNASKD TRGNNNNQDE SDFQTGNGSG SNGHGSRQGS QFPHFNNLTY 

       250        260        270        280        290        300 
KSGMNSDSDF LQGINEGTDL YAFLFGEKNP KDNANGNEKK KNRGAQRYST KTAPPLQSLK 

       310        320 
PDEVTEDISL IRELTGQPPA PFRLRSD 

« Hide

References

« Hide 'large scale' references
[1]"Evidence that the transcriptional regulators SIN3 and RPD3, and a novel gene (SDS3) with similar functions, are involved in transcriptional silencing in S. cerevisiae."
Vannier D., Balderes D., Shore D.
Genetics 144:1343-1353(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
Strain: ATCC 200060 / W303.
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome IX."
Churcher C.M., Bowman S., Badcock K., Bankier A.T., Brown D., Chillingworth T., Connor R., Devlin K., Gentles S., Hamlin N., Harris D.E., Horsnell T., Hunt S., Jagels K., Jones M., Lye G., Moule S., Odell C. expand/collapse author list , Pearson D., Rajandream M.A., Rice P., Rowley N., Skelton J., Smith V., Walsh S.V., Whitehead S., Barrell B.G.
Nature 387:84-87(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[5]"Roles for the Saccharomyces cerevisiae SDS3, CBK1 and HYM1 genes in transcriptional repression by SIN3."
Dorland S., Deegenaars M.L., Stillman D.J.
Genetics 154:573-586(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, IDENTIFICATION IN THE RPD3 COMPLEX.
[6]"Sds3 (suppressor of defective silencing 3) is an integral component of the yeast Sin3[middle dot]Rpd3 histone deacetylase complex and is required for histone deacetylase activity."
Lechner T., Carrozza M.J., Yu Y., Grant P.A., Eberharter A., Vannier D., Brosch G., Stillman D.J., Shore D., Workman J.L.
J. Biol. Chem. 275:40961-40966(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, IDENTIFICATION IN THE RPD3 COMPLEX.
[7]"A role for Sds3p, a component of the Rpd3p/Sin3p deacetylase complex, in maintaining cellular integrity in Saccharomyces cerevisiae."
Vannier D., Damay P., Shore D.
Mol. Genet. Genomics 265:560-568(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[8]"Opposite role of yeast ING family members in p53-dependent transcriptional activation."
Nourani A., Howe L., Pray-Grant M.G., Workman J.L., Grant P.A., Cote J.
J. Biol. Chem. 278:19171-19175(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN THE RPD3 COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
[9]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[10]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[11]"Stable incorporation of sequence specific repressors Ash1 and Ume6 into the Rpd3L complex."
Carrozza M.J., Florens L., Swanson S.K., Shia W.-J., Anderson S., Yates J., Washburn M.P., Workman J.L.
Biochim. Biophys. Acta 1731:77-87(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN THE RPD3C(L) COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
[12]"Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex."
Keogh M.-C., Kurdistani S.K., Morris S.A., Ahn S.H., Podolny V., Collins S.R., Schuldiner M., Chin K., Punna T., Thompson N.J., Boone C., Emili A., Weissman J.S., Hughes T.R., Strahl B.D., Grunstein M., Greenblatt J.F., Buratowski S., Krogan N.J.
Cell 123:593-605(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN THE RPD3C(L) COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
[13]"Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-166 AND SER-211, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[14]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U62525 Genomic DNA. Translation: AAB40993.1.
Z46728 Genomic DNA. Translation: CAA86710.1.
AY692879 Genomic DNA. Translation: AAT92898.1.
BK006942 Genomic DNA. Translation: DAA08468.1.
PIRS49796.
RefSeqNP_012182.1. NM_001179432.1.

3D structure databases

ProteinModelPortalP40505.
SMRP40505. Positions 14-51.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid34908. 319 interactions.
DIPDIP-2706N.
IntActP40505. 20 interactions.
MINTMINT-556150.
STRING4932.YIL084C.

Proteomic databases

PaxDbP40505.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYIL084C; YIL084C; YIL084C.
GeneID854725.
KEGGsce:YIL084C.

Organism-specific databases

CYGDYIL084c.
SGDS000001346. SDS3.

Phylogenomic databases

eggNOGNOG299411.
HOGENOMHOG000141851.
OMAQKNTRSH.
OrthoDBEOG74TX8T.

Enzyme and pathway databases

BioCycYEAST:G3O-31346-MONOMER.

Gene expression databases

GenevestigatorP40505.

Family and domain databases

InterProIPR013907. Sds3.
[Graphical view]
PfamPF08598. Sds3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio977412.

Entry information

Entry nameSDS3_YEAST
AccessionPrimary (citable) accession number: P40505
Secondary accession number(s): D6VVK2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 16, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome IX

Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families