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P40505

- SDS3_YEAST

UniProt

P40505 - SDS3_YEAST

Protein

Transcriptional regulatory protein SDS3

Gene

SDS3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. SDS3 is required for the HDAC activity of the complex and for the RPD3-SIN3 association.4 Publications

    GO - Biological processi

    1. chromatin silencing Source: SGD
    2. histone deacetylation Source: SGD
    3. negative regulation of chromatin silencing at rDNA Source: SGD
    4. negative regulation of chromatin silencing at silent mating-type cassette Source: SGD
    5. negative regulation of chromatin silencing at telomere Source: SGD
    6. positive regulation of transcription from RNA polymerase II promoter Source: SGD
    7. positive regulation of transcription from RNA polymerase II promoter in response to heat stress Source: SGD
    8. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulator, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31346-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcriptional regulatory protein SDS3
    Alternative name(s):
    Suppressor of defective silencing protein 3
    Gene namesi
    Name:SDS3
    Ordered Locus Names:YIL084C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome IX

    Organism-specific databases

    CYGDiYIL084c.
    SGDiS000001346. SDS3.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. cytosol Source: SGD
    2. nucleus Source: SGD
    3. Rpd3L complex Source: SGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 327327Transcriptional regulatory protein SDS3PRO_0000097654Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei166 – 1661Phosphoserine1 Publication
    Modified residuei211 – 2111Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP40505.
    PaxDbiP40505.

    Expressioni

    Gene expression databases

    GenevestigatoriP40505.

    Interactioni

    Subunit structurei

    Component of the RPD3C(L) complex composed of at least ASH1, CTI6, DEP1, PHO23, RPD3, RXT2, RXT3, SAP30, SDS3, SIN3, UME1 and UME6.5 Publications

    Protein-protein interaction databases

    BioGridi34908. 319 interactions.
    DIPiDIP-2706N.
    IntActiP40505. 20 interactions.
    MINTiMINT-556150.
    STRINGi4932.YIL084C.

    Structurei

    3D structure databases

    ProteinModelPortaliP40505.
    SMRiP40505. Positions 14-51.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili61 – 13575Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the SDS3 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG299411.
    HOGENOMiHOG000141851.
    OMAiQKNTRSH.
    OrthoDBiEOG74TX8T.

    Family and domain databases

    InterProiIPR013907. Sds3.
    [Graphical view]
    PfamiPF08598. Sds3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P40505-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAIQKVSNKD LSRKDKRRFN IESKVNKIYQ NFYSERDNQY KDRLTALQTD    50
    LTSLHQGDNG QYARQVRDLE EERDLELVRL RLFEEYRVSR SGIEFQEDIE 100
    KAKAEHEKLI KLCKERLYSS IEQKIKKLQE ERLLMDVANV HSYAMNYSRP 150
    QYQKNTRSHT VSGWDSSSNE YGRDTANESA TDTGAGNDRR TLRRRNASKD 200
    TRGNNNNQDE SDFQTGNGSG SNGHGSRQGS QFPHFNNLTY KSGMNSDSDF 250
    LQGINEGTDL YAFLFGEKNP KDNANGNEKK KNRGAQRYST KTAPPLQSLK 300
    PDEVTEDISL IRELTGQPPA PFRLRSD 327
    Length:327
    Mass (Da):37,625
    Last modified:February 1, 1995 - v1
    Checksum:i4A6186E68BFE0CC7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U62525 Genomic DNA. Translation: AAB40993.1.
    Z46728 Genomic DNA. Translation: CAA86710.1.
    AY692879 Genomic DNA. Translation: AAT92898.1.
    BK006942 Genomic DNA. Translation: DAA08468.1.
    PIRiS49796.
    RefSeqiNP_012182.1. NM_001179432.1.

    Genome annotation databases

    EnsemblFungiiYIL084C; YIL084C; YIL084C.
    GeneIDi854725.
    KEGGisce:YIL084C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U62525 Genomic DNA. Translation: AAB40993.1 .
    Z46728 Genomic DNA. Translation: CAA86710.1 .
    AY692879 Genomic DNA. Translation: AAT92898.1 .
    BK006942 Genomic DNA. Translation: DAA08468.1 .
    PIRi S49796.
    RefSeqi NP_012182.1. NM_001179432.1.

    3D structure databases

    ProteinModelPortali P40505.
    SMRi P40505. Positions 14-51.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 34908. 319 interactions.
    DIPi DIP-2706N.
    IntActi P40505. 20 interactions.
    MINTi MINT-556150.
    STRINGi 4932.YIL084C.

    Proteomic databases

    MaxQBi P40505.
    PaxDbi P40505.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YIL084C ; YIL084C ; YIL084C .
    GeneIDi 854725.
    KEGGi sce:YIL084C.

    Organism-specific databases

    CYGDi YIL084c.
    SGDi S000001346. SDS3.

    Phylogenomic databases

    eggNOGi NOG299411.
    HOGENOMi HOG000141851.
    OMAi QKNTRSH.
    OrthoDBi EOG74TX8T.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31346-MONOMER.

    Miscellaneous databases

    NextBioi 977412.

    Gene expression databases

    Genevestigatori P40505.

    Family and domain databases

    InterProi IPR013907. Sds3.
    [Graphical view ]
    Pfami PF08598. Sds3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evidence that the transcriptional regulators SIN3 and RPD3, and a novel gene (SDS3) with similar functions, are involved in transcriptional silencing in S. cerevisiae."
      Vannier D., Balderes D., Shore D.
      Genetics 144:1343-1353(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
      Strain: ATCC 200060 / W303.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    5. "Roles for the Saccharomyces cerevisiae SDS3, CBK1 and HYM1 genes in transcriptional repression by SIN3."
      Dorland S., Deegenaars M.L., Stillman D.J.
      Genetics 154:573-586(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, IDENTIFICATION IN THE RPD3 COMPLEX.
    6. "Sds3 (suppressor of defective silencing 3) is an integral component of the yeast Sin3[middle dot]Rpd3 histone deacetylase complex and is required for histone deacetylase activity."
      Lechner T., Carrozza M.J., Yu Y., Grant P.A., Eberharter A., Vannier D., Brosch G., Stillman D.J., Shore D., Workman J.L.
      J. Biol. Chem. 275:40961-40966(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, IDENTIFICATION IN THE RPD3 COMPLEX.
    7. "A role for Sds3p, a component of the Rpd3p/Sin3p deacetylase complex, in maintaining cellular integrity in Saccharomyces cerevisiae."
      Vannier D., Damay P., Shore D.
      Mol. Genet. Genomics 265:560-568(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    8. "Opposite role of yeast ING family members in p53-dependent transcriptional activation."
      Nourani A., Howe L., Pray-Grant M.G., Workman J.L., Grant P.A., Cote J.
      J. Biol. Chem. 278:19171-19175(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE RPD3 COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
    9. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    10. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    11. "Stable incorporation of sequence specific repressors Ash1 and Ume6 into the Rpd3L complex."
      Carrozza M.J., Florens L., Swanson S.K., Shia W.-J., Anderson S., Yates J., Washburn M.P., Workman J.L.
      Biochim. Biophys. Acta 1731:77-87(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE RPD3C(L) COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
    12. Cited for: IDENTIFICATION IN THE RPD3C(L) COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
    13. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-166 AND SER-211, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSDS3_YEAST
    AccessioniPrimary (citable) accession number: P40505
    Secondary accession number(s): D6VVK2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 105 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome IX
      Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

    External Data

    Dasty 3