Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P40505

- SDS3_YEAST

UniProt

P40505 - SDS3_YEAST

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Transcriptional regulatory protein SDS3

Gene

SDS3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. SDS3 is required for the HDAC activity of the complex and for the RPD3-SIN3 association.4 Publications

GO - Biological processi

  1. chromatin silencing Source: SGD
  2. histone deacetylation Source: SGD
  3. negative regulation of chromatin silencing at rDNA Source: SGD
  4. negative regulation of chromatin silencing at silent mating-type cassette Source: SGD
  5. negative regulation of chromatin silencing at telomere Source: SGD
  6. positive regulation of transcription from RNA polymerase II promoter Source: SGD
  7. positive regulation of transcription from RNA polymerase II promoter in response to heat stress Source: SGD
  8. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-31346-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulatory protein SDS3
Alternative name(s):
Suppressor of defective silencing protein 3
Gene namesi
Name:SDS3
Ordered Locus Names:YIL084C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IX

Organism-specific databases

CYGDiYIL084c.
SGDiS000001346. SDS3.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. cytosol Source: SGD
  2. nucleus Source: SGD
  3. Rpd3L complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 327327Transcriptional regulatory protein SDS3PRO_0000097654Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei166 – 1661Phosphoserine1 Publication
Modified residuei211 – 2111Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP40505.
PaxDbiP40505.

Expressioni

Gene expression databases

GenevestigatoriP40505.

Interactioni

Subunit structurei

Component of the RPD3C(L) complex composed of at least ASH1, CTI6, DEP1, PHO23, RPD3, RXT2, RXT3, SAP30, SDS3, SIN3, UME1 and UME6.5 Publications

Protein-protein interaction databases

BioGridi34908. 323 interactions.
DIPiDIP-2706N.
IntActiP40505. 20 interactions.
MINTiMINT-556150.
STRINGi4932.YIL084C.

Structurei

3D structure databases

ProteinModelPortaliP40505.
SMRiP40505. Positions 14-51.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili61 – 13575Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the SDS3 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG299411.
HOGENOMiHOG000141851.
InParanoidiP40505.
OMAiQKNTRSH.
OrthoDBiEOG74TX8T.

Family and domain databases

InterProiIPR013907. Sds3.
[Graphical view]
PfamiPF08598. Sds3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40505-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAIQKVSNKD LSRKDKRRFN IESKVNKIYQ NFYSERDNQY KDRLTALQTD
60 70 80 90 100
LTSLHQGDNG QYARQVRDLE EERDLELVRL RLFEEYRVSR SGIEFQEDIE
110 120 130 140 150
KAKAEHEKLI KLCKERLYSS IEQKIKKLQE ERLLMDVANV HSYAMNYSRP
160 170 180 190 200
QYQKNTRSHT VSGWDSSSNE YGRDTANESA TDTGAGNDRR TLRRRNASKD
210 220 230 240 250
TRGNNNNQDE SDFQTGNGSG SNGHGSRQGS QFPHFNNLTY KSGMNSDSDF
260 270 280 290 300
LQGINEGTDL YAFLFGEKNP KDNANGNEKK KNRGAQRYST KTAPPLQSLK
310 320
PDEVTEDISL IRELTGQPPA PFRLRSD
Length:327
Mass (Da):37,625
Last modified:February 1, 1995 - v1
Checksum:i4A6186E68BFE0CC7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62525 Genomic DNA. Translation: AAB40993.1.
Z46728 Genomic DNA. Translation: CAA86710.1.
AY692879 Genomic DNA. Translation: AAT92898.1.
BK006942 Genomic DNA. Translation: DAA08468.1.
PIRiS49796.
RefSeqiNP_012182.1. NM_001179432.1.

Genome annotation databases

EnsemblFungiiYIL084C; YIL084C; YIL084C.
GeneIDi854725.
KEGGisce:YIL084C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62525 Genomic DNA. Translation: AAB40993.1 .
Z46728 Genomic DNA. Translation: CAA86710.1 .
AY692879 Genomic DNA. Translation: AAT92898.1 .
BK006942 Genomic DNA. Translation: DAA08468.1 .
PIRi S49796.
RefSeqi NP_012182.1. NM_001179432.1.

3D structure databases

ProteinModelPortali P40505.
SMRi P40505. Positions 14-51.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 34908. 323 interactions.
DIPi DIP-2706N.
IntActi P40505. 20 interactions.
MINTi MINT-556150.
STRINGi 4932.YIL084C.

Proteomic databases

MaxQBi P40505.
PaxDbi P40505.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YIL084C ; YIL084C ; YIL084C .
GeneIDi 854725.
KEGGi sce:YIL084C.

Organism-specific databases

CYGDi YIL084c.
SGDi S000001346. SDS3.

Phylogenomic databases

eggNOGi NOG299411.
HOGENOMi HOG000141851.
InParanoidi P40505.
OMAi QKNTRSH.
OrthoDBi EOG74TX8T.

Enzyme and pathway databases

BioCyci YEAST:G3O-31346-MONOMER.

Miscellaneous databases

NextBioi 977412.

Gene expression databases

Genevestigatori P40505.

Family and domain databases

InterProi IPR013907. Sds3.
[Graphical view ]
Pfami PF08598. Sds3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Evidence that the transcriptional regulators SIN3 and RPD3, and a novel gene (SDS3) with similar functions, are involved in transcriptional silencing in S. cerevisiae."
    Vannier D., Balderes D., Shore D.
    Genetics 144:1343-1353(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
    Strain: ATCC 200060 / W303.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. "Roles for the Saccharomyces cerevisiae SDS3, CBK1 and HYM1 genes in transcriptional repression by SIN3."
    Dorland S., Deegenaars M.L., Stillman D.J.
    Genetics 154:573-586(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN THE RPD3 COMPLEX.
  6. "Sds3 (suppressor of defective silencing 3) is an integral component of the yeast Sin3[middle dot]Rpd3 histone deacetylase complex and is required for histone deacetylase activity."
    Lechner T., Carrozza M.J., Yu Y., Grant P.A., Eberharter A., Vannier D., Brosch G., Stillman D.J., Shore D., Workman J.L.
    J. Biol. Chem. 275:40961-40966(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN THE RPD3 COMPLEX.
  7. "A role for Sds3p, a component of the Rpd3p/Sin3p deacetylase complex, in maintaining cellular integrity in Saccharomyces cerevisiae."
    Vannier D., Damay P., Shore D.
    Mol. Genet. Genomics 265:560-568(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "Opposite role of yeast ING family members in p53-dependent transcriptional activation."
    Nourani A., Howe L., Pray-Grant M.G., Workman J.L., Grant P.A., Cote J.
    J. Biol. Chem. 278:19171-19175(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE RPD3 COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
  9. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  10. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  11. "Stable incorporation of sequence specific repressors Ash1 and Ume6 into the Rpd3L complex."
    Carrozza M.J., Florens L., Swanson S.K., Shia W.-J., Anderson S., Yates J., Washburn M.P., Workman J.L.
    Biochim. Biophys. Acta 1731:77-87(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE RPD3C(L) COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
  12. Cited for: IDENTIFICATION IN THE RPD3C(L) COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
  13. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-166 AND SER-211, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSDS3_YEAST
AccessioniPrimary (citable) accession number: P40505
Secondary accession number(s): D6VVK2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 29, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 105 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

External Data

Dasty 3