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Protein

Transcriptional regulatory protein SDS3

Gene

SDS3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. SDS3 is required for the HDAC activity of the complex and for the RPD3-SIN3 association.4 Publications

GO - Molecular functioni

GO - Biological processi

  • cell adhesion involved in single-species biofilm formation Source: SGD
  • chromatin silencing Source: SGD
  • histone deacetylation Source: SGD
  • negative regulation of chromatin silencing at rDNA Source: SGD
  • negative regulation of chromatin silencing at silent mating-type cassette Source: SGD
  • negative regulation of chromatin silencing at telomere Source: SGD
  • negative regulation of transcription from RNA polymerase II promoter Source: SGD
  • positive regulation of transcription from RNA polymerase II promoter Source: SGD
  • positive regulation of transcription from RNA polymerase II promoter in response to heat stress Source: SGD
  • regulation of invasive growth in response to glucose limitation Source: SGD
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-31346-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulatory protein SDS3
Alternative name(s):
Suppressor of defective silencing protein 3
Gene namesi
Name:SDS3
Ordered Locus Names:YIL084C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IX

Organism-specific databases

EuPathDBiFungiDB:YIL084C.
SGDiS000001346. SDS3.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: SGD
  • nucleus Source: SGD
  • Rpd3L complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 327327Transcriptional regulatory protein SDS3PRO_0000097654Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei166 – 1661PhosphoserineCombined sources
Modified residuei211 – 2111PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP40505.

PTM databases

iPTMnetiP40505.

Interactioni

Subunit structurei

Component of the RPD3C(L) complex composed of at least ASH1, CTI6, DEP1, PHO23, RPD3, RXT2, RXT3, SAP30, SDS3, SIN3, UME1 and UME6.5 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi34908. 325 interactions.
DIPiDIP-2706N.
IntActiP40505. 20 interactions.
MINTiMINT-556150.

Structurei

3D structure databases

ProteinModelPortaliP40505.
SMRiP40505. Positions 55-138.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili61 – 13575Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the SDS3 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000141851.
InParanoidiP40505.
OMAiRHNIESK.
OrthoDBiEOG092C3NV9.

Family and domain databases

InterProiIPR013907. Sds3.
[Graphical view]
PfamiPF08598. Sds3. 1 hit.
[Graphical view]
SMARTiSM01401. Sds3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40505-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIQKVSNKD LSRKDKRRFN IESKVNKIYQ NFYSERDNQY KDRLTALQTD
60 70 80 90 100
LTSLHQGDNG QYARQVRDLE EERDLELVRL RLFEEYRVSR SGIEFQEDIE
110 120 130 140 150
KAKAEHEKLI KLCKERLYSS IEQKIKKLQE ERLLMDVANV HSYAMNYSRP
160 170 180 190 200
QYQKNTRSHT VSGWDSSSNE YGRDTANESA TDTGAGNDRR TLRRRNASKD
210 220 230 240 250
TRGNNNNQDE SDFQTGNGSG SNGHGSRQGS QFPHFNNLTY KSGMNSDSDF
260 270 280 290 300
LQGINEGTDL YAFLFGEKNP KDNANGNEKK KNRGAQRYST KTAPPLQSLK
310 320
PDEVTEDISL IRELTGQPPA PFRLRSD
Length:327
Mass (Da):37,625
Last modified:February 1, 1995 - v1
Checksum:i4A6186E68BFE0CC7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62525 Genomic DNA. Translation: AAB40993.1.
Z46728 Genomic DNA. Translation: CAA86710.1.
AY692879 Genomic DNA. Translation: AAT92898.1.
BK006942 Genomic DNA. Translation: DAA08468.1.
PIRiS49796.
RefSeqiNP_012182.1. NM_001179432.1.

Genome annotation databases

EnsemblFungiiYIL084C; YIL084C; YIL084C.
GeneIDi854725.
KEGGisce:YIL084C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62525 Genomic DNA. Translation: AAB40993.1.
Z46728 Genomic DNA. Translation: CAA86710.1.
AY692879 Genomic DNA. Translation: AAT92898.1.
BK006942 Genomic DNA. Translation: DAA08468.1.
PIRiS49796.
RefSeqiNP_012182.1. NM_001179432.1.

3D structure databases

ProteinModelPortaliP40505.
SMRiP40505. Positions 55-138.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34908. 325 interactions.
DIPiDIP-2706N.
IntActiP40505. 20 interactions.
MINTiMINT-556150.

PTM databases

iPTMnetiP40505.

Proteomic databases

MaxQBiP40505.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYIL084C; YIL084C; YIL084C.
GeneIDi854725.
KEGGisce:YIL084C.

Organism-specific databases

EuPathDBiFungiDB:YIL084C.
SGDiS000001346. SDS3.

Phylogenomic databases

HOGENOMiHOG000141851.
InParanoidiP40505.
OMAiRHNIESK.
OrthoDBiEOG092C3NV9.

Enzyme and pathway databases

BioCyciYEAST:G3O-31346-MONOMER.

Miscellaneous databases

PROiP40505.

Family and domain databases

InterProiIPR013907. Sds3.
[Graphical view]
PfamiPF08598. Sds3. 1 hit.
[Graphical view]
SMARTiSM01401. Sds3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSDS3_YEAST
AccessioniPrimary (citable) accession number: P40505
Secondary accession number(s): D6VVK2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 7, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 105 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.