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P40501

- AVT7_YEAST

UniProt

P40501 - AVT7_YEAST

Protein

Vacuolar amino acid transporter 7

Gene

AVT7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Probable amino acid transporter of unknown specificity.1 Publication

    GO - Molecular functioni

    1. amino acid transmembrane transporter activity Source: SGD

    GO - Biological processi

    1. amino acid transmembrane transport Source: GOC
    2. amino acid transport Source: SGD

    Keywords - Biological processi

    Amino-acid transport, Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31348-MONOMER.

    Protein family/group databases

    TCDBi2.A.18.6.19. the amino acid/auxin permease (aaap) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vacuolar amino acid transporter 7
    Gene namesi
    Name:AVT7
    Ordered Locus Names:YIL088C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome IX

    Organism-specific databases

    CYGDiYIL088c.
    SGDiS000001350. AVT7.

    Subcellular locationi

    Vacuole membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. fungal-type vacuole Source: SGD
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: SGD
    4. vacuolar membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 490490Vacuolar amino acid transporter 7PRO_0000093840Add
    BLAST

    Proteomic databases

    MaxQBiP40501.
    PaxDbiP40501.

    Expressioni

    Gene expression databases

    GenevestigatoriP40501.

    Interactioni

    Protein-protein interaction databases

    BioGridi34905. 13 interactions.
    DIPiDIP-7299N.
    MINTiMINT-4489877.
    STRINGi4932.YIL088C.

    Structurei

    3D structure databases

    ProteinModelPortaliP40501.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 66CytoplasmicSequence Analysis
    Topological domaini28 – 347VacuolarSequence Analysis
    Topological domaini56 – 8429CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini106 – 1083VacuolarSequence Analysis
    Topological domaini130 – 14314CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini165 – 19026VacuolarSequence AnalysisAdd
    BLAST
    Topological domaini212 – 22110CytoplasmicSequence Analysis
    Topological domaini243 – 26422VacuolarSequence AnalysisAdd
    BLAST
    Topological domaini286 – 397112CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini419 – 42810VacuolarSequence Analysis
    Topological domaini450 – 46314CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini485 – 4906VacuolarSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 2721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei35 – 5521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei85 – 10521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei109 – 12921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei144 – 16421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei191 – 21121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei222 – 24221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei265 – 28521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei398 – 41821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei429 – 44921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei464 – 48421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0814.
    GeneTreeiENSGT00710000106751.
    HOGENOMiHOG000173527.
    OMAiCFGCAIS.
    OrthoDBiEOG7C8GSX.

    Family and domain databases

    InterProiIPR013057. AA_transpt_TM.
    [Graphical view]
    PfamiPF01490. Aa_trans. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P40501-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEATSSALSS TANLVKTIVG AGTLAIPYSF KSDGVLVGVI LTLLAAVTSG    50
    LGLFVLSKCS KTLINPRNSS FFTLCMLTYP TLAPIFDLAM IVQCFGVGLS 100
    YLVLIGDLFP GLFGGERNYW IIASAVIIIP LCLVKKLDQL KYSSILGLFA 150
    LAYISILVFS HFVFELGKGE LTNILRNDIC WWKIHDFKGL LSTFSIIIFA 200
    FTGSMNLFPM INELKDNSME NITFVINNSI SLSTALFLIV GLSGYLTFGN 250
    ETLGNLMLNY DPNSIWIVIG KFCLGSMLIL SFPLLFHPLR IAVNNVIIWI 300
    EITYGGANPE EDPQVSEYTR ASNLRPISMT VEDPAQPSDA LDATSYNEQE 350
    CLLPNGNFDN GSIESQENNN DERGTMAVAG DNEHHAPFVK SRFYWITALL 400
    LISMYTLALS VQSFALVLSF VGATGSTSIS FTLPGLLGYK LIGLDSLAIG 450
    KMIPPKDRFY KRCSLLLVFY GLSVMFLSLY VTVFNRSDEA 490
    Length:490
    Mass (Da):53,737
    Last modified:February 1, 1995 - v1
    Checksum:iD3D15CD8253220A1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46728 Genomic DNA. Translation: CAA86706.1.
    BK006942 Genomic DNA. Translation: DAA08465.1.
    PIRiS49792.
    RefSeqiNP_012178.1. NM_001179436.1.

    Genome annotation databases

    EnsemblFungiiYIL088C; YIL088C; YIL088C.
    GeneIDi854721.
    KEGGisce:YIL088C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46728 Genomic DNA. Translation: CAA86706.1 .
    BK006942 Genomic DNA. Translation: DAA08465.1 .
    PIRi S49792.
    RefSeqi NP_012178.1. NM_001179436.1.

    3D structure databases

    ProteinModelPortali P40501.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 34905. 13 interactions.
    DIPi DIP-7299N.
    MINTi MINT-4489877.
    STRINGi 4932.YIL088C.

    Protein family/group databases

    TCDBi 2.A.18.6.19. the amino acid/auxin permease (aaap) family.

    Proteomic databases

    MaxQBi P40501.
    PaxDbi P40501.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YIL088C ; YIL088C ; YIL088C .
    GeneIDi 854721.
    KEGGi sce:YIL088C.

    Organism-specific databases

    CYGDi YIL088c.
    SGDi S000001350. AVT7.

    Phylogenomic databases

    eggNOGi COG0814.
    GeneTreei ENSGT00710000106751.
    HOGENOMi HOG000173527.
    OMAi CFGCAIS.
    OrthoDBi EOG7C8GSX.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31348-MONOMER.

    Miscellaneous databases

    NextBioi 977403.
    PROi P40501.

    Gene expression databases

    Genevestigatori P40501.

    Family and domain databases

    InterProi IPR013057. AA_transpt_TM.
    [Graphical view ]
    Pfami PF01490. Aa_trans. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "A family of yeast proteins mediating bidirectional vacuolar amino acid transport."
      Russnak R., Konczal D., McIntire S.L.
      J. Biol. Chem. 276:23849-23857(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    5. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.

    Entry informationi

    Entry nameiAVT7_YEAST
    AccessioniPrimary (citable) accession number: P40501
    Secondary accession number(s): D6VVJ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 195 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome IX
      Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

    External Data

    Dasty 3