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P40501

- AVT7_YEAST

UniProt

P40501 - AVT7_YEAST

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Protein

Vacuolar amino acid transporter 7

Gene

AVT7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Probable amino acid transporter of unknown specificity.1 Publication

GO - Molecular functioni

  1. amino acid transmembrane transporter activity Source: SGD

GO - Biological processi

  1. amino acid transmembrane transport Source: GOC
  2. amino acid transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31348-MONOMER.

Protein family/group databases

TCDBi2.A.18.6.19. the amino acid/auxin permease (aaap) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar amino acid transporter 7
Gene namesi
Name:AVT7
Ordered Locus Names:YIL088C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IX

Organism-specific databases

CYGDiYIL088c.
SGDiS000001350. AVT7.

Subcellular locationi

Vacuole membrane 1 Publication; Multi-pass membrane protein 1 Publication

GO - Cellular componenti

  1. fungal-type vacuole Source: SGD
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 490490Vacuolar amino acid transporter 7PRO_0000093840Add
BLAST

Proteomic databases

MaxQBiP40501.
PaxDbiP40501.

Expressioni

Gene expression databases

GenevestigatoriP40501.

Interactioni

Protein-protein interaction databases

BioGridi34905. 13 interactions.
DIPiDIP-7299N.
MINTiMINT-4489877.
STRINGi4932.YIL088C.

Structurei

3D structure databases

ProteinModelPortaliP40501.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 66CytoplasmicSequence Analysis
Topological domaini28 – 347VacuolarSequence Analysis
Topological domaini56 – 8429CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini106 – 1083VacuolarSequence Analysis
Topological domaini130 – 14314CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini165 – 19026VacuolarSequence AnalysisAdd
BLAST
Topological domaini212 – 22110CytoplasmicSequence Analysis
Topological domaini243 – 26422VacuolarSequence AnalysisAdd
BLAST
Topological domaini286 – 397112CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini419 – 42810VacuolarSequence Analysis
Topological domaini450 – 46314CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini485 – 4906VacuolarSequence Analysis

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2721HelicalSequence AnalysisAdd
BLAST
Transmembranei35 – 5521HelicalSequence AnalysisAdd
BLAST
Transmembranei85 – 10521HelicalSequence AnalysisAdd
BLAST
Transmembranei109 – 12921HelicalSequence AnalysisAdd
BLAST
Transmembranei144 – 16421HelicalSequence AnalysisAdd
BLAST
Transmembranei191 – 21121HelicalSequence AnalysisAdd
BLAST
Transmembranei222 – 24221HelicalSequence AnalysisAdd
BLAST
Transmembranei265 – 28521HelicalSequence AnalysisAdd
BLAST
Transmembranei398 – 41821HelicalSequence AnalysisAdd
BLAST
Transmembranei429 – 44921HelicalSequence AnalysisAdd
BLAST
Transmembranei464 – 48421HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0814.
GeneTreeiENSGT00710000106751.
HOGENOMiHOG000173527.
InParanoidiP40501.
OMAiCFGCAIS.
OrthoDBiEOG7C8GSX.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40501-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEATSSALSS TANLVKTIVG AGTLAIPYSF KSDGVLVGVI LTLLAAVTSG
60 70 80 90 100
LGLFVLSKCS KTLINPRNSS FFTLCMLTYP TLAPIFDLAM IVQCFGVGLS
110 120 130 140 150
YLVLIGDLFP GLFGGERNYW IIASAVIIIP LCLVKKLDQL KYSSILGLFA
160 170 180 190 200
LAYISILVFS HFVFELGKGE LTNILRNDIC WWKIHDFKGL LSTFSIIIFA
210 220 230 240 250
FTGSMNLFPM INELKDNSME NITFVINNSI SLSTALFLIV GLSGYLTFGN
260 270 280 290 300
ETLGNLMLNY DPNSIWIVIG KFCLGSMLIL SFPLLFHPLR IAVNNVIIWI
310 320 330 340 350
EITYGGANPE EDPQVSEYTR ASNLRPISMT VEDPAQPSDA LDATSYNEQE
360 370 380 390 400
CLLPNGNFDN GSIESQENNN DERGTMAVAG DNEHHAPFVK SRFYWITALL
410 420 430 440 450
LISMYTLALS VQSFALVLSF VGATGSTSIS FTLPGLLGYK LIGLDSLAIG
460 470 480 490
KMIPPKDRFY KRCSLLLVFY GLSVMFLSLY VTVFNRSDEA
Length:490
Mass (Da):53,737
Last modified:February 1, 1995 - v1
Checksum:iD3D15CD8253220A1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z46728 Genomic DNA. Translation: CAA86706.1.
BK006942 Genomic DNA. Translation: DAA08465.1.
PIRiS49792.
RefSeqiNP_012178.1. NM_001179436.1.

Genome annotation databases

EnsemblFungiiYIL088C; YIL088C; YIL088C.
GeneIDi854721.
KEGGisce:YIL088C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z46728 Genomic DNA. Translation: CAA86706.1 .
BK006942 Genomic DNA. Translation: DAA08465.1 .
PIRi S49792.
RefSeqi NP_012178.1. NM_001179436.1.

3D structure databases

ProteinModelPortali P40501.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 34905. 13 interactions.
DIPi DIP-7299N.
MINTi MINT-4489877.
STRINGi 4932.YIL088C.

Protein family/group databases

TCDBi 2.A.18.6.19. the amino acid/auxin permease (aaap) family.

Proteomic databases

MaxQBi P40501.
PaxDbi P40501.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YIL088C ; YIL088C ; YIL088C .
GeneIDi 854721.
KEGGi sce:YIL088C.

Organism-specific databases

CYGDi YIL088c.
SGDi S000001350. AVT7.

Phylogenomic databases

eggNOGi COG0814.
GeneTreei ENSGT00710000106751.
HOGENOMi HOG000173527.
InParanoidi P40501.
OMAi CFGCAIS.
OrthoDBi EOG7C8GSX.

Enzyme and pathway databases

BioCyci YEAST:G3O-31348-MONOMER.

Miscellaneous databases

NextBioi 977403.
PROi P40501.

Gene expression databases

Genevestigatori P40501.

Family and domain databases

InterProi IPR013057. AA_transpt_TM.
[Graphical view ]
Pfami PF01490. Aa_trans. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "A family of yeast proteins mediating bidirectional vacuolar amino acid transport."
    Russnak R., Konczal D., McIntire S.L.
    J. Biol. Chem. 276:23849-23857(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.

Entry informationi

Entry nameiAVT7_YEAST
AccessioniPrimary (citable) accession number: P40501
Secondary accession number(s): D6VVJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 29, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 195 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

External Data

Dasty 3