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P40501 (AVT7_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Vacuolar amino acid transporter 7
Gene names
Name:AVT7
Ordered Locus Names:YIL088C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length490 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probable amino acid transporter of unknown specificity. Ref.3

Subcellular location

Vacuole membrane; Multi-pass membrane protein Ref.3.

Miscellaneous

Present with 195 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the amino acid/polyamine transporter 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 490490Vacuolar amino acid transporter 7
PRO_0000093840

Regions

Topological domain1 – 66Cytoplasmic Potential
Transmembrane7 – 2721Helical; Potential
Topological domain28 – 347Vacuolar Potential
Transmembrane35 – 5521Helical; Potential
Topological domain56 – 8429Cytoplasmic Potential
Transmembrane85 – 10521Helical; Potential
Topological domain106 – 1083Vacuolar Potential
Transmembrane109 – 12921Helical; Potential
Topological domain130 – 14314Cytoplasmic Potential
Transmembrane144 – 16421Helical; Potential
Topological domain165 – 19026Vacuolar Potential
Transmembrane191 – 21121Helical; Potential
Topological domain212 – 22110Cytoplasmic Potential
Transmembrane222 – 24221Helical; Potential
Topological domain243 – 26422Vacuolar Potential
Transmembrane265 – 28521Helical; Potential
Topological domain286 – 397112Cytoplasmic Potential
Transmembrane398 – 41821Helical; Potential
Topological domain419 – 42810Vacuolar Potential
Transmembrane429 – 44921Helical; Potential
Topological domain450 – 46314Cytoplasmic Potential
Transmembrane464 – 48421Helical; Potential
Topological domain485 – 4906Vacuolar Potential

Sequences

Sequence LengthMass (Da)Tools
P40501 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: D3D15CD8253220A1

FASTA49053,737
        10         20         30         40         50         60 
MEATSSALSS TANLVKTIVG AGTLAIPYSF KSDGVLVGVI LTLLAAVTSG LGLFVLSKCS 

        70         80         90        100        110        120 
KTLINPRNSS FFTLCMLTYP TLAPIFDLAM IVQCFGVGLS YLVLIGDLFP GLFGGERNYW 

       130        140        150        160        170        180 
IIASAVIIIP LCLVKKLDQL KYSSILGLFA LAYISILVFS HFVFELGKGE LTNILRNDIC 

       190        200        210        220        230        240 
WWKIHDFKGL LSTFSIIIFA FTGSMNLFPM INELKDNSME NITFVINNSI SLSTALFLIV 

       250        260        270        280        290        300 
GLSGYLTFGN ETLGNLMLNY DPNSIWIVIG KFCLGSMLIL SFPLLFHPLR IAVNNVIIWI 

       310        320        330        340        350        360 
EITYGGANPE EDPQVSEYTR ASNLRPISMT VEDPAQPSDA LDATSYNEQE CLLPNGNFDN 

       370        380        390        400        410        420 
GSIESQENNN DERGTMAVAG DNEHHAPFVK SRFYWITALL LISMYTLALS VQSFALVLSF 

       430        440        450        460        470        480 
VGATGSTSIS FTLPGLLGYK LIGLDSLAIG KMIPPKDRFY KRCSLLLVFY GLSVMFLSLY 

       490 
VTVFNRSDEA 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome IX."
Churcher C.M., Bowman S., Badcock K., Bankier A.T., Brown D., Chillingworth T., Connor R., Devlin K., Gentles S., Hamlin N., Harris D.E., Horsnell T., Hunt S., Jagels K., Jones M., Lye G., Moule S., Odell C. expand/collapse author list , Pearson D., Rajandream M.A., Rice P., Rowley N., Skelton J., Smith V., Walsh S.V., Whitehead S., Barrell B.G.
Nature 387:84-87(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"A family of yeast proteins mediating bidirectional vacuolar amino acid transport."
Russnak R., Konczal D., McIntire S.L.
J. Biol. Chem. 276:23849-23857(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z46728 Genomic DNA. Translation: CAA86706.1.
BK006942 Genomic DNA. Translation: DAA08465.1.
PIRS49792.
RefSeqNP_012178.1. NM_001179436.1.

3D structure databases

ProteinModelPortalP40501.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid34905. 13 interactions.
DIPDIP-7299N.
MINTMINT-4489877.
STRING4932.YIL088C.

Protein family/group databases

TCDB2.A.18.6.19. the amino acid/auxin permease (aaap) family.

Proteomic databases

PaxDbP40501.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYIL088C; YIL088C; YIL088C.
GeneID854721.
KEGGsce:YIL088C.

Organism-specific databases

CYGDYIL088c.
SGDS000001350. AVT7.

Phylogenomic databases

eggNOGCOG0814.
GeneTreeENSGT00710000106751.
HOGENOMHOG000173527.
OMACFGCAIS.
OrthoDBEOG7C8GSX.

Enzyme and pathway databases

BioCycYEAST:G3O-31348-MONOMER.

Gene expression databases

GenevestigatorP40501.

Family and domain databases

InterProIPR013057. AA_transpt_TM.
[Graphical view]
PfamPF01490. Aa_trans. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio977403.
PROP40501.

Entry information

Entry nameAVT7_YEAST
AccessionPrimary (citable) accession number: P40501
Secondary accession number(s): D6VVJ9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 16, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome IX

Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families