Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein FYV10

Gene

FYV10

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase and required for survival upon exposure to K1 killer toxin.2 Publications

GO - Biological processi

  • negative regulation of apoptotic process Source: SGD
  • negative regulation of gluconeogenesis Source: SGD
  • proteasome-mediated ubiquitin-dependent protein catabolic process Source: SGD
  • protein ubiquitination Source: GOC
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-31356-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FYV10
Alternative name(s):
Function required for yeast viability protein 10
Glucose-induced degradation protein 9
Gene namesi
Name:FYV10
Synonyms:GID9
Ordered Locus Names:YIL097W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IX

Organism-specific databases

EuPathDBiFungiDB:YIL097W.
SGDiS000001359. FYV10.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • GID complex Source: SGD
  • nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 516516Protein FYV10PRO_0000202970Add
BLAST

Proteomic databases

MaxQBiP40492.

Interactioni

Protein-protein interaction databases

BioGridi34894. 96 interactions.
DIPiDIP-4148N.
IntActiP40492. 4 interactions.
MINTiMINT-521459.

Structurei

3D structure databases

ProteinModelPortaliP40492.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini187 – 24559CTLHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the FYV10 family.Curated
Contains 1 CTLH domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00720000108841.
HOGENOMiHOG000000964.
InParanoidiP40492.
KOiK18624.
OMAiLLSNERW.
OrthoDBiEOG79W9FR.

Family and domain databases

InterProiIPR024964. CTLH/CRA.
IPR006595. CTLH_C.
[Graphical view]
PfamiPF10607. CLTH. 1 hit.
[Graphical view]
SMARTiSM00668. CTLH. 1 hit.
[Graphical view]
PROSITEiPS50897. CTLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40492-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEKSIFNEP DVDFHLKLNQ QLFHIPYELL SKRIKHTQAV INKETKSLHE
60 70 80 90 100
HTAALNQIFE HNDVEHDELA LAKITEMIRK VDHIERFLNT QIKSYCQILN
110 120 130 140 150
RIKKRLEFFH ELKDIKSQNS GTSHNGNNEG TRTKLIQWYQ SYTNILIGDY
160 170 180 190 200
LTRNNPIKYN SETKDHWNSG VVFLKQSQLD DLIDYDVLLE ANRISTSLLH
210 220 230 240 250
ERNLLPLISW INENKKTLTK KSSILEFQAR LQEYIELLKV DNYTDAIVCF
260 270 280 290 300
QRFLLPFVKS NFTDLKLASG LLIFIKYCND QKPTSSTSSG FDTEEIKSQS
310 320 330 340 350
LPMKKDRIFQ HFFHKSLPRI TSKPAVNTTD YDKSSLINLQ SGDFERYLNL
360 370 380 390 400
LDDQRWSVLN DLFLSDFYSM YGISQNDPLL IYLSLGISSL KTRDCLHPSD
410 420 430 440 450
DENGNQETET ATTAEKEVED LQLFTLHSLK RKNCPVCSET FKPITQALPF
460 470 480 490 500
AHHIQSQLFE NPILLPNGNV YDSKKLKKLA KTLKKQNLIS LNPGQIMDPV
510
DMKIFCESDS IKMYPT
Length:516
Mass (Da):59,894
Last modified:February 1, 1995 - v1
Checksum:i2EACCF8C6C314D56
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38125 Genomic DNA. Translation: CAA86284.1.
AY692905 Genomic DNA. Translation: AAT92924.1.
BK006942 Genomic DNA. Translation: DAA08456.1.
PIRiS48476.
RefSeqiNP_012169.1. NM_001179445.1.

Genome annotation databases

EnsemblFungiiYIL097W; YIL097W; YIL097W.
GeneIDi854710.
KEGGisce:YIL097W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38125 Genomic DNA. Translation: CAA86284.1.
AY692905 Genomic DNA. Translation: AAT92924.1.
BK006942 Genomic DNA. Translation: DAA08456.1.
PIRiS48476.
RefSeqiNP_012169.1. NM_001179445.1.

3D structure databases

ProteinModelPortaliP40492.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34894. 96 interactions.
DIPiDIP-4148N.
IntActiP40492. 4 interactions.
MINTiMINT-521459.

Proteomic databases

MaxQBiP40492.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYIL097W; YIL097W; YIL097W.
GeneIDi854710.
KEGGisce:YIL097W.

Organism-specific databases

EuPathDBiFungiDB:YIL097W.
SGDiS000001359. FYV10.

Phylogenomic databases

GeneTreeiENSGT00720000108841.
HOGENOMiHOG000000964.
InParanoidiP40492.
KOiK18624.
OMAiLLSNERW.
OrthoDBiEOG79W9FR.

Enzyme and pathway databases

BioCyciYEAST:G3O-31356-MONOMER.

Miscellaneous databases

PROiP40492.

Family and domain databases

InterProiIPR024964. CTLH/CRA.
IPR006595. CTLH_C.
[Graphical view]
PfamiPF10607. CLTH. 1 hit.
[Graphical view]
SMARTiSM00668. CTLH. 1 hit.
[Graphical view]
PROSITEiPS50897. CTLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. "A Saccharomyces cerevisiae genome-wide mutant screen for altered sensitivity to K1 killer toxin."
    Page N., Gerard-Vincent M., Menard P., Beaulieu M., Azuma M., Dijkgraaf G.J.P., Li H., Marcoux J., Nguyen T., Dowse T., Sdicu A.-M., Bussey H.
    Genetics 163:875-894(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "Catabolite degradation of fructose-1,6-bisphosphatase in the yeast Saccharomyces cerevisiae: a genome-wide screen identifies eight novel GID genes and indicates the existence of two degradation pathways."
    Regelmann J., Schuele T., Josupeit F.S., Horak J., Rose M., Entian K.-D., Thumm M., Wolf D.H.
    Mol. Biol. Cell 14:1652-1663(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiFYV10_YEAST
AccessioniPrimary (citable) accession number: P40492
Secondary accession number(s): D6VVJ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: July 6, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 784 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.