Reviewed, UniProtKB/Swiss-Prot P40491 (FMC1_YEAST)

Names and origin

Protein names

Recommended name:
    ATP synthase assembly factor FMC1, mitochondrial
Alternative name(s):
    Formation of mitochondrial complexes protein 1

Gene names

Name:	FMC1
Ordered Locus Names:	YIL098C

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	155 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Needed for the assembly of the mitochondrial F1-F0 complex at high temperature. Ref.3
Subcellular location	Mitochondrion.
Miscellaneous	Present with 589 molecules/cell in log phase SD medium. Ref.6

Ontologies

Keywords
Biological process	Stress response
Cellular component	Mitochondrion
Domain	Transit peptide
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	mitochondrial proton-transporting ATP synthase complex assembly Ref.3 Inferred from genetic interaction. Source: SGD response to drug Inferred from mutant phenotype. Source: SGD response to stress Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrial matrix Ref.3 Inferred from direct assay. Source: SGD
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ATP12	P22135	1	EBI-25141,EBI-3312

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – ?		Mitochondrion Potential
	Chain	? – 155		ATP synthase assembly factor FMC1, mitochondrial		PRO_0000202969

Sequences

	Sequence		Length	Mass (Da)
	P40491-1 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: EAE988BFACA1F330	FASTA	155	18,364
	10 20 30 40 50 60 MDRPRTLRTY RGLIRAILKY ERPSKIVNWG NLRKAMITKL EYAKKQNQRD SHENINRQLE 70 80 90 100 110 120 KWKKLDPVSD RSLNLFIADS KSLRSILQND IKWEKKVAQG QNVDEIFEHA LDIIKFLDNQ 130 140 150 REYEELVDRY NPGNKLTQDE KVKRTANVVG LDVPT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome IX." Churcher C.M., Bowman S., Badcock K., Bankier A.T., Brown D., Chillingworth T., Connor R., Devlin K., Gentles S., Hamlin N., Harris D.E., Horsnell T., Hunt S., Jagels K., Jones M., Lye G., Moule S., Odell C. , Pearson D., Rajandream M.A., Rice P., Rowley N., Skelton J., Smith V., Walsh S.V., Whitehead S., Barrell B.G. Nature 387:84-87(1997) [PubMed: 9169870] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[3]	"Identification of a nuclear gene (FMC1) required for the assembly/stability of yeast mitochondrial F(1)-ATPase in heat stress conditions." Lefebvre-Legendre L., Vaillier J., Benabdelhak H., Velours J., Slonimski P.P., di Rago J.-P. J. Biol. Chem. 276:6789-6796(2001) [PubMed: 11096112] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
[4]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed: 14562095] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[5]	"The proteome of Saccharomyces cerevisiae mitochondria." Sickmann A., Reinders J., Wagner Y., Joppich C., Zahedi R.P., Meyer H.E., Schoenfisch B., Perschil I., Chacinska A., Guiard B., Rehling P., Pfanner N., Meisinger C. Proc. Natl. Acad. Sci. U.S.A. 100:13207-13212(2003) [PubMed: 14576278] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[6]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z38125 Genomic DNA. Translation: CAA86283.1. AY558072 Genomic DNA. Translation: AAS56398.1.
PIR	S48475.
RefSeq	NP_012168.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:5652N.
IntAct	P40491. 2 interactions.
STRING	P40491.
Genome annotation databases
Ensembl	YIL098C; YIL098C; YIL098C; Saccharomyces cerevisiae. [Genome view]
GeneID	854709.
KEGG	sce:YIL098C.
NMPDR	fig|4932.3.peg.1695.
Organism-specific databases
CYGD	YIL098c.
SGD	S000001360. FMC1.
Phylogenomic databases
HOGENOM	P40491.
OrthoDB	EOG95MPNQ
Gene expression databases
ArrayExpress	P40491.
Genevestigator	P40491.
GermOnline	YIL098C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR018471. ATP_synth-assembly_fac_FMC1_mt. [Graphical view]
Pfam	PF10560. FMC1. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	977369.

Entry information

Entry name

FMC1_YEAST

Accession

Primary (citable) accession number: P40491

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	November 24, 2009
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)