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Protein

Protein SHQ1

Gene

SHQ1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the early biogenesis steps of box H/ACA snoRNP assembly.1 Publication

GO - Molecular functioni

  • unfolded protein binding Source: SGD

GO - Biological processi

  • box H/ACA snoRNP assembly Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-31360-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SHQ1
Alternative name(s):
Small nucleolar RNAs of the box H/ACA family quantitative accumulation protein 1
Gene namesi
Name:SHQ1
Ordered Locus Names:YIL104C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IX

Organism-specific databases

EuPathDBiFungiDB:YIL104C.
SGDiS000001366. SHQ1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: SGD
  • nucleoplasm Source: SGD
  • nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 507507Protein SHQ1PRO_0000202966Add
BLAST

Proteomic databases

MaxQBiP40486.
PeptideAtlasiP40486.

Interactioni

Subunit structurei

Interacts with CBF5, NAF1 and NHP2. The interaction with NAF1 and SHQ1 does not occur when NAF1 is associated with the chromatin.2 Publications

GO - Molecular functioni

  • unfolded protein binding Source: SGD

Protein-protein interaction databases

BioGridi34887. 21 interactions.
DIPiDIP-4970N.
IntActiP40486. 10 interactions.
MINTiMINT-479871.

Structurei

Secondary structure

1
507
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi6 – 105Combined sources
Beta strandi12 – 209Combined sources
Beta strandi28 – 303Combined sources
Beta strandi32 – 365Combined sources
Beta strandi39 – 446Combined sources
Beta strandi47 – 526Combined sources
Beta strandi64 – 685Combined sources
Turni69 – 724Combined sources
Beta strandi73 – 8210Combined sources
Helixi93 – 964Combined sources
Helixi172 – 1743Combined sources
Helixi179 – 1846Combined sources
Turni185 – 1873Combined sources
Helixi196 – 1983Combined sources
Helixi201 – 21515Combined sources
Helixi218 – 23013Combined sources
Helixi233 – 2397Combined sources
Helixi241 – 2455Combined sources
Helixi250 – 25910Combined sources
Helixi275 – 28410Combined sources
Helixi296 – 31520Combined sources
Turni316 – 3183Combined sources
Helixi324 – 3318Combined sources
Helixi333 – 3364Combined sources
Helixi364 – 37613Combined sources
Beta strandi379 – 3813Combined sources
Helixi385 – 40117Combined sources
Helixi403 – 41816Combined sources
Turni421 – 4244Combined sources
Helixi425 – 4295Combined sources
Helixi431 – 44111Combined sources
Helixi444 – 46017Combined sources
Helixi463 – 4653Combined sources
Beta strandi467 – 4715Combined sources
Turni476 – 4783Combined sources
Beta strandi483 – 4875Combined sources
Helixi488 – 50417Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2K8QNMR-A1-134[»]
3EUDX-ray2.40A/B/C/D/E/F1-98[»]
3UAHX-ray1.60A147-507[»]
3UAIX-ray3.06D147-507[»]
3ZUZX-ray1.50A143-507[»]
3ZV0X-ray2.80A/B145-507[»]
ProteinModelPortaliP40486.
SMRiP40486. Positions 2-134, 165-507.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP40486.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 9191CSPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the SHQ1 family.Curated
Contains 1 CS domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000007605.
HOGENOMiHOG000248098.
InParanoidiP40486.
KOiK14764.
OMAiITDYCIW.
OrthoDBiEOG7MD50M.

Family and domain databases

InterProiIPR007052. CS_dom.
IPR008978. HSP20-like_chaperone.
IPR007009. SHQ1.
[Graphical view]
PfamiPF04925. SHQ1. 1 hit.
[Graphical view]
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS51203. CS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40486-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MITPRFSITQ DEEFIFLKIF ISNIRFSAVG LEIIIQENMI IFHLSPYYLR
60 70 80 90 100
LRFPHELIDD ERSTAQYDSK DECINVKVAK LNKNEYFEDL DLPTKLLARQ
110 120 130 140 150
GDLAGADALT ENTDAKKTQK PLIQEVETDG VSNNIKDDVK TIGQMGEGFN
160 170 180 190 200
WEIEQKMDSS TNNGILKTKY GFDNLYDTVI SVSTSNGNDI NELDDPEHTD
210 220 230 240 250
ANDRVIERLR KENLKFDPEY YVSEYMTHKY GNEEDLEING IKELLKFTPS
260 270 280 290 300
IVKQYLQWYK DSTNPNLVMP IEFTDEEQKQ MQDNLPKKSY LVEDIKPLYV
310 320 330 340 350
TILSVLFSYV FEQIENEGTH TTESAWTMGK LCPQISFLDQ QLKQVNELQD
360 370 380 390 400
GMKEISKVNK DSSLIKIAII TGIRRALSYP LHRNYDLAMK AWTFVYYILR
410 420 430 440 450
GGKRLVIRAL LDIHETFRFH DVYYVYDKVL LDDLTAWFIS QGSENVIRSL
460 470 480 490 500
ALEMRKEQES LSKQDIEFEC IASFNEQTGE PEWETLNIRE MEILAESEYR

EQQQNPQ
Length:507
Mass (Da):59,151
Last modified:February 1, 1995 - v1
Checksum:i15A6A66C66E70C39
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38125 Genomic DNA. Translation: CAA86276.1.
BK006942 Genomic DNA. Translation: DAA08449.1.
PIRiS48468.
RefSeqiNP_012162.3. NM_001179452.3.

Genome annotation databases

EnsemblFungiiYIL104C; YIL104C; YIL104C.
GeneIDi854702.
KEGGisce:YIL104C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38125 Genomic DNA. Translation: CAA86276.1.
BK006942 Genomic DNA. Translation: DAA08449.1.
PIRiS48468.
RefSeqiNP_012162.3. NM_001179452.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2K8QNMR-A1-134[»]
3EUDX-ray2.40A/B/C/D/E/F1-98[»]
3UAHX-ray1.60A147-507[»]
3UAIX-ray3.06D147-507[»]
3ZUZX-ray1.50A143-507[»]
3ZV0X-ray2.80A/B145-507[»]
ProteinModelPortaliP40486.
SMRiP40486. Positions 2-134, 165-507.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34887. 21 interactions.
DIPiDIP-4970N.
IntActiP40486. 10 interactions.
MINTiMINT-479871.

Proteomic databases

MaxQBiP40486.
PeptideAtlasiP40486.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYIL104C; YIL104C; YIL104C.
GeneIDi854702.
KEGGisce:YIL104C.

Organism-specific databases

EuPathDBiFungiDB:YIL104C.
SGDiS000001366. SHQ1.

Phylogenomic databases

GeneTreeiENSGT00390000007605.
HOGENOMiHOG000248098.
InParanoidiP40486.
KOiK14764.
OMAiITDYCIW.
OrthoDBiEOG7MD50M.

Enzyme and pathway databases

BioCyciYEAST:G3O-31360-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP40486.
NextBioi977352.
PROiP40486.

Family and domain databases

InterProiIPR007052. CS_dom.
IPR008978. HSP20-like_chaperone.
IPR007009. SHQ1.
[Graphical view]
PfamiPF04925. SHQ1. 1 hit.
[Graphical view]
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS51203. CS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "The Shq1p.Naf1p complex is required for box H/ACA small nucleolar ribonucleoprotein particle biogenesis."
    Yang P.K., Rotondo G., Porras T., Legrain P., Chanfreau G.
    J. Biol. Chem. 277:45235-45242(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CBF5; NAF1 AND NHP2.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "Cotranscriptional recruitment of the pseudouridylsynthetase Cbf5p and of the RNA binding protein Naf1p during H/ACA snoRNP assembly."
    Yang P.K., Hoareau C., Froment C., Monsarrat B., Henry Y., Chanfreau G.
    Mol. Cell. Biol. 25:3295-3304(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NAF1.

Entry informationi

Entry nameiSHQ1_YEAST
AccessioniPrimary (citable) accession number: P40486
Secondary accession number(s): D6VVI3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 11, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 7060 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.