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P40483

- YIK8_YEAST

UniProt

P40483 - YIK8_YEAST

Protein

Putative zinc metalloproteinase YIL108W

Gene

YIL108W

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Cofactori

    Binds 1 zinc ion.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi318 – 3181Zinc; catalyticPROSITE-ProRule annotation
    Active sitei319 – 3191PROSITE-ProRule annotation
    Metal bindingi322 – 3221Zinc; catalyticPROSITE-ProRule annotation
    Metal bindingi328 – 3281Zinc; catalyticPROSITE-ProRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. metallopeptidase activity Source: UniProtKB-KW
    3. protein binding Source: IntAct

    Keywords - Molecular functioni

    Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31363-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative zinc metalloproteinase YIL108W (EC:3.4.24.-)
    Gene namesi
    Ordered Locus Names:YIL108W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome IX

    Organism-specific databases

    CYGDiYIL108w.
    SGDiS000001370. YIL108W.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 696696Putative zinc metalloproteinase YIL108WPRO_0000078181Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei361 – 3611Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP40483.
    PaxDbiP40483.
    PeptideAtlasiP40483.

    Expressioni

    Gene expression databases

    GenevestigatoriP40483.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PIN3Q064493EBI-25176,EBI-35523

    Protein-protein interaction databases

    BioGridi34883. 13 interactions.
    DIPiDIP-5657N.
    IntActiP40483. 4 interactions.
    MINTiMINT-2493057.
    STRINGi4932.YIL108W.

    Structurei

    3D structure databases

    ProteinModelPortaliP40483.
    SMRiP40483. Positions 610-693.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M10B family.Curated

    Phylogenomic databases

    eggNOGiNOG283285.
    GeneTreeiENSGT00730000114706.
    HOGENOMiHOG000197526.
    KOiK01417.
    OMAiDCTRTDT.
    OrthoDBiEOG747PSH.

    Family and domain databases

    Gene3Di2.100.10.30. 2 hits.
    3.40.390.10. 1 hit.
    InterProiIPR001229. Mannose-bd_lectin.
    IPR024079. MetalloPept_cat_dom.
    IPR021917. Unchr_Zn-peptidase-like.
    [Graphical view]
    PfamiPF01419. Jacalin. 1 hit.
    PF12044. Metallopep. 1 hit.
    [Graphical view]
    SUPFAMiSSF51101. SSF51101. 2 hits.
    PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P40483-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVGSKDIDLF NLRENEQIVS PCLIVHGKCN KQNGAKTVQV QHPQLPPITY    50
    PIHNQFFKAT VILTPGENKL TFVTDTNTAR TIVCYYTPLT QNPPVHLCLI 100
    LAKDSPLQFD SPREQKDREG GNGLELAIKK LRLGARLMQA YTNEQMLRNS 150
    MGNRTFPFVE EFTWDTLFER PAMRNTIKIH VVRSEKTVKE IQDPDIAQQN 200
    SKGKNTGALF GIAMDALKSY GGPFTNNEKP VQAACMFLDT HWDGKLIRGH 250
    AALGGGDDSI KLAIFGSHGL YSWPTCLEQL VPYFTDETRS STSEVANDCN 300
    ECGTYWECLT ITLGAFMHEI GHLLGCPHQE SGVMLRGYTT LNRSFLTKEA 350
    YSVRTNSTGA SPPIFPKEEC TWNRLDTVRF LYHPSFTLPQ DYYDPSFMRP 400
    TKLGGYPNIK HSVYPLGNGS CRILSPTGIY LIEIICDDLA RGHIEYLPVS 450
    LGGQGPQREV IVTLDDLRAR LPKNELAKFG NTFKLKILSV NAPETEFDKF 500
    PSLLDVQPLD MSKYGFSKNV QGIKSPLYGR SDGGNAVGVV AFDVRLVTAV 550
    RIYHGYALDG VRFYYKEKPT GTKDAPASKP SVPPRNYFSK ITHSIKNHAS 600
    INEENLKSVL FGHETQNFTD ATLEPGEIII GFNLRCGAWV DAIQIITSHG 650
    RMTDMFGNKD GGGFAELQPP NGQYILGVTG RVGQWVDAFG IIYGAL 696
    Length:696
    Mass (Da):77,414
    Last modified:February 1, 1995 - v1
    Checksum:i89ED15503933653B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti696 – 6961L → F in AAT92711. (PubMed:17322287)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z38125 Genomic DNA. Translation: CAA86272.1.
    AY692692 Genomic DNA. Translation: AAT92711.1.
    BK006942 Genomic DNA. Translation: DAA08445.1.
    PIRiS48464.
    RefSeqiNP_012158.1. NM_001179456.1.

    Genome annotation databases

    EnsemblFungiiYIL108W; YIL108W; YIL108W.
    GeneIDi854698.
    KEGGisce:YIL108W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z38125 Genomic DNA. Translation: CAA86272.1 .
    AY692692 Genomic DNA. Translation: AAT92711.1 .
    BK006942 Genomic DNA. Translation: DAA08445.1 .
    PIRi S48464.
    RefSeqi NP_012158.1. NM_001179456.1.

    3D structure databases

    ProteinModelPortali P40483.
    SMRi P40483. Positions 610-693.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 34883. 13 interactions.
    DIPi DIP-5657N.
    IntActi P40483. 4 interactions.
    MINTi MINT-2493057.
    STRINGi 4932.YIL108W.

    Proteomic databases

    MaxQBi P40483.
    PaxDbi P40483.
    PeptideAtlasi P40483.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YIL108W ; YIL108W ; YIL108W .
    GeneIDi 854698.
    KEGGi sce:YIL108W.

    Organism-specific databases

    CYGDi YIL108w.
    SGDi S000001370. YIL108W.

    Phylogenomic databases

    eggNOGi NOG283285.
    GeneTreei ENSGT00730000114706.
    HOGENOMi HOG000197526.
    KOi K01417.
    OMAi DCTRTDT.
    OrthoDBi EOG747PSH.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31363-MONOMER.

    Miscellaneous databases

    NextBioi 977340.

    Gene expression databases

    Genevestigatori P40483.

    Family and domain databases

    Gene3Di 2.100.10.30. 2 hits.
    3.40.390.10. 1 hit.
    InterProi IPR001229. Mannose-bd_lectin.
    IPR024079. MetalloPept_cat_dom.
    IPR021917. Unchr_Zn-peptidase-like.
    [Graphical view ]
    Pfami PF01419. Jacalin. 1 hit.
    PF12044. Metallopep. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51101. SSF51101. 2 hits.
    PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-361, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Sites of ubiquitin attachment in Saccharomyces cerevisiae."
      Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.
      Proteomics 12:236-240(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiYIK8_YEAST
    AccessioniPrimary (citable) accession number: P40483
    Secondary accession number(s): D6VVH9, Q6B2N8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 195 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome IX
      Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

    External Data

    Dasty 3