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P40483

- YIK8_YEAST

UniProt

P40483 - YIK8_YEAST

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Protein

Putative zinc metalloproteinase YIL108W

Gene

YIL108W

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Cofactori

Binds 1 zinc ion.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi318 – 3181Zinc; catalyticPROSITE-ProRule annotation
Active sitei319 – 3191PROSITE-ProRule annotation
Metal bindingi322 – 3221Zinc; catalyticPROSITE-ProRule annotation
Metal bindingi328 – 3281Zinc; catalyticPROSITE-ProRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. metallopeptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-31363-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative zinc metalloproteinase YIL108W (EC:3.4.24.-)
Gene namesi
Ordered Locus Names:YIL108W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IX

Organism-specific databases

CYGDiYIL108w.
SGDiS000001370. YIL108W.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 696696Putative zinc metalloproteinase YIL108WPRO_0000078181Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei361 – 3611Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP40483.
PaxDbiP40483.
PeptideAtlasiP40483.

Expressioni

Gene expression databases

GenevestigatoriP40483.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PIN3Q064493EBI-25176,EBI-35523

Protein-protein interaction databases

BioGridi34883. 14 interactions.
DIPiDIP-5657N.
IntActiP40483. 4 interactions.
MINTiMINT-2493057.
STRINGi4932.YIL108W.

Structurei

3D structure databases

ProteinModelPortaliP40483.
SMRiP40483. Positions 610-693.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M10B family.Curated

Phylogenomic databases

eggNOGiNOG283285.
GeneTreeiENSGT00730000114706.
HOGENOMiHOG000197526.
InParanoidiP40483.
KOiK01417.
OMAiDCTRTDT.
OrthoDBiEOG747PSH.

Family and domain databases

Gene3Di2.100.10.30. 2 hits.
3.40.390.10. 1 hit.
InterProiIPR001229. Mannose-bd_lectin.
IPR024079. MetalloPept_cat_dom.
IPR021917. Unchr_Zn-peptidase-like.
[Graphical view]
PfamiPF01419. Jacalin. 1 hit.
PF12044. Metallopep. 1 hit.
[Graphical view]
SUPFAMiSSF51101. SSF51101. 2 hits.
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40483 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVGSKDIDLF NLRENEQIVS PCLIVHGKCN KQNGAKTVQV QHPQLPPITY
60 70 80 90 100
PIHNQFFKAT VILTPGENKL TFVTDTNTAR TIVCYYTPLT QNPPVHLCLI
110 120 130 140 150
LAKDSPLQFD SPREQKDREG GNGLELAIKK LRLGARLMQA YTNEQMLRNS
160 170 180 190 200
MGNRTFPFVE EFTWDTLFER PAMRNTIKIH VVRSEKTVKE IQDPDIAQQN
210 220 230 240 250
SKGKNTGALF GIAMDALKSY GGPFTNNEKP VQAACMFLDT HWDGKLIRGH
260 270 280 290 300
AALGGGDDSI KLAIFGSHGL YSWPTCLEQL VPYFTDETRS STSEVANDCN
310 320 330 340 350
ECGTYWECLT ITLGAFMHEI GHLLGCPHQE SGVMLRGYTT LNRSFLTKEA
360 370 380 390 400
YSVRTNSTGA SPPIFPKEEC TWNRLDTVRF LYHPSFTLPQ DYYDPSFMRP
410 420 430 440 450
TKLGGYPNIK HSVYPLGNGS CRILSPTGIY LIEIICDDLA RGHIEYLPVS
460 470 480 490 500
LGGQGPQREV IVTLDDLRAR LPKNELAKFG NTFKLKILSV NAPETEFDKF
510 520 530 540 550
PSLLDVQPLD MSKYGFSKNV QGIKSPLYGR SDGGNAVGVV AFDVRLVTAV
560 570 580 590 600
RIYHGYALDG VRFYYKEKPT GTKDAPASKP SVPPRNYFSK ITHSIKNHAS
610 620 630 640 650
INEENLKSVL FGHETQNFTD ATLEPGEIII GFNLRCGAWV DAIQIITSHG
660 670 680 690
RMTDMFGNKD GGGFAELQPP NGQYILGVTG RVGQWVDAFG IIYGAL
Length:696
Mass (Da):77,414
Last modified:February 1, 1995 - v1
Checksum:i89ED15503933653B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti696 – 6961L → F in AAT92711. (PubMed:17322287)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z38125 Genomic DNA. Translation: CAA86272.1.
AY692692 Genomic DNA. Translation: AAT92711.1.
BK006942 Genomic DNA. Translation: DAA08445.1.
PIRiS48464.
RefSeqiNP_012158.1. NM_001179456.1.

Genome annotation databases

EnsemblFungiiYIL108W; YIL108W; YIL108W.
GeneIDi854698.
KEGGisce:YIL108W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z38125 Genomic DNA. Translation: CAA86272.1 .
AY692692 Genomic DNA. Translation: AAT92711.1 .
BK006942 Genomic DNA. Translation: DAA08445.1 .
PIRi S48464.
RefSeqi NP_012158.1. NM_001179456.1.

3D structure databases

ProteinModelPortali P40483.
SMRi P40483. Positions 610-693.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 34883. 14 interactions.
DIPi DIP-5657N.
IntActi P40483. 4 interactions.
MINTi MINT-2493057.
STRINGi 4932.YIL108W.

Proteomic databases

MaxQBi P40483.
PaxDbi P40483.
PeptideAtlasi P40483.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YIL108W ; YIL108W ; YIL108W .
GeneIDi 854698.
KEGGi sce:YIL108W.

Organism-specific databases

CYGDi YIL108w.
SGDi S000001370. YIL108W.

Phylogenomic databases

eggNOGi NOG283285.
GeneTreei ENSGT00730000114706.
HOGENOMi HOG000197526.
InParanoidi P40483.
KOi K01417.
OMAi DCTRTDT.
OrthoDBi EOG747PSH.

Enzyme and pathway databases

BioCyci YEAST:G3O-31363-MONOMER.

Miscellaneous databases

NextBioi 977340.

Gene expression databases

Genevestigatori P40483.

Family and domain databases

Gene3Di 2.100.10.30. 2 hits.
3.40.390.10. 1 hit.
InterProi IPR001229. Mannose-bd_lectin.
IPR024079. MetalloPept_cat_dom.
IPR021917. Unchr_Zn-peptidase-like.
[Graphical view ]
Pfami PF01419. Jacalin. 1 hit.
PF12044. Metallopep. 1 hit.
[Graphical view ]
SUPFAMi SSF51101. SSF51101. 2 hits.
PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-361, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Sites of ubiquitin attachment in Saccharomyces cerevisiae."
    Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.
    Proteomics 12:236-240(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiYIK8_YEAST
AccessioniPrimary (citable) accession number: P40483
Secondary accession number(s): D6VVH9, Q6B2N8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 29, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 195 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

External Data

Dasty 3