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P40483 (YIK8_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative zinc metalloproteinase YIL108W

EC=3.4.24.-
Gene names
Ordered Locus Names:YIL108W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length696 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Cofactor

Binds 1 zinc ion By similarity.

Subcellular location

Cytoplasm Ref.4.

Miscellaneous

Present with 195 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the peptidase M10B family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
Metalloprotease
Protease
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processproteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

metallopeptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

PIN3Q064493EBI-25176,EBI-35523

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 696696Putative zinc metalloproteinase YIL108W
PRO_0000078181

Sites

Active site3191 By similarity
Metal binding3181Zinc; catalytic By similarity
Metal binding3221Zinc; catalytic By similarity
Metal binding3281Zinc; catalytic By similarity

Amino acid modifications

Modified residue3611Phosphoserine Ref.6

Experimental info

Sequence conflict6961L → F in AAT92711. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P40483 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 89ED15503933653B

FASTA69677,414
        10         20         30         40         50         60 
MVGSKDIDLF NLRENEQIVS PCLIVHGKCN KQNGAKTVQV QHPQLPPITY PIHNQFFKAT 

        70         80         90        100        110        120 
VILTPGENKL TFVTDTNTAR TIVCYYTPLT QNPPVHLCLI LAKDSPLQFD SPREQKDREG 

       130        140        150        160        170        180 
GNGLELAIKK LRLGARLMQA YTNEQMLRNS MGNRTFPFVE EFTWDTLFER PAMRNTIKIH 

       190        200        210        220        230        240 
VVRSEKTVKE IQDPDIAQQN SKGKNTGALF GIAMDALKSY GGPFTNNEKP VQAACMFLDT 

       250        260        270        280        290        300 
HWDGKLIRGH AALGGGDDSI KLAIFGSHGL YSWPTCLEQL VPYFTDETRS STSEVANDCN 

       310        320        330        340        350        360 
ECGTYWECLT ITLGAFMHEI GHLLGCPHQE SGVMLRGYTT LNRSFLTKEA YSVRTNSTGA 

       370        380        390        400        410        420 
SPPIFPKEEC TWNRLDTVRF LYHPSFTLPQ DYYDPSFMRP TKLGGYPNIK HSVYPLGNGS 

       430        440        450        460        470        480 
CRILSPTGIY LIEIICDDLA RGHIEYLPVS LGGQGPQREV IVTLDDLRAR LPKNELAKFG 

       490        500        510        520        530        540 
NTFKLKILSV NAPETEFDKF PSLLDVQPLD MSKYGFSKNV QGIKSPLYGR SDGGNAVGVV 

       550        560        570        580        590        600 
AFDVRLVTAV RIYHGYALDG VRFYYKEKPT GTKDAPASKP SVPPRNYFSK ITHSIKNHAS 

       610        620        630        640        650        660 
INEENLKSVL FGHETQNFTD ATLEPGEIII GFNLRCGAWV DAIQIITSHG RMTDMFGNKD 

       670        680        690 
GGGFAELQPP NGQYILGVTG RVGQWVDAFG IIYGAL 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome IX."
Churcher C.M., Bowman S., Badcock K., Bankier A.T., Brown D., Chillingworth T., Connor R., Devlin K., Gentles S., Hamlin N., Harris D.E., Horsnell T., Hunt S., Jagels K., Jones M., Lye G., Moule S., Odell C. expand/collapse author list , Pearson D., Rajandream M.A., Rice P., Rowley N., Skelton J., Smith V., Walsh S.V., Whitehead S., Barrell B.G.
Nature 387:84-87(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[5]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-361, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[7]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]"Sites of ubiquitin attachment in Saccharomyces cerevisiae."
Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.
Proteomics 12:236-240(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z38125 Genomic DNA. Translation: CAA86272.1.
AY692692 Genomic DNA. Translation: AAT92711.1.
BK006942 Genomic DNA. Translation: DAA08445.1.
PIRS48464.
RefSeqNP_012158.1. NM_001179456.1.

3D structure databases

ProteinModelPortalP40483.
SMRP40483. Positions 610-693.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid34883. 13 interactions.
DIPDIP-5657N.
IntActP40483. 4 interactions.
MINTMINT-2493057.
STRING4932.YIL108W.

Proteomic databases

PaxDbP40483.
PeptideAtlasP40483.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYIL108W; YIL108W; YIL108W.
GeneID854698.
KEGGsce:YIL108W.

Organism-specific databases

CYGDYIL108w.
SGDS000001370. YIL108W.

Phylogenomic databases

eggNOGNOG283285.
GeneTreeENSGT00730000114706.
HOGENOMHOG000197526.
KOK01417.
OMADCTRTDT.
OrthoDBEOG747PSH.

Enzyme and pathway databases

BioCycYEAST:G3O-31363-MONOMER.

Gene expression databases

GenevestigatorP40483.

Family and domain databases

Gene3D2.100.10.30. 2 hits.
3.40.390.10. 1 hit.
InterProIPR001229. Mannose-bd_lectin.
IPR024079. MetalloPept_cat_dom.
IPR021917. Unchr_Zn-peptidase-like.
[Graphical view]
PfamPF01419. Jacalin. 1 hit.
PF12044. Metallopep. 1 hit.
[Graphical view]
SUPFAMSSF51101. SSF51101. 2 hits.
PROSITEPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio977340.

Entry information

Entry nameYIK8_YEAST
AccessionPrimary (citable) accession number: P40483
Secondary accession number(s): D6VVH9, Q6B2N8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: March 19, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome IX

Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries