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P40483

- YIK8_YEAST

UniProt

P40483 - YIK8_YEAST

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Protein
Putative zinc metalloproteinase YIL108W
Gene
YIL108W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Cofactori

Binds 1 zinc ion By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi318 – 3181Zinc; catalytic By similarity
Active sitei319 – 3191 By similarity
Metal bindingi322 – 3221Zinc; catalytic By similarity
Metal bindingi328 – 3281Zinc; catalytic By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. metallopeptidase activity Source: UniProtKB-KW
  3. protein binding Source: IntAct
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-31363-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative zinc metalloproteinase YIL108W (EC:3.4.24.-)
Gene namesi
Ordered Locus Names:YIL108W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IX

Organism-specific databases

CYGDiYIL108w.
SGDiS000001370. YIL108W.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 696696Putative zinc metalloproteinase YIL108W
PRO_0000078181Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei361 – 3611Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP40483.
PaxDbiP40483.
PeptideAtlasiP40483.

Expressioni

Gene expression databases

GenevestigatoriP40483.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PIN3Q064493EBI-25176,EBI-35523

Protein-protein interaction databases

BioGridi34883. 13 interactions.
DIPiDIP-5657N.
IntActiP40483. 4 interactions.
MINTiMINT-2493057.
STRINGi4932.YIL108W.

Structurei

3D structure databases

ProteinModelPortaliP40483.
SMRiP40483. Positions 610-693.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M10B family.

Phylogenomic databases

eggNOGiNOG283285.
GeneTreeiENSGT00730000114706.
HOGENOMiHOG000197526.
KOiK01417.
OMAiDCTRTDT.
OrthoDBiEOG747PSH.

Family and domain databases

Gene3Di2.100.10.30. 2 hits.
3.40.390.10. 1 hit.
InterProiIPR001229. Mannose-bd_lectin.
IPR024079. MetalloPept_cat_dom.
IPR021917. Unchr_Zn-peptidase-like.
[Graphical view]
PfamiPF01419. Jacalin. 1 hit.
PF12044. Metallopep. 1 hit.
[Graphical view]
SUPFAMiSSF51101. SSF51101. 2 hits.
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40483-1 [UniParc]FASTAAdd to Basket

« Hide

MVGSKDIDLF NLRENEQIVS PCLIVHGKCN KQNGAKTVQV QHPQLPPITY    50
PIHNQFFKAT VILTPGENKL TFVTDTNTAR TIVCYYTPLT QNPPVHLCLI 100
LAKDSPLQFD SPREQKDREG GNGLELAIKK LRLGARLMQA YTNEQMLRNS 150
MGNRTFPFVE EFTWDTLFER PAMRNTIKIH VVRSEKTVKE IQDPDIAQQN 200
SKGKNTGALF GIAMDALKSY GGPFTNNEKP VQAACMFLDT HWDGKLIRGH 250
AALGGGDDSI KLAIFGSHGL YSWPTCLEQL VPYFTDETRS STSEVANDCN 300
ECGTYWECLT ITLGAFMHEI GHLLGCPHQE SGVMLRGYTT LNRSFLTKEA 350
YSVRTNSTGA SPPIFPKEEC TWNRLDTVRF LYHPSFTLPQ DYYDPSFMRP 400
TKLGGYPNIK HSVYPLGNGS CRILSPTGIY LIEIICDDLA RGHIEYLPVS 450
LGGQGPQREV IVTLDDLRAR LPKNELAKFG NTFKLKILSV NAPETEFDKF 500
PSLLDVQPLD MSKYGFSKNV QGIKSPLYGR SDGGNAVGVV AFDVRLVTAV 550
RIYHGYALDG VRFYYKEKPT GTKDAPASKP SVPPRNYFSK ITHSIKNHAS 600
INEENLKSVL FGHETQNFTD ATLEPGEIII GFNLRCGAWV DAIQIITSHG 650
RMTDMFGNKD GGGFAELQPP NGQYILGVTG RVGQWVDAFG IIYGAL 696
Length:696
Mass (Da):77,414
Last modified:February 1, 1995 - v1
Checksum:i89ED15503933653B
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti696 – 6961L → F in AAT92711. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z38125 Genomic DNA. Translation: CAA86272.1.
AY692692 Genomic DNA. Translation: AAT92711.1.
BK006942 Genomic DNA. Translation: DAA08445.1.
PIRiS48464.
RefSeqiNP_012158.1. NM_001179456.1.

Genome annotation databases

EnsemblFungiiYIL108W; YIL108W; YIL108W.
GeneIDi854698.
KEGGisce:YIL108W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z38125 Genomic DNA. Translation: CAA86272.1 .
AY692692 Genomic DNA. Translation: AAT92711.1 .
BK006942 Genomic DNA. Translation: DAA08445.1 .
PIRi S48464.
RefSeqi NP_012158.1. NM_001179456.1.

3D structure databases

ProteinModelPortali P40483.
SMRi P40483. Positions 610-693.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 34883. 13 interactions.
DIPi DIP-5657N.
IntActi P40483. 4 interactions.
MINTi MINT-2493057.
STRINGi 4932.YIL108W.

Proteomic databases

MaxQBi P40483.
PaxDbi P40483.
PeptideAtlasi P40483.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YIL108W ; YIL108W ; YIL108W .
GeneIDi 854698.
KEGGi sce:YIL108W.

Organism-specific databases

CYGDi YIL108w.
SGDi S000001370. YIL108W.

Phylogenomic databases

eggNOGi NOG283285.
GeneTreei ENSGT00730000114706.
HOGENOMi HOG000197526.
KOi K01417.
OMAi DCTRTDT.
OrthoDBi EOG747PSH.

Enzyme and pathway databases

BioCyci YEAST:G3O-31363-MONOMER.

Miscellaneous databases

NextBioi 977340.

Gene expression databases

Genevestigatori P40483.

Family and domain databases

Gene3Di 2.100.10.30. 2 hits.
3.40.390.10. 1 hit.
InterProi IPR001229. Mannose-bd_lectin.
IPR024079. MetalloPept_cat_dom.
IPR021917. Unchr_Zn-peptidase-like.
[Graphical view ]
Pfami PF01419. Jacalin. 1 hit.
PF12044. Metallopep. 1 hit.
[Graphical view ]
SUPFAMi SSF51101. SSF51101. 2 hits.
PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-361, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Sites of ubiquitin attachment in Saccharomyces cerevisiae."
    Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.
    Proteomics 12:236-240(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiYIK8_YEAST
AccessioniPrimary (citable) accession number: P40483
Secondary accession number(s): D6VVH9, Q6B2N8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 11, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 195 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

External Data

Dasty 3

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