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Protein

Putative zinc metalloproteinase YIL108W

Gene

YIL108W

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Present with 195 molecules/cell in log phase SD medium.1 Publication

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi318Zinc; catalyticPROSITE-ProRule annotation1
Active sitei319PROSITE-ProRule annotation1
Metal bindingi322Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi328Zinc; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-31363-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Putative zinc metalloproteinase YIL108W (EC:3.4.24.-)
Gene namesi
Ordered Locus Names:YIL108W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IX

Organism-specific databases

EuPathDBiFungiDB:YIL108W
SGDiS000001370 YIL108W

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000781811 – 696Putative zinc metalloproteinase YIL108WAdd BLAST696

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki245Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Modified residuei361PhosphoserineCombined sources1
Cross-linki478Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Cross-linki518Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Cross-linki579Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Cross-linki590Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Cross-linki596Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP40483
PaxDbiP40483
PRIDEiP40483

PTM databases

iPTMnetiP40483

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PIN3Q064493EBI-25176,EBI-35523

Protein-protein interaction databases

BioGridi34883, 34 interactors
DIPiDIP-5657N
IntActiP40483, 5 interactors
MINTiP40483
STRINGi4932.YIL108W

Structurei

3D structure databases

ProteinModelPortaliP40483
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini522 – 695Jacalin-type lectinPROSITE-ProRule annotationAdd BLAST174

Sequence similaritiesi

Belongs to the peptidase M10B family.Curated

Phylogenomic databases

GeneTreeiENSGT00730000114706
HOGENOMiHOG000197526
InParanoidiP40483
OMAiIFGSHCL
OrthoDBiEOG092C10QU

Family and domain databases

CDDicd09613 Jacalin_metallopeptidase_like, 1 hit
Gene3Di2.100.10.30, 1 hit
InterProiView protein in InterPro
IPR001229 Jacalin-like_lectin_dom
IPR036404 Jacalin-like_lectin_dom_sf
IPR033862 Jacalin-like_metallopeptidase
IPR021917 Unchr_Zn-peptidase-like
PfamiView protein in Pfam
PF12044 Metallopep, 1 hit
SUPFAMiSSF51101 SSF51101, 2 hits
PROSITEiView protein in PROSITE
PS51752 JACALIN_LECTIN, 1 hit
PS00142 ZINC_PROTEASE, 1 hit

Sequencei

Sequence statusi: Complete.

P40483-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGSKDIDLF NLRENEQIVS PCLIVHGKCN KQNGAKTVQV QHPQLPPITY
60 70 80 90 100
PIHNQFFKAT VILTPGENKL TFVTDTNTAR TIVCYYTPLT QNPPVHLCLI
110 120 130 140 150
LAKDSPLQFD SPREQKDREG GNGLELAIKK LRLGARLMQA YTNEQMLRNS
160 170 180 190 200
MGNRTFPFVE EFTWDTLFER PAMRNTIKIH VVRSEKTVKE IQDPDIAQQN
210 220 230 240 250
SKGKNTGALF GIAMDALKSY GGPFTNNEKP VQAACMFLDT HWDGKLIRGH
260 270 280 290 300
AALGGGDDSI KLAIFGSHGL YSWPTCLEQL VPYFTDETRS STSEVANDCN
310 320 330 340 350
ECGTYWECLT ITLGAFMHEI GHLLGCPHQE SGVMLRGYTT LNRSFLTKEA
360 370 380 390 400
YSVRTNSTGA SPPIFPKEEC TWNRLDTVRF LYHPSFTLPQ DYYDPSFMRP
410 420 430 440 450
TKLGGYPNIK HSVYPLGNGS CRILSPTGIY LIEIICDDLA RGHIEYLPVS
460 470 480 490 500
LGGQGPQREV IVTLDDLRAR LPKNELAKFG NTFKLKILSV NAPETEFDKF
510 520 530 540 550
PSLLDVQPLD MSKYGFSKNV QGIKSPLYGR SDGGNAVGVV AFDVRLVTAV
560 570 580 590 600
RIYHGYALDG VRFYYKEKPT GTKDAPASKP SVPPRNYFSK ITHSIKNHAS
610 620 630 640 650
INEENLKSVL FGHETQNFTD ATLEPGEIII GFNLRCGAWV DAIQIITSHG
660 670 680 690
RMTDMFGNKD GGGFAELQPP NGQYILGVTG RVGQWVDAFG IIYGAL
Length:696
Mass (Da):77,414
Last modified:February 1, 1995 - v1
Checksum:i89ED15503933653B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti696L → F in AAT92711 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38125 Genomic DNA Translation: CAA86272.1
AY692692 Genomic DNA Translation: AAT92711.1
BK006942 Genomic DNA Translation: DAA08445.1
PIRiS48464
RefSeqiNP_012158.1, NM_001179456.1

Genome annotation databases

EnsemblFungiiYIL108W; YIL108W; YIL108W
GeneIDi854698
KEGGisce:YIL108W

Similar proteinsi

Entry informationi

Entry nameiYIK8_YEAST
AccessioniPrimary (citable) accession number: P40483
Secondary accession number(s): D6VVH9, Q6B2N8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

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