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Protein

Histidine protein methyltransferase 1

Gene

HPM1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for histidine methylation of RPL3 at 'His-243'.1 Publication

Catalytic activityi

S-adenosyl-L-methionine + protein L-histidine = S-adenosyl-L-homocysteine + protein N(tau)-methyl-L-histidine.

GO - Molecular functioni

  • protein-histidine N-methyltransferase activity Source: SGD
  • S-adenosylmethionine-dependent methyltransferase activity Source: SGD

GO - Biological processi

  • peptidyl-histidine methylation, to form tele-methylhistidine Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciYEAST:G3O-31365-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine protein methyltransferase 1 (EC:2.1.1.85)
Alternative name(s):
Mitotic exit network interactor 1
Gene namesi
Name:HPM1
Synonyms:MNI1
Ordered Locus Names:YIL110W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IX

Organism-specific databases

EuPathDBiFungiDB:YIL110W.
SGDiS000001372. HPM1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

A haploid deletion mutant leads to hypersensitivity to echinocandin-like antifungal lipopeptide caspofungin, a 1,3-beta-glucan synthase inhibitor. Deletion confers sensitivity to the synthetic tripeptide arsenical 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO).1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002029641 – 377Histidine protein methyltransferase 1Add BLAST377

Proteomic databases

MaxQBiP40481.
PRIDEiP40481.

Interactioni

Protein-protein interaction databases

BioGridi34881. 26 interactors.
DIPiDIP-4710N.
MINTiMINT-524742.

Structurei

3D structure databases

ProteinModelPortaliP40481.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000000464.
InParanoidiP40481.
KOiK18803.
OMAiIHWASTL.
OrthoDBiEOG092C3LN2.

Family and domain databases

Gene3Di3.40.50.150. 2 hits.
InterProiIPR029063. SAM-dependent_MTases.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40481-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFSFGFTSN DFDDDELVAQ PETFVESSKE NENTTAYINP LDSDFLSQAG
60 70 80 90 100
VVQPNVEDLG TILESLKDVR LTFEEFQSPI YRKPLIKREL FDVKHQLMLE
110 120 130 140 150
TDAQSNNNST ELDILLGDTS EDLRKNIYEG GLKSWECSYD LVDLLSENVD
160 170 180 190 200
RISNDIDAVV EIGCGTALPS EFLFRSALLR NDRSKGLKFV LTDYNASVLR
210 220 230 240 250
LVTIPNLVIT WAKTVLTKEQ WYALQKDECE DIPINNEELL LTSKLLAAFY
260 270 280 290 300
DDVQSRNISV TLISGSWGRK FSNLIHEVLS GSQKVLSLSS ETIYQPDNLP
310 320 330 340 350
VIAETILDIH NLPQTDVKTY VAAKDIYFGV GGSITEFEAY LDDKINSEHL
360 370
PIHSERFKVN SGLKRSIICI ETNKAIR
Length:377
Mass (Da):42,515
Last modified:February 1, 1995 - v1
Checksum:iC90C67433B5BCA7A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38125 Genomic DNA. Translation: CAA86270.1.
AY558076 Genomic DNA. Translation: AAS56402.1.
BK006942 Genomic DNA. Translation: DAA08443.1.
PIRiS48462.
RefSeqiNP_012156.1. NM_001179458.1.

Genome annotation databases

EnsemblFungiiYIL110W; YIL110W; YIL110W.
GeneIDi854696.
KEGGisce:YIL110W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38125 Genomic DNA. Translation: CAA86270.1.
AY558076 Genomic DNA. Translation: AAS56402.1.
BK006942 Genomic DNA. Translation: DAA08443.1.
PIRiS48462.
RefSeqiNP_012156.1. NM_001179458.1.

3D structure databases

ProteinModelPortaliP40481.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34881. 26 interactors.
DIPiDIP-4710N.
MINTiMINT-524742.

Proteomic databases

MaxQBiP40481.
PRIDEiP40481.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYIL110W; YIL110W; YIL110W.
GeneIDi854696.
KEGGisce:YIL110W.

Organism-specific databases

EuPathDBiFungiDB:YIL110W.
SGDiS000001372. HPM1.

Phylogenomic databases

GeneTreeiENSGT00390000000464.
InParanoidiP40481.
KOiK18803.
OMAiIHWASTL.
OrthoDBiEOG092C3LN2.

Enzyme and pathway databases

BioCyciYEAST:G3O-31365-MONOMER.

Miscellaneous databases

PROiP40481.

Family and domain databases

Gene3Di3.40.50.150. 2 hits.
InterProiIPR029063. SAM-dependent_MTases.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHPM1_YEAST
AccessioniPrimary (citable) accession number: P40481
Secondary accession number(s): D6VVH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.