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Protein

Histidine protein methyltransferase 1

Gene

HPM1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for histidine methylation of RPL3 at 'His-243'.1 Publication

Catalytic activityi

S-adenosyl-L-methionine + protein L-histidine = S-adenosyl-L-homocysteine + protein N(tau)-methyl-L-histidine.

GO - Molecular functioni

  • protein-histidine N-methyltransferase activity Source: SGD
  • S-adenosylmethionine-dependent methyltransferase activity Source: SGD

GO - Biological processi

  • peptidyl-histidine methylation, to form tele-methylhistidine Source: SGD
  • positive regulation of translational fidelity Source: SGD
  • ribosomal large subunit assembly Source: SGD

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciYEAST:G3O-31365-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine protein methyltransferase 1 (EC:2.1.1.85)
Alternative name(s):
Mitotic exit network interactor 1
Gene namesi
Name:HPM1
Synonyms:MNI1
Ordered Locus Names:YIL110W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IX

Organism-specific databases

EuPathDBiFungiDB:YIL110W
SGDiS000001372 HPM1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

A haploid deletion mutant leads to hypersensitivity to echinocandin-like antifungal lipopeptide caspofungin, a 1,3-beta-glucan synthase inhibitor. Deletion confers sensitivity to the synthetic tripeptide arsenical 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO).1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002029641 – 377Histidine protein methyltransferase 1Add BLAST377

Proteomic databases

MaxQBiP40481
PaxDbiP40481
PRIDEiP40481

Interactioni

Protein-protein interaction databases

BioGridi34881, 146 interactors
DIPiDIP-4710N
IntActiP40481, 1 interactor
STRINGi4932.YIL110W

Structurei

3D structure databases

ProteinModelPortaliP40481
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000000464
InParanoidiP40481
KOiK18803
OMAiGAWSPEF
OrthoDBiEOG092C3LN2

Sequencei

Sequence statusi: Complete.

P40481-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFSFGFTSN DFDDDELVAQ PETFVESSKE NENTTAYINP LDSDFLSQAG
60 70 80 90 100
VVQPNVEDLG TILESLKDVR LTFEEFQSPI YRKPLIKREL FDVKHQLMLE
110 120 130 140 150
TDAQSNNNST ELDILLGDTS EDLRKNIYEG GLKSWECSYD LVDLLSENVD
160 170 180 190 200
RISNDIDAVV EIGCGTALPS EFLFRSALLR NDRSKGLKFV LTDYNASVLR
210 220 230 240 250
LVTIPNLVIT WAKTVLTKEQ WYALQKDECE DIPINNEELL LTSKLLAAFY
260 270 280 290 300
DDVQSRNISV TLISGSWGRK FSNLIHEVLS GSQKVLSLSS ETIYQPDNLP
310 320 330 340 350
VIAETILDIH NLPQTDVKTY VAAKDIYFGV GGSITEFEAY LDDKINSEHL
360 370
PIHSERFKVN SGLKRSIICI ETNKAIR
Length:377
Mass (Da):42,515
Last modified:February 1, 1995 - v1
Checksum:iC90C67433B5BCA7A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38125 Genomic DNA Translation: CAA86270.1
AY558076 Genomic DNA Translation: AAS56402.1
BK006942 Genomic DNA Translation: DAA08443.1
PIRiS48462
RefSeqiNP_012156.1, NM_001179458.1

Genome annotation databases

EnsemblFungiiYIL110W; YIL110W; YIL110W
GeneIDi854696
KEGGisce:YIL110W

Similar proteinsi

Entry informationi

Entry nameiHPM1_YEAST
AccessioniPrimary (citable) accession number: P40481
Secondary accession number(s): D6VVH7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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