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Protein

Dual-specificity protein phosphatase SDP1

Gene

SDP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates dephosphorylation of MAPK substrates such as SLT2, acquiring enhanced catalytic activity under oxidative conditions.2 Publications

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei111Phosphotyrosine1
Active sitei140Phosphocysteine intermediate1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Enzyme and pathway databases

BioCyciYEAST:G3O-31367-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Dual-specificity protein phosphatase SDP1 (EC:3.1.3.48)
Alternative name(s):
Stress-inducible MAPK phosphatase
Gene namesi
Name:SDP1
Ordered Locus Names:YIL113W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IX

Organism-specific databases

EuPathDBiFungiDB:YIL113W.
SGDiS000001375. SDP1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: SGD
  • nucleus Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000949241 – 209Dual-specificity protein phosphatase SDP1Add BLAST209

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi47 ↔ 1421 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP40479.

PTM databases

iPTMnetiP40479.

Interactioni

Protein-protein interaction databases

BioGridi34878. 19 interactors.
DIPiDIP-1899N.
IntActiP40479. 4 interactors.
MINTiMINT-395807.

Structurei

Secondary structure

1209
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi58 – 64Combined sources7
Turni65 – 67Combined sources3
Beta strandi68 – 73Combined sources6
Turni76 – 81Combined sources6
Beta strandi83 – 87Combined sources5
Helixi96 – 98Combined sources3
Beta strandi103 – 106Combined sources4
Helixi112 – 118Combined sources7
Helixi119 – 131Combined sources13
Beta strandi136 – 142Combined sources7
Helixi146 – 158Combined sources13
Helixi163 – 173Combined sources11
Helixi181 – 195Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2J16X-ray2.70A/B17-198[»]
2J17X-ray2.84A/B17-198[»]
ProteinModelPortaliP40479.
SMRiP40479.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP40479.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00680000100889.
InParanoidiP40479.
KOiK19812.
OMAiNCAREIP.
OrthoDBiEOG092C1CH8.

Family and domain databases

CDDicd00127. DSPc. 1 hit.
Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40479-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIYTSPTRT PNIAPKSGQR PSLPMLATDE RSTDKESPNE DREFVPCSSL
60 70 80 90 100
DVRRIYPKGP LLVLPEKIYL YSEPTVKELL PFDVVINVAE EANDLRMQVP
110 120 130 140 150
AVEYHHYRWE HDSQIALDLP SLTSIIHAAT TKREKILIHC QCGLSRSATL
160 170 180 190 200
IIAYIMKYHN LSLRHSYDLL KSRADKINPS IGLIFQLMEW EVALNAKTNV

QANSYRKVP
Length:209
Mass (Da):23,886
Last modified:February 1, 1995 - v1
Checksum:i678371462A890A69
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38125 Genomic DNA. Translation: CAA86267.1.
BK006942 Genomic DNA. Translation: DAA08440.1.
PIRiS48459.
RefSeqiNP_012153.1. NM_001179461.1.

Genome annotation databases

EnsemblFungiiYIL113W; YIL113W; YIL113W.
GeneIDi854693.
KEGGisce:YIL113W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38125 Genomic DNA. Translation: CAA86267.1.
BK006942 Genomic DNA. Translation: DAA08440.1.
PIRiS48459.
RefSeqiNP_012153.1. NM_001179461.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2J16X-ray2.70A/B17-198[»]
2J17X-ray2.84A/B17-198[»]
ProteinModelPortaliP40479.
SMRiP40479.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34878. 19 interactors.
DIPiDIP-1899N.
IntActiP40479. 4 interactors.
MINTiMINT-395807.

PTM databases

iPTMnetiP40479.

Proteomic databases

PRIDEiP40479.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYIL113W; YIL113W; YIL113W.
GeneIDi854693.
KEGGisce:YIL113W.

Organism-specific databases

EuPathDBiFungiDB:YIL113W.
SGDiS000001375. SDP1.

Phylogenomic databases

GeneTreeiENSGT00680000100889.
InParanoidiP40479.
KOiK19812.
OMAiNCAREIP.
OrthoDBiEOG092C1CH8.

Enzyme and pathway databases

BioCyciYEAST:G3O-31367-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP40479.
PROiP40479.

Family and domain databases

CDDicd00127. DSPc. 1 hit.
Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSDP1_YEAST
AccessioniPrimary (citable) accession number: P40479
Secondary accession number(s): D6VVH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 30, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.