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P40479

- SDP1_YEAST

UniProt

P40479 - SDP1_YEAST

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Protein
Dual-specificity protein phosphatase SDP1
Gene
SDP1, YIL113W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Mediates dephosphorylation of MAPK substrates such as SLT2, acquiring enhanced catalytic activity under oxidative conditions.2 Publications

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei111 – 1111Phosphotyrosine
Active sitei140 – 1401Phosphocysteine intermediate

GO - Molecular functioni

  1. MAP kinase tyrosine phosphatase activity Source: SGD
  2. protein tyrosine/serine/threonine phosphatase activity Source: InterPro

GO - Biological processi

  1. MAPK cascade involved in cell wall organization or biogenesis Source: SGD
  2. inactivation of MAPK activity involved in cell wall organization or biogenesis Source: SGD
  3. peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Enzyme and pathway databases

BioCyciYEAST:G3O-31367-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Dual-specificity protein phosphatase SDP1 (EC:3.1.3.48)
Alternative name(s):
Stress-inducible MAPK phosphatase
Gene namesi
Name:SDP1
Ordered Locus Names:YIL113W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IX

Organism-specific databases

CYGDiYIL113w.
SGDiS000001375. SDP1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: SGD
  2. nucleus Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 209209Dual-specificity protein phosphatase SDP1
PRO_0000094924Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi47 ↔ 1421 Publication

Keywords - PTMi

Disulfide bond

Expressioni

Gene expression databases

GenevestigatoriP40479.

Interactioni

Protein-protein interaction databases

BioGridi34878. 18 interactions.
DIPiDIP-1899N.
IntActiP40479. 4 interactions.
MINTiMINT-395807.
STRINGi4932.YIL113W.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi58 – 647
Turni65 – 673
Beta strandi68 – 736
Turni76 – 816
Beta strandi83 – 875
Helixi96 – 983
Beta strandi103 – 1064
Helixi112 – 1187
Helixi119 – 13113
Beta strandi136 – 1427
Helixi146 – 15813
Helixi163 – 17311
Helixi181 – 19515

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2J16X-ray2.70A/B17-198[»]
2J17X-ray2.84A/B17-198[»]
ProteinModelPortaliP40479.
SMRiP40479. Positions 54-196.

Miscellaneous databases

EvolutionaryTraceiP40479.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2453.
GeneTreeiENSGT00680000100889.
KOiK01104.
OMAiNCAREIP.
OrthoDBiEOG7HF1WG.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40479-1 [UniParc]FASTAAdd to Basket

« Hide

MNIYTSPTRT PNIAPKSGQR PSLPMLATDE RSTDKESPNE DREFVPCSSL    50
DVRRIYPKGP LLVLPEKIYL YSEPTVKELL PFDVVINVAE EANDLRMQVP 100
AVEYHHYRWE HDSQIALDLP SLTSIIHAAT TKREKILIHC QCGLSRSATL 150
IIAYIMKYHN LSLRHSYDLL KSRADKINPS IGLIFQLMEW EVALNAKTNV 200
QANSYRKVP 209
Length:209
Mass (Da):23,886
Last modified:February 1, 1995 - v1
Checksum:i678371462A890A69
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z38125 Genomic DNA. Translation: CAA86267.1.
BK006942 Genomic DNA. Translation: DAA08440.1.
PIRiS48459.
RefSeqiNP_012153.1. NM_001179461.1.

Genome annotation databases

EnsemblFungiiYIL113W; YIL113W; YIL113W.
GeneIDi854693.
KEGGisce:YIL113W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z38125 Genomic DNA. Translation: CAA86267.1 .
BK006942 Genomic DNA. Translation: DAA08440.1 .
PIRi S48459.
RefSeqi NP_012153.1. NM_001179461.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2J16 X-ray 2.70 A/B 17-198 [» ]
2J17 X-ray 2.84 A/B 17-198 [» ]
ProteinModelPortali P40479.
SMRi P40479. Positions 54-196.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 34878. 18 interactions.
DIPi DIP-1899N.
IntActi P40479. 4 interactions.
MINTi MINT-395807.
STRINGi 4932.YIL113W.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YIL113W ; YIL113W ; YIL113W .
GeneIDi 854693.
KEGGi sce:YIL113W.

Organism-specific databases

CYGDi YIL113w.
SGDi S000001375. SDP1.

Phylogenomic databases

eggNOGi COG2453.
GeneTreei ENSGT00680000100889.
KOi K01104.
OMAi NCAREIP.
OrthoDBi EOG7HF1WG.

Enzyme and pathway databases

BioCyci YEAST:G3O-31367-MONOMER.

Miscellaneous databases

EvolutionaryTracei P40479.
NextBioi 977325.

Gene expression databases

Genevestigatori P40479.

Family and domain databases

Gene3Di 3.90.190.10. 1 hit.
InterProi IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view ]
PANTHERi PTHR10159. PTHR10159. 1 hit.
Pfami PF00782. DSPc. 1 hit.
[Graphical view ]
SMARTi SM00195. DSPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "YIL113w encodes a functional dual-specificity protein phosphatase which specifically interacts with and inactivates the Slt2/Mpk1p MAP kinase in S. cerevisiae."
    Collister M., Didmon M.P., MacIsaac F., Stark M.J., MacDonald N.Q., Keyse S.M.
    FEBS Lett. 527:186-192(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  5. Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 17-198 OF WILD TYPE AND MUTANT SER-142, FUNCTION, DISULFIDE BOND.

Entry informationi

Entry nameiSDP1_YEAST
AccessioniPrimary (citable) accession number: P40479
Secondary accession number(s): D6VVH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 11, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

External Data

Dasty 3

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