Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Dual-specificity protein phosphatase SDP1

Gene

SDP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates dephosphorylation of MAPK substrates such as SLT2, acquiring enhanced catalytic activity under oxidative conditions.2 Publications

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei111Phosphotyrosine1
Active sitei140Phosphocysteine intermediate1

GO - Molecular functioni

  • MAP kinase tyrosine/serine/threonine phosphatase activity Source: SGD
  • MAP kinase tyrosine phosphatase activity Source: SGD

GO - Biological processi

  • adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion Source: GO_Central
  • inactivation of MAPK activity Source: SGD
  • MAPK cascade involved in cell wall organization or biogenesis Source: SGD
  • peptidyl-threonine dephosphorylation Source: SGD
  • peptidyl-tyrosine dephosphorylation Source: SGD
  • regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion Source: GO_Central

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

BioCyciYEAST:G3O-31367-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Dual-specificity protein phosphatase SDP1 (EC:3.1.3.48)
Alternative name(s):
Stress-inducible MAPK phosphatase
Gene namesi
Name:SDP1
Ordered Locus Names:YIL113W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IX

Organism-specific databases

EuPathDBiFungiDB:YIL113W
SGDiS000001375 SDP1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000949241 – 209Dual-specificity protein phosphatase SDP1Add BLAST209

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi47 ↔ 1421 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP40479
PRIDEiP40479

PTM databases

iPTMnetiP40479

Interactioni

Protein-protein interaction databases

BioGridi34878, 68 interactors
DIPiDIP-1899N
IntActiP40479, 9 interactors
MINTiP40479
STRINGi4932.YIL113W

Structurei

Secondary structure

1209
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi58 – 64Combined sources7
Turni65 – 67Combined sources3
Beta strandi68 – 73Combined sources6
Turni76 – 81Combined sources6
Beta strandi83 – 87Combined sources5
Helixi96 – 98Combined sources3
Beta strandi103 – 106Combined sources4
Helixi112 – 118Combined sources7
Helixi119 – 131Combined sources13
Beta strandi136 – 142Combined sources7
Helixi146 – 158Combined sources13
Helixi163 – 173Combined sources11
Helixi181 – 195Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2J16X-ray2.70A/B17-198[»]
2J17X-ray2.84A/B17-198[»]
ProteinModelPortaliP40479
SMRiP40479
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP40479

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00680000100889
InParanoidiP40479
KOiK19812
OMAiIHIPWEH
OrthoDBiEOG092C1CH8

Family and domain databases

CDDicd00127 DSPc, 1 hit
Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR000340 Dual-sp_phosphatase_cat-dom
IPR024950 DUSP
IPR029021 Prot-tyrosine_phosphatase-like
IPR016130 Tyr_Pase_AS
IPR000387 TYR_PHOSPHATASE_dom
IPR020422 TYR_PHOSPHATASE_DUAL_dom
PANTHERiPTHR10159 PTHR10159, 1 hit
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
SMARTiView protein in SMART
SM00195 DSPc, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50054 TYR_PHOSPHATASE_DUAL, 1 hit

Sequencei

Sequence statusi: Complete.

P40479-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIYTSPTRT PNIAPKSGQR PSLPMLATDE RSTDKESPNE DREFVPCSSL
60 70 80 90 100
DVRRIYPKGP LLVLPEKIYL YSEPTVKELL PFDVVINVAE EANDLRMQVP
110 120 130 140 150
AVEYHHYRWE HDSQIALDLP SLTSIIHAAT TKREKILIHC QCGLSRSATL
160 170 180 190 200
IIAYIMKYHN LSLRHSYDLL KSRADKINPS IGLIFQLMEW EVALNAKTNV

QANSYRKVP
Length:209
Mass (Da):23,886
Last modified:February 1, 1995 - v1
Checksum:i678371462A890A69
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38125 Genomic DNA Translation: CAA86267.1
BK006942 Genomic DNA Translation: DAA08440.1
PIRiS48459
RefSeqiNP_012153.1, NM_001179461.1

Genome annotation databases

EnsemblFungiiYIL113W; YIL113W; YIL113W
GeneIDi854693
KEGGisce:YIL113W

Similar proteinsi

Entry informationi

Entry nameiSDP1_YEAST
AccessioniPrimary (citable) accession number: P40479
Secondary accession number(s): D6VVH4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health