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P40479

- SDP1_YEAST

UniProt

P40479 - SDP1_YEAST

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Protein

Dual-specificity protein phosphatase SDP1

Gene

SDP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Mediates dephosphorylation of MAPK substrates such as SLT2, acquiring enhanced catalytic activity under oxidative conditions.2 Publications

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei111 – 1111Phosphotyrosine
Active sitei140 – 1401Phosphocysteine intermediate

GO - Molecular functioni

  1. MAP kinase tyrosine phosphatase activity Source: SGD
  2. protein tyrosine/serine/threonine phosphatase activity Source: InterPro

GO - Biological processi

  1. inactivation of MAPK activity involved in cell wall organization or biogenesis Source: SGD
  2. MAPK cascade involved in cell wall organization or biogenesis Source: SGD
  3. peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Enzyme and pathway databases

BioCyciYEAST:G3O-31367-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Dual-specificity protein phosphatase SDP1 (EC:3.1.3.48)
Alternative name(s):
Stress-inducible MAPK phosphatase
Gene namesi
Name:SDP1
Ordered Locus Names:YIL113W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IX

Organism-specific databases

CYGDiYIL113w.
SGDiS000001375. SDP1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: SGD
  2. nucleus Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 209209Dual-specificity protein phosphatase SDP1PRO_0000094924Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi47 ↔ 1421 Publication

Keywords - PTMi

Disulfide bond

Expressioni

Gene expression databases

GenevestigatoriP40479.

Interactioni

Protein-protein interaction databases

BioGridi34878. 18 interactions.
DIPiDIP-1899N.
IntActiP40479. 4 interactions.
MINTiMINT-395807.
STRINGi4932.YIL113W.

Structurei

Secondary structure

1
209
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi58 – 647
Turni65 – 673
Beta strandi68 – 736
Turni76 – 816
Beta strandi83 – 875
Helixi96 – 983
Beta strandi103 – 1064
Helixi112 – 1187
Helixi119 – 13113
Beta strandi136 – 1427
Helixi146 – 15813
Helixi163 – 17311
Helixi181 – 19515

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2J16X-ray2.70A/B17-198[»]
2J17X-ray2.84A/B17-198[»]
ProteinModelPortaliP40479.
SMRiP40479. Positions 54-196.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP40479.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2453.
GeneTreeiENSGT00680000100889.
InParanoidiP40479.
KOiK01104.
OMAiNCAREIP.
OrthoDBiEOG7HF1WG.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40479-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNIYTSPTRT PNIAPKSGQR PSLPMLATDE RSTDKESPNE DREFVPCSSL
60 70 80 90 100
DVRRIYPKGP LLVLPEKIYL YSEPTVKELL PFDVVINVAE EANDLRMQVP
110 120 130 140 150
AVEYHHYRWE HDSQIALDLP SLTSIIHAAT TKREKILIHC QCGLSRSATL
160 170 180 190 200
IIAYIMKYHN LSLRHSYDLL KSRADKINPS IGLIFQLMEW EVALNAKTNV

QANSYRKVP
Length:209
Mass (Da):23,886
Last modified:February 1, 1995 - v1
Checksum:i678371462A890A69
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z38125 Genomic DNA. Translation: CAA86267.1.
BK006942 Genomic DNA. Translation: DAA08440.1.
PIRiS48459.
RefSeqiNP_012153.1. NM_001179461.1.

Genome annotation databases

EnsemblFungiiYIL113W; YIL113W; YIL113W.
GeneIDi854693.
KEGGisce:YIL113W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z38125 Genomic DNA. Translation: CAA86267.1 .
BK006942 Genomic DNA. Translation: DAA08440.1 .
PIRi S48459.
RefSeqi NP_012153.1. NM_001179461.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2J16 X-ray 2.70 A/B 17-198 [» ]
2J17 X-ray 2.84 A/B 17-198 [» ]
ProteinModelPortali P40479.
SMRi P40479. Positions 54-196.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 34878. 18 interactions.
DIPi DIP-1899N.
IntActi P40479. 4 interactions.
MINTi MINT-395807.
STRINGi 4932.YIL113W.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YIL113W ; YIL113W ; YIL113W .
GeneIDi 854693.
KEGGi sce:YIL113W.

Organism-specific databases

CYGDi YIL113w.
SGDi S000001375. SDP1.

Phylogenomic databases

eggNOGi COG2453.
GeneTreei ENSGT00680000100889.
InParanoidi P40479.
KOi K01104.
OMAi NCAREIP.
OrthoDBi EOG7HF1WG.

Enzyme and pathway databases

BioCyci YEAST:G3O-31367-MONOMER.

Miscellaneous databases

EvolutionaryTracei P40479.
NextBioi 977325.

Gene expression databases

Genevestigatori P40479.

Family and domain databases

Gene3Di 3.90.190.10. 1 hit.
InterProi IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view ]
PANTHERi PTHR10159. PTHR10159. 1 hit.
Pfami PF00782. DSPc. 1 hit.
[Graphical view ]
SMARTi SM00195. DSPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "YIL113w encodes a functional dual-specificity protein phosphatase which specifically interacts with and inactivates the Slt2/Mpk1p MAP kinase in S. cerevisiae."
    Collister M., Didmon M.P., MacIsaac F., Stark M.J., MacDonald N.Q., Keyse S.M.
    FEBS Lett. 527:186-192(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  5. Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 17-198 OF WILD TYPE AND MUTANT SER-142, FUNCTION, DISULFIDE BOND.

Entry informationi

Entry nameiSDP1_YEAST
AccessioniPrimary (citable) accession number: P40479
Secondary accession number(s): D6VVH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 29, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

External Data

Dasty 3