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Protein

Quinidine resistance protein 1

Gene

QDR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Multidrug resistance transporter involved in resistance and adaptation to quinidine and ketoconazole.1 Publication

GO - Molecular functioni

  • drug transmembrane transporter activity Source: SGD

GO - Biological processi

  • ascospore wall assembly Source: SGD
  • drug transmembrane transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31373-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Quinidine resistance protein 1
Gene namesi
Name:QDR1
Ordered Locus Names:YIL120W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IX

Organism-specific databases

EuPathDBiFungiDB:YIL120W.
SGDiS000001382. QDR1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 75CytoplasmicSequence analysisAdd BLAST75
Transmembranei76 – 96HelicalSequence analysisAdd BLAST21
Topological domaini97 – 108ExtracellularSequence analysisAdd BLAST12
Transmembranei109 – 129HelicalSequence analysisAdd BLAST21
Topological domaini130 – 135CytoplasmicSequence analysis6
Transmembranei136 – 156HelicalSequence analysisAdd BLAST21
Topological domaini157 – 165ExtracellularSequence analysis9
Transmembranei166 – 186HelicalSequence analysisAdd BLAST21
Topological domaini187 – 195CytoplasmicSequence analysis9
Transmembranei196 – 216HelicalSequence analysisAdd BLAST21
Topological domaini217 – 224ExtracellularSequence analysis8
Transmembranei225 – 245HelicalSequence analysisAdd BLAST21
Topological domaini246 – 296CytoplasmicSequence analysisAdd BLAST51
Transmembranei297 – 317HelicalSequence analysisAdd BLAST21
Topological domaini318 – 341ExtracellularSequence analysisAdd BLAST24
Transmembranei342 – 362HelicalSequence analysisAdd BLAST21
Topological domaini363 – 421CytoplasmicSequence analysisAdd BLAST59
Transmembranei422 – 442HelicalSequence analysisAdd BLAST21
Topological domaini443 – 445ExtracellularSequence analysis3
Transmembranei446 – 466HelicalSequence analysisAdd BLAST21
Topological domaini467 – 481CytoplasmicSequence analysisAdd BLAST15
Transmembranei482 – 502HelicalSequence analysisAdd BLAST21
Topological domaini503 – 511ExtracellularSequence analysis9
Transmembranei512 – 532HelicalSequence analysisAdd BLAST21
Topological domaini533 – 563CytoplasmicSequence analysisAdd BLAST31

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001734411 – 563Quinidine resistance protein 1Add BLAST563

Proteomic databases

PRIDEiP40475.

Interactioni

Protein-protein interaction databases

BioGridi34871. 19 interactors.
DIPiDIP-8146N.
IntActiP40475. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliP40475.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00620000088227.
HOGENOMiHOG000248839.
InParanoidiP40475.
OMAiHPGKAGT.
OrthoDBiEOG092C19MN.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40475-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKQQTSVMR NASIAKEERE GSDNNNVDRS SSDAISDNDA ERSNSHSEID
60 70 80 90 100
NESNFDMVPY SRFSHKQKML LVVQCAFTGF FSTVAGSIYY PVLTIIERKF
110 120 130 140 150
NITEELANVT IVVYFIFQGV APSIMGGLAD TFGRRPIVLW AILAYFCACI
160 170 180 190 200
GLACAHNYAQ ILALRCLQAA GISPVIAINS GIMGDVTTKV ERGGYVGLVA
210 220 230 240 250
GFQVVGTAFG ALIGAGLSSK WGWRAIFWFL AIGSGICLVF STLLMPETKR
260 270 280 290 300
TLVGNGSVTP RSFLNRSLIL HVGSVKKTLH LDDPDPETLE PRTSVDFLAP
310 320 330 340 350
LKILHIREID ILLSIAGLQF STWTTHQTAL TIVLSKKYNL SVAKIGLCFL
360 370 380 390 400
PAGISTLTSI ISAGRYLNWS YRTRKVKYNR WIKEQELQLM EKYKGDKNKV
410 420 430 440 450
AELIHSNSHY AFNLVEARLH PAFVTLLLSS IGFTAFGWCI SVKTPLAAVL
460 470 480 490 500
CTSAFASLFS NCILTFSTTL IVDLFPSKAS TATGCLNLFR CLLSAIFIAA
510 520 530 540 550
LTKMVEKMRY GGVFTFLSAI TSSSSLLLFY LLKNGKQLSF DRIRANDKSA
560
GRSVGKNSEK VST
Length:563
Mass (Da):61,759
Last modified:February 1, 1995 - v1
Checksum:i5FDBA6F9F7C71C72
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46833 Genomic DNA. Translation: CAA86872.1.
BK006942 Genomic DNA. Translation: DAA08433.1.
PIRiS49889.
RefSeqiNP_012146.1. NM_001179468.1.

Genome annotation databases

EnsemblFungiiYIL120W; YIL120W; YIL120W.
GeneIDi854686.
KEGGisce:YIL120W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46833 Genomic DNA. Translation: CAA86872.1.
BK006942 Genomic DNA. Translation: DAA08433.1.
PIRiS49889.
RefSeqiNP_012146.1. NM_001179468.1.

3D structure databases

ProteinModelPortaliP40475.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34871. 19 interactors.
DIPiDIP-8146N.
IntActiP40475. 1 interactor.

Proteomic databases

PRIDEiP40475.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYIL120W; YIL120W; YIL120W.
GeneIDi854686.
KEGGisce:YIL120W.

Organism-specific databases

EuPathDBiFungiDB:YIL120W.
SGDiS000001382. QDR1.

Phylogenomic databases

GeneTreeiENSGT00620000088227.
HOGENOMiHOG000248839.
InParanoidiP40475.
OMAiHPGKAGT.
OrthoDBiEOG092C19MN.

Enzyme and pathway databases

BioCyciYEAST:G3O-31373-MONOMER.

Miscellaneous databases

PROiP40475.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQDR1_YEAST
AccessioniPrimary (citable) accession number: P40475
Secondary accession number(s): D6VVG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.