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P40475 (QDR1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Quinidine resistance protein 1
Gene names
Name:QDR1
Ordered Locus Names:YIL120W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›

Protein attributes

Sequence length563 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Multidrug resistance transporter involved in resistance and adaptation to quinidine and ketoconazole. Ref.3

Subcellular location

Cell membrane; Multi-pass membrane protein Ref.3.

Sequence similarities

Belongs to the major facilitator superfamily. CAR1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 563563Quinidine resistance protein 1
PRO_0000173441

Regions

Topological domain1 – 7575Cytoplasmic Potential
Transmembrane76 – 9621Helical; Potential
Topological domain97 – 10812Extracellular Potential
Transmembrane109 – 12921Helical; Potential
Topological domain130 – 1356Cytoplasmic Potential
Transmembrane136 – 15621Helical; Potential
Topological domain157 – 1659Extracellular Potential
Transmembrane166 – 18621Helical; Potential
Topological domain187 – 1959Cytoplasmic Potential
Transmembrane196 – 21621Helical; Potential
Topological domain217 – 2248Extracellular Potential
Transmembrane225 – 24521Helical; Potential
Topological domain246 – 29651Cytoplasmic Potential
Transmembrane297 – 31721Helical; Potential
Topological domain318 – 34124Extracellular Potential
Transmembrane342 – 36221Helical; Potential
Topological domain363 – 42159Cytoplasmic Potential
Transmembrane422 – 44221Helical; Potential
Topological domain443 – 4453Extracellular Potential
Transmembrane446 – 46621Helical; Potential
Topological domain467 – 48115Cytoplasmic Potential
Transmembrane482 – 50221Helical; Potential
Topological domain503 – 5119Extracellular Potential
Transmembrane512 – 53221Helical; Potential
Topological domain533 – 56331Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
P40475 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 5FDBA6F9F7C71C72

FASTA56361,759
        10         20         30         40         50         60 
MTKQQTSVMR NASIAKEERE GSDNNNVDRS SSDAISDNDA ERSNSHSEID NESNFDMVPY 

        70         80         90        100        110        120 
SRFSHKQKML LVVQCAFTGF FSTVAGSIYY PVLTIIERKF NITEELANVT IVVYFIFQGV 

       130        140        150        160        170        180 
APSIMGGLAD TFGRRPIVLW AILAYFCACI GLACAHNYAQ ILALRCLQAA GISPVIAINS 

       190        200        210        220        230        240 
GIMGDVTTKV ERGGYVGLVA GFQVVGTAFG ALIGAGLSSK WGWRAIFWFL AIGSGICLVF 

       250        260        270        280        290        300 
STLLMPETKR TLVGNGSVTP RSFLNRSLIL HVGSVKKTLH LDDPDPETLE PRTSVDFLAP 

       310        320        330        340        350        360 
LKILHIREID ILLSIAGLQF STWTTHQTAL TIVLSKKYNL SVAKIGLCFL PAGISTLTSI 

       370        380        390        400        410        420 
ISAGRYLNWS YRTRKVKYNR WIKEQELQLM EKYKGDKNKV AELIHSNSHY AFNLVEARLH 

       430        440        450        460        470        480 
PAFVTLLLSS IGFTAFGWCI SVKTPLAAVL CTSAFASLFS NCILTFSTTL IVDLFPSKAS 

       490        500        510        520        530        540 
TATGCLNLFR CLLSAIFIAA LTKMVEKMRY GGVFTFLSAI TSSSSLLLFY LLKNGKQLSF 

       550        560 
DRIRANDKSA GRSVGKNSEK VST

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome IX."
Churcher C.M., Bowman S., Badcock K., Bankier A.T., Brown D., Chillingworth T., Connor R., Devlin K., Gentles S., Hamlin N., Harris D.E., Horsnell T., Hunt S., Jagels K., Jones M., Lye G., Moule S., Odell C. expand/collapse author list , Pearson D., Rajandream M.A., Rice P., Rowley N., Skelton J., Smith V., Walsh S.V., Whitehead S., Barrell B.G.
Nature 387:84-87(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Resistance and adaptation to quinidine in Saccharomyces cerevisiae: role of QDR1 (YIL120w), encoding a plasma membrane transporter of the major facilitator superfamily required for multidrug resistance."
Nunes P.A., Tenreiro S., Sa-Correia I.
Antimicrob. Agents Chemother. 45:1528-1534(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[4]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Z46833 Genomic DNA. Translation: CAA86872.1.
BK006942 Genomic DNA. Translation: DAA08433.1.
PIRS49889.
RefSeqNP_012146.1. NM_001179468.1.

3D structure databases

ProteinModelPortalP40475.
SMRP40475. Positions 84-249.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-8146N.
IntActP40475. 1 interaction.
STRING4932.YIL120W.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYIL120W; YIL120W; YIL120W.
GeneID854686.
KEGGsce:YIL120W.

Organism-specific databases

CYGDYIL120w.
SGDS000001382. QDR1.

Phylogenomic databases

eggNOGCOG0477.
GeneTreeENSGT00620000088227.
HOGENOMHOG000248839.
OMAAERGKYM.
OrthoDBEOG422DTG.

Enzyme and pathway databases

BioCycYEAST:G3O-31373-MONOMER.

Gene expression databases

GenevestigatorP40475.
GermOnlineYIL120W. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PfamPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMSSF103473. MFS_gen_substrate_transporter. 1 hit.
PROSITEPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio977304.

Entry information

Entry nameQDR1_YEAST
AccessionPrimary (citable) accession number: P40475
Secondary accession number(s): D6VVG7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 29, 2013
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome IX

Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

SIMILARITY comments

Index of protein domains and families

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