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P40475

- QDR1_YEAST

UniProt

P40475 - QDR1_YEAST

Protein

Quinidine resistance protein 1

Gene

QDR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Multidrug resistance transporter involved in resistance and adaptation to quinidine and ketoconazole.1 Publication

    GO - Molecular functioni

    1. drug transmembrane transporter activity Source: SGD

    GO - Biological processi

    1. ascospore wall assembly Source: SGD
    2. drug transmembrane transport Source: SGD

    Keywords - Biological processi

    Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31373-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Quinidine resistance protein 1
    Gene namesi
    Name:QDR1
    Ordered Locus Names:YIL120W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome IX

    Organism-specific databases

    CYGDiYIL120w.
    SGDiS000001382. QDR1.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: SGD

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 563563Quinidine resistance protein 1PRO_0000173441Add
    BLAST

    Expressioni

    Gene expression databases

    GenevestigatoriP40475.

    Interactioni

    Protein-protein interaction databases

    BioGridi34871. 19 interactions.
    DIPiDIP-8146N.
    IntActiP40475. 1 interaction.
    STRINGi4932.YIL120W.

    Structurei

    3D structure databases

    ProteinModelPortaliP40475.
    SMRiP40475. Positions 91-248.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 7575CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini97 – 10812ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini130 – 1356CytoplasmicSequence Analysis
    Topological domaini157 – 1659ExtracellularSequence Analysis
    Topological domaini187 – 1959CytoplasmicSequence Analysis
    Topological domaini217 – 2248ExtracellularSequence Analysis
    Topological domaini246 – 29651CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini318 – 34124ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini363 – 42159CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini443 – 4453ExtracellularSequence Analysis
    Topological domaini467 – 48115CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini503 – 5119ExtracellularSequence Analysis
    Topological domaini533 – 56331CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei76 – 9621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei109 – 12921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei136 – 15621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei166 – 18621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei196 – 21621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei225 – 24521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei297 – 31721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei342 – 36221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei422 – 44221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei446 – 46621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei482 – 50221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei512 – 53221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0477.
    GeneTreeiENSGT00620000088227.
    HOGENOMiHOG000248839.
    OMAiGITPMFL.
    OrthoDBiEOG75F4PT.

    Family and domain databases

    InterProiIPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view]
    PfamiPF07690. MFS_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 3 hits.
    PROSITEiPS50850. MFS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P40475-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKQQTSVMR NASIAKEERE GSDNNNVDRS SSDAISDNDA ERSNSHSEID    50
    NESNFDMVPY SRFSHKQKML LVVQCAFTGF FSTVAGSIYY PVLTIIERKF 100
    NITEELANVT IVVYFIFQGV APSIMGGLAD TFGRRPIVLW AILAYFCACI 150
    GLACAHNYAQ ILALRCLQAA GISPVIAINS GIMGDVTTKV ERGGYVGLVA 200
    GFQVVGTAFG ALIGAGLSSK WGWRAIFWFL AIGSGICLVF STLLMPETKR 250
    TLVGNGSVTP RSFLNRSLIL HVGSVKKTLH LDDPDPETLE PRTSVDFLAP 300
    LKILHIREID ILLSIAGLQF STWTTHQTAL TIVLSKKYNL SVAKIGLCFL 350
    PAGISTLTSI ISAGRYLNWS YRTRKVKYNR WIKEQELQLM EKYKGDKNKV 400
    AELIHSNSHY AFNLVEARLH PAFVTLLLSS IGFTAFGWCI SVKTPLAAVL 450
    CTSAFASLFS NCILTFSTTL IVDLFPSKAS TATGCLNLFR CLLSAIFIAA 500
    LTKMVEKMRY GGVFTFLSAI TSSSSLLLFY LLKNGKQLSF DRIRANDKSA 550
    GRSVGKNSEK VST 563
    Length:563
    Mass (Da):61,759
    Last modified:February 1, 1995 - v1
    Checksum:i5FDBA6F9F7C71C72
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46833 Genomic DNA. Translation: CAA86872.1.
    BK006942 Genomic DNA. Translation: DAA08433.1.
    PIRiS49889.
    RefSeqiNP_012146.1. NM_001179468.1.

    Genome annotation databases

    EnsemblFungiiYIL120W; YIL120W; YIL120W.
    GeneIDi854686.
    KEGGisce:YIL120W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46833 Genomic DNA. Translation: CAA86872.1 .
    BK006942 Genomic DNA. Translation: DAA08433.1 .
    PIRi S49889.
    RefSeqi NP_012146.1. NM_001179468.1.

    3D structure databases

    ProteinModelPortali P40475.
    SMRi P40475. Positions 91-248.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 34871. 19 interactions.
    DIPi DIP-8146N.
    IntActi P40475. 1 interaction.
    STRINGi 4932.YIL120W.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YIL120W ; YIL120W ; YIL120W .
    GeneIDi 854686.
    KEGGi sce:YIL120W.

    Organism-specific databases

    CYGDi YIL120w.
    SGDi S000001382. QDR1.

    Phylogenomic databases

    eggNOGi COG0477.
    GeneTreei ENSGT00620000088227.
    HOGENOMi HOG000248839.
    OMAi GITPMFL.
    OrthoDBi EOG75F4PT.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31373-MONOMER.

    Miscellaneous databases

    NextBioi 977304.

    Gene expression databases

    Genevestigatori P40475.

    Family and domain databases

    InterProi IPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view ]
    Pfami PF07690. MFS_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 3 hits.
    PROSITEi PS50850. MFS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "Resistance and adaptation to quinidine in Saccharomyces cerevisiae: role of QDR1 (YIL120w), encoding a plasma membrane transporter of the major facilitator superfamily required for multidrug resistance."
      Nunes P.A., Tenreiro S., Sa-Correia I.
      Antimicrob. Agents Chemother. 45:1528-1534(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    4. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.

    Entry informationi

    Entry nameiQDR1_YEAST
    AccessioniPrimary (citable) accession number: P40475
    Secondary accession number(s): D6VVG7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome IX
      Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

    External Data

    Dasty 3