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Protein

Quinidine resistance protein 1

Gene

QDR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Multidrug resistance transporter involved in resistance and adaptation to quinidine and ketoconazole.1 Publication

GO - Molecular functioni

  1. drug transmembrane transporter activity Source: SGD

GO - Biological processi

  1. ascospore wall assembly Source: SGD
  2. drug transmembrane transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31373-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Quinidine resistance protein 1
Gene namesi
Name:QDR1
Ordered Locus Names:YIL120W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome IX

Organism-specific databases

CYGDiYIL120w.
EuPathDBiFungiDB:YIL120W.
SGDiS000001382. QDR1.

Subcellular locationi

  1. Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7575CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei76 – 9621HelicalSequence AnalysisAdd
BLAST
Topological domaini97 – 10812ExtracellularSequence AnalysisAdd
BLAST
Transmembranei109 – 12921HelicalSequence AnalysisAdd
BLAST
Topological domaini130 – 1356CytoplasmicSequence Analysis
Transmembranei136 – 15621HelicalSequence AnalysisAdd
BLAST
Topological domaini157 – 1659ExtracellularSequence Analysis
Transmembranei166 – 18621HelicalSequence AnalysisAdd
BLAST
Topological domaini187 – 1959CytoplasmicSequence Analysis
Transmembranei196 – 21621HelicalSequence AnalysisAdd
BLAST
Topological domaini217 – 2248ExtracellularSequence Analysis
Transmembranei225 – 24521HelicalSequence AnalysisAdd
BLAST
Topological domaini246 – 29651CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei297 – 31721HelicalSequence AnalysisAdd
BLAST
Topological domaini318 – 34124ExtracellularSequence AnalysisAdd
BLAST
Transmembranei342 – 36221HelicalSequence AnalysisAdd
BLAST
Topological domaini363 – 42159CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei422 – 44221HelicalSequence AnalysisAdd
BLAST
Topological domaini443 – 4453ExtracellularSequence Analysis
Transmembranei446 – 46621HelicalSequence AnalysisAdd
BLAST
Topological domaini467 – 48115CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei482 – 50221HelicalSequence AnalysisAdd
BLAST
Topological domaini503 – 5119ExtracellularSequence Analysis
Transmembranei512 – 53221HelicalSequence AnalysisAdd
BLAST
Topological domaini533 – 56331CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 563563Quinidine resistance protein 1PRO_0000173441Add
BLAST

Expressioni

Gene expression databases

GenevestigatoriP40475.

Interactioni

Protein-protein interaction databases

BioGridi34871. 19 interactions.
DIPiDIP-8146N.
IntActiP40475. 1 interaction.
STRINGi4932.YIL120W.

Structurei

3D structure databases

ProteinModelPortaliP40475.
SMRiP40475. Positions 84-249.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00620000088227.
HOGENOMiHOG000248839.
InParanoidiP40475.
OMAiGITPMFL.
OrthoDBiEOG75F4PT.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40475-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKQQTSVMR NASIAKEERE GSDNNNVDRS SSDAISDNDA ERSNSHSEID
60 70 80 90 100
NESNFDMVPY SRFSHKQKML LVVQCAFTGF FSTVAGSIYY PVLTIIERKF
110 120 130 140 150
NITEELANVT IVVYFIFQGV APSIMGGLAD TFGRRPIVLW AILAYFCACI
160 170 180 190 200
GLACAHNYAQ ILALRCLQAA GISPVIAINS GIMGDVTTKV ERGGYVGLVA
210 220 230 240 250
GFQVVGTAFG ALIGAGLSSK WGWRAIFWFL AIGSGICLVF STLLMPETKR
260 270 280 290 300
TLVGNGSVTP RSFLNRSLIL HVGSVKKTLH LDDPDPETLE PRTSVDFLAP
310 320 330 340 350
LKILHIREID ILLSIAGLQF STWTTHQTAL TIVLSKKYNL SVAKIGLCFL
360 370 380 390 400
PAGISTLTSI ISAGRYLNWS YRTRKVKYNR WIKEQELQLM EKYKGDKNKV
410 420 430 440 450
AELIHSNSHY AFNLVEARLH PAFVTLLLSS IGFTAFGWCI SVKTPLAAVL
460 470 480 490 500
CTSAFASLFS NCILTFSTTL IVDLFPSKAS TATGCLNLFR CLLSAIFIAA
510 520 530 540 550
LTKMVEKMRY GGVFTFLSAI TSSSSLLLFY LLKNGKQLSF DRIRANDKSA
560
GRSVGKNSEK VST
Length:563
Mass (Da):61,759
Last modified:February 1, 1995 - v1
Checksum:i5FDBA6F9F7C71C72
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46833 Genomic DNA. Translation: CAA86872.1.
BK006942 Genomic DNA. Translation: DAA08433.1.
PIRiS49889.
RefSeqiNP_012146.1. NM_001179468.1.

Genome annotation databases

EnsemblFungiiYIL120W; YIL120W; YIL120W.
GeneIDi854686.
KEGGisce:YIL120W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46833 Genomic DNA. Translation: CAA86872.1.
BK006942 Genomic DNA. Translation: DAA08433.1.
PIRiS49889.
RefSeqiNP_012146.1. NM_001179468.1.

3D structure databases

ProteinModelPortaliP40475.
SMRiP40475. Positions 84-249.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34871. 19 interactions.
DIPiDIP-8146N.
IntActiP40475. 1 interaction.
STRINGi4932.YIL120W.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYIL120W; YIL120W; YIL120W.
GeneIDi854686.
KEGGisce:YIL120W.

Organism-specific databases

CYGDiYIL120w.
EuPathDBiFungiDB:YIL120W.
SGDiS000001382. QDR1.

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00620000088227.
HOGENOMiHOG000248839.
InParanoidiP40475.
OMAiGITPMFL.
OrthoDBiEOG75F4PT.

Enzyme and pathway databases

BioCyciYEAST:G3O-31373-MONOMER.

Miscellaneous databases

NextBioi977304.
PROiP40475.

Gene expression databases

GenevestigatoriP40475.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Resistance and adaptation to quinidine in Saccharomyces cerevisiae: role of QDR1 (YIL120w), encoding a plasma membrane transporter of the major facilitator superfamily required for multidrug resistance."
    Nunes P.A., Tenreiro S., Sa-Correia I.
    Antimicrob. Agents Chemother. 45:1528-1534(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  4. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.

Entry informationi

Entry nameiQDR1_YEAST
AccessioniPrimary (citable) accession number: P40475
Secondary accession number(s): D6VVG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 29, 2015
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.