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Protein

Quinidine resistance protein 2

Gene

QDR2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Multidrug resistance transporter involved in resistance and adaptation to quinidine and to the herbicide barban (4-chloro-2-butynyl [3-chlorophenyl] carbamate). Implicated in potassium uptake.2 Publications

GO - Molecular functioni

  • cation transmembrane transporter activity Source: SGD
  • drug transmembrane transporter activity Source: SGD

GO - Biological processi

  • copper ion export Source: SGD
  • drug transmembrane transport Source: SGD
  • potassium ion import Source: SGD
Complete GO annotation...

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

BioCyciYEAST:G3O-31374-MONOMER.

Protein family/group databases

TCDBi2.A.1.2.31. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Quinidine resistance protein 2
Gene namesi
Name:QDR2
Ordered Locus Names:YIL121W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IX

Organism-specific databases

EuPathDBiFungiDB:YIL121W.
SGDiS000001383. QDR2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 67CytoplasmicSequence analysisAdd BLAST67
Transmembranei68 – 88HelicalSequence analysisAdd BLAST21
Topological domaini89 – 100ExtracellularSequence analysisAdd BLAST12
Transmembranei101 – 121HelicalSequence analysisAdd BLAST21
Topological domaini122 – 127CytoplasmicSequence analysis6
Transmembranei128 – 148HelicalSequence analysisAdd BLAST21
Topological domaini149ExtracellularSequence analysis1
Transmembranei150 – 170HelicalSequence analysisAdd BLAST21
Topological domaini171 – 187CytoplasmicSequence analysisAdd BLAST17
Transmembranei188 – 208HelicalSequence analysisAdd BLAST21
Topological domaini209 – 216ExtracellularSequence analysis8
Transmembranei217 – 237HelicalSequence analysisAdd BLAST21
Topological domaini238 – 300CytoplasmicSequence analysisAdd BLAST63
Transmembranei301 – 321HelicalSequence analysisAdd BLAST21
Topological domaini322 – 333ExtracellularSequence analysisAdd BLAST12
Transmembranei334 – 354HelicalSequence analysisAdd BLAST21
Topological domaini355 – 413CytoplasmicSequence analysisAdd BLAST59
Transmembranei414 – 434HelicalSequence analysisAdd BLAST21
Topological domaini435 – 437ExtracellularSequence analysis3
Transmembranei438 – 458HelicalSequence analysisAdd BLAST21
Topological domaini459 – 472CytoplasmicSequence analysisAdd BLAST14
Transmembranei473 – 493HelicalSequence analysisAdd BLAST21
Topological domaini494 – 503ExtracellularSequence analysis10
Transmembranei504 – 524HelicalSequence analysisAdd BLAST21
Topological domaini525 – 542CytoplasmicSequence analysisAdd BLAST18

GO - Cellular componenti

  • integral component of plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001734421 – 542Quinidine resistance protein 2Add BLAST542

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21PhosphoserineCombined sources1
Modified residuei38PhosphothreonineCombined sources1
Modified residuei40PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP40474.
PRIDEiP40474.

PTM databases

iPTMnetiP40474.

Interactioni

Protein-protein interaction databases

BioGridi34870. 38 interactors.
DIPiDIP-5661N.
IntActiP40474. 17 interactors.
MINTiMINT-535603.

Structurei

3D structure databases

ProteinModelPortaliP40474.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00620000088227.
HOGENOMiHOG000248839.
InParanoidiP40474.
OMAiSAYWLLV.
OrthoDBiEOG092C19MN.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40474-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGATSSIIR ENDFEDELAE SMQSYNRETA DKLALTRTES VKPEPEITAP
60 70 80 90 100
PHSRFSRSFK TVLIAQCAFT GFFSTIAGAI YYPVLSVIER KFDIDEELVN
110 120 130 140 150
VTVVVYFVFQ GLAPTFMGGF ADSLGRRPVV LVAIVIYFGA CIGLACAQTY
160 170 180 190 200
AQIIVLRCLQ AAGISPVIAI NSGIMGDVTT RAERGGYVGY VAGFQVLGSA
210 220 230 240 250
FGALIGAGLS SRWGWRAIFW FLAIGSGICF LASFLILPET KRNISGNGSV
260 270 280 290 300
TPKSYLNRAP ILVLPTVRKS LHLDNPDYET LELPTQLNLL APFKILKAYE
310 320 330 340 350
ICILMLVAGL QFAMYTTHLT ALSTALSKQY HLTVAKVGLC YLPSGICTLC
360 370 380 390 400
SIVIAGRYLN WNYRRRLKYY QNWLGKKRSK LLEEHDNDLN LVQRIIENDP
410 420 430 440 450
KYTFNIFKAR LQPAFVTLLL SSSGFCAYGW CITVKAPLAA VLCMSGFASL
460 470 480 490 500
FSNCILTFST TLIVDLFPTK TSTATGCLNL FRCILSAVFI AALSKMVEKM
510 520 530 540
KFGGVFTFLG ALTSSSSILL FILLRKGKEL AFKRKKQELG VN
Length:542
Mass (Da):59,618
Last modified:February 1, 1995 - v1
Checksum:i96649B74E940F63E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46833 Genomic DNA. Translation: CAA86871.1.
AY692735 Genomic DNA. Translation: AAT92754.1.
BK006942 Genomic DNA. Translation: DAA08432.1.
PIRiS49888.
RefSeqiNP_012145.1. NM_001179469.1.

Genome annotation databases

EnsemblFungiiYIL121W; YIL121W; YIL121W.
GeneIDi854685.
KEGGisce:YIL121W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46833 Genomic DNA. Translation: CAA86871.1.
AY692735 Genomic DNA. Translation: AAT92754.1.
BK006942 Genomic DNA. Translation: DAA08432.1.
PIRiS49888.
RefSeqiNP_012145.1. NM_001179469.1.

3D structure databases

ProteinModelPortaliP40474.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34870. 38 interactors.
DIPiDIP-5661N.
IntActiP40474. 17 interactors.
MINTiMINT-535603.

Protein family/group databases

TCDBi2.A.1.2.31. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiP40474.

Proteomic databases

MaxQBiP40474.
PRIDEiP40474.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYIL121W; YIL121W; YIL121W.
GeneIDi854685.
KEGGisce:YIL121W.

Organism-specific databases

EuPathDBiFungiDB:YIL121W.
SGDiS000001383. QDR2.

Phylogenomic databases

GeneTreeiENSGT00620000088227.
HOGENOMiHOG000248839.
InParanoidiP40474.
OMAiSAYWLLV.
OrthoDBiEOG092C19MN.

Enzyme and pathway databases

BioCyciYEAST:G3O-31374-MONOMER.

Miscellaneous databases

PROiP40474.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQDR2_YEAST
AccessioniPrimary (citable) accession number: P40474
Secondary accession number(s): D6VVG6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.