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Protein

Quinidine resistance protein 2

Gene

QDR2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Multidrug resistance transporter involved in resistance and adaptation to quinidine and to the herbicide barban (4-chloro-2-butynyl [3-chlorophenyl] carbamate). Implicated in potassium uptake.2 Publications

GO - Molecular functioni

  • cation transmembrane transporter activity Source: SGD
  • drug transmembrane transporter activity Source: SGD

GO - Biological processi

  • copper ion export Source: SGD
  • drug transmembrane transport Source: SGD
  • potassium ion import Source: SGD

Keywordsi

Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

BioCyciYEAST:G3O-31374-MONOMER

Protein family/group databases

TCDBi2.A.1.2.31 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Quinidine resistance protein 2
Gene namesi
Name:QDR2
Ordered Locus Names:YIL121W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IX

Organism-specific databases

EuPathDBiFungiDB:YIL121W
SGDiS000001383 QDR2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 67CytoplasmicSequence analysisAdd BLAST67
Transmembranei68 – 88HelicalSequence analysisAdd BLAST21
Topological domaini89 – 100ExtracellularSequence analysisAdd BLAST12
Transmembranei101 – 121HelicalSequence analysisAdd BLAST21
Topological domaini122 – 127CytoplasmicSequence analysis6
Transmembranei128 – 148HelicalSequence analysisAdd BLAST21
Topological domaini149ExtracellularSequence analysis1
Transmembranei150 – 170HelicalSequence analysisAdd BLAST21
Topological domaini171 – 187CytoplasmicSequence analysisAdd BLAST17
Transmembranei188 – 208HelicalSequence analysisAdd BLAST21
Topological domaini209 – 216ExtracellularSequence analysis8
Transmembranei217 – 237HelicalSequence analysisAdd BLAST21
Topological domaini238 – 300CytoplasmicSequence analysisAdd BLAST63
Transmembranei301 – 321HelicalSequence analysisAdd BLAST21
Topological domaini322 – 333ExtracellularSequence analysisAdd BLAST12
Transmembranei334 – 354HelicalSequence analysisAdd BLAST21
Topological domaini355 – 413CytoplasmicSequence analysisAdd BLAST59
Transmembranei414 – 434HelicalSequence analysisAdd BLAST21
Topological domaini435 – 437ExtracellularSequence analysis3
Transmembranei438 – 458HelicalSequence analysisAdd BLAST21
Topological domaini459 – 472CytoplasmicSequence analysisAdd BLAST14
Transmembranei473 – 493HelicalSequence analysisAdd BLAST21
Topological domaini494 – 503ExtracellularSequence analysis10
Transmembranei504 – 524HelicalSequence analysisAdd BLAST21
Topological domaini525 – 542CytoplasmicSequence analysisAdd BLAST18

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001734421 – 542Quinidine resistance protein 2Add BLAST542

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21PhosphoserineCombined sources1
Modified residuei38PhosphothreonineCombined sources1
Modified residuei40PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP40474
PaxDbiP40474
PRIDEiP40474

PTM databases

iPTMnetiP40474

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ASF1P324472EBI-25203,EBI-3003

Protein-protein interaction databases

BioGridi34870, 54 interactors
DIPiDIP-5661N
IntActiP40474, 19 interactors
MINTiP40474
STRINGi4932.YIL121W

Structurei

3D structure databases

ProteinModelPortaliP40474
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00620000088227
HOGENOMiHOG000248839
InParanoidiP40474
OMAiPMTANIY
OrthoDBiEOG092C19MN

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 3 hits
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequencei

Sequence statusi: Complete.

P40474-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGATSSIIR ENDFEDELAE SMQSYNRETA DKLALTRTES VKPEPEITAP
60 70 80 90 100
PHSRFSRSFK TVLIAQCAFT GFFSTIAGAI YYPVLSVIER KFDIDEELVN
110 120 130 140 150
VTVVVYFVFQ GLAPTFMGGF ADSLGRRPVV LVAIVIYFGA CIGLACAQTY
160 170 180 190 200
AQIIVLRCLQ AAGISPVIAI NSGIMGDVTT RAERGGYVGY VAGFQVLGSA
210 220 230 240 250
FGALIGAGLS SRWGWRAIFW FLAIGSGICF LASFLILPET KRNISGNGSV
260 270 280 290 300
TPKSYLNRAP ILVLPTVRKS LHLDNPDYET LELPTQLNLL APFKILKAYE
310 320 330 340 350
ICILMLVAGL QFAMYTTHLT ALSTALSKQY HLTVAKVGLC YLPSGICTLC
360 370 380 390 400
SIVIAGRYLN WNYRRRLKYY QNWLGKKRSK LLEEHDNDLN LVQRIIENDP
410 420 430 440 450
KYTFNIFKAR LQPAFVTLLL SSSGFCAYGW CITVKAPLAA VLCMSGFASL
460 470 480 490 500
FSNCILTFST TLIVDLFPTK TSTATGCLNL FRCILSAVFI AALSKMVEKM
510 520 530 540
KFGGVFTFLG ALTSSSSILL FILLRKGKEL AFKRKKQELG VN
Length:542
Mass (Da):59,618
Last modified:February 1, 1995 - v1
Checksum:i96649B74E940F63E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46833 Genomic DNA Translation: CAA86871.1
AY692735 Genomic DNA Translation: AAT92754.1
BK006942 Genomic DNA Translation: DAA08432.1
PIRiS49888
RefSeqiNP_012145.1, NM_001179469.1

Genome annotation databases

EnsemblFungiiYIL121W; YIL121W; YIL121W
GeneIDi854685
KEGGisce:YIL121W

Similar proteinsi

Entry informationi

Entry nameiQDR2_YEAST
AccessioniPrimary (citable) accession number: P40474
Secondary accession number(s): D6VVG6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 25, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health