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Protein

Quinidine resistance protein 2

Gene

QDR2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Multidrug resistance transporter involved in resistance and adaptation to quinidine and to the herbicide barban (4-chloro-2-butynyl [3-chlorophenyl] carbamate). Implicated in potassium uptake.2 Publications

GO - Molecular functioni

  • cation transmembrane transporter activity Source: SGD
  • drug transmembrane transporter activity Source: SGD

GO - Biological processi

  • copper ion export Source: SGD
  • drug transmembrane transport Source: SGD
  • potassium ion import Source: SGD
Complete GO annotation...

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

BioCyciYEAST:G3O-31374-MONOMER.

Protein family/group databases

TCDBi2.A.1.2.31. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Quinidine resistance protein 2
Gene namesi
Name:QDR2
Ordered Locus Names:YIL121W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IX

Organism-specific databases

EuPathDBiFungiDB:YIL121W.
SGDiS000001383. QDR2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6767CytoplasmicSequence analysisAdd
BLAST
Transmembranei68 – 8821HelicalSequence analysisAdd
BLAST
Topological domaini89 – 10012ExtracellularSequence analysisAdd
BLAST
Transmembranei101 – 12121HelicalSequence analysisAdd
BLAST
Topological domaini122 – 1276CytoplasmicSequence analysis
Transmembranei128 – 14821HelicalSequence analysisAdd
BLAST
Topological domaini149 – 1491ExtracellularSequence analysis
Transmembranei150 – 17021HelicalSequence analysisAdd
BLAST
Topological domaini171 – 18717CytoplasmicSequence analysisAdd
BLAST
Transmembranei188 – 20821HelicalSequence analysisAdd
BLAST
Topological domaini209 – 2168ExtracellularSequence analysis
Transmembranei217 – 23721HelicalSequence analysisAdd
BLAST
Topological domaini238 – 30063CytoplasmicSequence analysisAdd
BLAST
Transmembranei301 – 32121HelicalSequence analysisAdd
BLAST
Topological domaini322 – 33312ExtracellularSequence analysisAdd
BLAST
Transmembranei334 – 35421HelicalSequence analysisAdd
BLAST
Topological domaini355 – 41359CytoplasmicSequence analysisAdd
BLAST
Transmembranei414 – 43421HelicalSequence analysisAdd
BLAST
Topological domaini435 – 4373ExtracellularSequence analysis
Transmembranei438 – 45821HelicalSequence analysisAdd
BLAST
Topological domaini459 – 47214CytoplasmicSequence analysisAdd
BLAST
Transmembranei473 – 49321HelicalSequence analysisAdd
BLAST
Topological domaini494 – 50310ExtracellularSequence analysis
Transmembranei504 – 52421HelicalSequence analysisAdd
BLAST
Topological domaini525 – 54218CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 542542Quinidine resistance protein 2PRO_0000173442Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei21 – 211PhosphoserineCombined sources
Modified residuei38 – 381PhosphothreonineCombined sources
Modified residuei40 – 401PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP40474.

PTM databases

iPTMnetiP40474.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ASF1P324472EBI-25203,EBI-3003

Protein-protein interaction databases

BioGridi34870. 38 interactions.
DIPiDIP-5661N.
IntActiP40474. 17 interactions.
MINTiMINT-535603.

Structurei

3D structure databases

ProteinModelPortaliP40474.
SMRiP40474. Positions 76-241.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00620000088227.
HOGENOMiHOG000248839.
InParanoidiP40474.
OMAiYCISAAM.
OrthoDBiEOG75F4PT.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40474-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGATSSIIR ENDFEDELAE SMQSYNRETA DKLALTRTES VKPEPEITAP
60 70 80 90 100
PHSRFSRSFK TVLIAQCAFT GFFSTIAGAI YYPVLSVIER KFDIDEELVN
110 120 130 140 150
VTVVVYFVFQ GLAPTFMGGF ADSLGRRPVV LVAIVIYFGA CIGLACAQTY
160 170 180 190 200
AQIIVLRCLQ AAGISPVIAI NSGIMGDVTT RAERGGYVGY VAGFQVLGSA
210 220 230 240 250
FGALIGAGLS SRWGWRAIFW FLAIGSGICF LASFLILPET KRNISGNGSV
260 270 280 290 300
TPKSYLNRAP ILVLPTVRKS LHLDNPDYET LELPTQLNLL APFKILKAYE
310 320 330 340 350
ICILMLVAGL QFAMYTTHLT ALSTALSKQY HLTVAKVGLC YLPSGICTLC
360 370 380 390 400
SIVIAGRYLN WNYRRRLKYY QNWLGKKRSK LLEEHDNDLN LVQRIIENDP
410 420 430 440 450
KYTFNIFKAR LQPAFVTLLL SSSGFCAYGW CITVKAPLAA VLCMSGFASL
460 470 480 490 500
FSNCILTFST TLIVDLFPTK TSTATGCLNL FRCILSAVFI AALSKMVEKM
510 520 530 540
KFGGVFTFLG ALTSSSSILL FILLRKGKEL AFKRKKQELG VN
Length:542
Mass (Da):59,618
Last modified:February 1, 1995 - v1
Checksum:i96649B74E940F63E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46833 Genomic DNA. Translation: CAA86871.1.
AY692735 Genomic DNA. Translation: AAT92754.1.
BK006942 Genomic DNA. Translation: DAA08432.1.
PIRiS49888.
RefSeqiNP_012145.1. NM_001179469.1.

Genome annotation databases

EnsemblFungiiYIL121W; YIL121W; YIL121W.
GeneIDi854685.
KEGGisce:YIL121W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46833 Genomic DNA. Translation: CAA86871.1.
AY692735 Genomic DNA. Translation: AAT92754.1.
BK006942 Genomic DNA. Translation: DAA08432.1.
PIRiS49888.
RefSeqiNP_012145.1. NM_001179469.1.

3D structure databases

ProteinModelPortaliP40474.
SMRiP40474. Positions 76-241.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34870. 38 interactions.
DIPiDIP-5661N.
IntActiP40474. 17 interactions.
MINTiMINT-535603.

Protein family/group databases

TCDBi2.A.1.2.31. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiP40474.

Proteomic databases

MaxQBiP40474.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYIL121W; YIL121W; YIL121W.
GeneIDi854685.
KEGGisce:YIL121W.

Organism-specific databases

EuPathDBiFungiDB:YIL121W.
SGDiS000001383. QDR2.

Phylogenomic databases

GeneTreeiENSGT00620000088227.
HOGENOMiHOG000248839.
InParanoidiP40474.
OMAiYCISAAM.
OrthoDBiEOG75F4PT.

Enzyme and pathway databases

BioCyciYEAST:G3O-31374-MONOMER.

Miscellaneous databases

NextBioi977301.
PROiP40474.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. "Saccharomyces cerevisiae multidrug transporter Qdr2p (Yil121wp): localization and function as a quinidine resistance determinant."
    Vargas R.C., Tenreiro S., Teixeira M.C., Fernandes A.R., Sa-Correia I.
    Antimicrob. Agents Chemother. 48:2531-2537(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  5. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.
  6. "Saccharomyces cerevisiae multidrug resistance transporter Qdr2 is implicated in potassium uptake, providing a physiological advantage to quinidine-stressed cells."
    Vargas R.C., Garcia-Salcedo R., Tenreiro S., Teixeira M.C., Fernandes A.R., Ramos J., Sa-Correia I.
    Eukaryot. Cell 6:134-142(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21; THR-38 AND SER-40, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiQDR2_YEAST
AccessioniPrimary (citable) accession number: P40474
Secondary accession number(s): D6VVG6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 11, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.