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Protein

Transcriptional activator POG1

Gene

POG1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional activator which promotes cell cycle recovery with CLN2, after pheromone induced G1 arrest, probably inhibiting the ability of STE20 to activate the pheromone response pathway. Binds the promoters of genes that function in cell cycle regulation, cytoskeletal organization, and spindle assembly. May also be involved in stress-resistance.3 Publications

Miscellaneous

Present with 736 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • RNA polymerase II proximal promoter sequence-specific DNA binding Source: SGD

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • positive regulation of transcription by RNA polymerase II Source: SGD
  • re-entry into mitotic cell cycle after pheromone arrest Source: SGD
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator
Biological processCell cycle, Cell division, Mitosis, Stress response, Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-31375-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional activator POG1
Alternative name(s):
Promoter of growth protein 1
Gene namesi
Name:POG1
Ordered Locus Names:YIL122W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IX

Organism-specific databases

EuPathDBiFungiDB:YIL122W
SGDiS000001384 POG1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002029621 – 351Transcriptional activator POG1Add BLAST351

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei152PhosphoserineCombined sources1
Modified residuei168PhosphoserineCombined sources1
Modified residuei314PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated by CDC28.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP40473
PaxDbiP40473
PRIDEiP40473

PTM databases

iPTMnetiP40473

Expressioni

Inductioni

Expressed periodically during cell division. Regulated by the SBF complex which is one critical regulator of the start of the cell cycle.2 Publications

Interactioni

Protein-protein interaction databases

BioGridi34869, 109 interactors
DIPiDIP-2755N
IntActiP40473, 8 interactors
MINTiP40473
STRINGi4932.YIL122W

Structurei

3D structure databases

ProteinModelPortaliP40473
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi193 – 302Gln-richAdd BLAST110

Sequence similaritiesi

Belongs to the POG1 family.Curated

Phylogenomic databases

InParanoidiP40473
OMAiNFLIHTP
OrthoDBiEOG092C38GV

Sequencei

Sequence statusi: Complete.

P40473-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQEPHRQSE EKEKPKGPMA VEREQHTSLS SGTTVTASTG DESTNSRPVE
60 70 80 90 100
SSQTEKSLSL RIRILKQLGF DDIQELNACD TGLVEQFLNV RLINDTKELE
110 120 130 140 150
KIRESNLAKL NQIIDKCMES DKISDSTLNK ILDMSMNRDT NNDNNNHLTI
160 170 180 190 200
PSPITTKKRK INASELASPR GHRRYRSDIP TVSEVETGVG YPQIHQQPGA
210 220 230 240 250
YTLPMPANQW MSNPYMQPPQ PQVQQIMPQY LYPPGMGPQA QLPTMSSNSE
260 270 280 290 300
SQTPVMSSQF LSLNQHGLYQ QNIGAHPVMS MGPQANIYGQ QHQLQPGQER
310 320 330 340 350
DQSRKSFSHR RSQSANISMA NFRSPMRNPQ PASSQRPVNF LIHTPKHPPP

T
Length:351
Mass (Da):39,498
Last modified:February 1, 1995 - v1
Checksum:i35EE3E9F93FDCE0C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46833 Genomic DNA Translation: CAA86870.1
BK006942 Genomic DNA Translation: DAA08431.1
PIRiS49887
RefSeqiNP_012144.1, NM_001179470.1

Genome annotation databases

EnsemblFungiiYIL122W; YIL122W; YIL122W
GeneIDi854684
KEGGisce:YIL122W

Similar proteinsi

Entry informationi

Entry nameiPOG1_YEAST
AccessioniPrimary (citable) accession number: P40473
Secondary accession number(s): D6VVG5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 20, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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