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P40473 (POG1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcriptional activator POG1
Alternative name(s):
Promoter of growth protein 1
Gene names
Name:POG1
Ordered Locus Names:YIL122W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length351 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcriptional activator which promotes cell cycle recovery with CLN2, after pheromone induced G1 arrest, probably inhibiting the ability of STE20 to activate the pheromone response pathway. Binds the promoters of genes that function in cell cycle regulation, cytoskeletal organization, and spindle assembly. May also be involved in stress-resistance. Ref.3 Ref.4 Ref.9

Subcellular location

Nucleus Ref.5.

Induction

Expressed periodically during cell division. Regulated by the SBF complex which is one critical regulator of the start of the cell cycle. Ref.4 Ref.8

Post-translational modification

Phosphorylated by CDC28 Probable. Ref.7

Miscellaneous

Present with 736 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the POG1 family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

GTS1P409563EBI-25207,EBI-7968

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 351351Transcriptional activator POG1
PRO_0000202962

Regions

Compositional bias193 – 302110Gln-rich

Amino acid modifications

Modified residue1521Phosphoserine Ref.10
Modified residue1681Phosphoserine Ref.11
Modified residue3141Phosphoserine Ref.11

Sequences

Sequence LengthMass (Da)Tools
P40473 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 35EE3E9F93FDCE0C

FASTA35139,498
        10         20         30         40         50         60 
MKQEPHRQSE EKEKPKGPMA VEREQHTSLS SGTTVTASTG DESTNSRPVE SSQTEKSLSL 

        70         80         90        100        110        120 
RIRILKQLGF DDIQELNACD TGLVEQFLNV RLINDTKELE KIRESNLAKL NQIIDKCMES 

       130        140        150        160        170        180 
DKISDSTLNK ILDMSMNRDT NNDNNNHLTI PSPITTKKRK INASELASPR GHRRYRSDIP 

       190        200        210        220        230        240 
TVSEVETGVG YPQIHQQPGA YTLPMPANQW MSNPYMQPPQ PQVQQIMPQY LYPPGMGPQA 

       250        260        270        280        290        300 
QLPTMSSNSE SQTPVMSSQF LSLNQHGLYQ QNIGAHPVMS MGPQANIYGQ QHQLQPGQER 

       310        320        330        340        350 
DQSRKSFSHR RSQSANISMA NFRSPMRNPQ PASSQRPVNF LIHTPKHPPP T 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome IX."
Churcher C.M., Bowman S., Badcock K., Bankier A.T., Brown D., Chillingworth T., Connor R., Devlin K., Gentles S., Hamlin N., Harris D.E., Horsnell T., Hunt S., Jagels K., Jones M., Lye G., Moule S., Odell C. expand/collapse author list , Pearson D., Rajandream M.A., Rice P., Rowley N., Skelton J., Smith V., Walsh S.V., Whitehead S., Barrell B.G.
Nature 387:84-87(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"POG1, a novel yeast gene, promotes recovery from pheromone arrest via the G1 cyclin CLN2."
Leza M.A., Elion E.A.
Genetics 151:531-543(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[4]"Complex transcriptional circuitry at the G1/S transition in Saccharomyces cerevisiae."
Horak C.E., Luscombe N.M., Qian J., Bertone P., Piccirrillo S., Gerstein M., Snyder M.
Genes Dev. 16:3017-3033(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INDUCTION.
[5]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[6]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[7]"Targets of the cyclin-dependent kinase Cdk1."
Ubersax J.A., Woodbury E.L., Quang P.N., Paraz M., Blethrow J.D., Shah K., Shokat K.M., Morgan D.O.
Nature 425:859-864(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION BY CDC28.
[8]"New weakly expressed cell cycle-regulated genes in yeast."
de Lichtenberg U., Wernersson R., Jensen T.S., Nielsen H.B., Fausboell A., Schmidt P., Hansen F.B., Knudsen S., Brunak S.
Yeast 22:1191-1201(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[9]"Overexpression of two transcriptional factors, Kin28 and Pog1, suppresses the stress sensitivity caused by the rsp5 mutation in Saccharomyces cerevisiae."
Demae M., Murata Y., Hisano M., Haitani Y., Shima J., Takagi H.
FEMS Microbiol. Lett. 277:70-78(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[10]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-152, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[11]"Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-168 AND SER-314, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z46833 Genomic DNA. Translation: CAA86870.1.
BK006942 Genomic DNA. Translation: DAA08431.1.
PIRS49887.
RefSeqNP_012144.1. NM_001179470.1.

3D structure databases

ProteinModelPortalP40473.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid34869. 40 interactions.
DIPDIP-2755N.
IntActP40473. 8 interactions.
MINTMINT-472738.
STRING4932.YIL122W.

Proteomic databases

MaxQBP40473.
PaxDbP40473.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYIL122W; YIL122W; YIL122W.
GeneID854684.
KEGGsce:YIL122W.

Organism-specific databases

CYGDYIL122w.
SGDS000001384. POG1.

Phylogenomic databases

eggNOGNOG78928.
OrthoDBEOG7PZS79.

Enzyme and pathway databases

BioCycYEAST:G3O-31375-MONOMER.

Gene expression databases

GenevestigatorP40473.

Family and domain databases

ProtoNetSearch...

Other

NextBio977298.

Entry information

Entry namePOG1_YEAST
AccessionPrimary (citable) accession number: P40473
Secondary accession number(s): D6VVG5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 11, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome IX

Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families