P40473 (POG1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transcriptional activator POG1

Alternative name(s):
Promoter of growth protein 1

Gene names

Name:	POG1
Ordered Locus Names:	YIL122W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	351 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Transcriptional activator which promotes cell cycle recovery with CLN2, after pheromone induced G1 arrest, probably inhibiting the ability of STE20 to activate the pheromone response pathway. Binds the promoters of genes that function in cell cycle regulation, cytoskeletal organization, and spindle assembly. May also be involved in stress-resistance. Ref.3 Ref.4 Ref.9
Subcellular location	Nucleus Ref.5.
Induction	Expressed periodically during cell division. Regulated by the SBF complex which is one critical regulator of the start of the cell cycle. Ref.4 Ref.8
Post-translational modification	Phosphorylated by CDC28 Probable. Ref.7
Miscellaneous	Present with 736 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the POG1 family.

Ontologies

Keywords
Biological process	Cell cycle Cell division Mitosis Stress response Transcription Transcription regulation
Cellular component	Nucleus
Molecular function	Activator
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell division Inferred from electronic annotation. Source: UniProtKB-KW mitosis Inferred from electronic annotation. Source: UniProtKB-KW re-entry into mitotic cell cycle after pheromone arrest Inferred from mutant phenotype Ref.3. Source: SGD regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW response to stress Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nuclear chromatin Inferred from direct assay Ref.4. Source: SGD
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
GTS1	P40956	3	EBI-25207,EBI-7968

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 351	351	Transcriptional activator POG1		PRO_0000202962
Regions
	Compositional bias	193 – 302	110	Gln-rich
Amino acid modifications
	Modified residue	152	1	Phosphoserine Ref.10

Sequences

	Sequence		Length	Mass (Da)
	P40473 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: 35EE3E9F93FDCE0C	FASTA	351	39,498
	10 20 30 40 50 60 MKQEPHRQSE EKEKPKGPMA VEREQHTSLS SGTTVTASTG DESTNSRPVE SSQTEKSLSL 70 80 90 100 110 120 RIRILKQLGF DDIQELNACD TGLVEQFLNV RLINDTKELE KIRESNLAKL NQIIDKCMES 130 140 150 160 170 180 DKISDSTLNK ILDMSMNRDT NNDNNNHLTI PSPITTKKRK INASELASPR GHRRYRSDIP 190 200 210 220 230 240 TVSEVETGVG YPQIHQQPGA YTLPMPANQW MSNPYMQPPQ PQVQQIMPQY LYPPGMGPQA 250 260 270 280 290 300 QLPTMSSNSE SQTPVMSSQF LSLNQHGLYQ QNIGAHPVMS MGPQANIYGQ QHQLQPGQER 310 320 330 340 350 DQSRKSFSHR RSQSANISMA NFRSPMRNPQ PASSQRPVNF LIHTPKHPPP T

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome IX." Churcher C.M., Bowman S., Badcock K., Bankier A.T., Brown D., Chillingworth T., Connor R., Devlin K., Gentles S., Hamlin N., Harris D.E., Horsnell T., Hunt S., Jagels K., Jones M., Lye G., Moule S., Odell C. , Pearson D., Rajandream M.A., Rice P., Rowley N., Skelton J., Smith V., Walsh S.V., Whitehead S., Barrell B.G. Nature 387:84-87(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"POG1, a novel yeast gene, promotes recovery from pheromone arrest via the G1 cyclin CLN2." Leza M.A., Elion E.A. Genetics 151:531-543(1999) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[4]	"Complex transcriptional circuitry at the G1/S transition in Saccharomyces cerevisiae." Horak C.E., Luscombe N.M., Qian J., Bertone P., Piccirrillo S., Gerstein M., Snyder M. Genes Dev. 16:3017-3033(2002) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INDUCTION.
[5]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[6]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[7]	"Targets of the cyclin-dependent kinase Cdk1." Ubersax J.A., Woodbury E.L., Quang P.N., Paraz M., Blethrow J.D., Shah K., Shokat K.M., Morgan D.O. Nature 425:859-864(2003) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION BY CDC28.
[8]	"New weakly expressed cell cycle-regulated genes in yeast." de Lichtenberg U., Wernersson R., Jensen T.S., Nielsen H.B., Fausboell A., Schmidt P., Hansen F.B., Knudsen S., Brunak S. Yeast 22:1191-1201(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION.
[9]	"Overexpression of two transcriptional factors, Kin28 and Pog1, suppresses the stress sensitivity caused by the rsp5 mutation in Saccharomyces cerevisiae." Demae M., Murata Y., Hisano M., Haitani Y., Shima J., Takagi H. FEMS Microbiol. Lett. 277:70-78(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[10]	"A multidimensional chromatography technology for in-depth phosphoproteome analysis." Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H. Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-152, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z46833 Genomic DNA. Translation: CAA86870.1. BK006942 Genomic DNA. Translation: DAA08431.1.
PIR	S49887.
RefSeq	NP_012144.1. NM_001179470.1.
3D structure databases
ProteinModelPortal	P40473.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-2755N.
IntAct	P40473. 8 interactions.
MINT	MINT-472738.
STRING	4932.YIL122W.
Proteomic databases
PaxDb	P40473.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YIL122W; YIL122W; YIL122W.
GeneID	854684.
KEGG	sce:YIL122W.
Organism-specific databases
CYGD	YIL122w.
SGD	S000001384. POG1.
Phylogenomic databases
eggNOG	NOG78928.
OrthoDB	EOG4H49DP.
Enzyme and pathway databases
BioCyc	YEAST:G3O-31375-MONOMER.
Gene expression databases
Genevestigator	P40473.
GermOnline	YIL122W. Saccharomyces cerevisiae.
Family and domain databases
ProtoNet	Search...
Other
NextBio	977298.

Entry information

Entry name

POG1_YEAST

Accession

Primary (citable) accession number: P40473
Secondary accession number(s): D6VVG5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	May 29, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program