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P40473

- POG1_YEAST

UniProt

P40473 - POG1_YEAST

Protein

Transcriptional activator POG1

Gene

POG1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Transcriptional activator which promotes cell cycle recovery with CLN2, after pheromone induced G1 arrest, probably inhibiting the ability of STE20 to activate the pheromone response pathway. Binds the promoters of genes that function in cell cycle regulation, cytoskeletal organization, and spindle assembly. May also be involved in stress-resistance.3 Publications

    GO - Molecular functioni

    1. core promoter binding Source: SGD
    2. protein binding Source: IntAct

    GO - Biological processi

    1. mitotic nuclear division Source: UniProtKB-KW
    2. re-entry into mitotic cell cycle after pheromone arrest Source: SGD
    3. regulation of transcription from RNA polymerase II promoter Source: SGD
    4. response to stress Source: UniProtKB-KW
    5. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis, Stress response, Transcription, Transcription regulation

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31375-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcriptional activator POG1
    Alternative name(s):
    Promoter of growth protein 1
    Gene namesi
    Name:POG1
    Ordered Locus Names:YIL122W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome IX

    Organism-specific databases

    CYGDiYIL122w.
    SGDiS000001384. POG1.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. nuclear chromatin Source: SGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 351351Transcriptional activator POG1PRO_0000202962Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei152 – 1521Phosphoserine2 Publications
    Modified residuei168 – 1681Phosphoserine2 Publications
    Modified residuei314 – 3141Phosphoserine2 Publications

    Post-translational modificationi

    Phosphorylated by CDC28.3 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP40473.
    PaxDbiP40473.

    Expressioni

    Inductioni

    Expressed periodically during cell division. Regulated by the SBF complex which is one critical regulator of the start of the cell cycle.2 Publications

    Gene expression databases

    GenevestigatoriP40473.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    GTS1P409563EBI-25207,EBI-7968

    Protein-protein interaction databases

    BioGridi34869. 40 interactions.
    DIPiDIP-2755N.
    IntActiP40473. 8 interactions.
    MINTiMINT-472738.
    STRINGi4932.YIL122W.

    Structurei

    3D structure databases

    ProteinModelPortaliP40473.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi193 – 302110Gln-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the POG1 family.Curated

    Phylogenomic databases

    eggNOGiNOG78928.
    OrthoDBiEOG7PZS79.

    Sequencei

    Sequence statusi: Complete.

    P40473-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKQEPHRQSE EKEKPKGPMA VEREQHTSLS SGTTVTASTG DESTNSRPVE    50
    SSQTEKSLSL RIRILKQLGF DDIQELNACD TGLVEQFLNV RLINDTKELE 100
    KIRESNLAKL NQIIDKCMES DKISDSTLNK ILDMSMNRDT NNDNNNHLTI 150
    PSPITTKKRK INASELASPR GHRRYRSDIP TVSEVETGVG YPQIHQQPGA 200
    YTLPMPANQW MSNPYMQPPQ PQVQQIMPQY LYPPGMGPQA QLPTMSSNSE 250
    SQTPVMSSQF LSLNQHGLYQ QNIGAHPVMS MGPQANIYGQ QHQLQPGQER 300
    DQSRKSFSHR RSQSANISMA NFRSPMRNPQ PASSQRPVNF LIHTPKHPPP 350
    T 351
    Length:351
    Mass (Da):39,498
    Last modified:February 1, 1995 - v1
    Checksum:i35EE3E9F93FDCE0C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46833 Genomic DNA. Translation: CAA86870.1.
    BK006942 Genomic DNA. Translation: DAA08431.1.
    PIRiS49887.
    RefSeqiNP_012144.1. NM_001179470.1.

    Genome annotation databases

    EnsemblFungiiYIL122W; YIL122W; YIL122W.
    GeneIDi854684.
    KEGGisce:YIL122W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46833 Genomic DNA. Translation: CAA86870.1 .
    BK006942 Genomic DNA. Translation: DAA08431.1 .
    PIRi S49887.
    RefSeqi NP_012144.1. NM_001179470.1.

    3D structure databases

    ProteinModelPortali P40473.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 34869. 40 interactions.
    DIPi DIP-2755N.
    IntActi P40473. 8 interactions.
    MINTi MINT-472738.
    STRINGi 4932.YIL122W.

    Proteomic databases

    MaxQBi P40473.
    PaxDbi P40473.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YIL122W ; YIL122W ; YIL122W .
    GeneIDi 854684.
    KEGGi sce:YIL122W.

    Organism-specific databases

    CYGDi YIL122w.
    SGDi S000001384. POG1.

    Phylogenomic databases

    eggNOGi NOG78928.
    OrthoDBi EOG7PZS79.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31375-MONOMER.

    Miscellaneous databases

    NextBioi 977298.

    Gene expression databases

    Genevestigatori P40473.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "POG1, a novel yeast gene, promotes recovery from pheromone arrest via the G1 cyclin CLN2."
      Leza M.A., Elion E.A.
      Genetics 151:531-543(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    4. "Complex transcriptional circuitry at the G1/S transition in Saccharomyces cerevisiae."
      Horak C.E., Luscombe N.M., Qian J., Bertone P., Piccirrillo S., Gerstein M., Snyder M.
      Genes Dev. 16:3017-3033(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION.
    5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    7. Cited for: PHOSPHORYLATION BY CDC28.
    8. Cited for: INDUCTION.
    9. "Overexpression of two transcriptional factors, Kin28 and Pog1, suppresses the stress sensitivity caused by the rsp5 mutation in Saccharomyces cerevisiae."
      Demae M., Murata Y., Hisano M., Haitani Y., Shima J., Takagi H.
      FEMS Microbiol. Lett. 277:70-78(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    10. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-152, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-168 AND SER-314, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPOG1_YEAST
    AccessioniPrimary (citable) accession number: P40473
    Secondary accession number(s): D6VVG5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 736 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome IX
      Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

    External Data

    Dasty 3