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Protein

Activator of stress genes 1

Gene

ASG1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable transcription factor involved in the stress response.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi21 – 4727Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Stress response, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-31381-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Activator of stress genes 1
Gene namesi
Name:ASG1
Ordered Locus Names:YIL130W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IX

Organism-specific databases

EuPathDBiFungiDB:YIL130W.
SGDiS000001392. ASG1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

No growth on non-fermentable carbon sources like glycerol and lactate and sensitivity to calcofluor white.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 964964Activator of stress genes 1PRO_0000114997Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei166 – 1661Phosphoserine; by ATM or ATRCombined sources
Modified residuei186 – 1861PhosphoserineCombined sources
Modified residuei963 – 9631PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP40467.
TopDownProteomicsiP40467.

PTM databases

iPTMnetiP40467.

Interactioni

Protein-protein interaction databases

BioGridi34861. 30 interactions.
DIPiDIP-820N.
IntActiP40467. 4 interactions.
MINTiMINT-598320.

Structurei

3D structure databases

ProteinModelPortaliP40467.
SMRiP40467. Positions 19-50.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi832 – 8376Poly-Asn
Compositional biasi840 – 86930Poly-AsnAdd
BLAST
Compositional biasi875 – 88713Poly-AsnAdd
BLAST

Sequence similaritiesi

Belongs to the ASG1 family.Curated
Contains 1 Zn(2)-C6 fungal-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00530000068025.
HOGENOMiHOG000247856.
InParanoidiP40467.
OMAiIRGERHQ.
OrthoDBiEOG7WDN9X.

Family and domain databases

Gene3Di4.10.240.10. 1 hit.
InterProiIPR007219. Transcription_factor_dom_fun.
IPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
PfamiPF04082. Fungal_trans. 1 hit.
PF00172. Zn_clus. 1 hit.
[Graphical view]
SMARTiSM00906. Fungal_trans. 1 hit.
SM00066. GAL4. 1 hit.
[Graphical view]
SUPFAMiSSF57701. SSF57701. 1 hit.
PROSITEiPS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40467-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEQAQQGEQ SVKRRRVTRA CDECRKKKVK CDGQQPCIHC TVYSYECTYK
60 70 80 90 100
KPTKRTQNSG NSGVLTLGNV TTGPSSSTVV AAAASNPNKL LSNIKTERAI
110 120 130 140 150
LPGASTIPAS NNPSKPRKYK TKSTRLQSKI DRYKQIFDEV FPQLPDIDNL
160 170 180 190 200
DIPVFLQIFH NFKRDSQSFL DDTVKEYTLI VNDSSSPIQP VLSSNSKNST
210 220 230 240 250
PDEFLPNMKS DSNSASSNRE QDSVDTYSNI PVGREIKIIL PPKAIALQFV
260 270 280 290 300
KSTWEHCCVL LRFYHRPSFI RQLDELYETD PNNYTSKQMQ FLPLCYAAIA
310 320 330 340 350
VGALFSKSIV SNDSSREKFL QDEGYKYFIA ARKLIDITNA RDLNSIQAIL
360 370 380 390 400
MLIIFLQCSA RLSTCYTYIG VAMRSALRAG FHRKLSPNSG FSPIEIEMRK
410 420 430 440 450
RLFYTIYKLD VYINAMLGLP RSISPDDFDQ TLPLDLSDEN ITEVAYLPEN
460 470 480 490 500
QHSVLSSTGI SNEHTKLFLI LNEIISELYP IKKTSNIISH ETVTSLELKL
510 520 530 540 550
RNWLDSLPKE LIPNAENIDP EYERANRLLH LSFLHVQIIL YRPFIHYLSR
560 570 580 590 600
NMNAENVDPL CYRRARNSIA VARTVIKLAK EMVSNNLLTG SYWYACYTIF
610 620 630 640 650
YSVAGLLFYI HEAQLPDKDS AREYYDILKD AETGRSVLIQ LKDSSMAASR
660 670 680 690 700
TYNLLNQIFE KLNSKTIQLT ALHSSPSNES AFLVTNNSSA LKPHLGDSLQ
710 720 730 740 750
PPVFFSSQDT KNSFSLAKSE ESTNDYAMAN YLNNTPISEN PLNEAQQQDQ
760 770 780 790 800
VSQGTTNMSN ERDPNNFLSI DIRLDNNGQS NILDATDDVF IRNDGDIPTN
810 820 830 840 850
SAFDFSSSKS NASNNSNPDT INNNYNNVSG KNNNNNNITN NSNNNHNNNN
860 870 880 890 900
NDNNNNNNNN NNNNNNNNNS GNSSNNNNNN NNNKNNNDFG IKIDNNSPSY
910 920 930 940 950
EGFPQLQIPL SQDNLNIEDK EEMSPNIEIK NEQNMTDSND ILGVFDQLDA
960
QLFGKYLPLN YPSE
Length:964
Mass (Da):108,781
Last modified:February 1, 1995 - v1
Checksum:iAD5ABE59E4B022CC
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti77 – 771S → N in strain: SK1. 1 Publication
Natural varianti149 – 1491N → S in strain: SK1. 1 Publication
Natural varianti353 – 3531I → F in strain: SK1. 1 Publication
Natural varianti682 – 6821F → S in strain: SK1. 1 Publication
Natural varianti707 – 7071S → F in strain: SK1. 1 Publication
Natural varianti770 – 7701I → T in strain: SK1. 1 Publication
Natural varianti811 – 8111N → S in strain: SK1. 1 Publication
Natural varianti852 – 8521D → NDNNN in strain: SK1.
Natural varianti887 – 8871N → NN in strain: SK1. 1 Publication
Natural varianti926 – 9338Missing in strain: SK1. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ115392 Genomic DNA. Translation: AAZ22497.1.
Z38059 Genomic DNA. Translation: CAA86148.1.
BK006942 Genomic DNA. Translation: DAA08423.1.
PIRiS48404.
RefSeqiNP_012136.1. NM_001179478.1.

Genome annotation databases

EnsemblFungiiYIL130W; YIL130W; YIL130W.
GeneIDi854676.
KEGGisce:YIL130W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ115392 Genomic DNA. Translation: AAZ22497.1.
Z38059 Genomic DNA. Translation: CAA86148.1.
BK006942 Genomic DNA. Translation: DAA08423.1.
PIRiS48404.
RefSeqiNP_012136.1. NM_001179478.1.

3D structure databases

ProteinModelPortaliP40467.
SMRiP40467. Positions 19-50.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34861. 30 interactions.
DIPiDIP-820N.
IntActiP40467. 4 interactions.
MINTiMINT-598320.

PTM databases

iPTMnetiP40467.

Proteomic databases

MaxQBiP40467.
TopDownProteomicsiP40467.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYIL130W; YIL130W; YIL130W.
GeneIDi854676.
KEGGisce:YIL130W.

Organism-specific databases

EuPathDBiFungiDB:YIL130W.
SGDiS000001392. ASG1.

Phylogenomic databases

GeneTreeiENSGT00530000068025.
HOGENOMiHOG000247856.
InParanoidiP40467.
OMAiIRGERHQ.
OrthoDBiEOG7WDN9X.

Enzyme and pathway databases

BioCyciYEAST:G3O-31381-MONOMER.

Miscellaneous databases

PROiP40467.

Family and domain databases

Gene3Di4.10.240.10. 1 hit.
InterProiIPR007219. Transcription_factor_dom_fun.
IPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
PfamiPF04082. Fungal_trans. 1 hit.
PF00172. Zn_clus. 1 hit.
[Graphical view]
SMARTiSM00906. Fungal_trans. 1 hit.
SM00066. GAL4. 1 hit.
[Graphical view]
SUPFAMiSSF57701. SSF57701. 1 hit.
PROSITEiPS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Quantitative trait loci mapped to single-nucleotide resolution in yeast."
    Deutschbauer A.M., Davis R.W.
    Nat. Genet. 37:1333-1340(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ASN-77; SER-149; PHE-353; SER-682; PHE-707; THR-770; SER-811; ASN-ASP-ASN-ASN-ASN-852 INS; ASN-887 INS AND 926-ASN--GLN-933 DEL.
    Strain: SK1.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Phenotypic analysis of genes encoding yeast zinc cluster proteins."
    Akache B., Wu K., Turcotte B.
    Nucleic Acids Res. 29:2181-2190(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE, FUNCTION.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-963, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  8. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-166 AND SER-963, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-186 AND SER-963, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiASG1_YEAST
AccessioniPrimary (citable) accession number: P40467
Secondary accession number(s): D6VVF7, Q45U13
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: July 6, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 396 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.