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Protein

Activator of stress genes 1

Gene

ASG1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable transcription factor involved in the stress response.1 Publication

Miscellaneous

Present with 396 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi21 – 47Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd BLAST27

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processStress response, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-31381-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Activator of stress genes 1
Gene namesi
Name:ASG1
Ordered Locus Names:YIL130W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IX

Organism-specific databases

EuPathDBiFungiDB:YIL130W
SGDiS000001392 ASG1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

No growth on non-fermentable carbon sources like glycerol and lactate and sensitivity to calcofluor white.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001149971 – 964Activator of stress genes 1Add BLAST964

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei166Phosphoserine; by ATM or ATRCombined sources1
Modified residuei186PhosphoserineCombined sources1
Modified residuei963PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP40467
PaxDbiP40467
PRIDEiP40467
TopDownProteomicsiP40467

PTM databases

iPTMnetiP40467

Interactioni

Protein-protein interaction databases

BioGridi34861, 65 interactors
DIPiDIP-820N
IntActiP40467, 4 interactors
MINTiP40467
STRINGi4932.YIL130W

Structurei

3D structure databases

ProteinModelPortaliP40467
SMRiP40467
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi832 – 837Poly-Asn6
Compositional biasi840 – 869Poly-AsnAdd BLAST30
Compositional biasi875 – 887Poly-AsnAdd BLAST13

Sequence similaritiesi

Belongs to the ASG1 family.Curated

Phylogenomic databases

GeneTreeiENSGT00530000068025
HOGENOMiHOG000247856
InParanoidiP40467
OMAiPFAYPNQ
OrthoDBiEOG092C12SH

Family and domain databases

CDDicd00067 GAL4, 1 hit
Gene3Di4.10.240.10, 1 hit
InterProiView protein in InterPro
IPR007219 Transcription_factor_dom_fun
IPR001138 Zn2-C6_fun-type_DNA-bd
IPR036864 Zn2-C6_fun-type_DNA-bd_sf
PfamiView protein in Pfam
PF04082 Fungal_trans, 1 hit
PF00172 Zn_clus, 1 hit
SMARTiView protein in SMART
SM00906 Fungal_trans, 1 hit
SM00066 GAL4, 1 hit
SUPFAMiSSF57701 SSF57701, 1 hit
PROSITEiView protein in PROSITE
PS00463 ZN2_CY6_FUNGAL_1, 1 hit
PS50048 ZN2_CY6_FUNGAL_2, 1 hit

Sequencei

Sequence statusi: Complete.

P40467-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEQAQQGEQ SVKRRRVTRA CDECRKKKVK CDGQQPCIHC TVYSYECTYK
60 70 80 90 100
KPTKRTQNSG NSGVLTLGNV TTGPSSSTVV AAAASNPNKL LSNIKTERAI
110 120 130 140 150
LPGASTIPAS NNPSKPRKYK TKSTRLQSKI DRYKQIFDEV FPQLPDIDNL
160 170 180 190 200
DIPVFLQIFH NFKRDSQSFL DDTVKEYTLI VNDSSSPIQP VLSSNSKNST
210 220 230 240 250
PDEFLPNMKS DSNSASSNRE QDSVDTYSNI PVGREIKIIL PPKAIALQFV
260 270 280 290 300
KSTWEHCCVL LRFYHRPSFI RQLDELYETD PNNYTSKQMQ FLPLCYAAIA
310 320 330 340 350
VGALFSKSIV SNDSSREKFL QDEGYKYFIA ARKLIDITNA RDLNSIQAIL
360 370 380 390 400
MLIIFLQCSA RLSTCYTYIG VAMRSALRAG FHRKLSPNSG FSPIEIEMRK
410 420 430 440 450
RLFYTIYKLD VYINAMLGLP RSISPDDFDQ TLPLDLSDEN ITEVAYLPEN
460 470 480 490 500
QHSVLSSTGI SNEHTKLFLI LNEIISELYP IKKTSNIISH ETVTSLELKL
510 520 530 540 550
RNWLDSLPKE LIPNAENIDP EYERANRLLH LSFLHVQIIL YRPFIHYLSR
560 570 580 590 600
NMNAENVDPL CYRRARNSIA VARTVIKLAK EMVSNNLLTG SYWYACYTIF
610 620 630 640 650
YSVAGLLFYI HEAQLPDKDS AREYYDILKD AETGRSVLIQ LKDSSMAASR
660 670 680 690 700
TYNLLNQIFE KLNSKTIQLT ALHSSPSNES AFLVTNNSSA LKPHLGDSLQ
710 720 730 740 750
PPVFFSSQDT KNSFSLAKSE ESTNDYAMAN YLNNTPISEN PLNEAQQQDQ
760 770 780 790 800
VSQGTTNMSN ERDPNNFLSI DIRLDNNGQS NILDATDDVF IRNDGDIPTN
810 820 830 840 850
SAFDFSSSKS NASNNSNPDT INNNYNNVSG KNNNNNNITN NSNNNHNNNN
860 870 880 890 900
NDNNNNNNNN NNNNNNNNNS GNSSNNNNNN NNNKNNNDFG IKIDNNSPSY
910 920 930 940 950
EGFPQLQIPL SQDNLNIEDK EEMSPNIEIK NEQNMTDSND ILGVFDQLDA
960
QLFGKYLPLN YPSE
Length:964
Mass (Da):108,781
Last modified:February 1, 1995 - v1
Checksum:iAD5ABE59E4B022CC
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti77S → N in strain: SK1. 1 Publication1
Natural varianti149N → S in strain: SK1. 1 Publication1
Natural varianti353I → F in strain: SK1. 1 Publication1
Natural varianti682F → S in strain: SK1. 1 Publication1
Natural varianti707S → F in strain: SK1. 1 Publication1
Natural varianti770I → T in strain: SK1. 1 Publication1
Natural varianti811N → S in strain: SK1. 1 Publication1
Natural varianti852D → NDNNN in strain: SK1. 1
Natural varianti887N → NN in strain: SK1. 1 Publication1
Natural varianti926 – 933Missing in strain: SK1. 1 Publication8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ115392 Genomic DNA Translation: AAZ22497.1
Z38059 Genomic DNA Translation: CAA86148.1
BK006942 Genomic DNA Translation: DAA08423.1
PIRiS48404
RefSeqiNP_012136.1, NM_001179478.1

Genome annotation databases

EnsemblFungiiYIL130W; YIL130W; YIL130W
GeneIDi854676
KEGGisce:YIL130W

Similar proteinsi

Entry informationi

Entry nameiASG1_YEAST
AccessioniPrimary (citable) accession number: P40467
Secondary accession number(s): D6VVF7, Q45U13
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 20, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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