Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Fork head protein homolog 1

Gene

FKH1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Present with 1720 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi302 – 393Fork-headPROSITE-ProRule annotationAdd BLAST92

GO - Molecular functioni

  • centromeric DNA binding Source: SGD
  • chromatin binding Source: SGD
  • DNA replication origin binding Source: SGD
  • RNA polymerase II proximal promoter sequence-specific DNA binding Source: SGD
  • sequence-specific DNA binding Source: SGD
  • transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: SGD
  • transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: SGD

GO - Biological processi

  • anatomical structure morphogenesis Source: GO_Central
  • cellular response to methylmercury Source: SGD
  • chromatin remodeling Source: SGD
  • donor selection Source: SGD
  • mRNA 3'-end processing Source: SGD
  • negative regulation of pseudohyphal growth Source: SGD
  • negative regulation of transcription elongation from RNA polymerase II promoter Source: SGD
  • negative regulation of transcription involved in G1/S transition of mitotic cell cycle Source: SGD
  • negative regulation of transcription involved in G2/M transition of mitotic cell cycle Source: SGD
  • positive regulation of chromatin silencing at silent mating-type cassette Source: SGD
  • positive regulation of DNA-dependent DNA replication initiation Source: SGD
  • positive regulation of DNA replication initiation Source: SGD
  • positive regulation of transcription involved in G2/M transition of mitotic cell cycle Source: SGD
  • termination of RNA polymerase II transcription Source: SGD

Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31382-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Fork head protein homolog 1
Gene namesi
Name:FKH1
Ordered Locus Names:YIL131C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IX

Organism-specific databases

EuPathDBiFungiDB:YIL131C
SGDiS000001393 FKH1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000919031 – 484Fork head protein homolog 1Add BLAST484

Proteomic databases

MaxQBiP40466
PaxDbiP40466
PRIDEiP40466

Interactioni

Protein-protein interaction databases

BioGridi34860127 interactors.
DIPiDIP-5220N
IntActiP40466 37 interactors.
STRINGi4932.YIL131C

Structurei

3D structure databases

ProteinModelPortaliP40466
SMRiP40466
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini76 – 142FHAPROSITE-ProRule annotationAdd BLAST67

Phylogenomic databases

GeneTreeiENSGT00910000144055
InParanoidiP40466
OMAiMFILPDA
OrthoDBiEOG092C0D3W

Family and domain databases

CDDicd00059 FH, 1 hit
cd00060 FHA, 1 hit
Gene3Di1.10.10.101 hit
InterProiView protein in InterPro
IPR000253 FHA_dom
IPR001766 Fork_head_dom
IPR008984 SMAD_FHA_dom_sf
IPR018122 TF_fork_head_CS_1
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00498 FHA, 1 hit
PF00250 Forkhead, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SM00240 FHA, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF49879 SSF49879, 1 hit
PROSITEiView protein in PROSITE
PS50006 FHA_DOMAIN, 1 hit
PS00657 FORK_HEAD_1, 1 hit
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit

Sequencei

Sequence statusi: Complete.

P40466-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVTSREQKF SGKYSSYTAQ DRQGLVNAVT CVLSSSSDPV AVSSDYSNSL
60 70 80 90 100
SIAREVNAYA KIAGCDWTYY VQKLEVTIGR NTDSLNLNAV PGTVVKKNID
110 120 130 140 150
IDLGPAKIVS RKHAAIRFNL ESGSWELQIF GRNGAKVNFR RIPTGPDSPP
160 170 180 190 200
TVLQSGCIID IGGVQMIFIL PEQETIISDY CLNHLMPKLL STYGTNGNNN
210 220 230 240 250
PLLRNIIEGS TYLREQRLQE EARLQQLDHL HTPLSSSSDV NPIGDPHGDT
260 270 280 290 300
IMMEEDEEDE NYTRGGIRPN TYTSSSNNAV TNGNVPHIEN PSDLSLDENR
310 320 330 340 350
YIKPPQSYAS MITQAILSTP EGSISLADIY KFISDNYAFY RFSQMAWQNS
360 370 380 390 400
VRHNLSLNKA FEKVPKRAGQ QGKGMNWKIS DEVRRDFLNK WNAGKLSKIR
410 420 430 440 450
RGASVTRQLQ LHMSKFGEIP APESSSIDPR GIKAQKVKKS LQATSSILGE
460 470 480
SAPQLQRTQL TGQISTTTSM DVTTNANVNN SSLS
Length:484
Mass (Da):53,490
Last modified:February 1, 1995 - v1
Checksum:i7159073EB979C489
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38848 Genomic DNA Translation: AAA60938.1
DQ115392 Genomic DNA Translation: AAZ22496.1
Z38059 Genomic DNA Translation: CAA86147.1
BK006942 Genomic DNA Translation: DAA08422.1
PIRiS48403
RefSeqiNP_012135.1, NM_001179479.1

Genome annotation databases

EnsemblFungiiYIL131C; YIL131C; YIL131C
GeneIDi854675
KEGGisce:YIL131C

Similar proteinsi

Entry informationi

Entry nameiFKH1_YEAST
AccessioniPrimary (citable) accession number: P40466
Secondary accession number(s): D6VVF6, Q45U14
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: March 28, 2018
This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome