P40466 (FKH1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fork head protein homolog 1

Gene names

Name:	FKH1
Ordered Locus Names:	YIL131C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	484 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Nucleus Potential.
Miscellaneous	Present with 1720 molecules/cell in log phase SD medium. Ref.5
Sequence similarities	Contains 1 FHA domain. Contains 1 fork-head DNA-binding domain.

Ontologies

Keywords
Cellular component	Nucleus
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cellular response to methylmercury Inferred from mutant phenotype. Source: SGD chromatin remodeling Inferred from mutant phenotype. Source: SGD chromatin silencing at silent mating-type cassette Inferred from mutant phenotype. Source: SGD donor selection Inferred from mutant phenotype. Source: SGD mRNA 3'-end processing Inferred from mutant phenotype. Source: SGD mitochondrion organization Inferred from Biological aspect of Ancestor. Source: RefGenome negative regulation of cell cycle Inferred from mutant phenotype. Source: SGD negative regulation of transcription elongation from RNA polymerase II promoter Inferred from mutant phenotype. Source: SGD positive regulation of cell cycle Inferred from genetic interaction. Source: SGD positive regulation of transcription involved in G2/M-phase of mitotic cell cycle Inferred from genetic interaction. Source: SGD pseudohyphal growth Inferred from genetic interaction. Source: SGD regulation of sequence-specific DNA binding transcription factor activity Inferred from Biological aspect of Ancestor. Source: RefGenome termination of RNA polymerase II transcription Inferred from mutant phenotype. Source: SGD
Cellular component	nuclear chromatin Inferred from Biological aspect of Ancestor. Source: RefGenome transcription factor complex Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular function	centromeric DNA binding Inferred from direct assay. Source: SGD double-stranded DNA binding Inferred from Biological aspect of Ancestor. Source: RefGenome sequence-specific distal enhancer binding RNA polymerase II transcription factor activity Inferred from Biological aspect of Ancestor. Source: RefGenome transcription factor binding Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 484	484	Fork head protein homolog 1		PRO_0000091903
Regions
	Domain	76 – 142	67	FHA
	DNA binding	302 – 393	92	Fork-head

Sequences

	Sequence		Length	Mass (Da)
	P40466 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: 7159073EB979C489	FASTA	484	53,490
	10 20 30 40 50 60 MSVTSREQKF SGKYSSYTAQ DRQGLVNAVT CVLSSSSDPV AVSSDYSNSL SIAREVNAYA 70 80 90 100 110 120 KIAGCDWTYY VQKLEVTIGR NTDSLNLNAV PGTVVKKNID IDLGPAKIVS RKHAAIRFNL 130 140 150 160 170 180 ESGSWELQIF GRNGAKVNFR RIPTGPDSPP TVLQSGCIID IGGVQMIFIL PEQETIISDY 190 200 210 220 230 240 CLNHLMPKLL STYGTNGNNN PLLRNIIEGS TYLREQRLQE EARLQQLDHL HTPLSSSSDV 250 260 270 280 290 300 NPIGDPHGDT IMMEEDEEDE NYTRGGIRPN TYTSSSNNAV TNGNVPHIEN PSDLSLDENR 310 320 330 340 350 360 YIKPPQSYAS MITQAILSTP EGSISLADIY KFISDNYAFY RFSQMAWQNS VRHNLSLNKA 370 380 390 400 410 420 FEKVPKRAGQ QGKGMNWKIS DEVRRDFLNK WNAGKLSKIR RGASVTRQLQ LHMSKFGEIP 430 440 450 460 470 480 APESSSIDPR GIKAQKVKKS LQATSSILGE SAPQLQRTQL TGQISTTTSM DVTTNANVNN SSLS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Two fork head homologs in S. cerevisiae." Zhu G., Davis T.N. Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[2]	"Quantitative trait loci mapped to single-nucleotide resolution in yeast." Deutschbauer A.M., Davis R.W. Nat. Genet. 37:1333-1340(2005) [PubMed: 16273108] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: SK1.
[3]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome IX." Churcher C.M., Bowman S., Badcock K., Bankier A.T., Brown D., Chillingworth T., Connor R., Devlin K., Gentles S., Hamlin N., Harris D.E., Horsnell T., Hunt S., Jagels K., Jones M., Lye G., Moule S., Odell C. , Pearson D., Rajandream M.A., Rice P., Rowley N., Skelton J., Smith V., Walsh S.V., Whitehead S., Barrell B.G. Nature 387:84-87(1997) [PubMed: 9169870] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[4]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[5]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L38848 Genomic DNA. Translation: AAA60938.1. DQ115392 Genomic DNA. Translation: AAZ22496.1. Z38059 Genomic DNA. Translation: CAA86147.1. BK006942 Genomic DNA. Translation: DAA08422.1.
PIR	S48403.
RefSeq	NP_012135.1. NM_001179479.1.
3D structure databases
ProteinModelPortal	P40466.
SMR	P40466. Positions 75-172, 302-393.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-5220N.
IntAct	P40466. 27 interactions.
MINT	MINT-528267.
STRING	P40466.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YIL131C; YIL131C; YIL131C.
GeneID	854675.
KEGG	sce:YIL131C.
NMPDR	fig|4932.3.peg.1659.
Organism-specific databases
CYGD	YIL131c.
SGD	S000001393. FKH1.
Phylogenomic databases
eggNOG	fuNOG04906.
GeneTree	EFGT00050000000171.
OMA	TIMMEED.
OrthoDB	EOG4R7ZKG.
Gene expression databases
ArrayExpress	P40466.
Genevestigator	P40466.
GermOnline	YIL131C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR000253. FHA_dom. IPR008984. SMAD_FHA_domain. IPR001766. TF_fork_head. IPR018122. TF_fork_head_CS. IPR011991. WHTH_trsnscrt_rep_DNA-bd. [Graphical view]
Gene3D	G3DSA:2.60.200.20. FHA. 1 hit. G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit.
Pfam	PF00498. FHA. 1 hit. PF00250. Fork_head. 1 hit. [Graphical view]
PRINTS	PR00053. FORKHEAD.
SMART	SM00339. FH. 1 hit. SM00240. FHA. 1 hit. [Graphical view]
SUPFAM	SSF49879. SMAD_FHA. 1 hit.
PROSITE	PS50006. FHA_DOMAIN. 1 hit. PS00657. FORK_HEAD_1. 1 hit. PS00658. FORK_HEAD_2. 1 hit. PS50039. FORK_HEAD_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	977271.

Entry information

Entry name

FKH1_YEAST

Accession

Primary (citable) accession number: P40466
Secondary accession number(s): D6VVF6, Q45U14

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	January 25, 2012
This is version 104 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program