Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Fork head protein homolog 1

Gene

FKH1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi302 – 39392Fork-headPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • centromeric DNA binding Source: SGD
  • chromatin binding Source: SGD
  • DNA replication origin binding Source: SGD
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: SGD
  • sequence-specific DNA binding Source: SGD
  • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding Source: SGD
  • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding Source: SGD

GO - Biological processi

  • cellular response to methylmercury Source: SGD
  • chromatin remodeling Source: SGD
  • donor selection Source: SGD
  • mRNA 3'-end processing Source: SGD
  • negative regulation of pseudohyphal growth Source: SGD
  • negative regulation of transcription elongation from RNA polymerase II promoter Source: SGD
  • negative regulation of transcription involved in G1/S transition of mitotic cell cycle Source: SGD
  • negative regulation of transcription involved in G2/M transition of mitotic cell cycle Source: SGD
  • positive regulation of chromatin silencing at silent mating-type cassette Source: SGD
  • positive regulation of DNA-dependent DNA replication initiation Source: SGD
  • positive regulation of DNA replication initiation Source: SGD
  • positive regulation of transcription involved in G2/M transition of mitotic cell cycle Source: SGD
  • termination of RNA polymerase II transcription Source: SGD
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31382-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Fork head protein homolog 1
Gene namesi
Name:FKH1
Ordered Locus Names:YIL131C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IX

Organism-specific databases

EuPathDBiFungiDB:YIL131C.
SGDiS000001393. FKH1.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • cytosol Source: SGD
  • nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 484484Fork head protein homolog 1PRO_0000091903Add
BLAST

Proteomic databases

MaxQBiP40466.

Interactioni

Protein-protein interaction databases

BioGridi34860. 97 interactions.
DIPiDIP-5220N.
IntActiP40466. 2 interactions.
MINTiMINT-528267.

Structurei

3D structure databases

ProteinModelPortaliP40466.
SMRiP40466. Positions 303-379.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini76 – 14267FHAPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 FHA domain.PROSITE-ProRule annotation
Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00800000124014.
InParanoidiP40466.
OMAiTIMMEED.
OrthoDBiEOG092C0D3W.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.60.200.20. 1 hit.
InterProiIPR000253. FHA_dom.
IPR001766. Fork_head_dom.
IPR008984. SMAD_FHA_domain.
IPR018122. TF_fork_head_CS_1.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00498. FHA. 1 hit.
PF00250. Forkhead. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
SM00240. FHA. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF49879. SSF49879. 1 hit.
PROSITEiPS50006. FHA_DOMAIN. 1 hit.
PS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40466-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVTSREQKF SGKYSSYTAQ DRQGLVNAVT CVLSSSSDPV AVSSDYSNSL
60 70 80 90 100
SIAREVNAYA KIAGCDWTYY VQKLEVTIGR NTDSLNLNAV PGTVVKKNID
110 120 130 140 150
IDLGPAKIVS RKHAAIRFNL ESGSWELQIF GRNGAKVNFR RIPTGPDSPP
160 170 180 190 200
TVLQSGCIID IGGVQMIFIL PEQETIISDY CLNHLMPKLL STYGTNGNNN
210 220 230 240 250
PLLRNIIEGS TYLREQRLQE EARLQQLDHL HTPLSSSSDV NPIGDPHGDT
260 270 280 290 300
IMMEEDEEDE NYTRGGIRPN TYTSSSNNAV TNGNVPHIEN PSDLSLDENR
310 320 330 340 350
YIKPPQSYAS MITQAILSTP EGSISLADIY KFISDNYAFY RFSQMAWQNS
360 370 380 390 400
VRHNLSLNKA FEKVPKRAGQ QGKGMNWKIS DEVRRDFLNK WNAGKLSKIR
410 420 430 440 450
RGASVTRQLQ LHMSKFGEIP APESSSIDPR GIKAQKVKKS LQATSSILGE
460 470 480
SAPQLQRTQL TGQISTTTSM DVTTNANVNN SSLS
Length:484
Mass (Da):53,490
Last modified:February 1, 1995 - v1
Checksum:i7159073EB979C489
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38848 Genomic DNA. Translation: AAA60938.1.
DQ115392 Genomic DNA. Translation: AAZ22496.1.
Z38059 Genomic DNA. Translation: CAA86147.1.
BK006942 Genomic DNA. Translation: DAA08422.1.
PIRiS48403.
RefSeqiNP_012135.1. NM_001179479.1.

Genome annotation databases

EnsemblFungiiYIL131C; YIL131C; YIL131C.
GeneIDi854675.
KEGGisce:YIL131C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38848 Genomic DNA. Translation: AAA60938.1.
DQ115392 Genomic DNA. Translation: AAZ22496.1.
Z38059 Genomic DNA. Translation: CAA86147.1.
BK006942 Genomic DNA. Translation: DAA08422.1.
PIRiS48403.
RefSeqiNP_012135.1. NM_001179479.1.

3D structure databases

ProteinModelPortaliP40466.
SMRiP40466. Positions 303-379.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34860. 97 interactions.
DIPiDIP-5220N.
IntActiP40466. 2 interactions.
MINTiMINT-528267.

Proteomic databases

MaxQBiP40466.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYIL131C; YIL131C; YIL131C.
GeneIDi854675.
KEGGisce:YIL131C.

Organism-specific databases

EuPathDBiFungiDB:YIL131C.
SGDiS000001393. FKH1.

Phylogenomic databases

GeneTreeiENSGT00800000124014.
InParanoidiP40466.
OMAiTIMMEED.
OrthoDBiEOG092C0D3W.

Enzyme and pathway databases

BioCyciYEAST:G3O-31382-MONOMER.

Miscellaneous databases

PROiP40466.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.60.200.20. 1 hit.
InterProiIPR000253. FHA_dom.
IPR001766. Fork_head_dom.
IPR008984. SMAD_FHA_domain.
IPR018122. TF_fork_head_CS_1.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00498. FHA. 1 hit.
PF00250. Forkhead. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
SM00240. FHA. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF49879. SSF49879. 1 hit.
PROSITEiPS50006. FHA_DOMAIN. 1 hit.
PS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFKH1_YEAST
AccessioniPrimary (citable) accession number: P40466
Secondary accession number(s): D6VVF6, Q45U14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 7, 2016
This is version 148 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1720 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.