Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mitochondrial FAD carrier protein FLX1

Gene

FLX1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Transport of FAD from the cytosol to the mitochondrial matrix.

GO - Molecular functioni

  • FAD transmembrane transporter activity Source: SGD

GO - Biological processi

  • FAD transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31385-MONOMER.

Protein family/group databases

TCDBi2.A.29.10.1. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial FAD carrier protein FLX1
Gene namesi
Name:FLX1
Ordered Locus Names:YIL134W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IX

Organism-specific databases

EuPathDBiFungiDB:YIL134W.
SGDiS000001396. FLX1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei13 – 33Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei77 – 97Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei129 – 149Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei183 – 203Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei230 – 250Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei266 – 286Helical; Name=6Sequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: UniProtKB-SubCell
  • mitochondrion Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906821 – 311Mitochondrial FAD carrier protein FLX1Add BLAST311

Proteomic databases

PRIDEiP40464.

Interactioni

Protein-protein interaction databases

BioGridi34857. 77 interactors.
DIPiDIP-5662N.
IntActiP40464. 2 interactors.
MINTiMINT-555706.

Structurei

3D structure databases

ProteinModelPortaliP40464.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati7 – 101Solcar 1Add BLAST95
Repeati123 – 210Solcar 2Add BLAST88
Repeati224 – 310Solcar 3Add BLAST87

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00860000134541.
HOGENOMiHOG000188210.
InParanoidiP40464.
KOiK15115.
OMAiYFLCYGK.
OrthoDBiEOG092C43EV.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40464-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDHQWTPLQ KEVISGLSAG SVTTLVVHPL DLLKVRLQLS ATSAQKAHYG
60 70 80 90 100
PFMVIKEIIR SSANSGRSVT NELYRGLSIN LFGNAIAWGV YFGLYGVTKE
110 120 130 140 150
LIYKSVAKPG ETQLKGVGND HKMNSLIYLS AGASSGLMTA ILTNPIWVIK
160 170 180 190 200
TRIMSTSKGA QGAYTSMYNG VQQLLRTDGF QGLWKGLVPA LFGVSQGALY
210 220 230 240 250
FAVYDTLKQR KLRRKRENGL DIHLTNLETI EITSLGKMVS VTLVYPFQLL
260 270 280 290 300
KSNLQSFRAN EQKFRLFPLI KLIIANDGFV GLYKGLSANL VRAIPSTCIT
310
FCVYENLKHR L
Length:311
Mass (Da):34,409
Last modified:February 1, 1995 - v1
Checksum:i9309FFD0E3BCBEE2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38059 Genomic DNA. Translation: CAA86144.1.
L41168 Genomic DNA. Translation: AAA64973.1.
AY692757 Genomic DNA. Translation: AAT92776.1.
BK006942 Genomic DNA. Translation: DAA08419.1.
PIRiS48400.
RefSeqiNP_012132.3. NM_001179482.3.

Genome annotation databases

EnsemblFungiiYIL134W; YIL134W; YIL134W.
GeneIDi854672.
KEGGisce:YIL134W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38059 Genomic DNA. Translation: CAA86144.1.
L41168 Genomic DNA. Translation: AAA64973.1.
AY692757 Genomic DNA. Translation: AAT92776.1.
BK006942 Genomic DNA. Translation: DAA08419.1.
PIRiS48400.
RefSeqiNP_012132.3. NM_001179482.3.

3D structure databases

ProteinModelPortaliP40464.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34857. 77 interactors.
DIPiDIP-5662N.
IntActiP40464. 2 interactors.
MINTiMINT-555706.

Protein family/group databases

TCDBi2.A.29.10.1. the mitochondrial carrier (mc) family.

Proteomic databases

PRIDEiP40464.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYIL134W; YIL134W; YIL134W.
GeneIDi854672.
KEGGisce:YIL134W.

Organism-specific databases

EuPathDBiFungiDB:YIL134W.
SGDiS000001396. FLX1.

Phylogenomic databases

GeneTreeiENSGT00860000134541.
HOGENOMiHOG000188210.
InParanoidiP40464.
KOiK15115.
OMAiYFLCYGK.
OrthoDBiEOG092C43EV.

Enzyme and pathway databases

BioCyciYEAST:G3O-31385-MONOMER.

Miscellaneous databases

PROiP40464.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFLX1_YEAST
AccessioniPrimary (citable) accession number: P40464
Secondary accession number(s): D6VVF3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 30, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.