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P40459

- PANC_YEAST

UniProt

P40459 - PANC_YEAST

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Protein

Pantoate--beta-alanine ligase

Gene

PAN6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Required for pantothenic acid biosynthesis.1 Publication

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. pantoate-beta-alanine ligase activity Source: SGD

GO - Biological processi

  1. pantothenate biosynthetic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:YIL145C-MONOMER.
YEAST:YIL145C-MONOMER.
UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantoate--beta-alanine ligase (EC:6.3.2.1)
Alternative name(s):
Pantoate-activating enzyme
Pantothenate synthetase
Gene namesi
Name:PAN6
Ordered Locus Names:YIL145C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IX

Organism-specific databases

CYGDiYIL145c.
SGDiS000001407. PAN6.

Subcellular locationi

Cytoplasm 1 Publication. Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Pantoate--beta-alanine ligasePRO_0000128298Add
BLAST

Proteomic databases

MaxQBiP40459.
PaxDbiP40459.
PeptideAtlasiP40459.

Expressioni

Gene expression databases

GenevestigatoriP40459.

Interactioni

Protein-protein interaction databases

BioGridi34847. 19 interactions.
DIPiDIP-4613N.
IntActiP40459. 2 interactions.
MINTiMINT-560279.
STRINGi4932.YIL145C.

Structurei

3D structure databases

ProteinModelPortaliP40459.
SMRiP40459. Positions 1-309.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pantothenate synthetase family.Curated

Phylogenomic databases

eggNOGiCOG0414.
HOGENOMiHOG000175516.
InParanoidiP40459.
KOiK01918.
OMAiRTWDSDV.
OrthoDBiEOG7V1G1D.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
InterProiIPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

P40459-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKIFHTVEEV VQWRTQELRE TRFRETIGFV PTMGCLHSGH ASLISQSVKE
60 70 80 90 100
NTYTVVSIFV NPSQFAPTED LDNYPRTLPD DIKLLESLKV DVLFAPNAHV
110 120 130 140 150
MYPQGIPLDI EEQKGPFVSV LGLSEKLEGK TRPNFFRGVA TVVTKLFNIV
160 170 180 190 200
MADVAYFGQK DIQQFIVLQC MVDELFVNTR LQMMPIVRNN NGLALSSRNK
210 220 230 240 250
YLCPESLKIS ENLYRGLKAA ENAIRRLAPG GRLSRSEIID TVTQIWAPYV
260 270 280 290 300
DSHDFKIDYV SLADFKTLDE LSDVENTSEQ QPIVISCAVY VTDREKPDTV

VRLIDNIVI
Length:309
Mass (Da):35,032
Last modified:December 20, 2005 - v2
Checksum:i9787B366795B5D81
GO

Sequence cautioni

The sequence CAA86133.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z38059 Genomic DNA. Translation: CAA86133.1. Different initiation.
BK006942 Genomic DNA. Translation: DAA08408.1.
PIRiS48389.
RefSeqiNP_012121.2. NM_001179493.1.

Genome annotation databases

EnsemblFungiiYIL145C; YIL145C; YIL145C.
GeneIDi854661.
KEGGisce:YIL145C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z38059 Genomic DNA. Translation: CAA86133.1 . Different initiation.
BK006942 Genomic DNA. Translation: DAA08408.1 .
PIRi S48389.
RefSeqi NP_012121.2. NM_001179493.1.

3D structure databases

ProteinModelPortali P40459.
SMRi P40459. Positions 1-309.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 34847. 19 interactions.
DIPi DIP-4613N.
IntActi P40459. 2 interactions.
MINTi MINT-560279.
STRINGi 4932.YIL145C.

Proteomic databases

MaxQBi P40459.
PaxDbi P40459.
PeptideAtlasi P40459.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YIL145C ; YIL145C ; YIL145C .
GeneIDi 854661.
KEGGi sce:YIL145C.

Organism-specific databases

CYGDi YIL145c.
SGDi S000001407. PAN6.

Phylogenomic databases

eggNOGi COG0414.
HOGENOMi HOG000175516.
InParanoidi P40459.
KOi K01918.
OMAi RTWDSDV.
OrthoDBi EOG7V1G1D.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00005 .
BioCyci MetaCyc:YIL145C-MONOMER.
YEAST:YIL145C-MONOMER.

Miscellaneous databases

NextBioi 977232.

Gene expression databases

Genevestigatori P40459.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00158. PanC.
InterProi IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR21299:SF1. PTHR21299:SF1. 1 hit.
Pfami PF02569. Pantoate_ligase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00018. panC. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Saccharomyces cerevisiae is capable of de novo pantothenic acid biosynthesis involving a novel pathway of beta-alanine production from spermine."
    White W.H., Gunyuzlu P.L., Toyn J.H.
    J. Biol. Chem. 276:10794-10800(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "Sequencing and comparison of yeast species to identify genes and regulatory elements."
    Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S.
    Nature 423:241-254(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION OF PROBABLE INITIATION SITE.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPANC_YEAST
AccessioniPrimary (citable) accession number: P40459
Secondary accession number(s): D6VVE2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: December 20, 2005
Last modified: October 29, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2400 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

External Data

Dasty 3