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P40459

- PANC_YEAST

UniProt

P40459 - PANC_YEAST

Protein

Pantoate--beta-alanine ligase

Gene

PAN6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 2 (20 Dec 2005)
      Previous versions | rss
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    Functioni

    Required for pantothenic acid biosynthesis.1 Publication

    Catalytic activityi

    ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. pantoate-beta-alanine ligase activity Source: SGD

    GO - Biological processi

    1. pantothenate biosynthetic process Source: SGD

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Pantothenate biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMetaCyc:YIL145C-MONOMER.
    YEAST:YIL145C-MONOMER.
    UniPathwayiUPA00028; UER00005.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pantoate--beta-alanine ligase (EC:6.3.2.1)
    Alternative name(s):
    Pantoate-activating enzyme
    Pantothenate synthetase
    Gene namesi
    Name:PAN6
    Ordered Locus Names:YIL145C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome IX

    Organism-specific databases

    CYGDiYIL145c.
    SGDiS000001407. PAN6.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 309309Pantoate--beta-alanine ligasePRO_0000128298Add
    BLAST

    Proteomic databases

    MaxQBiP40459.
    PaxDbiP40459.
    PeptideAtlasiP40459.

    Expressioni

    Gene expression databases

    GenevestigatoriP40459.

    Interactioni

    Protein-protein interaction databases

    BioGridi34847. 18 interactions.
    DIPiDIP-4613N.
    IntActiP40459. 2 interactions.
    MINTiMINT-560279.
    STRINGi4932.YIL145C.

    Structurei

    3D structure databases

    ProteinModelPortaliP40459.
    SMRiP40459. Positions 1-309.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the pantothenate synthetase family.Curated

    Phylogenomic databases

    eggNOGiCOG0414.
    HOGENOMiHOG000175516.
    KOiK01918.
    OMAiRTWDSDV.
    OrthoDBiEOG7V1G1D.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_00158. PanC.
    InterProiIPR003721. Pantoate_ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
    PfamiPF02569. Pantoate_ligase. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00018. panC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P40459-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKIFHTVEEV VQWRTQELRE TRFRETIGFV PTMGCLHSGH ASLISQSVKE    50
    NTYTVVSIFV NPSQFAPTED LDNYPRTLPD DIKLLESLKV DVLFAPNAHV 100
    MYPQGIPLDI EEQKGPFVSV LGLSEKLEGK TRPNFFRGVA TVVTKLFNIV 150
    MADVAYFGQK DIQQFIVLQC MVDELFVNTR LQMMPIVRNN NGLALSSRNK 200
    YLCPESLKIS ENLYRGLKAA ENAIRRLAPG GRLSRSEIID TVTQIWAPYV 250
    DSHDFKIDYV SLADFKTLDE LSDVENTSEQ QPIVISCAVY VTDREKPDTV 300
    VRLIDNIVI 309
    Length:309
    Mass (Da):35,032
    Last modified:December 20, 2005 - v2
    Checksum:i9787B366795B5D81
    GO

    Sequence cautioni

    The sequence CAA86133.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z38059 Genomic DNA. Translation: CAA86133.1. Different initiation.
    BK006942 Genomic DNA. Translation: DAA08408.1.
    PIRiS48389.
    RefSeqiNP_012121.2. NM_001179493.1.

    Genome annotation databases

    EnsemblFungiiYIL145C; YIL145C; YIL145C.
    GeneIDi854661.
    KEGGisce:YIL145C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z38059 Genomic DNA. Translation: CAA86133.1 . Different initiation.
    BK006942 Genomic DNA. Translation: DAA08408.1 .
    PIRi S48389.
    RefSeqi NP_012121.2. NM_001179493.1.

    3D structure databases

    ProteinModelPortali P40459.
    SMRi P40459. Positions 1-309.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 34847. 18 interactions.
    DIPi DIP-4613N.
    IntActi P40459. 2 interactions.
    MINTi MINT-560279.
    STRINGi 4932.YIL145C.

    Proteomic databases

    MaxQBi P40459.
    PaxDbi P40459.
    PeptideAtlasi P40459.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YIL145C ; YIL145C ; YIL145C .
    GeneIDi 854661.
    KEGGi sce:YIL145C.

    Organism-specific databases

    CYGDi YIL145c.
    SGDi S000001407. PAN6.

    Phylogenomic databases

    eggNOGi COG0414.
    HOGENOMi HOG000175516.
    KOi K01918.
    OMAi RTWDSDV.
    OrthoDBi EOG7V1G1D.

    Enzyme and pathway databases

    UniPathwayi UPA00028 ; UER00005 .
    BioCyci MetaCyc:YIL145C-MONOMER.
    YEAST:YIL145C-MONOMER.

    Miscellaneous databases

    NextBioi 977232.

    Gene expression databases

    Genevestigatori P40459.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_00158. PanC.
    InterProi IPR003721. Pantoate_ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR21299:SF1. PTHR21299:SF1. 1 hit.
    Pfami PF02569. Pantoate_ligase. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00018. panC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "Saccharomyces cerevisiae is capable of de novo pantothenic acid biosynthesis involving a novel pathway of beta-alanine production from spermine."
      White W.H., Gunyuzlu P.L., Toyn J.H.
      J. Biol. Chem. 276:10794-10800(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    4. "Sequencing and comparison of yeast species to identify genes and regulatory elements."
      Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S.
      Nature 423:241-254(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION OF PROBABLE INITIATION SITE.
    5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPANC_YEAST
    AccessioniPrimary (citable) accession number: P40459
    Secondary accession number(s): D6VVE2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: December 20, 2005
    Last modified: October 1, 2014
    This is version 117 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 2400 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome IX
      Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

    External Data

    Dasty 3