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P40459 (PANC_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pantoate--beta-alanine ligase

EC=6.3.2.1
Alternative name(s):
Pantoate-activating enzyme
Pantothenate synthetase
Gene names
Name:PAN6
Ordered Locus Names:YIL145C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length309 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for pantothenic acid biosynthesis. Ref.3

Catalytic activity

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate. HAMAP-Rule MF_00158

Pathway

Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1. HAMAP-Rule MF_00158

Subcellular location

Cytoplasm. Nucleus Ref.5.

Miscellaneous

Present with 2400 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the pantothenate synthetase family.

Sequence caution

The sequence CAA86133.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processPantothenate biosynthesis
   Cellular componentCytoplasm
Nucleus
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processpantothenate biosynthetic process

Inferred from mutant phenotype Ref.3. Source: SGD

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

pantoate-beta-alanine ligase activity

Inferred from direct assay PubMed 10417331. Source: SGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 309309Pantoate--beta-alanine ligase HAMAP-Rule MF_00158
PRO_0000128298

Sequences

Sequence LengthMass (Da)Tools
P40459 [UniParc].

Last modified December 20, 2005. Version 2.
Checksum: 9787B366795B5D81

FASTA30935,032
        10         20         30         40         50         60 
MKIFHTVEEV VQWRTQELRE TRFRETIGFV PTMGCLHSGH ASLISQSVKE NTYTVVSIFV 

        70         80         90        100        110        120 
NPSQFAPTED LDNYPRTLPD DIKLLESLKV DVLFAPNAHV MYPQGIPLDI EEQKGPFVSV 

       130        140        150        160        170        180 
LGLSEKLEGK TRPNFFRGVA TVVTKLFNIV MADVAYFGQK DIQQFIVLQC MVDELFVNTR 

       190        200        210        220        230        240 
LQMMPIVRNN NGLALSSRNK YLCPESLKIS ENLYRGLKAA ENAIRRLAPG GRLSRSEIID 

       250        260        270        280        290        300 
TVTQIWAPYV DSHDFKIDYV SLADFKTLDE LSDVENTSEQ QPIVISCAVY VTDREKPDTV 


VRLIDNIVI 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome IX."
Churcher C.M., Bowman S., Badcock K., Bankier A.T., Brown D., Chillingworth T., Connor R., Devlin K., Gentles S., Hamlin N., Harris D.E., Horsnell T., Hunt S., Jagels K., Jones M., Lye G., Moule S., Odell C. expand/collapse author list , Pearson D., Rajandream M.A., Rice P., Rowley N., Skelton J., Smith V., Walsh S.V., Whitehead S., Barrell B.G.
Nature 387:84-87(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Saccharomyces cerevisiae is capable of de novo pantothenic acid biosynthesis involving a novel pathway of beta-alanine production from spermine."
White W.H., Gunyuzlu P.L., Toyn J.H.
J. Biol. Chem. 276:10794-10800(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[4]"Sequencing and comparison of yeast species to identify genes and regulatory elements."
Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S.
Nature 423:241-254(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION OF PROBABLE INITIATION SITE.
[5]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[6]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z38059 Genomic DNA. Translation: CAA86133.1. Different initiation.
BK006942 Genomic DNA. Translation: DAA08408.1.
PIRS48389.
RefSeqNP_012121.2. NM_001179493.1.

3D structure databases

ProteinModelPortalP40459.
SMRP40459. Positions 1-309.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid34847. 18 interactions.
DIPDIP-4613N.
IntActP40459. 2 interactions.
MINTMINT-560279.
STRING4932.YIL145C.

Proteomic databases

PaxDbP40459.
PeptideAtlasP40459.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYIL145C; YIL145C; YIL145C.
GeneID854661.
KEGGsce:YIL145C.

Organism-specific databases

CYGDYIL145c.
SGDS000001407. PAN6.

Phylogenomic databases

eggNOGCOG0414.
HOGENOMHOG000175516.
KOK01918.
OMARTWDSDV.
OrthoDBEOG7V1G1D.

Enzyme and pathway databases

BioCycMetaCyc:YIL145C-MONOMER.
YEAST:YIL145C-MONOMER.
UniPathwayUPA00028; UER00005.

Gene expression databases

GenevestigatorP40459.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_00158. PanC.
InterProIPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERPTHR21299:SF1. PTHR21299:SF1. 1 hit.
PfamPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00018. panC. 1 hit.
ProtoNetSearch...

Other

NextBio977232.

Entry information

Entry namePANC_YEAST
AccessionPrimary (citable) accession number: P40459
Secondary accession number(s): D6VVE2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: December 20, 2005
Last modified: February 19, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome IX

Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways