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Protein

Pantoate--beta-alanine ligase

Gene

PAN6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for pantothenic acid biosynthesis.1 Publication

Miscellaneous

Present with 2400 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.

Pathwayi: (R)-pantothenate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine.
Proteins known to be involved in this subpathway in this organism are:
  1. Pantoate--beta-alanine ligase (PAN6)
This subpathway is part of the pathway (R)-pantothenate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine, the pathway (R)-pantothenate biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

  • pantothenate biosynthetic process Source: SGD
  • pantothenate biosynthetic process from valine Source: GO_Central

Keywordsi

Molecular functionLigase
Biological processPantothenate biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:YIL145C-MONOMER
YEAST:YIL145C-MONOMER
UniPathwayiUPA00028; UER00005

Names & Taxonomyi

Protein namesi
Recommended name:
Pantoate--beta-alanine ligase (EC:6.3.2.1)
Alternative name(s):
Pantoate-activating enzyme
Pantothenate synthetase
Gene namesi
Name:PAN6
Ordered Locus Names:YIL145C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IX

Organism-specific databases

EuPathDBiFungiDB:YIL145C
SGDiS000001407 PAN6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001282981 – 309Pantoate--beta-alanine ligaseAdd BLAST309

Proteomic databases

MaxQBiP40459
PaxDbiP40459
PRIDEiP40459

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi34847, 101 interactors
DIPiDIP-4613N
IntActiP40459, 5 interactors
STRINGi4932.YIL145C

Structurei

3D structure databases

ProteinModelPortaliP40459
SMRiP40459
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pantothenate synthetase family.Curated

Phylogenomic databases

HOGENOMiHOG000175516
InParanoidiP40459
KOiK01918
OMAiLFNMVQP
OrthoDBiEOG092C4EU1

Family and domain databases

CDDicd00560 PanC, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00158 PanC, 1 hit
InterProiView protein in InterPro
IPR003721 Pantoate_ligase
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR21299:SF1 PTHR21299:SF1, 1 hit
PfamiView protein in Pfam
PF02569 Pantoate_ligase, 1 hit
TIGRFAMsiTIGR00018 panC, 1 hit

Sequencei

Sequence statusi: Complete.

P40459-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIFHTVEEV VQWRTQELRE TRFRETIGFV PTMGCLHSGH ASLISQSVKE
60 70 80 90 100
NTYTVVSIFV NPSQFAPTED LDNYPRTLPD DIKLLESLKV DVLFAPNAHV
110 120 130 140 150
MYPQGIPLDI EEQKGPFVSV LGLSEKLEGK TRPNFFRGVA TVVTKLFNIV
160 170 180 190 200
MADVAYFGQK DIQQFIVLQC MVDELFVNTR LQMMPIVRNN NGLALSSRNK
210 220 230 240 250
YLCPESLKIS ENLYRGLKAA ENAIRRLAPG GRLSRSEIID TVTQIWAPYV
260 270 280 290 300
DSHDFKIDYV SLADFKTLDE LSDVENTSEQ QPIVISCAVY VTDREKPDTV

VRLIDNIVI
Length:309
Mass (Da):35,032
Last modified:December 20, 2005 - v2
Checksum:i9787B366795B5D81
GO

Sequence cautioni

The sequence CAA86133 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38059 Genomic DNA Translation: CAA86133.1 Different initiation.
BK006942 Genomic DNA Translation: DAA08408.1
PIRiS48389
RefSeqiNP_012121.2, NM_001179493.1

Genome annotation databases

EnsemblFungiiYIL145C; YIL145C; YIL145C
GeneIDi854661
KEGGisce:YIL145C

Similar proteinsi

Entry informationi

Entry nameiPANC_YEAST
AccessioniPrimary (citable) accession number: P40459
Secondary accession number(s): D6VVE2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: December 20, 2005
Last modified: March 28, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health