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P40453

- UBP7_YEAST

UniProt

P40453 - UBP7_YEAST

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Protein
Ubiquitin carboxyl-terminal hydrolase 7
Gene
UBP7, YIL156W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in the sorting of ubiquitinated cargo proteins at the multivesicular body (MVB).1 Publication

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei618 – 6181Nucleophile By similarity
Active sitei1014 – 10141Proton acceptor By similarity

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. ubiquitin-specific protease activity Source: SGD

GO - Biological processi

  1. protein deubiquitination Source: SGD
  2. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

BioCyciYEAST:G3O-31404-MONOMER.

Protein family/group databases

MEROPSiC19.101.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 7 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 7
Ubiquitin thioesterase 7
Ubiquitin-specific-processing protease 7
Gene namesi
Name:UBP7
Ordered Locus Names:YIL156W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IX

Organism-specific databases

CYGDiYIL156w.
SGDiS000001418. UBP7.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10711071Ubiquitin carboxyl-terminal hydrolase 7
PRO_0000080592Add
BLAST

Proteomic databases

MaxQBiP40453.
PaxDbiP40453.

Expressioni

Gene expression databases

GenevestigatoriP40453.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
BZZ1P388223EBI-19857,EBI-3889
HOF1Q050802EBI-19857,EBI-5412
HSE1P387534EBI-19857,EBI-1382
LSB3P436032EBI-19857,EBI-22980
MYO3P360063EBI-19857,EBI-11670
MYO5Q044394EBI-19857,EBI-11687
PEX13P806672EBI-19857,EBI-13206

Protein-protein interaction databases

BioGridi34836. 51 interactions.
DIPiDIP-6272N.
IntActiP40453. 13 interactions.
MINTiMINT-598347.
STRINGi4932.YIL156W.

Structurei

3D structure databases

ProteinModelPortaliP40453.
SMRiP40453. Positions 593-884, 943-1071.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini609 – 1069461USP
Add
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.
Contains 1 USP domain.

Phylogenomic databases

eggNOGiCOG5533.
GeneTreeiENSGT00670000099202.
HOGENOMiHOG000142088.
KOiK11871.
OMAiGENAWDC.
OrthoDBiEOG7R2BSX.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR001763. Rhodanese-like_dom.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00581. Rhodanese. 1 hit.
PF00443. UCH. 1 hit.
[Graphical view]
SMARTiSM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMiSSF52821. SSF52821. 1 hit.
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40453-1 [UniParc]FASTAAdd to Basket

« Hide

MLDDDKGTAM HPHITPFTPE YSNELLRRVQ DLYHEDIKHY YPQLKLEKLL     50
DLLEHTEYLF ELYLDSIHHD RPNDALTAFI IGCYYVFLII PQSLQFQTRN 100
KSYSIYTDLK KMYENEMNMT NVVLMVKKEI GVVLDESVKH GAGIEHRITK 150
KRAFSVPADD LSGQVASLSL DTAAPQDHGL KGTFTEDDAE QSSPVWTAPN 200
LEPNDQLKLA LLPEVIPTPA FREPERKTSV PVRPSVLLED VPSIYHEDDT 250
SFASLNPPFR EITADRSVTH RKDSYHSVYM VDSGNLKEDN DDLFNVENDG 300
FIQSLDILQK QSIITAPELF SILSNRVERE KVLLIDLRIP QRSAINHIVA 350
PNLVNVDPNL LWDKQTNTPI YKDDILEHLL KENENFINRN KFDYIVYYTD 400
VKTFMTINFD YAFIFFYLML TSQKTPLTTV PTTLLGGYEK WKKTLHSYAQ 450
EYHISIEDYL YRPYSQKARL QQEQQQQQQQ PDSQDSFSAK ESSTKVPEPP 500
SWKPPDLPIR LRKRPPPPPP VSMPTTPEIP PPLPPKIMVH SQVSSISRKP 550
PIPAKQHVKK EQLNSNEIIQ RKRQHQHQHY DQQILQPQRA YNIPTIERSP 600
NVYVSLSITG LRNLGNTCYI NSMIQCLFAA KTFRTLFISS KYKSYLQPIR 650
SNGSHYSPKL SNSLSMLFNK MYLNGGCSVV PTGFLKVINQ LRPDLKIPDD 700
QQDTQEFLMI LLDRLHDELS DQQHVANDYP NLLLYNADAL KVSNNEYKHW 750
FDKNVIGNGI SPIDDIFQGQ MENSLQCKRC GYTTFNYSTF YVLSLAIPRR 800
SMKLSKLGRS TEKRVKLEDC INMFTSDEVL SGENAWDCPR CGPTASVSTS 850
VSALENEPSI VKSKKKKSRF FTLHTGTKRR HLDFFGDGIT EGHNSNNNNT 900
TIFERERSRS PFRMLGGSGK RSSSSTPFST GGNDSNNSSD YKNKKLTTVK 950
TINFVTLPKI LVIHLSRFYY DLTKKNNTVV TYPLILNIIL KNNDTMKYKL 1000
FGVVNHTGTL ISGHYTSLVN KDLEHNVNIG RSKWYYFDDE VVKADRKHGS 1050
DKNLKISSSD VYVLFYERVY D 1071
Length:1,071
Mass (Da):123,134
Last modified:February 1, 1995 - v1
Checksum:i82683A01063CEC74
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z38059 Genomic DNA. Translation: CAA86122.1.
BK006942 Genomic DNA. Translation: DAA08397.1.
PIRiS48378.
RefSeqiNP_012110.1. NM_001179504.1.

Genome annotation databases

EnsemblFungiiYIL156W; YIL156W; YIL156W.
GeneIDi854650.
KEGGisce:YIL156W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z38059 Genomic DNA. Translation: CAA86122.1 .
BK006942 Genomic DNA. Translation: DAA08397.1 .
PIRi S48378.
RefSeqi NP_012110.1. NM_001179504.1.

3D structure databases

ProteinModelPortali P40453.
SMRi P40453. Positions 593-884, 943-1071.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 34836. 51 interactions.
DIPi DIP-6272N.
IntActi P40453. 13 interactions.
MINTi MINT-598347.
STRINGi 4932.YIL156W.

Protein family/group databases

MEROPSi C19.101.

Proteomic databases

MaxQBi P40453.
PaxDbi P40453.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YIL156W ; YIL156W ; YIL156W .
GeneIDi 854650.
KEGGi sce:YIL156W.

Organism-specific databases

CYGDi YIL156w.
SGDi S000001418. UBP7.

Phylogenomic databases

eggNOGi COG5533.
GeneTreei ENSGT00670000099202.
HOGENOMi HOG000142088.
KOi K11871.
OMAi GENAWDC.
OrthoDBi EOG7R2BSX.

Enzyme and pathway databases

BioCyci YEAST:G3O-31404-MONOMER.

Miscellaneous databases

NextBioi 977199.

Gene expression databases

Genevestigatori P40453.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR001763. Rhodanese-like_dom.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00581. Rhodanese. 1 hit.
PF00443. UCH. 1 hit.
[Graphical view ]
SMARTi SM00450. RHOD. 1 hit.
[Graphical view ]
SUPFAMi SSF52821. SSF52821. 1 hit.
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "Hse1, a component of the yeast Hrs-STAM ubiquitin-sorting complex, associates with ubiquitin peptidases and a ligase to control sorting efficiency into multivesicular bodies."
    Ren J., Kee Y., Huibregtse J.M., Piper R.C.
    Mol. Biol. Cell 18:324-335(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH HSE1.
  6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiUBP7_YEAST
AccessioniPrimary (citable) accession number: P40453
Secondary accession number(s): D6VVD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 11, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 606 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

External Data

Dasty 3

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