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Protein

Cytochrome c oxidase assembly factor 1

Gene

COA1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for efficient assembly of cytochrome c oxidase in the mitochondrial inner membrane. Involved in a step coupling MSS51-dependent cotranslational insertion of COX1 to the addition of its heme A and copper B cofactors.2 Publications

Miscellaneous

Present with 1680 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • mitochondrial respiratory chain complex IV assembly Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-31405-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase assembly factor 1
Gene namesi
Name:COA1
Synonyms:FMP35
Ordered Locus Names:YIL157C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IX

Organism-specific databases

EuPathDBiFungiDB:YIL157C.
SGDiS000001419. COA1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 73Mitochondrial matrixSequence analysisAdd BLAST73
Transmembranei74 – 94HelicalSequence analysisAdd BLAST21
Topological domaini95 – 197Mitochondrial intermembraneSequence analysisAdd BLAST103

GO - Cellular componenti

  • integral component of mitochondrial inner membrane Source: SGD
  • integral component of mitochondrial membrane Source: SGD

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002029541 – 197Cytochrome c oxidase assembly factor 1Add BLAST197

Proteomic databases

MaxQBiP40452.
PRIDEiP40452.

PTM databases

iPTMnetiP40452.

Interactioni

Subunit structurei

Interacts with COX1, COX14, MSS51 and SHY1.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi34835. 76 interactors.
DIPiDIP-4708N.
IntActiP40452. 6 interactors.
MINTiMINT-539339.
STRINGi4932.YIL157C.

Structurei

3D structure databases

ProteinModelPortaliP40452.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the COA1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000187652.
InParanoidiP40452.
KOiK18173.
OMAiSVAIFNY.
OrthoDBiEOG092C5RLW.

Family and domain databases

InterProiView protein in InterPro
IPR014807. Cyt_oxidase_assembly-1.
PfamiView protein in Pfam
PF08695. Coa1. 1 hit.

Sequencei

Sequence statusi: Complete.

P40452-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLRLVTKGL PKVTPSAAKA VLVRGSLLHS FSTSARFNNS VAEDEAKIVL
60 70 80 90 100
KDKNRPLRID RELPDPTTER RKRIAGFLLF SVAIGSALSL IFNYEKTESP
110 120 130 140 150
IISNTLYYIR RSPATKNILG ESIEFDGIIP WVYGELNSVK GRINITFYIK
160 170 180 190
GDKNVTGTVR LVADRNTHDE EFLIHEWSVT AAGQKIDLLA ENTKTPI
Length:197
Mass (Da):22,044
Last modified:February 1, 1995 - v1
Checksum:i2CE6635E5D043C37
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38059 Genomic DNA. Translation: CAA86121.1.
BK006942 Genomic DNA. Translation: DAA08395.1.
PIRiS48377.
RefSeqiNP_012109.1. NM_001179505.1.

Genome annotation databases

EnsemblFungiiYIL157C; YIL157C; YIL157C.
GeneIDi854649.
KEGGisce:YIL157C.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCOA1_YEAST
AccessioniPrimary (citable) accession number: P40452
Secondary accession number(s): D6VVC9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: July 5, 2017
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names