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P40452

- COA1_YEAST

UniProt

P40452 - COA1_YEAST

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Protein

Cytochrome c oxidase assembly factor 1

Gene
COA1, FMP35, YIL157C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Required for efficient assembly of cytochrome c oxidase in the mitochondrial inner membrane. Involved in a step coupling MSS51-dependent cotranslational insertion of COX1 to the addition of its heme A and copper B cofactors.2 Publications

GO - Molecular functioni

  1. protein binding Source: IntAct

GO - Biological processi

  1. mitochondrial respiratory chain complex IV assembly Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-31405-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase assembly factor 1
Gene namesi
Name:COA1
Synonyms:FMP35
Ordered Locus Names:YIL157C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IX

Organism-specific databases

CYGDiYIL157c.
SGDiS000001419. COA1.

Subcellular locationi

Mitochondrion inner membrane; Single-pass membrane protein Reviewed prediction 4 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7373Mitochondrial matrix Reviewed predictionAdd
BLAST
Transmembranei74 – 9421Helical; Reviewed predictionAdd
BLAST
Topological domaini95 – 197103Mitochondrial intermembrane Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of mitochondrial inner membrane Source: SGD
  2. integral component of mitochondrial membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 197197Cytochrome c oxidase assembly factor 1PRO_0000202954Add
BLAST

Proteomic databases

MaxQBiP40452.
PaxDbiP40452.
PeptideAtlasiP40452.

Expressioni

Gene expression databases

GenevestigatoriP40452.

Interactioni

Subunit structurei

Interacts with COX1, COX14, MSS51 and SHY1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
COX14P391032EBI-25287,EBI-5113
MSS51P323353EBI-25287,EBI-11318
SHY1P532665EBI-25287,EBI-17111

Protein-protein interaction databases

BioGridi34835. 13 interactions.
DIPiDIP-4708N.
IntActiP40452. 6 interactions.
MINTiMINT-539339.
STRINGi4932.YIL157C.

Structurei

3D structure databases

ProteinModelPortaliP40452.

Family & Domainsi

Sequence similaritiesi

Belongs to the COA1 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG71901.
HOGENOMiHOG000187652.
KOiK18173.
OMAiNYEKTTS.
OrthoDBiEOG7N0CH8.

Family and domain databases

InterProiIPR014807. Cyt_oxidase_assembly-1.
[Graphical view]
PfamiPF08695. Coa1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40452-1 [UniParc]FASTAAdd to Basket

« Hide

MMLRLVTKGL PKVTPSAAKA VLVRGSLLHS FSTSARFNNS VAEDEAKIVL    50
KDKNRPLRID RELPDPTTER RKRIAGFLLF SVAIGSALSL IFNYEKTESP 100
IISNTLYYIR RSPATKNILG ESIEFDGIIP WVYGELNSVK GRINITFYIK 150
GDKNVTGTVR LVADRNTHDE EFLIHEWSVT AAGQKIDLLA ENTKTPI 197
Length:197
Mass (Da):22,044
Last modified:February 1, 1995 - v1
Checksum:i2CE6635E5D043C37
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z38059 Genomic DNA. Translation: CAA86121.1.
BK006942 Genomic DNA. Translation: DAA08395.1.
PIRiS48377.
RefSeqiNP_012109.1. NM_001179505.1.

Genome annotation databases

EnsemblFungiiYIL157C; YIL157C; YIL157C.
GeneIDi854649.
KEGGisce:YIL157C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z38059 Genomic DNA. Translation: CAA86121.1 .
BK006942 Genomic DNA. Translation: DAA08395.1 .
PIRi S48377.
RefSeqi NP_012109.1. NM_001179505.1.

3D structure databases

ProteinModelPortali P40452.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 34835. 13 interactions.
DIPi DIP-4708N.
IntActi P40452. 6 interactions.
MINTi MINT-539339.
STRINGi 4932.YIL157C.

Proteomic databases

MaxQBi P40452.
PaxDbi P40452.
PeptideAtlasi P40452.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YIL157C ; YIL157C ; YIL157C .
GeneIDi 854649.
KEGGi sce:YIL157C.

Organism-specific databases

CYGDi YIL157c.
SGDi S000001419. COA1.

Phylogenomic databases

eggNOGi NOG71901.
HOGENOMi HOG000187652.
KOi K18173.
OMAi NYEKTTS.
OrthoDBi EOG7N0CH8.

Enzyme and pathway databases

BioCyci YEAST:G3O-31405-MONOMER.

Miscellaneous databases

NextBioi 977196.

Gene expression databases

Genevestigatori P40452.

Family and domain databases

InterProi IPR014807. Cyt_oxidase_assembly-1.
[Graphical view ]
Pfami PF08695. Coa1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Strain: ATCC 76625 / YPH499.
  6. "Coa1 links the Mss51 post-translational function to Cox1 cofactor insertion in cytochrome c oxidase assembly."
    Pierrel F., Bestwick M.L., Cobine P.A., Khalimonchuk O., Cricco J.A., Winge D.R.
    EMBO J. 26:4335-4346(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH COX1; COX14; MSS51 AND SHY1.
  7. "Shy1 couples Cox1 translational regulation to cytochrome c oxidase assembly."
    Mick D.U., Wagner K., van der Laan M., Frazier A.E., Perschil I., Pawlas M., Meyer H.E., Warscheid B., Rehling P.
    EMBO J. 26:4347-4358(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY, INTERACTION WITH MSS51 AND SHY1.

Entry informationi

Entry nameiCOA1_YEAST
AccessioniPrimary (citable) accession number: P40452
Secondary accession number(s): D6VVC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 3, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1680 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

External Data

Dasty 3

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