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P40452

- COA1_YEAST

UniProt

P40452 - COA1_YEAST

Protein

Cytochrome c oxidase assembly factor 1

Gene

COA1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Required for efficient assembly of cytochrome c oxidase in the mitochondrial inner membrane. Involved in a step coupling MSS51-dependent cotranslational insertion of COX1 to the addition of its heme A and copper B cofactors.2 Publications

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. mitochondrial respiratory chain complex IV assembly Source: SGD

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31405-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase assembly factor 1
    Gene namesi
    Name:COA1
    Synonyms:FMP35
    Ordered Locus Names:YIL157C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome IX

    Organism-specific databases

    CYGDiYIL157c.
    SGDiS000001419. COA1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of mitochondrial inner membrane Source: SGD
    2. integral component of mitochondrial membrane Source: SGD

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 197197Cytochrome c oxidase assembly factor 1PRO_0000202954Add
    BLAST

    Proteomic databases

    MaxQBiP40452.
    PaxDbiP40452.
    PeptideAtlasiP40452.

    Expressioni

    Gene expression databases

    GenevestigatoriP40452.

    Interactioni

    Subunit structurei

    Interacts with COX1, COX14, MSS51 and SHY1.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    COX14P391032EBI-25287,EBI-5113
    MSS51P323353EBI-25287,EBI-11318
    SHY1P532665EBI-25287,EBI-17111

    Protein-protein interaction databases

    BioGridi34835. 13 interactions.
    DIPiDIP-4708N.
    IntActiP40452. 6 interactions.
    MINTiMINT-539339.
    STRINGi4932.YIL157C.

    Structurei

    3D structure databases

    ProteinModelPortaliP40452.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 7373Mitochondrial matrixSequence AnalysisAdd
    BLAST
    Topological domaini95 – 197103Mitochondrial intermembraneSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei74 – 9421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the COA1 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG71901.
    HOGENOMiHOG000187652.
    KOiK18173.
    OMAiNYEKTTS.
    OrthoDBiEOG7N0CH8.

    Family and domain databases

    InterProiIPR014807. Cyt_oxidase_assembly-1.
    [Graphical view]
    PfamiPF08695. Coa1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P40452-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMLRLVTKGL PKVTPSAAKA VLVRGSLLHS FSTSARFNNS VAEDEAKIVL    50
    KDKNRPLRID RELPDPTTER RKRIAGFLLF SVAIGSALSL IFNYEKTESP 100
    IISNTLYYIR RSPATKNILG ESIEFDGIIP WVYGELNSVK GRINITFYIK 150
    GDKNVTGTVR LVADRNTHDE EFLIHEWSVT AAGQKIDLLA ENTKTPI 197
    Length:197
    Mass (Da):22,044
    Last modified:February 1, 1995 - v1
    Checksum:i2CE6635E5D043C37
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z38059 Genomic DNA. Translation: CAA86121.1.
    BK006942 Genomic DNA. Translation: DAA08395.1.
    PIRiS48377.
    RefSeqiNP_012109.1. NM_001179505.1.

    Genome annotation databases

    EnsemblFungiiYIL157C; YIL157C; YIL157C.
    GeneIDi854649.
    KEGGisce:YIL157C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z38059 Genomic DNA. Translation: CAA86121.1 .
    BK006942 Genomic DNA. Translation: DAA08395.1 .
    PIRi S48377.
    RefSeqi NP_012109.1. NM_001179505.1.

    3D structure databases

    ProteinModelPortali P40452.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 34835. 13 interactions.
    DIPi DIP-4708N.
    IntActi P40452. 6 interactions.
    MINTi MINT-539339.
    STRINGi 4932.YIL157C.

    Proteomic databases

    MaxQBi P40452.
    PaxDbi P40452.
    PeptideAtlasi P40452.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YIL157C ; YIL157C ; YIL157C .
    GeneIDi 854649.
    KEGGi sce:YIL157C.

    Organism-specific databases

    CYGDi YIL157c.
    SGDi S000001419. COA1.

    Phylogenomic databases

    eggNOGi NOG71901.
    HOGENOMi HOG000187652.
    KOi K18173.
    OMAi NYEKTTS.
    OrthoDBi EOG7N0CH8.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31405-MONOMER.

    Miscellaneous databases

    NextBioi 977196.

    Gene expression databases

    Genevestigatori P40452.

    Family and domain databases

    InterProi IPR014807. Cyt_oxidase_assembly-1.
    [Graphical view ]
    Pfami PF08695. Coa1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
      Strain: ATCC 76625 / YPH499.
    6. "Coa1 links the Mss51 post-translational function to Cox1 cofactor insertion in cytochrome c oxidase assembly."
      Pierrel F., Bestwick M.L., Cobine P.A., Khalimonchuk O., Cricco J.A., Winge D.R.
      EMBO J. 26:4335-4346(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH COX1; COX14; MSS51 AND SHY1.
    7. "Shy1 couples Cox1 translational regulation to cytochrome c oxidase assembly."
      Mick D.U., Wagner K., van der Laan M., Frazier A.E., Perschil I., Pawlas M., Meyer H.E., Warscheid B., Rehling P.
      EMBO J. 26:4347-4358(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY, INTERACTION WITH MSS51 AND SHY1.

    Entry informationi

    Entry nameiCOA1_YEAST
    AccessioniPrimary (citable) accession number: P40452
    Secondary accession number(s): D6VVC9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 1680 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome IX
      Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

    External Data

    Dasty 3