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P40452

- COA1_YEAST

UniProt

P40452 - COA1_YEAST

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Protein

Cytochrome c oxidase assembly factor 1

Gene

COA1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Required for efficient assembly of cytochrome c oxidase in the mitochondrial inner membrane. Involved in a step coupling MSS51-dependent cotranslational insertion of COX1 to the addition of its heme A and copper B cofactors.2 Publications

GO - Biological processi

  1. mitochondrial respiratory chain complex IV assembly Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-31405-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase assembly factor 1
Gene namesi
Name:COA1
Synonyms:FMP35
Ordered Locus Names:YIL157C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IX

Organism-specific databases

CYGDiYIL157c.
SGDiS000001419. COA1.

Subcellular locationi

GO - Cellular componenti

  1. integral component of mitochondrial inner membrane Source: SGD
  2. integral component of mitochondrial membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 197197Cytochrome c oxidase assembly factor 1PRO_0000202954Add
BLAST

Proteomic databases

MaxQBiP40452.
PaxDbiP40452.
PeptideAtlasiP40452.

Expressioni

Gene expression databases

GenevestigatoriP40452.

Interactioni

Subunit structurei

Interacts with COX1, COX14, MSS51 and SHY1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
COX14P391032EBI-25287,EBI-5113
MSS51P323353EBI-25287,EBI-11318
SHY1P532665EBI-25287,EBI-17111

Protein-protein interaction databases

BioGridi34835. 14 interactions.
DIPiDIP-4708N.
IntActiP40452. 6 interactions.
MINTiMINT-539339.
STRINGi4932.YIL157C.

Structurei

3D structure databases

ProteinModelPortaliP40452.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7373Mitochondrial matrixSequence AnalysisAdd
BLAST
Topological domaini95 – 197103Mitochondrial intermembraneSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei74 – 9421HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the COA1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG71901.
HOGENOMiHOG000187652.
InParanoidiP40452.
KOiK18173.
OMAiNYEKTTS.
OrthoDBiEOG7N0CH8.

Family and domain databases

InterProiIPR014807. Cyt_oxidase_assembly-1.
[Graphical view]
PfamiPF08695. Coa1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40452-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMLRLVTKGL PKVTPSAAKA VLVRGSLLHS FSTSARFNNS VAEDEAKIVL
60 70 80 90 100
KDKNRPLRID RELPDPTTER RKRIAGFLLF SVAIGSALSL IFNYEKTESP
110 120 130 140 150
IISNTLYYIR RSPATKNILG ESIEFDGIIP WVYGELNSVK GRINITFYIK
160 170 180 190
GDKNVTGTVR LVADRNTHDE EFLIHEWSVT AAGQKIDLLA ENTKTPI
Length:197
Mass (Da):22,044
Last modified:February 1, 1995 - v1
Checksum:i2CE6635E5D043C37
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z38059 Genomic DNA. Translation: CAA86121.1.
BK006942 Genomic DNA. Translation: DAA08395.1.
PIRiS48377.
RefSeqiNP_012109.1. NM_001179505.1.

Genome annotation databases

EnsemblFungiiYIL157C; YIL157C; YIL157C.
GeneIDi854649.
KEGGisce:YIL157C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z38059 Genomic DNA. Translation: CAA86121.1 .
BK006942 Genomic DNA. Translation: DAA08395.1 .
PIRi S48377.
RefSeqi NP_012109.1. NM_001179505.1.

3D structure databases

ProteinModelPortali P40452.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 34835. 14 interactions.
DIPi DIP-4708N.
IntActi P40452. 6 interactions.
MINTi MINT-539339.
STRINGi 4932.YIL157C.

Proteomic databases

MaxQBi P40452.
PaxDbi P40452.
PeptideAtlasi P40452.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YIL157C ; YIL157C ; YIL157C .
GeneIDi 854649.
KEGGi sce:YIL157C.

Organism-specific databases

CYGDi YIL157c.
SGDi S000001419. COA1.

Phylogenomic databases

eggNOGi NOG71901.
HOGENOMi HOG000187652.
InParanoidi P40452.
KOi K18173.
OMAi NYEKTTS.
OrthoDBi EOG7N0CH8.

Enzyme and pathway databases

BioCyci YEAST:G3O-31405-MONOMER.

Miscellaneous databases

NextBioi 977196.

Gene expression databases

Genevestigatori P40452.

Family and domain databases

InterProi IPR014807. Cyt_oxidase_assembly-1.
[Graphical view ]
Pfami PF08695. Coa1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Strain: ATCC 76625 / YPH499.
  6. "Coa1 links the Mss51 post-translational function to Cox1 cofactor insertion in cytochrome c oxidase assembly."
    Pierrel F., Bestwick M.L., Cobine P.A., Khalimonchuk O., Cricco J.A., Winge D.R.
    EMBO J. 26:4335-4346(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH COX1; COX14; MSS51 AND SHY1.
  7. "Shy1 couples Cox1 translational regulation to cytochrome c oxidase assembly."
    Mick D.U., Wagner K., van der Laan M., Frazier A.E., Perschil I., Pawlas M., Meyer H.E., Warscheid B., Rehling P.
    EMBO J. 26:4347-4358(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY, INTERACTION WITH MSS51 AND SHY1.

Entry informationi

Entry nameiCOA1_YEAST
AccessioniPrimary (citable) accession number: P40452
Secondary accession number(s): D6VVC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 29, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1680 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

External Data

Dasty 3