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P40452 (COA1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase assembly factor 1
Gene names
Name:COA1
Synonyms:FMP35
Ordered Locus Names:YIL157C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length197 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for efficient assembly of cytochrome c oxidase in the mitochondrial inner membrane. Involved in a step coupling MSS51-dependent cotranslational insertion of COX1 to the addition of its heme A and copper B cofactors. Ref.6 Ref.7

Subunit structure

Interacts with COX1, COX14, MSS51 and SHY1. Ref.6 Ref.7

Subcellular location

Mitochondrion inner membrane; Single-pass membrane protein Potential Ref.3 Ref.5 Ref.6 Ref.7.

Miscellaneous

Present with 1680 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the COA1 family.

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 197197Cytochrome c oxidase assembly factor 1
PRO_0000202954

Regions

Topological domain1 – 7373Mitochondrial matrix Potential
Transmembrane74 – 9421Helical; Potential
Topological domain95 – 197103Mitochondrial intermembrane Potential

Sequences

Sequence LengthMass (Da)Tools
P40452 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 2CE6635E5D043C37

FASTA19722,044
        10         20         30         40         50         60 
MMLRLVTKGL PKVTPSAAKA VLVRGSLLHS FSTSARFNNS VAEDEAKIVL KDKNRPLRID 

        70         80         90        100        110        120 
RELPDPTTER RKRIAGFLLF SVAIGSALSL IFNYEKTESP IISNTLYYIR RSPATKNILG 

       130        140        150        160        170        180 
ESIEFDGIIP WVYGELNSVK GRINITFYIK GDKNVTGTVR LVADRNTHDE EFLIHEWSVT 

       190 
AAGQKIDLLA ENTKTPI 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome IX."
Churcher C.M., Bowman S., Badcock K., Bankier A.T., Brown D., Chillingworth T., Connor R., Devlin K., Gentles S., Hamlin N., Harris D.E., Horsnell T., Hunt S., Jagels K., Jones M., Lye G., Moule S., Odell C. expand/collapse author list , Pearson D., Rajandream M.A., Rice P., Rowley N., Skelton J., Smith V., Walsh S.V., Whitehead S., Barrell B.G.
Nature 387:84-87(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]"The proteome of Saccharomyces cerevisiae mitochondria."
Sickmann A., Reinders J., Wagner Y., Joppich C., Zahedi R.P., Meyer H.E., Schoenfisch B., Perschil I., Chacinska A., Guiard B., Rehling P., Pfanner N., Meisinger C.
Proc. Natl. Acad. Sci. U.S.A. 100:13207-13212(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
Strain: ATCC 76625 / YPH499.
[6]"Coa1 links the Mss51 post-translational function to Cox1 cofactor insertion in cytochrome c oxidase assembly."
Pierrel F., Bestwick M.L., Cobine P.A., Khalimonchuk O., Cricco J.A., Winge D.R.
EMBO J. 26:4335-4346(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH COX1; COX14; MSS51 AND SHY1.
[7]"Shy1 couples Cox1 translational regulation to cytochrome c oxidase assembly."
Mick D.U., Wagner K., van der Laan M., Frazier A.E., Perschil I., Pawlas M., Meyer H.E., Warscheid B., Rehling P.
EMBO J. 26:4347-4358(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY, INTERACTION WITH MSS51 AND SHY1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z38059 Genomic DNA. Translation: CAA86121.1.
BK006942 Genomic DNA. Translation: DAA08395.1.
PIRS48377.
RefSeqNP_012109.1. NM_001179505.1.

3D structure databases

ProteinModelPortalP40452.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid34835. 13 interactions.
DIPDIP-4708N.
IntActP40452. 6 interactions.
MINTMINT-539339.
STRING4932.YIL157C.

Proteomic databases

PaxDbP40452.
PeptideAtlasP40452.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYIL157C; YIL157C; YIL157C.
GeneID854649.
KEGGsce:YIL157C.

Organism-specific databases

CYGDYIL157c.
SGDS000001419. YIL157C.

Phylogenomic databases

eggNOGNOG71901.
HOGENOMHOG000187652.
OMAPMRIDRE.
OrthoDBEOG7N0CH8.

Enzyme and pathway databases

BioCycYEAST:G3O-31405-MONOMER.

Gene expression databases

GenevestigatorP40452.

Family and domain databases

InterProIPR014807. Cyt_oxidase_assembly-1.
[Graphical view]
PfamPF08695. Coa1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio977196.

Entry information

Entry nameCOA1_YEAST
AccessionPrimary (citable) accession number: P40452
Secondary accession number(s): D6VVC9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 16, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome IX

Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families