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Protein

Putative hexose transporter 12

Gene

HXT12

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein uncertaini

Functioni

Probable glucose transporter.

GO - Molecular functioni

  1. substrate-specific transmembrane transporter activity Source: InterPro

GO - Biological processi

  1. carbohydrate transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Putative hexose transporter 12
Gene namesi
Name:HXT12
Ordered Locus Names:YIL170W
ORF Names:YI9402.06B
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome IX

Organism-specific databases

CYGDiYIL170w.
SGDiS000001432. HXT12.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 22CytoplasmicSequence Analysis
Transmembranei3 – 2321Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini24 – 296ExtracellularSequence Analysis
Transmembranei30 – 5021Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini51 – 6010CytoplasmicSequence Analysis
Transmembranei61 – 8121Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini82 – 876ExtracellularSequence Analysis
Transmembranei88 – 10821Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini109 – 12214CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei123 – 14321Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini144 – 247104ExtracellularSequence AnalysisAdd
BLAST
Transmembranei248 – 26821Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini269 – 2746CytoplasmicSequence Analysis
Transmembranei275 – 29521Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini296 – 31924ExtracellularSequence AnalysisAdd
BLAST
Transmembranei320 – 34021Helical; Name=8Sequence AnalysisAdd
BLAST
Topological domaini341 – 35313CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei354 – 37421Helical; Name=9Sequence AnalysisAdd
BLAST
Topological domaini375 – 3795ExtracellularSequence Analysis
Transmembranei380 – 40021Helical; Name=10Sequence AnalysisAdd
BLAST
Topological domaini401 – 45757CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 457457Putative hexose transporter 12PRO_0000050408Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi194 – 1941N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Expressioni

Gene expression databases

ExpressionAtlasiP40441. differential.
GenevestigatoriP40441.

Interactioni

Protein-protein interaction databases

DIPiDIP-7421N.
IntActiP40441. 2 interactions.
MINTiMINT-1361084.
STRINGi4932.YOL156W.

Structurei

3D structure databases

ProteinModelPortaliP40441.
SMRiP40441. Positions 1-416.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiP40441.
OrthoDBiEOG73JM4H.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40441-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLIVSIFNI GCAIGGIVLS KVGDIYGRRI GLITVTAIYV VGILIQITSI
60 70 80 90 100
NKWYQYFIGR IISGIGVGGI AVLSPMLISE VAPKHIRGTL VQLYQLMGTM
110 120 130 140 150
GIFLGYCTNY GTKNYHNATQ WRVGLGLCFA WATFMVSGMM FVPESPRYLI
160 170 180 190 200
EVGKDEEAKH SLSKSNKVSV DDPALLAEYD TIKAGIEIEK LAGNASWSEL
210 220 230 240 250
LSTKTKVFQR VLMGVIIQSL QQLTGDNYFF YYGTTIFKSV GLKDSFQTSI
260 270 280 290 300
IIGVVNFFSS FIAVYTIERF GRRTCLLWGA ASMLCCFAVF ASVGVTKLWP
310 320 330 340 350
QGSSHQDITS QGAGNCMIVF TMFFIFSFAT TWAGGCFVIV SETFPLRAKS
360 370 380 390 400
RGMAIATAAN WMWGFLISFF TPFITGAINF YYGYVFLGCL VFAYFYVFFF
410 420 430 440 450
VPETKGLTLE EVNTMWLEGV PAWKSASWVP PERRTADYDA DAIDHDNRPI

YKRFFSS
Length:457
Mass (Da):50,830
Last modified:February 1, 1995 - v1
Checksum:iFBEE8186BAC88B88
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46881 Genomic DNA. Translation: CAA87022.1.
BK006942 Genomic DNA. No translation available.
PIRiS50357.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46881 Genomic DNA. Translation: CAA87022.1.
BK006942 Genomic DNA. No translation available.
PIRiS50357.

3D structure databases

ProteinModelPortaliP40441.
SMRiP40441. Positions 1-416.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-7421N.
IntActiP40441. 2 interactions.
MINTiMINT-1361084.
STRINGi4932.YOL156W.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

CYGDiYIL170w.
SGDiS000001432. HXT12.

Phylogenomic databases

InParanoidiP40441.
OrthoDBiEOG73JM4H.

Gene expression databases

ExpressionAtlasiP40441. differential.
GenevestigatoriP40441.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.

Entry informationi

Entry nameiHXT12_YEAST
AccessioniPrimary (citable) accession number: P40441
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: January 7, 2015
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Caution

Could be the product of a pseudogene. YIL171W and YIL170W represent the N- and C-terminal of a putative transporter.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.