Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P40441 (HXT12_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative hexose transporter 12
Gene names
Name:HXT12
Ordered Locus Names:YIL170W
ORF Names:YI9402.06B
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length457 AA.
Sequence statusComplete.
Protein existenceUncertain

General annotation (Comments)

Function

Probable glucose transporter.

Subcellular location

Membrane; Multi-pass membrane protein Probable.

Sequence similarities

Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. [View classification]

Caution

Could be the product of a pseudogene. YIL171W and YIL170W represent the N- and C-terminal of a putative transporter.

Ontologies

Keywords
   Biological processSugar transport
Transport
   Cellular componentMembrane
   DomainRepeat
Transmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcarbohydrate transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionsubstrate-specific transmembrane transporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 457457Putative hexose transporter 12
PRO_0000050408

Regions

Topological domain1 – 22Cytoplasmic Potential
Transmembrane3 – 2321Helical; Name=1; Potential
Topological domain24 – 296Extracellular Potential
Transmembrane30 – 5021Helical; Name=2; Potential
Topological domain51 – 6010Cytoplasmic Potential
Transmembrane61 – 8121Helical; Name=3; Potential
Topological domain82 – 876Extracellular Potential
Transmembrane88 – 10821Helical; Name=4; Potential
Topological domain109 – 12214Cytoplasmic Potential
Transmembrane123 – 14321Helical; Name=5; Potential
Topological domain144 – 247104Extracellular Potential
Transmembrane248 – 26821Helical; Name=6; Potential
Topological domain269 – 2746Cytoplasmic Potential
Transmembrane275 – 29521Helical; Name=7; Potential
Topological domain296 – 31924Extracellular Potential
Transmembrane320 – 34021Helical; Name=8; Potential
Topological domain341 – 35313Cytoplasmic Potential
Transmembrane354 – 37421Helical; Name=9; Potential
Topological domain375 – 3795Extracellular Potential
Transmembrane380 – 40021Helical; Name=10; Potential
Topological domain401 – 45757Cytoplasmic Potential

Amino acid modifications

Glycosylation1941N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P40441 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: FBEE8186BAC88B88

FASTA45750,830
        10         20         30         40         50         60 
MGLIVSIFNI GCAIGGIVLS KVGDIYGRRI GLITVTAIYV VGILIQITSI NKWYQYFIGR 

        70         80         90        100        110        120 
IISGIGVGGI AVLSPMLISE VAPKHIRGTL VQLYQLMGTM GIFLGYCTNY GTKNYHNATQ 

       130        140        150        160        170        180 
WRVGLGLCFA WATFMVSGMM FVPESPRYLI EVGKDEEAKH SLSKSNKVSV DDPALLAEYD 

       190        200        210        220        230        240 
TIKAGIEIEK LAGNASWSEL LSTKTKVFQR VLMGVIIQSL QQLTGDNYFF YYGTTIFKSV 

       250        260        270        280        290        300 
GLKDSFQTSI IIGVVNFFSS FIAVYTIERF GRRTCLLWGA ASMLCCFAVF ASVGVTKLWP 

       310        320        330        340        350        360 
QGSSHQDITS QGAGNCMIVF TMFFIFSFAT TWAGGCFVIV SETFPLRAKS RGMAIATAAN 

       370        380        390        400        410        420 
WMWGFLISFF TPFITGAINF YYGYVFLGCL VFAYFYVFFF VPETKGLTLE EVNTMWLEGV 

       430        440        450 
PAWKSASWVP PERRTADYDA DAIDHDNRPI YKRFFSS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z46881 Genomic DNA. Translation: CAA87022.1.
BK006942 Genomic DNA. No translation available.
PIRS50357.

3D structure databases

ProteinModelPortalP40441.
SMRP40441. Positions 1-416.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-7421N.
IntActP40441. 2 interactions.
MINTMINT-1361084.
STRING4932.YOL156W.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

CYGDYIL170w.
SGDS000001432. HXT12.

Phylogenomic databases

OrthoDBEOG73JM4H.

Gene expression databases

GenevestigatorP40441.

Family and domain databases

InterProIPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSPR00171. SUGRTRNSPORT.
SUPFAMSSF103473. SSF103473. 1 hit.
TIGRFAMsTIGR00879. SP. 1 hit.
PROSITEPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHXT12_YEAST
AccessionPrimary (citable) accession number: P40441
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 14, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome IX

Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families