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P40441

- HXT12_YEAST

UniProt

P40441 - HXT12_YEAST

Protein

Putative hexose transporter 12

Gene

HXT12

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein uncertaini
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Probable glucose transporter.

    GO - Molecular functioni

    1. substrate-specific transmembrane transporter activity Source: InterPro

    GO - Biological processi

    1. carbohydrate transport Source: UniProtKB-KW

    Keywords - Biological processi

    Sugar transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative hexose transporter 12
    Gene namesi
    Name:HXT12
    Ordered Locus Names:YIL170W
    ORF Names:YI9402.06B
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome IX

    Organism-specific databases

    CYGDiYIL170w.
    SGDiS000001432. HXT12.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 457457Putative hexose transporter 12PRO_0000050408Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi194 – 1941N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Expressioni

    Gene expression databases

    GenevestigatoriP40441.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-7421N.
    IntActiP40441. 2 interactions.
    MINTiMINT-1361084.
    STRINGi4932.YOL156W.

    Structurei

    3D structure databases

    ProteinModelPortaliP40441.
    SMRiP40441. Positions 1-416.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 22CytoplasmicSequence Analysis
    Topological domaini24 – 296ExtracellularSequence Analysis
    Topological domaini51 – 6010CytoplasmicSequence Analysis
    Topological domaini82 – 876ExtracellularSequence Analysis
    Topological domaini109 – 12214CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini144 – 247104ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini269 – 2746CytoplasmicSequence Analysis
    Topological domaini296 – 31924ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini341 – 35313CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini375 – 3795ExtracellularSequence Analysis
    Topological domaini401 – 45757CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei3 – 2321Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei30 – 5021Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei61 – 8121Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei88 – 10821Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei123 – 14321Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei248 – 26821Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei275 – 29521Helical; Name=7Sequence AnalysisAdd
    BLAST
    Transmembranei320 – 34021Helical; Name=8Sequence AnalysisAdd
    BLAST
    Transmembranei354 – 37421Helical; Name=9Sequence AnalysisAdd
    BLAST
    Transmembranei380 – 40021Helical; Name=10Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    OrthoDBiEOG73JM4H.

    Family and domain databases

    InterProiIPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR005828. Sub_transporter.
    IPR003663. Sugar/inositol_transpt.
    IPR005829. Sugar_transporter_CS.
    [Graphical view]
    PfamiPF00083. Sugar_tr. 1 hit.
    [Graphical view]
    PRINTSiPR00171. SUGRTRNSPORT.
    SUPFAMiSSF103473. SSF103473. 1 hit.
    TIGRFAMsiTIGR00879. SP. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    PS00216. SUGAR_TRANSPORT_1. 1 hit.
    PS00217. SUGAR_TRANSPORT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P40441-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGLIVSIFNI GCAIGGIVLS KVGDIYGRRI GLITVTAIYV VGILIQITSI    50
    NKWYQYFIGR IISGIGVGGI AVLSPMLISE VAPKHIRGTL VQLYQLMGTM 100
    GIFLGYCTNY GTKNYHNATQ WRVGLGLCFA WATFMVSGMM FVPESPRYLI 150
    EVGKDEEAKH SLSKSNKVSV DDPALLAEYD TIKAGIEIEK LAGNASWSEL 200
    LSTKTKVFQR VLMGVIIQSL QQLTGDNYFF YYGTTIFKSV GLKDSFQTSI 250
    IIGVVNFFSS FIAVYTIERF GRRTCLLWGA ASMLCCFAVF ASVGVTKLWP 300
    QGSSHQDITS QGAGNCMIVF TMFFIFSFAT TWAGGCFVIV SETFPLRAKS 350
    RGMAIATAAN WMWGFLISFF TPFITGAINF YYGYVFLGCL VFAYFYVFFF 400
    VPETKGLTLE EVNTMWLEGV PAWKSASWVP PERRTADYDA DAIDHDNRPI 450
    YKRFFSS 457
    Length:457
    Mass (Da):50,830
    Last modified:February 1, 1995 - v1
    Checksum:iFBEE8186BAC88B88
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46881 Genomic DNA. Translation: CAA87022.1.
    BK006942 Genomic DNA. No translation available.
    PIRiS50357.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46881 Genomic DNA. Translation: CAA87022.1 .
    BK006942 Genomic DNA. No translation available.
    PIRi S50357.

    3D structure databases

    ProteinModelPortali P40441.
    SMRi P40441. Positions 1-416.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-7421N.
    IntActi P40441. 2 interactions.
    MINTi MINT-1361084.
    STRINGi 4932.YOL156W.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    CYGDi YIL170w.
    SGDi S000001432. HXT12.

    Phylogenomic databases

    OrthoDBi EOG73JM4H.

    Gene expression databases

    Genevestigatori P40441.

    Family and domain databases

    InterProi IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR005828. Sub_transporter.
    IPR003663. Sugar/inositol_transpt.
    IPR005829. Sugar_transporter_CS.
    [Graphical view ]
    Pfami PF00083. Sugar_tr. 1 hit.
    [Graphical view ]
    PRINTSi PR00171. SUGRTRNSPORT.
    SUPFAMi SSF103473. SSF103473. 1 hit.
    TIGRFAMsi TIGR00879. SP. 1 hit.
    PROSITEi PS50850. MFS. 1 hit.
    PS00216. SUGAR_TRANSPORT_1. 1 hit.
    PS00217. SUGAR_TRANSPORT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.

    Entry informationi

    Entry nameiHXT12_YEAST
    AccessioniPrimary (citable) accession number: P40441
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Caution

    Could be the product of a pseudogene. YIL171W and YIL170W represent the N- and C-terminal of a putative transporter.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome IX
      Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

    External Data

    Dasty 3