P40441 (HXT12_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative hexose transporter 12

Gene names

Name:	HXT12
Ordered Locus Names:	YIL170W
ORF Names:	YI9402.06B

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	457 AA.
Sequence status	Complete.
Protein existence	Uncertain

General annotation (Comments)

Function	Probable glucose transporter.
Subcellular location	Membrane; Multi-pass membrane protein Probable.
Sequence similarities	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. [View classification]
Caution	Could be the product of a pseudogene. YIL171W and YIL170W represent the N- and C-terminal of a putative transporter.

Ontologies

Keywords
Biological process	Sugar transport Transport
Cellular component	Membrane
Domain	Repeat Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	carbohydrate transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	substrate-specific transmembrane transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 457	457	Putative hexose transporter 12		PRO_0000050408
Regions
	Topological domain	1 – 2	2	Cytoplasmic Potential
	Transmembrane	3 – 23	21	Helical; Name=1; Potential
	Topological domain	24 – 29	6	Extracellular Potential
	Transmembrane	30 – 50	21	Helical; Name=2; Potential
	Topological domain	51 – 60	10	Cytoplasmic Potential
	Transmembrane	61 – 81	21	Helical; Name=3; Potential
	Topological domain	82 – 87	6	Extracellular Potential
	Transmembrane	88 – 108	21	Helical; Name=4; Potential
	Topological domain	109 – 122	14	Cytoplasmic Potential
	Transmembrane	123 – 143	21	Helical; Name=5; Potential
	Topological domain	144 – 247	104	Extracellular Potential
	Transmembrane	248 – 268	21	Helical; Name=6; Potential
	Topological domain	269 – 274	6	Cytoplasmic Potential
	Transmembrane	275 – 295	21	Helical; Name=7; Potential
	Topological domain	296 – 319	24	Extracellular Potential
	Transmembrane	320 – 340	21	Helical; Name=8; Potential
	Topological domain	341 – 353	13	Cytoplasmic Potential
	Transmembrane	354 – 374	21	Helical; Name=9; Potential
	Topological domain	375 – 379	5	Extracellular Potential
	Transmembrane	380 – 400	21	Helical; Name=10; Potential
	Topological domain	401 – 457	57	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	194	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	P40441 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: FBEE8186BAC88B88	FASTA	457	50,830
	10 20 30 40 50 60 MGLIVSIFNI GCAIGGIVLS KVGDIYGRRI GLITVTAIYV VGILIQITSI NKWYQYFIGR 70 80 90 100 110 120 IISGIGVGGI AVLSPMLISE VAPKHIRGTL VQLYQLMGTM GIFLGYCTNY GTKNYHNATQ 130 140 150 160 170 180 WRVGLGLCFA WATFMVSGMM FVPESPRYLI EVGKDEEAKH SLSKSNKVSV DDPALLAEYD 190 200 210 220 230 240 TIKAGIEIEK LAGNASWSEL LSTKTKVFQR VLMGVIIQSL QQLTGDNYFF YYGTTIFKSV 250 260 270 280 290 300 GLKDSFQTSI IIGVVNFFSS FIAVYTIERF GRRTCLLWGA ASMLCCFAVF ASVGVTKLWP 310 320 330 340 350 360 QGSSHQDITS QGAGNCMIVF TMFFIFSFAT TWAGGCFVIV SETFPLRAKS RGMAIATAAN 370 380 390 400 410 420 WMWGFLISFF TPFITGAINF YYGYVFLGCL VFAYFYVFFF VPETKGLTLE EVNTMWLEGV 430 440 450 PAWKSASWVP PERRTADYDA DAIDHDNRPI YKRFFSS

References

[1]

"The nucleotide sequence of Saccharomyces cerevisiae chromosome IX." Churcher C.M., Bowman S., Badcock K., Bankier A.T., Brown D., Chillingworth T., Connor R., Devlin K., Gentles S., Hamlin N., Harris D.E., Horsnell T., Hunt S., Jagels K., Jones M., Lye G., Moule S., Odell C. , Pearson D., Rajandream M.A., Rice P., Rowley N., Skelton J., Smith V., Walsh S.V., Whitehead S., Barrell B.G. Nature 387:84-87(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z46881 Genomic DNA. Translation: CAA87022.1.
PIR	S50357.
3D structure databases
ProteinModelPortal	P40441.
SMR	P40441. Positions 1-416.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-7421N.
IntAct	P40441. 1 interaction.
MINT	MINT-1361084.
STRING	4932.YOL156W.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
CYGD	YIL170w.
SGD	S000001432. HXT12.
Phylogenomic databases
OrthoDB	EOG43246F.
Gene expression databases
ArrayExpress	P40441.
Genevestigator	P40441.
GermOnline	YOL156W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR020846. MFS_dom. IPR016196. MFS_dom_general_subst_transpt. IPR005828. Sub_transporter. IPR003663. Sugar/inositol_transpt. IPR005829. Sugar_transporter_CS. [Graphical view]
Pfam	PF00083. Sugar_tr. 1 hit. [Graphical view]
PRINTS	PR00171. SUGRTRNSPORT.
SUPFAM	SSF103473. MFS_gen_substrate_transporter. 1 hit.
TIGRFAMs	TIGR00879. SP. 1 hit.
PROSITE	PS50850. MFS. 1 hit. PS00216. SUGAR_TRANSPORT_1. 1 hit. PS00217. SUGAR_TRANSPORT_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HXT12_YEAST

Accession

Primary (citable) accession number: P40441

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	May 1, 2013
This is version 95 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program