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Protein

60S ribosomal protein L13a

Gene

RPL13A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex. Involved in methylation of rRNA.4 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein
Biological processTranslation regulation

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
SIGNORiP40429

Protein family/group databases

MoonProtiP40429

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L13a
Alternative name(s):
23 kDa highly basic protein
Large ribosomal subunit protein uL131 Publication
Gene namesi
Name:RPL13A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000142541.16
HGNCiHGNC:10304 RPL13A
neXtProtiNX_P40429

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi77S → A: Loss of interferon-gamma induced phosphorylation. 1 Publication1

Organism-specific databases

DisGeNETi23521
OpenTargetsiENSG00000142541
PharmGKBiPA38122

Chemistry databases

DrugBankiDB02494 Alpha-Hydroxy-Beta-Phenyl-Propionic Acid
DB07374 Anisomycin
DB08437 Puromycin

Polymorphism and mutation databases

BioMutaiRPL13A
DMDMi730451

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources3 Publications
ChainiPRO_00001337692 – 20360S ribosomal protein L13aAdd BLAST202

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources3 Publications1
Modified residuei59CitrullineBy similarity1
Modified residuei77Phosphoserine; by ZIPK/DAPK31 Publication1
Modified residuei140CitrullineBy similarity1
Modified residuei191N6-acetyllysineCombined sources1

Post-translational modificationi

Phosphorylation at Ser-77 upon interferon-gamma treatment in monocytes involves a DAPK1-DAPK3 kinase cascade and is causing release from the ribosome, association with the GAIT complex and subsequent involvement in transcript-selective translation inhibition.2 Publications
Citrullinated by PADI4.By similarity

Keywords - PTMi

Acetylation, Citrullination, Phosphoprotein

Proteomic databases

EPDiP40429
MaxQBiP40429
PaxDbiP40429
PeptideAtlasiP40429
PRIDEiP40429
TopDownProteomicsiP40429

PTM databases

iPTMnetiP40429
PhosphoSitePlusiP40429
SwissPalmiP40429

Expressioni

Gene expression databases

BgeeiENSG00000142541
CleanExiHS_RPL13A
ExpressionAtlasiP40429 baseline and differential
GenevisibleiP40429 HS

Organism-specific databases

HPAiHPA038751

Interactioni

Subunit structurei

Component of the 60S ribosome. Component of the GAIT complex. Interacts with EIF4G1.1 Publication3 Publications

Protein-protein interaction databases

BioGridi117068, 142 interactors
CORUMiP40429
IntActiP40429, 51 interactors
MINTiP40429
STRINGi9606.ENSP00000375730

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-LO1-203[»]
4V6Xelectron microscopy5.00CO1-203[»]
5AJ0electron microscopy3.50AO1-203[»]
5LKSelectron microscopy3.60LO1-203[»]
5T2Celectron microscopy3.60I1-203[»]
6EK0electron microscopy2.90LO1-203[»]
ProteinModelPortaliP40429
SMRiP40429
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3204 Eukaryota
COG0102 LUCA
GeneTreeiENSGT00390000010799
HOGENOMiHOG000225289
HOVERGENiHBG062176
InParanoidiP40429
KOiK02872
PhylomeDBiP40429
TreeFamiTF300159

Family and domain databases

CDDicd00392 Ribosomal_L13, 1 hit
Gene3Di3.90.1180.10, 1 hit
HAMAPiMF_01366 Ribosomal_L13, 1 hit
InterProiView protein in InterPro
IPR005822 Ribosomal_L13
IPR023563 Ribosomal_L13_CS
IPR005755 Ribosomal_L13_euk/arc
IPR036899 Ribosomal_L13_sf
PANTHERiPTHR11545 PTHR11545, 1 hit
PTHR11545:SF3 PTHR11545:SF3, 1 hit
PfamiView protein in Pfam
PF00572 Ribosomal_L13, 1 hit
PIRSFiPIRSF002181 Ribosomal_L13, 1 hit
SUPFAMiSSF52161 SSF52161, 1 hit
TIGRFAMsiTIGR01077 L13_A_E, 1 hit
PROSITEiView protein in PROSITE
PS00783 RIBOSOMAL_L13, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P40429-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEVQVLVLD GRGHLLGRLA AIVAKQVLLG RKVVVVRCEG INISGNFYRN
60 70 80 90 100
KLKYLAFLRK RMNTNPSRGP YHFRAPSRIF WRTVRGMLPH KTKRGQAALD
110 120 130 140 150
RLKVFDGIPP PYDKKKRMVV PAALKVVRLK PTRKFAYLGR LAHEVGWKYQ
160 170 180 190 200
AVTATLEEKR KEKAKIHYRK KKQLMRLRKQ AEKNVEKKID KYTEVLKTHG

LLV
Length:203
Mass (Da):23,577
Last modified:January 23, 2007 - v2
Checksum:i3E80D0AB77A0D406
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56932 mRNA Translation: CAA40254.1
AB028893 Genomic DNA Translation: BAA88214.1
AK291120 mRNA Translation: BAF83809.1
CH471177 Genomic DNA Translation: EAW52495.1
BC000514 mRNA Translation: AAH00514.1
BC001675 mRNA Translation: AAH01675.1
BC001836 mRNA Translation: AAH01836.1
BC062537 mRNA Translation: AAH62537.1
BC065236 mRNA Translation: AAH65236.1
BC070223 mRNA Translation: AAH70223.1
BC071929 mRNA Translation: AAH71929.1
CCDSiCCDS12768.1
PIRiS29539
RefSeqiNP_001257420.1, NM_001270491.1
NP_036555.1, NM_012423.3
UniGeneiHs.523185

Genome annotation databases

EnsembliENST00000391857; ENSP00000375730; ENSG00000142541
GeneIDi23521
KEGGihsa:23521
UCSCiuc002pny.5 human

Similar proteinsi

Entry informationi

Entry nameiRL13A_HUMAN
AccessioniPrimary (citable) accession number: P40429
Secondary accession number(s): A8K505
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 175 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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