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P40426 (PBX3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 137. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pre-B-cell leukemia transcription factor 3
Alternative name(s):
Homeobox protein PBX3
Gene names
Name:PBX3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length434 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'.

Subunit structure

Interacts with PBXIP1. Ref.7

Subcellular location

Nucleus Probable.

Tissue specificity

Ubiquitously expressed.

Sequence similarities

Belongs to the TALE/PBX homeobox family.

Contains 1 homeobox DNA-binding domain.

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]
Isoform PBX3a (identifier: P40426-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform PBX3b (identifier: P40426-2)

The sequence of this isoform differs from the canonical sequence as follows:
     338-351: SSGSFNLPNSGDMF → GYPPSCYQSDGRLQ
     352-434: Missing.
Isoform PBX3c (identifier: P40426-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-181: Missing.
Isoform PBX3d (identifier: P40426-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-181: Missing.
     338-351: SSGSFNLPNSGDMF → GYPPSCYQSDGRLQ
     352-434: Missing.
Isoform 5 (identifier: P40426-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-75: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 434434Pre-B-cell leukemia transcription factor 3
PRO_0000049239

Regions

DNA binding235 – 29763Homeobox; TALE-type
Compositional bias130 – 1389Poly-Ala

Natural variations

Alternative sequence1 – 181181Missing in isoform PBX3c and isoform PBX3d.
VSP_002275
Alternative sequence1 – 7575Missing in isoform 5.
VSP_046311
Alternative sequence338 – 35114SSGSF…SGDMF → GYPPSCYQSDGRLQ in isoform PBX3b and isoform PBX3d.
VSP_002276
Alternative sequence352 – 43483Missing in isoform PBX3b and isoform PBX3d.
VSP_002277

Experimental info

Sequence conflict3231V → A in AAL09477. Ref.2
Sequence conflict3981Y → C in AAL09477. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform PBX3a [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 81987E4C80C22069

FASTA43447,190
        10         20         30         40         50         60 
MDDQSRMLQT LAGVNLAGHS VQGGMALPPP PHGHEGADGD GRKQDIGDIL HQIMTITDQS 

        70         80         90        100        110        120 
LDEAQAKKHA LNCHRMKPAL FSVLCEIKEK TGLSIRGAQE EDPPDPQLMR LDNMLLAEGV 

       130        140        150        160        170        180 
SGPEKGGGSA AAAAAAAASG GSSDNSIEHS DYRAKLTQIR QIYHTELEKY EQACNEFTTH 

       190        200        210        220        230        240 
VMNLLREQSR TRPISPKEIE RMVGIIHRKF SSIQMQLKQS TCEAVMILRS RFLDARRKRR 

       250        260        270        280        290        300 
NFSKQATEIL NEYFYSHLSN PYPSEEAKEE LAKKCSITVS QVSNWFGNKR IRYKKNIGKF 

       310        320        330        340        350        360 
QEEANLYAAK TAVTAAHAVA AAVQNNQTNS PTTPNSGSSG SFNLPNSGDM FMNMQSLNGD 

       370        380        390        400        410        420 
SYQGSQVGAN VQSQVDTLRH VINQTGGYSD GLGGNSLYSP HNLNANGGWQ DATTPSSVTS 

       430 
PTEGPGSVHS DTSN 

« Hide

Isoform PBX3b [UniParc].

Checksum: D9ACD64E34DF2C4D
Show »

FASTA35138,767
Isoform PBX3c [UniParc].

Checksum: B143A4C0AD1ECE9B
Show »

FASTA25327,842
Isoform PBX3d [UniParc].

Checksum: 1569EF6D0CFF6DFB
Show »

FASTA17019,419
Isoform 5 [UniParc].

Checksum: 0DDC2CEC05DCE51A
Show »

FASTA35939,175

References

« Hide 'large scale' references
[1]"PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1."
Monica K., Galili N., Nourse J., Saltman D., Cleary M.L.
Mol. Cell. Biol. 11:6149-6157(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS PBX3A AND PBX3B).
[2]"Novel alternative PBX3 isoforms in leukemia cells with distinct interaction specificities."
Milech N., Kees U.R., Watt P.M.
Genes Chromosomes Cancer 32:275-280(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS PBX3C AND PBX3D).
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS PBX3C AND 5).
Tissue: Adrenal gland and Teratocarcinoma.
[4]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM PBX3A).
Tissue: Blood.
[6]"Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation."
Lu Q., Wright D.D., Kamps M.P.
Mol. Cell. Biol. 14:3938-3948(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[7]"Functional cloning and characterization of a novel nonhomeodomain protein that inhibits the binding of PBX1-HOX complexes to DNA."
Abramovich C., Shen W.-F., Pineault N., Imren S., Montpetit B., Largman C., Humphries R.K.
J. Biol. Chem. 275:26172-26177(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH PBXIP1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X59841 mRNA. Translation: CAA42502.1.
AF355141 mRNA. Translation: AAL09477.1.
AF355142 mRNA. Translation: AAL09478.1.
AK289376 mRNA. Translation: BAF82065.1.
AK309713 mRNA. No translation available.
AL358074, AL445186 Genomic DNA. Translation: CAH73695.1.
AL445186, AL358074 Genomic DNA. Translation: CAI40243.1.
AL445186 Genomic DNA. Translation: CAI40245.1.
AL445186 Genomic DNA. Translation: CAI40244.1.
AL627303 Genomic DNA. No translation available.
BC094883 mRNA. Translation: AAH94883.1.
CCDSCCDS48021.1. [P40426-5]
CCDS6865.1. [P40426-1]
PIRS19010.
RefSeqNP_001128250.1. NM_001134778.1. [P40426-5]
NP_006186.1. NM_006195.5. [P40426-1]
XP_006717195.1. XM_006717132.1. [P40426-2]
UniGeneHs.428027.

3D structure databases

ProteinModelPortalP40426.
SMRP40426. Positions 235-307.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid111123. 5 interactions.
IntActP40426. 2 interactions.
STRING9606.ENSP00000362588.

PTM databases

PhosphoSiteP40426.

Polymorphism databases

DMDM730281.

Proteomic databases

MaxQBP40426.
PaxDbP40426.
PRIDEP40426.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000342287; ENSP00000341990; ENSG00000167081. [P40426-2]
ENST00000373483; ENSP00000362582; ENSG00000167081. [P40426-3]
ENST00000373489; ENSP00000362588; ENSG00000167081. [P40426-1]
ENST00000447726; ENSP00000387456; ENSG00000167081. [P40426-5]
GeneID5090.
KEGGhsa:5090.
UCSCuc004bqb.3. human. [P40426-1]
uc004bqd.3. human. [P40426-4]

Organism-specific databases

CTD5090.
GeneCardsGC09P128511.
HGNCHGNC:8634. PBX3.
HPAHPA003505.
MIM176312. gene.
neXtProtNX_P40426.
PharmGKBPA32972.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG248144.
HOGENOMHOG000266972.
HOVERGENHBG000122.
KOK15610.
OrthoDBEOG75XGM1.
PhylomeDBP40426.
TreeFamTF314340.

Gene expression databases

ArrayExpressP40426.
BgeeP40426.
CleanExHS_PBX3.
GenevestigatorP40426.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR005542. PBX.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
PF03792. PBC. 1 hit.
[Graphical view]
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPBX3. human.
GeneWikiPBX3.
GenomeRNAi5090.
NextBio19628.
PROP40426.
SOURCESearch...

Entry information

Entry namePBX3_HUMAN
AccessionPrimary (citable) accession number: P40426
Secondary accession number(s): E9PB27 expand/collapse secondary AC list , Q5JSA0, Q5JSA1, Q5VXL3, Q96PF9, Q96PG0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: July 9, 2014
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM