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P40426

- PBX3_HUMAN

UniProt

P40426 - PBX3_HUMAN

Protein

Pre-B-cell leukemia transcription factor 3

Gene

PBX3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 138 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi235 – 29763Homeobox; TALE-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: Ensembl
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. adult locomotory behavior Source: Ensembl
    2. anterior compartment pattern formation Source: ProtInc
    3. dorsal spinal cord development Source: Ensembl
    4. neuron development Source: Ensembl
    5. posterior compartment specification Source: ProtInc
    6. regulation of respiratory gaseous exchange by neurological system process Source: Ensembl
    7. respiratory gaseous exchange Source: Ensembl
    8. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pre-B-cell leukemia transcription factor 3
    Alternative name(s):
    Homeobox protein PBX3
    Gene namesi
    Name:PBX3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:8634. PBX3.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    2. transcription factor complex Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32972.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 434434Pre-B-cell leukemia transcription factor 3PRO_0000049239Add
    BLAST

    Proteomic databases

    MaxQBiP40426.
    PaxDbiP40426.
    PRIDEiP40426.

    PTM databases

    PhosphoSiteiP40426.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed.

    Gene expression databases

    ArrayExpressiP40426.
    BgeeiP40426.
    CleanExiHS_PBX3.
    GenevestigatoriP40426.

    Organism-specific databases

    HPAiHPA003505.

    Interactioni

    Subunit structurei

    Interacts with PBXIP1.1 Publication

    Protein-protein interaction databases

    BioGridi111123. 5 interactions.
    IntActiP40426. 2 interactions.
    STRINGi9606.ENSP00000362588.

    Structurei

    3D structure databases

    ProteinModelPortaliP40426.
    SMRiP40426. Positions 235-307.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi130 – 1389Poly-Ala

    Sequence similaritiesi

    Belongs to the TALE/PBX homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG248144.
    HOGENOMiHOG000266972.
    HOVERGENiHBG000122.
    KOiK15610.
    OrthoDBiEOG75XGM1.
    PhylomeDBiP40426.
    TreeFamiTF314340.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR005542. PBX.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF03792. PBC. 1 hit.
    [Graphical view]
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform PBX3a (identifier: P40426-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDDQSRMLQT LAGVNLAGHS VQGGMALPPP PHGHEGADGD GRKQDIGDIL    50
    HQIMTITDQS LDEAQAKKHA LNCHRMKPAL FSVLCEIKEK TGLSIRGAQE 100
    EDPPDPQLMR LDNMLLAEGV SGPEKGGGSA AAAAAAAASG GSSDNSIEHS 150
    DYRAKLTQIR QIYHTELEKY EQACNEFTTH VMNLLREQSR TRPISPKEIE 200
    RMVGIIHRKF SSIQMQLKQS TCEAVMILRS RFLDARRKRR NFSKQATEIL 250
    NEYFYSHLSN PYPSEEAKEE LAKKCSITVS QVSNWFGNKR IRYKKNIGKF 300
    QEEANLYAAK TAVTAAHAVA AAVQNNQTNS PTTPNSGSSG SFNLPNSGDM 350
    FMNMQSLNGD SYQGSQVGAN VQSQVDTLRH VINQTGGYSD GLGGNSLYSP 400
    HNLNANGGWQ DATTPSSVTS PTEGPGSVHS DTSN 434
    Length:434
    Mass (Da):47,190
    Last modified:February 1, 1995 - v1
    Checksum:i81987E4C80C22069
    GO
    Isoform PBX3b (identifier: P40426-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         338-351: SSGSFNLPNSGDMF → GYPPSCYQSDGRLQ
         352-434: Missing.

    Show »
    Length:351
    Mass (Da):38,767
    Checksum:iD9ACD64E34DF2C4D
    GO
    Isoform PBX3c (identifier: P40426-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-181: Missing.

    Show »
    Length:253
    Mass (Da):27,842
    Checksum:iB143A4C0AD1ECE9B
    GO
    Isoform PBX3d (identifier: P40426-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-181: Missing.
         338-351: SSGSFNLPNSGDMF → GYPPSCYQSDGRLQ
         352-434: Missing.

    Show »
    Length:170
    Mass (Da):19,419
    Checksum:i1569EF6D0CFF6DFB
    GO
    Isoform 5 (identifier: P40426-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-75: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:359
    Mass (Da):39,175
    Checksum:i0DDC2CEC05DCE51A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti323 – 3231V → A in AAL09477. (PubMed:11579467)Curated
    Sequence conflicti398 – 3981Y → C in AAL09477. (PubMed:11579467)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 181181Missing in isoform PBX3c and isoform PBX3d. 2 PublicationsVSP_002275Add
    BLAST
    Alternative sequencei1 – 7575Missing in isoform 5. 1 PublicationVSP_046311Add
    BLAST
    Alternative sequencei338 – 35114SSGSF…SGDMF → GYPPSCYQSDGRLQ in isoform PBX3b and isoform PBX3d. 2 PublicationsVSP_002276Add
    BLAST
    Alternative sequencei352 – 43483Missing in isoform PBX3b and isoform PBX3d. 2 PublicationsVSP_002277Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59841 mRNA. Translation: CAA42502.1.
    AF355141 mRNA. Translation: AAL09477.1.
    AF355142 mRNA. Translation: AAL09478.1.
    AK289376 mRNA. Translation: BAF82065.1.
    AK309713 mRNA. No translation available.
    AL358074, AL445186 Genomic DNA. Translation: CAH73695.1.
    AL445186, AL358074 Genomic DNA. Translation: CAI40243.1.
    AL445186 Genomic DNA. Translation: CAI40245.1.
    AL445186 Genomic DNA. Translation: CAI40244.1.
    AL627303 Genomic DNA. No translation available.
    BC094883 mRNA. Translation: AAH94883.1.
    CCDSiCCDS48021.1. [P40426-5]
    CCDS6865.1. [P40426-1]
    PIRiS19010.
    RefSeqiNP_001128250.1. NM_001134778.1. [P40426-5]
    NP_006186.1. NM_006195.5. [P40426-1]
    XP_006717195.1. XM_006717132.1. [P40426-2]
    UniGeneiHs.428027.

    Genome annotation databases

    EnsembliENST00000342287; ENSP00000341990; ENSG00000167081. [P40426-2]
    ENST00000373489; ENSP00000362588; ENSG00000167081. [P40426-1]
    ENST00000447726; ENSP00000387456; ENSG00000167081. [P40426-5]
    GeneIDi5090.
    KEGGihsa:5090.
    UCSCiuc004bqb.3. human. [P40426-1]
    uc004bqd.3. human. [P40426-4]

    Polymorphism databases

    DMDMi730281.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59841 mRNA. Translation: CAA42502.1 .
    AF355141 mRNA. Translation: AAL09477.1 .
    AF355142 mRNA. Translation: AAL09478.1 .
    AK289376 mRNA. Translation: BAF82065.1 .
    AK309713 mRNA. No translation available.
    AL358074 , AL445186 Genomic DNA. Translation: CAH73695.1 .
    AL445186 , AL358074 Genomic DNA. Translation: CAI40243.1 .
    AL445186 Genomic DNA. Translation: CAI40245.1 .
    AL445186 Genomic DNA. Translation: CAI40244.1 .
    AL627303 Genomic DNA. No translation available.
    BC094883 mRNA. Translation: AAH94883.1 .
    CCDSi CCDS48021.1. [P40426-5 ]
    CCDS6865.1. [P40426-1 ]
    PIRi S19010.
    RefSeqi NP_001128250.1. NM_001134778.1. [P40426-5 ]
    NP_006186.1. NM_006195.5. [P40426-1 ]
    XP_006717195.1. XM_006717132.1. [P40426-2 ]
    UniGenei Hs.428027.

    3D structure databases

    ProteinModelPortali P40426.
    SMRi P40426. Positions 235-307.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111123. 5 interactions.
    IntActi P40426. 2 interactions.
    STRINGi 9606.ENSP00000362588.

    PTM databases

    PhosphoSitei P40426.

    Polymorphism databases

    DMDMi 730281.

    Proteomic databases

    MaxQBi P40426.
    PaxDbi P40426.
    PRIDEi P40426.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000342287 ; ENSP00000341990 ; ENSG00000167081 . [P40426-2 ]
    ENST00000373489 ; ENSP00000362588 ; ENSG00000167081 . [P40426-1 ]
    ENST00000447726 ; ENSP00000387456 ; ENSG00000167081 . [P40426-5 ]
    GeneIDi 5090.
    KEGGi hsa:5090.
    UCSCi uc004bqb.3. human. [P40426-1 ]
    uc004bqd.3. human. [P40426-4 ]

    Organism-specific databases

    CTDi 5090.
    GeneCardsi GC09P128511.
    HGNCi HGNC:8634. PBX3.
    HPAi HPA003505.
    MIMi 176312. gene.
    neXtProti NX_P40426.
    PharmGKBi PA32972.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG248144.
    HOGENOMi HOG000266972.
    HOVERGENi HBG000122.
    KOi K15610.
    OrthoDBi EOG75XGM1.
    PhylomeDBi P40426.
    TreeFami TF314340.

    Miscellaneous databases

    ChiTaRSi PBX3. human.
    GeneWikii PBX3.
    GenomeRNAii 5090.
    NextBioi 19628.
    PROi P40426.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P40426.
    Bgeei P40426.
    CleanExi HS_PBX3.
    Genevestigatori P40426.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR005542. PBX.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF03792. PBC. 1 hit.
    [Graphical view ]
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1."
      Monica K., Galili N., Nourse J., Saltman D., Cleary M.L.
      Mol. Cell. Biol. 11:6149-6157(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS PBX3A AND PBX3B).
    2. "Novel alternative PBX3 isoforms in leukemia cells with distinct interaction specificities."
      Milech N., Kees U.R., Watt P.M.
      Genes Chromosomes Cancer 32:275-280(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS PBX3C AND PBX3D).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS PBX3C AND 5).
      Tissue: Adrenal gland and Teratocarcinoma.
    4. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM PBX3A).
      Tissue: Blood.
    6. "Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation."
      Lu Q., Wright D.D., Kamps M.P.
      Mol. Cell. Biol. 14:3938-3948(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    7. "Functional cloning and characterization of a novel nonhomeodomain protein that inhibits the binding of PBX1-HOX complexes to DNA."
      Abramovich C., Shen W.-F., Pineault N., Imren S., Montpetit B., Largman C., Humphries R.K.
      J. Biol. Chem. 275:26172-26177(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PBXIP1.

    Entry informationi

    Entry nameiPBX3_HUMAN
    AccessioniPrimary (citable) accession number: P40426
    Secondary accession number(s): E9PB27
    , Q5JSA0, Q5JSA1, Q5VXL3, Q96PF9, Q96PG0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 138 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3