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P40426

- PBX3_HUMAN

UniProt

P40426 - PBX3_HUMAN

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Protein
Pre-B-cell leukemia transcription factor 3
Gene
PBX3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi235 – 29763Homeobox; TALE-type
Add
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: Ensembl
  2. sequence-specific DNA binding transcription factor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. adult locomotory behavior Source: Ensembl
  2. anterior compartment pattern formation Source: ProtInc
  3. dorsal spinal cord development Source: Ensembl
  4. neuron development Source: Ensembl
  5. posterior compartment specification Source: ProtInc
  6. regulation of respiratory gaseous exchange by neurological system process Source: Ensembl
  7. respiratory gaseous exchange Source: Ensembl
  8. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-B-cell leukemia transcription factor 3
Alternative name(s):
Homeobox protein PBX3
Gene namesi
Name:PBX3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:8634. PBX3.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
  2. transcription factor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32972.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 434434Pre-B-cell leukemia transcription factor 3
PRO_0000049239Add
BLAST

Proteomic databases

MaxQBiP40426.
PaxDbiP40426.
PRIDEiP40426.

PTM databases

PhosphoSiteiP40426.

Expressioni

Tissue specificityi

Ubiquitously expressed.

Gene expression databases

ArrayExpressiP40426.
BgeeiP40426.
CleanExiHS_PBX3.
GenevestigatoriP40426.

Organism-specific databases

HPAiHPA003505.

Interactioni

Subunit structurei

Interacts with PBXIP1.1 Publication

Protein-protein interaction databases

BioGridi111123. 5 interactions.
IntActiP40426. 2 interactions.
STRINGi9606.ENSP00000362588.

Structurei

3D structure databases

ProteinModelPortaliP40426.
SMRiP40426. Positions 235-307.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi130 – 1389Poly-Ala

Sequence similaritiesi

Belongs to the TALE/PBX homeobox family.

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG248144.
HOGENOMiHOG000266972.
HOVERGENiHBG000122.
KOiK15610.
OrthoDBiEOG75XGM1.
PhylomeDBiP40426.
TreeFamiTF314340.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR005542. PBX.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03792. PBC. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform PBX3a (identifier: P40426-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDDQSRMLQT LAGVNLAGHS VQGGMALPPP PHGHEGADGD GRKQDIGDIL    50
HQIMTITDQS LDEAQAKKHA LNCHRMKPAL FSVLCEIKEK TGLSIRGAQE 100
EDPPDPQLMR LDNMLLAEGV SGPEKGGGSA AAAAAAAASG GSSDNSIEHS 150
DYRAKLTQIR QIYHTELEKY EQACNEFTTH VMNLLREQSR TRPISPKEIE 200
RMVGIIHRKF SSIQMQLKQS TCEAVMILRS RFLDARRKRR NFSKQATEIL 250
NEYFYSHLSN PYPSEEAKEE LAKKCSITVS QVSNWFGNKR IRYKKNIGKF 300
QEEANLYAAK TAVTAAHAVA AAVQNNQTNS PTTPNSGSSG SFNLPNSGDM 350
FMNMQSLNGD SYQGSQVGAN VQSQVDTLRH VINQTGGYSD GLGGNSLYSP 400
HNLNANGGWQ DATTPSSVTS PTEGPGSVHS DTSN 434
Length:434
Mass (Da):47,190
Last modified:February 1, 1995 - v1
Checksum:i81987E4C80C22069
GO
Isoform PBX3b (identifier: P40426-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     338-351: SSGSFNLPNSGDMF → GYPPSCYQSDGRLQ
     352-434: Missing.

Show »
Length:351
Mass (Da):38,767
Checksum:iD9ACD64E34DF2C4D
GO
Isoform PBX3c (identifier: P40426-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-181: Missing.

Show »
Length:253
Mass (Da):27,842
Checksum:iB143A4C0AD1ECE9B
GO
Isoform PBX3d (identifier: P40426-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-181: Missing.
     338-351: SSGSFNLPNSGDMF → GYPPSCYQSDGRLQ
     352-434: Missing.

Show »
Length:170
Mass (Da):19,419
Checksum:i1569EF6D0CFF6DFB
GO
Isoform 5 (identifier: P40426-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-75: Missing.

Note: No experimental confirmation available.

Show »
Length:359
Mass (Da):39,175
Checksum:i0DDC2CEC05DCE51A
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 181181Missing in isoform PBX3c and isoform PBX3d.
VSP_002275Add
BLAST
Alternative sequencei1 – 7575Missing in isoform 5.
VSP_046311Add
BLAST
Alternative sequencei338 – 35114SSGSF…SGDMF → GYPPSCYQSDGRLQ in isoform PBX3b and isoform PBX3d.
VSP_002276Add
BLAST
Alternative sequencei352 – 43483Missing in isoform PBX3b and isoform PBX3d.
VSP_002277Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti323 – 3231V → A in AAL09477. 1 Publication
Sequence conflicti398 – 3981Y → C in AAL09477. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59841 mRNA. Translation: CAA42502.1.
AF355141 mRNA. Translation: AAL09477.1.
AF355142 mRNA. Translation: AAL09478.1.
AK289376 mRNA. Translation: BAF82065.1.
AK309713 mRNA. No translation available.
AL358074, AL445186 Genomic DNA. Translation: CAH73695.1.
AL445186, AL358074 Genomic DNA. Translation: CAI40243.1.
AL445186 Genomic DNA. Translation: CAI40245.1.
AL445186 Genomic DNA. Translation: CAI40244.1.
AL627303 Genomic DNA. No translation available.
BC094883 mRNA. Translation: AAH94883.1.
CCDSiCCDS48021.1. [P40426-5]
CCDS6865.1. [P40426-1]
PIRiS19010.
RefSeqiNP_001128250.1. NM_001134778.1. [P40426-5]
NP_006186.1. NM_006195.5. [P40426-1]
XP_006717195.1. XM_006717132.1. [P40426-2]
UniGeneiHs.428027.

Genome annotation databases

EnsembliENST00000342287; ENSP00000341990; ENSG00000167081. [P40426-2]
ENST00000373483; ENSP00000362582; ENSG00000167081. [P40426-3]
ENST00000373489; ENSP00000362588; ENSG00000167081. [P40426-1]
ENST00000447726; ENSP00000387456; ENSG00000167081. [P40426-5]
GeneIDi5090.
KEGGihsa:5090.
UCSCiuc004bqb.3. human. [P40426-1]
uc004bqd.3. human. [P40426-4]

Polymorphism databases

DMDMi730281.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59841 mRNA. Translation: CAA42502.1 .
AF355141 mRNA. Translation: AAL09477.1 .
AF355142 mRNA. Translation: AAL09478.1 .
AK289376 mRNA. Translation: BAF82065.1 .
AK309713 mRNA. No translation available.
AL358074 , AL445186 Genomic DNA. Translation: CAH73695.1 .
AL445186 , AL358074 Genomic DNA. Translation: CAI40243.1 .
AL445186 Genomic DNA. Translation: CAI40245.1 .
AL445186 Genomic DNA. Translation: CAI40244.1 .
AL627303 Genomic DNA. No translation available.
BC094883 mRNA. Translation: AAH94883.1 .
CCDSi CCDS48021.1. [P40426-5 ]
CCDS6865.1. [P40426-1 ]
PIRi S19010.
RefSeqi NP_001128250.1. NM_001134778.1. [P40426-5 ]
NP_006186.1. NM_006195.5. [P40426-1 ]
XP_006717195.1. XM_006717132.1. [P40426-2 ]
UniGenei Hs.428027.

3D structure databases

ProteinModelPortali P40426.
SMRi P40426. Positions 235-307.
ModBasei Search...

Protein-protein interaction databases

BioGridi 111123. 5 interactions.
IntActi P40426. 2 interactions.
STRINGi 9606.ENSP00000362588.

PTM databases

PhosphoSitei P40426.

Polymorphism databases

DMDMi 730281.

Proteomic databases

MaxQBi P40426.
PaxDbi P40426.
PRIDEi P40426.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000342287 ; ENSP00000341990 ; ENSG00000167081 . [P40426-2 ]
ENST00000373483 ; ENSP00000362582 ; ENSG00000167081 . [P40426-3 ]
ENST00000373489 ; ENSP00000362588 ; ENSG00000167081 . [P40426-1 ]
ENST00000447726 ; ENSP00000387456 ; ENSG00000167081 . [P40426-5 ]
GeneIDi 5090.
KEGGi hsa:5090.
UCSCi uc004bqb.3. human. [P40426-1 ]
uc004bqd.3. human. [P40426-4 ]

Organism-specific databases

CTDi 5090.
GeneCardsi GC09P128511.
HGNCi HGNC:8634. PBX3.
HPAi HPA003505.
MIMi 176312. gene.
neXtProti NX_P40426.
PharmGKBi PA32972.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG248144.
HOGENOMi HOG000266972.
HOVERGENi HBG000122.
KOi K15610.
OrthoDBi EOG75XGM1.
PhylomeDBi P40426.
TreeFami TF314340.

Miscellaneous databases

ChiTaRSi PBX3. human.
GeneWikii PBX3.
GenomeRNAii 5090.
NextBioi 19628.
PROi P40426.
SOURCEi Search...

Gene expression databases

ArrayExpressi P40426.
Bgeei P40426.
CleanExi HS_PBX3.
Genevestigatori P40426.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR005542. PBX.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF03792. PBC. 1 hit.
[Graphical view ]
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1."
    Monica K., Galili N., Nourse J., Saltman D., Cleary M.L.
    Mol. Cell. Biol. 11:6149-6157(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS PBX3A AND PBX3B).
  2. "Novel alternative PBX3 isoforms in leukemia cells with distinct interaction specificities."
    Milech N., Kees U.R., Watt P.M.
    Genes Chromosomes Cancer 32:275-280(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS PBX3C AND PBX3D).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS PBX3C AND 5).
    Tissue: Adrenal gland and Teratocarcinoma.
  4. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM PBX3A).
    Tissue: Blood.
  6. "Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation."
    Lu Q., Wright D.D., Kamps M.P.
    Mol. Cell. Biol. 14:3938-3948(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  7. "Functional cloning and characterization of a novel nonhomeodomain protein that inhibits the binding of PBX1-HOX complexes to DNA."
    Abramovich C., Shen W.-F., Pineault N., Imren S., Montpetit B., Largman C., Humphries R.K.
    J. Biol. Chem. 275:26172-26177(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PBXIP1.

Entry informationi

Entry nameiPBX3_HUMAN
AccessioniPrimary (citable) accession number: P40426
Secondary accession number(s): E9PB27
, Q5JSA0, Q5JSA1, Q5VXL3, Q96PF9, Q96PG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: July 9, 2014
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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