SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P40425

- PBX2_HUMAN

UniProt

P40425 - PBX2_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Pre-B-cell leukemia transcription factor 2
Gene
PBX2, G17
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'. Activates transcription of PF4 in complex with MEIS1.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi244 – 30663Homeobox; TALE-type
Add
BLAST

GO - Molecular functioni

  1. chromatin binding Source: Ensembl
  2. sequence-specific DNA binding Source: Ensembl
  3. sequence-specific DNA binding transcription factor activity Source: Ensembl
  4. transcription factor binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. embryonic limb morphogenesis Source: Ensembl
  2. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  3. proximal/distal pattern formation Source: Ensembl
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-B-cell leukemia transcription factor 2
Alternative name(s):
Homeobox protein PBX2
Protein G17
Gene namesi
Name:PBX2
Synonyms:G17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:8633. PBX2.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB
  2. transcription factor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32971.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 430430Pre-B-cell leukemia transcription factor 2
PRO_0000049237Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei151 – 1511Phosphoserine3 Publications
Modified residuei330 – 3301Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP40425.
PaxDbiP40425.
PRIDEiP40425.

PTM databases

PhosphoSiteiP40425.

Expressioni

Tissue specificityi

Ubiquitously expressed.

Gene expression databases

BgeeiP40425.
CleanExiHS_PBX2.
GenevestigatoriP40425.

Organism-specific databases

HPAiHPA054000.
HPA061478.

Interactioni

Subunit structurei

Forms heterodimers with MEIS1 and heterotrimers with MEIS1 and HOXA9. Interacts with PBXIP1.2 Publications

Protein-protein interaction databases

BioGridi111122. 3 interactions.
IntActiP40425. 20 interactions.
MINTiMINT-1032522.
STRINGi9606.ENSP00000397177.

Structurei

3D structure databases

ProteinModelPortaliP40425.
SMRiP40425. Positions 244-316.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi137 – 1459Poly-Ala

Sequence similaritiesi

Belongs to the TALE/PBX homeobox family.

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG248144.
HOVERGENiHBG000122.
InParanoidiP40425.
KOiK15609.
OMAiGQIYSPR.
OrthoDBiEOG75XGM1.
PhylomeDBiP40425.
TreeFamiTF314340.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR005542. PBX.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03792. PBC. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40425-1 [UniParc]FASTAAdd to Basket

« Hide

MDERLLGPPP PGGGRGGLGL VSGEPGGPGE PPGGGDPGGG SGGVPGGRGK    50
QDIGDILQQI MTITDQSLDE AQAKKHALNC HRMKPALFSV LCEIKEKTGL 100
SIRSSQEEEP VDPQLMRLDN MLLAEGVAGP EKGGGSAAAA AAAAASGGGV 150
SPDNSIEHSD YRSKLAQIRH IYHSELEKYE QACNEFTTHV MNLLREQSRT 200
RPVAPKEMER MVSIIHRKFS AIQMQLKQST CEAVMILRSR FLDARRKRRN 250
FSKQATEVLN EYFYSHLSNP YPSEEAKEEL AKKCGITVSQ VSNWFGNKRI 300
RYKKNIGKFQ EEANIYAVKT AVSVTQGGHS RTSSPTPPSS AGSGGSFNLS 350
GSGDMFLGMP GLNGDSYSAS QVESLRHSMG PGGYGDNLGG GQMYSPREMR 400
ANGSWQEAVT PSSVTSPTEG PGSVHSDTSN 430
Length:430
Mass (Da):45,881
Last modified:February 1, 1996 - v2
Checksum:iEF2FFA158C4DAF68
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti393 – 3931M → I in CAA42503. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59842 mRNA. Translation: CAA42503.1.
X80700 Genomic DNA. Translation: CAA56717.1.
D28769 Genomic DNA. Translation: BAA05957.1.
U89336 Genomic DNA. Translation: AAB47490.1.
AL662884 Genomic DNA. Translation: CAI18358.1.
AL662830 Genomic DNA. Translation: CAI17539.1.
AL845464 Genomic DNA. Translation: CAI41814.1.
BX284686 Genomic DNA. Translation: CAM26228.1.
BX927239 Genomic DNA. Translation: CAQ06600.1.
CR933878 Genomic DNA. Translation: CAQ09629.1.
CR812478 Genomic DNA. Translation: CAQ10704.1.
CH471081 Genomic DNA. Translation: EAX03613.1.
BC082261 mRNA. Translation: AAH82261.1.
CCDSiCCDS4748.1.
PIRiA56002.
RefSeqiNP_002577.2. NM_002586.4.
UniGeneiHs.509545.
Hs.718462.

Genome annotation databases

EnsembliENST00000375050; ENSP00000364190; ENSG00000204304.
ENST00000383270; ENSP00000372757; ENSG00000206315.
ENST00000420432; ENSP00000410710; ENSG00000236353.
ENST00000431537; ENSP00000390009; ENSG00000232005.
ENST00000433552; ENSP00000391745; ENSG00000224952.
ENST00000453487; ENSP00000403948; ENSG00000225987.
ENST00000453961; ENSP00000397177; ENSG00000237344.
GeneIDi5089.
KEGGihsa:5089.
UCSCiuc003oav.1. human.

Polymorphism databases

DMDMi1352729.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59842 mRNA. Translation: CAA42503.1 .
X80700 Genomic DNA. Translation: CAA56717.1 .
D28769 Genomic DNA. Translation: BAA05957.1 .
U89336 Genomic DNA. Translation: AAB47490.1 .
AL662884 Genomic DNA. Translation: CAI18358.1 .
AL662830 Genomic DNA. Translation: CAI17539.1 .
AL845464 Genomic DNA. Translation: CAI41814.1 .
BX284686 Genomic DNA. Translation: CAM26228.1 .
BX927239 Genomic DNA. Translation: CAQ06600.1 .
CR933878 Genomic DNA. Translation: CAQ09629.1 .
CR812478 Genomic DNA. Translation: CAQ10704.1 .
CH471081 Genomic DNA. Translation: EAX03613.1 .
BC082261 mRNA. Translation: AAH82261.1 .
CCDSi CCDS4748.1.
PIRi A56002.
RefSeqi NP_002577.2. NM_002586.4.
UniGenei Hs.509545.
Hs.718462.

3D structure databases

ProteinModelPortali P40425.
SMRi P40425. Positions 244-316.
ModBasei Search...

Protein-protein interaction databases

BioGridi 111122. 3 interactions.
IntActi P40425. 20 interactions.
MINTi MINT-1032522.
STRINGi 9606.ENSP00000397177.

PTM databases

PhosphoSitei P40425.

Polymorphism databases

DMDMi 1352729.

Proteomic databases

MaxQBi P40425.
PaxDbi P40425.
PRIDEi P40425.

Protocols and materials databases

DNASUi 5089.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000375050 ; ENSP00000364190 ; ENSG00000204304 .
ENST00000383270 ; ENSP00000372757 ; ENSG00000206315 .
ENST00000420432 ; ENSP00000410710 ; ENSG00000236353 .
ENST00000431537 ; ENSP00000390009 ; ENSG00000232005 .
ENST00000433552 ; ENSP00000391745 ; ENSG00000224952 .
ENST00000453487 ; ENSP00000403948 ; ENSG00000225987 .
ENST00000453961 ; ENSP00000397177 ; ENSG00000237344 .
GeneIDi 5089.
KEGGi hsa:5089.
UCSCi uc003oav.1. human.

Organism-specific databases

CTDi 5089.
GeneCardsi GC06M032153.
GC06Mi32163.
GC06Mj32100.
GC06Ml32191.
GC06Mm32228.
GC06Mn32110.
GC06Mo32159.
HGNCi HGNC:8633. PBX2.
HPAi HPA054000.
HPA061478.
MIMi 176311. gene.
neXtProti NX_P40425.
PharmGKBi PA32971.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG248144.
HOVERGENi HBG000122.
InParanoidi P40425.
KOi K15609.
OMAi GQIYSPR.
OrthoDBi EOG75XGM1.
PhylomeDBi P40425.
TreeFami TF314340.

Miscellaneous databases

ChiTaRSi PBX2. human.
GeneWikii PBX2.
GenomeRNAii 5089.
NextBioi 19624.
PROi P40425.
SOURCEi Search...

Gene expression databases

Bgeei P40425.
CleanExi HS_PBX2.
Genevestigatori P40425.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR005542. PBX.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF03792. PBC. 1 hit.
[Graphical view ]
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1."
    Monica K., Galili N., Nourse J., Saltman D., Cleary M.L.
    Mol. Cell. Biol. 11:6149-6157(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The novel gene G17, located in the human major histocompatibility complex, encodes PBX2, a homeodomain-containing protein."
    Aguado B., Campbell R.D.
    Genomics 25:650-659(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3."
    Sugaya K., Fukagawa T., Matsumoto K., Mita K., Takahashi E., Ando A., Inoko H., Ikemura T.
    Genomics 23:408-419(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
    Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
    Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  8. "Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation."
    Lu Q., Wright D.D., Kamps M.P.
    Mol. Cell. Biol. 14:3938-3948(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  9. "Functional cloning and characterization of a novel nonhomeodomain protein that inhibits the binding of PBX1-HOX complexes to DNA."
    Abramovich C., Shen W.-F., Pineault N., Imren S., Montpetit B., Largman C., Humphries R.K.
    J. Biol. Chem. 275:26172-26177(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PBXIP1.
  10. "Homeodomain proteins MEIS1 and PBXs regulate the lineage-specific transcription of the platelet factor 4 gene."
    Okada Y., Nagai R., Sato T., Matsuura E., Minami T., Morita I., Doi T.
    Blood 101:4748-4756(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH MEIS1.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  12. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-151, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-151 AND SER-330, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-151, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-330, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPBX2_HUMAN
AccessioniPrimary (citable) accession number: P40425
Secondary accession number(s): A2BFJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1996
Last modified: July 9, 2014
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi