P40424 (PBX1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pre-B-cell leukemia transcription factor 1

Alternative name(s):
Homeobox protein PBX1
Homeobox protein PRL

Gene names

Name:	PBX1
Synonyms:	PRL

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	430 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds the sequence 5'-ATCAATCAA-3'. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator by the (1;19) translocation. May have a role in steroidogenesis and, subsequently, sexual development and differentiation. Isoform PBX1b as part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Probably in complex with MEIS2, is involved in transcriptional regulation by KLF4. Ref.11 Ref.15
Subunit structure	Forms a heterodimer with MEIS1 which binds DNA including a cAMP-responsive sequence in CYP17. Also forms heterotrimers with MEIS1 and a number of HOX proteins including HOXA9, HOXD4, HOXD9 and HOXD10. Interacts with PBXIP1 and TLX1. Isoform PBX1a interacts with MEIS2 isoform 4, SP1, SP3 and KLF4. Isoform PBX1b is part of a PDX1:PBX1b:MEIS2b complex; PBX1b recruits Meis2B to the complex. Ref.10 Ref.11 Ref.12 Ref.13 Ref.15
Subcellular location	Nucleus By similarity.
Tissue specificity	Expressed in all tissues except in cells of the B and T lineage.
Involvement in disease	A chromosomal aberration involving PBX1 is a cause of pre-B-cell acute lymphoblastic leukemia (B-ALL). Translocation t(1;19)(q23;p13.3) with TCF3. TCF3-PBX1 transforms cells by constitutively activating transcription of genes regulated by PBX1 or by other members of the PBX protein family.
Sequence similarities	Belongs to the TALE/PBX homeobox family. Contains 1 homeobox DNA-binding domain.
Sequence caution	The sequence AAA36764.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Differentiation Sexual differentiation Steroidogenesis Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Chromosomal rearrangement Polymorphism
Disease	Proto-oncogene
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Activator Repressor
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	adrenal gland development Inferred from electronic annotation. Source: Compara anterior/posterior pattern specification Inferred from electronic annotation. Source: Compara branching involved in ureteric bud morphogenesis Inferred from electronic annotation. Source: Compara embryonic hemopoiesis Inferred from electronic annotation. Source: Compara embryonic limb morphogenesis Inferred from electronic annotation. Source: Compara embryonic skeletal system development Inferred from electronic annotation. Source: Compara negative regulation of neuron differentiation Inferred from electronic annotation. Source: Compara negative regulation of sequence-specific DNA binding transcription factor activity Inferred from direct assay PubMed 15684392. Source: UniProtKB organ morphogenesis Inferred from electronic annotation. Source: Compara positive regulation of cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara proximal/distal pattern formation Inferred from electronic annotation. Source: Compara regulation of ossification Inferred from electronic annotation. Source: Compara sex differentiation Inferred from electronic annotation. Source: UniProtKB-KW spleen development Inferred from electronic annotation. Source: Compara steroid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW thymus development Inferred from electronic annotation. Source: Compara transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from direct assay PubMed 18973687. Source: UniProtKB nucleus Inferred from direct assay PubMed 18973687PubMed 15684392. Source: UniProtKB transcription factor complex Inferred from electronic annotation. Source: Compara
Molecular_function	DNA binding Inferred from direct assay Ref.16. Source: UniProtKB sequence-specific DNA binding Inferred from electronic annotation. Source: Compara sequence-specific DNA binding transcription factor activity Non-traceable author statement PubMed 10500199. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
FOXC1	Q12948	4	EBI-301611,EBI-1175253
TLX1	P31314	2	EBI-6390251,EBI-2820655

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform PBX1a (identifier: P40424-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform PBX1b (identifier: P40424-2)

The sequence of this isoform differs from the canonical sequence as follows:
     334-347: SSSSFNMSNSGDLF → GYPSPCYQPDRRIQ
     348-430: Missing.

Isoform 3 (identifier: P40424-3)

The sequence of this isoform differs from the canonical sequence as follows:
     401-430: ANGGWQDATTPSSVTSPTEGPGSVHSDTSN → HLPRHPRQAHYHFRLPTWHP

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 430

430

Pre-B-cell leukemia transcription factor 1

PRO_0000049235

Regions

DNA binding

233 – 295

63

Homeobox; TALE-type

Compositional bias

127 – 135

9

Poly-Ala

Sites

Site

88 – 89

2

Breakpoint for translocation to form TCF3-PBX1 oncogene

Natural variations

Alternative sequence

334 – 347

14

SSSSF…SGDLF → GYPSPCYQPDRRIQ in isoform PBX1b.

VSP_002271

Alternative sequence

348 – 430

83

Missing in isoform PBX1b.

VSP_002272

Alternative sequence

401 – 430

30

ANGGW…SDTSN → HLPRHPRQAHYHFRLPTWHP in isoform 3.

VSP_044499

Natural variant

31

1

G → S. Ref.3
Corresponds to variant rs2275558 [ dbSNP | Ensembl ].

VAR_068904

Experimental info

Sequence conflict

351

1

Q → H in BAG61583. Ref.3

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

430

Helix Strand Turn

Details...

Helix

242 – 254

13

Turn

255 – 257

3

Helix

263 – 273

11

Helix

277 – 293

17

Turn

295 – 300

6

Helix

301 – 304

4

Sequences

	Sequence		Length	Mass (Da)
	Isoform PBX1a [UniParc]. Last modified February 1, 1995. Version 1. Checksum: AD3FFACBC5A9E715	FASTA	430	46,626
	10 20 30 40 50 60 MDEQPRLMHS HAGVGMAGHP GLSQHLQDGA GGTEGEGGRK QDIGDILQQI MTITDQSLDE 70 80 90 100 110 120 AQARKHALNC HRMKPALFNV LCEIKEKTVL SIRGAQEEEP TDPQLMRLDN MLLAEGVAGP 130 140 150 160 170 180 EKGGGSAAAA AAAAASGGAG SDNSVEHSDY RAKLSQIRQI YHTELEKYEQ ACNEFTTHVM 190 200 210 220 230 240 NLLREQSRTR PISPKEIERM VSIIHRKFSS IQMQLKQSTC EAVMILRSRF LDARRKRRNF 250 260 270 280 290 300 NKQATEILNE YFYSHLSNPY PSEEAKEELA KKCGITVSQV SNWFGNKRIR YKKNIGKFQE 310 320 330 340 350 360 EANIYAAKTA VTATNVSAHG SQANSPSTPN SAGSSSSFNM SNSGDLFMSV QSLNGDSYQG 370 380 390 400 410 420 AQVGANVQSQ VDTLRHVISQ TGGYSDGLAA SQMYSPQGIS ANGGWQDATT PSSVTSPTEG 430 PGSVHSDTSN
	Isoform PBX1b [UniParc]. Checksum: C4A2BDDD4A410C20	FASTA	347	38,427
	10 20 30 40 50 60 MDEQPRLMHS HAGVGMAGHP GLSQHLQDGA GGTEGEGGRK QDIGDILQQI MTITDQSLDE 70 80 90 100 110 120 AQARKHALNC HRMKPALFNV LCEIKEKTVL SIRGAQEEEP TDPQLMRLDN MLLAEGVAGP 130 140 150 160 170 180 EKGGGSAAAA AAAAASGGAG SDNSVEHSDY RAKLSQIRQI YHTELEKYEQ ACNEFTTHVM 190 200 210 220 230 240 NLLREQSRTR PISPKEIERM VSIIHRKFSS IQMQLKQSTC EAVMILRSRF LDARRKRRNF 250 260 270 280 290 300 NKQATEILNE YFYSHLSNPY PSEEAKEELA KKCGITVSQV SNWFGNKRIR YKKNIGKFQE 310 320 330 340 EANIYAAKTA VTATNVSAHG SQANSPSTPN SAGGYPSPCY QPDRRIQ
	Isoform 3 [UniParc]. Checksum: 1CC4B8B2EA51E509	FASTA	420	46,265
	10 20 30 40 50 60 MDEQPRLMHS HAGVGMAGHP GLSQHLQDGA GGTEGEGGRK QDIGDILQQI MTITDQSLDE 70 80 90 100 110 120 AQARKHALNC HRMKPALFNV LCEIKEKTVL SIRGAQEEEP TDPQLMRLDN MLLAEGVAGP 130 140 150 160 170 180 EKGGGSAAAA AAAAASGGAG SDNSVEHSDY RAKLSQIRQI YHTELEKYEQ ACNEFTTHVM 190 200 210 220 230 240 NLLREQSRTR PISPKEIERM VSIIHRKFSS IQMQLKQSTC EAVMILRSRF LDARRKRRNF 250 260 270 280 290 300 NKQATEILNE YFYSHLSNPY PSEEAKEELA KKCGITVSQV SNWFGNKRIR YKKNIGKFQE 310 320 330 340 350 360 EANIYAAKTA VTATNVSAHG SQANSPSTPN SAGSSSSFNM SNSGDLFMSV QSLNGDSYQG 370 380 390 400 410 420 AQVGANVQSQ VDTLRHVISQ TGGYSDGLAA SQMYSPQGIS HLPRHPRQAH YHFRLPTWHP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1." Monica K., Galili N., Nourse J., Saltman D., Cleary M.L. Mol. Cell. Biol. 11:6149-6157(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PBX1A).
[2]	"Analysis of PBX1 as a candidate gene for type 2 diabetes mellitus in Pima Indians." Thameem F., Wolford J.K., Bogardus C., Prochazka M. Biochim. Biophys. Acta 1518:215-220(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM PBX1A).
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT SER-31. Tissue: Brain.
[4]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM PBX1A). Tissue: Brain.
[6]	"A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL." Kamps M.P., Murre C., Sun X.-H., Baltimore D. Cell 60:547-555(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 89-430, CHROMOSOMAL TRANSLOCATION WITH TCF3.
[7]	"The t(1;19)(q23;p13) results in consistent fusion of E2A and PBX1 coding sequences in acute lymphoblastic leukemias." Hunger S.P., Galili N., Carroll A.J., Crist W.M., Link M.P., Cleary M.L. Blood 77:687-693(1991) [PubMed] [Europe PMC] [Abstract] Cited for: CHROMOSOMAL TRANSLOCATION WITH TCF3.
[8]	"Pbx1 is converted into a transcriptional activator upon acquiring the N-terminal region of E2A in pre-B-cell acute lymphoblastoid leukemia." van Dijk M.A., Voorhoeve P.M., Murre C. Proc. Natl. Acad. Sci. U.S.A. 90:6061-6065(1993) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION.
[9]	"Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation." Lu Q., Wright D.D., Kamps M.P. Mol. Cell. Biol. 14:3938-3948(1994) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION.
[10]	"Functional cloning and characterization of a novel nonhomeodomain protein that inhibits the binding of PBX1-HOX complexes to DNA." Abramovich C., Shen W.-F., Pineault N., Imren S., Montpetit B., Largman C., Humphries R.K. J. Biol. Chem. 275:26172-26177(2000) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH PBXIP1.
[11]	"Homeodomain proteins MEIS1 and PBXs regulate the lineage-specific transcription of the platelet factor 4 gene." Okada Y., Nagai R., Sato T., Matsuura E., Minami T., Morita I., Doi T. Blood 101:4748-4756(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH MEIS1.
[12]	"An autoinhibitory effect of the homothorax domain of Meis2." Hyman-Walsh C., Bjerke G.A., Wotton D. FEBS J. 277:2584-2597(2010) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH MEIS2.
[13]	"MEIS proteins as partners of the TLX1/HOX11 oncoprotein." Milech N., Gottardo N.G., Ford J., D'Souza D., Greene W.K., Kees U.R., Watt P.M. Leuk. Res. 34:358-363(2010) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH TLX1.
[14]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[15]	"Cooperative transcriptional activation by Klf4, Meis2, and Pbx1." Bjerke G.A., Hyman-Walsh C., Wotton D. Mol. Cell. Biol. 31:3723-3733(2011) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH SP1; SP3 AND KLF4.
[16]	"Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation." Piper D.E., Batchelor A.H., Chang C.-P., Cleary M.L., Wolberger C. Cell 96:587-597(1999) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS) OF 233-319 IN COMPLEX WITH HOXB1.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

M86546 mRNA. Translation: AAA60031.1.
AF313404 , AF313396, AF313397, AF313398, AF313399, AF313400, AF313401, AF313402, AF313403 Genomic DNA. Translation: AAG30941.1.
AK299673 mRNA. Translation: BAG61583.1.
AL359255, AL357568, AL390119 Genomic DNA. Translation: CAI14854.1.
AL390119, AL359255, AL357568 Genomic DNA. Translation: CAH73499.1.
AL357568, AL390119, AL359255 Genomic DNA. Translation: CAI14908.1.
AL391001 Genomic DNA. No translation available.
BC101578 mRNA. Translation: AAI01579.1.
M31522 mRNA. Translation: AAA36764.1. Different initiation.

IPI

IPI00028415.
IPI00215683.
IPI01009062.

PIR

B34734.

RefSeq

NP_001191892.1. NM_001204963.1.
NP_002576.1. NM_002585.3.

UniGene

Hs.557097.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1B72	X-ray	2.35	B	233-319	[»]
1PUF	X-ray	1.90	B	233-305	[»]

ProteinModelPortal

P40424.

ModBase

Search...

Protein-protein interaction databases

IntAct

P40424. 6 interactions.

STRING

9606.ENSP00000405890.

PTM databases

PhosphoSite

P40424.

Polymorphism databases

DMDM

730279.

Proteomic databases

PaxDb

P40424.

PRIDE

P40424.

Protocols and materials databases

DNASU

5087.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000367897; ENSP00000356872; ENSG00000185630.
ENST00000401534; ENSP00000384856; ENSG00000185630.
ENST00000420696; ENSP00000405890; ENSG00000185630.
ENST00000540236; ENSP00000439943; ENSG00000185630.

GeneID

5087.

KEGG

hsa:5087.

UCSC

uc001gct.3. human.

Organism-specific databases

CTD

5087.

GeneCards

GC01P164524.

HGNC

HGNC:8632. PBX1.

HPA

CAB018768.
HPA003505.
HPA003881.

MIM

176310. gene.

neXtProt

NX_P40424.

Orphanet

99860. Precursor B-cell acute lymphoblastic leukemia.

PharmGKB

PA32970.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG248144.

HOGENOM

HOG000266972.

HOVERGEN

HBG000122.

InParanoid

P40424.

KO

K09355.

OMA

NIQSQVD.

OrthoDB

EOG45HRXQ.

PhylomeDB

P40424.

Gene expression databases

ArrayExpress

P40424.

Bgee

P40424.

CleanEx

HS_PBX1.
HS_PRL.

Genevestigator

P40424.

GermOnline

ENSG00000185630. Homo sapiens.

Family and domain databases

Gene3D

1.10.10.60. 1 hit.

InterPro

IPR017970. Homeobox_CS.
IPR001356. Homeodomain.
IPR009057. Homeodomain-like.
IPR005542. PBX.
[Graphical view]

Pfam

PF00046. Homeobox. 1 hit.
PF03792. PBC. 1 hit.
[Graphical view]

SMART

SM00389. HOX. 1 hit.
[Graphical view]

SUPFAM

SSF46689. Homeodomain_like. 1 hit.

PROSITE

PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

BindingDB

P40424.

ChEMBL

CHEMBL4587.

ChiTaRS

PBX1. human.

EvolutionaryTrace

P40424.

GenomeRNAi

5087.

NextBio

19618.

SOURCE

Search...

Entry information

Entry name

PBX1_HUMAN

Accession

Primary (citable) accession number: P40424
Secondary accession number(s): B4DSC1, F5H4U9, Q5T488

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	May 1, 2013
This is version 141 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.