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Protein

Myosin regulatory light chain sqh

Gene

sqh

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for cytokinesis, could regulate contractile ring function.1 Publication

Miscellaneous

This chain binds calcium.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi44 – 55PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • myosin heavy chain binding Source: FlyBase

GO - Biological processi

  • actin filament-based movement Source: FlyBase
  • apical constriction involved in gastrulation Source: FlyBase
  • border follicle cell migration Source: FlyBase
  • cell elongation involved in imaginal disc-derived wing morphogenesis Source: FlyBase
  • cytoskeleton-dependent cytoplasmic transport, nurse cell to oocyte Source: FlyBase
  • establishment of planar polarity Source: FlyBase
  • formation of a compartment boundary Source: FlyBase
  • imaginal disc-derived wing hair organization Source: FlyBase
  • mitotic cytokinesis Source: FlyBase
  • myosin II filament assembly Source: FlyBase
  • nuclear axial expansion Source: FlyBase
  • ovarian follicle cell development Source: FlyBase
  • ovarian nurse cell to oocyte transport Source: FlyBase
  • regulation of actin cytoskeleton organization Source: FlyBase
  • regulation of tube length, open tracheal system Source: FlyBase
  • spiracle morphogenesis, open tracheal system Source: FlyBase
  • tube formation Source: FlyBase
  • wound healing Source: FlyBase

Keywordsi

Molecular functionMotor protein, Myosin
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-DME-3928664. Ephrin signaling.
R-DME-445355. Smooth Muscle Contraction.
R-DME-5627123. RHO GTPases activate PAKs.

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin regulatory light chain sqh
Alternative name(s):
Myosin regulatory light chain, nonmuscle
Short name:
MRLC-C
Protein spaghetti-squash
Gene namesi
Name:sqh
ORF Names:CG3595
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0003514. sqh.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Disruption phenotypei

Mitotic defects including failure in cytokinesis.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001987471 – 174Myosin regulatory light chain sqhAdd BLAST174

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21Phosphothreonine2 Publications1
Modified residuei22Phosphoserine2 Publications1

Post-translational modificationi

Phosphorylation plays a central role in myosin regulation.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP40423.
PRIDEiP40423.

PTM databases

iPTMnetiP40423.

Expressioni

Gene expression databases

BgeeiFBgn0003514.
ExpressionAtlasiP40423. differential.
GenevisibleiP40423. DM.

Interactioni

Subunit structurei

Myosin is a hexamer of 2 heavy chains and 4 light chains.

GO - Molecular functioni

  • myosin heavy chain binding Source: FlyBase

Protein-protein interaction databases

BioGridi58046. 43 interactors.
IntActiP40423. 16 interactors.
STRINGi7227.FBpp0070842.

Structurei

3D structure databases

ProteinModelPortaliP40423.
SMRiP40423.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 66EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini100 – 135EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0031. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000119196.
InParanoidiP40423.
KOiK12757.
OMAiFNYREWV.
OrthoDBiEOG091G0QF6.
PhylomeDBiP40423.

Family and domain databases

CDDicd00051. EFh. 1 hit.
InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
PfamiView protein in Pfam
PF13405. EF-hand_6. 1 hit.
SMARTiView protein in SMART
SM00054. EFh. 2 hits.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.

Sequencei

Sequence statusi: Complete.

P40423-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSRKTAGRR ATTKKRAQRA TSNVFAMFDQ AQIAEFKEAF NMIDQNRDGF
60 70 80 90 100
VEKEDLHDML ASLGKNPTDD YLDGMMNEAP GPINFTMFLT LFGERLQGTD
110 120 130 140 150
PEDVIKNAFG CFDEENMGVL PEDRLRELLT TMGDRFTDED VDEMYREAPI
160 170
KNGLFDYLEF TRILKHGAKD KDEQ
Length:174
Mass (Da):19,954
Last modified:February 1, 1995 - v1
Checksum:i2D95C9F0460B8766
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M67494 Genomic DNA. Translation: AAC13367.1.
AE014298 Genomic DNA. Translation: AAF46132.1.
AY122159 mRNA. Translation: AAM52671.1.
PIRiA39932.
RefSeqiNP_001284928.1. NM_001297999.1.
NP_001284929.1. NM_001298000.1.
NP_001284930.1. NM_001298001.1.
NP_001284931.1. NM_001298002.1.
NP_511057.1. NM_078502.3.
UniGeneiDm.3.

Genome annotation databases

EnsemblMetazoaiFBtr0070877; FBpp0070842; FBgn0003514.
FBtr0339502; FBpp0308586; FBgn0003514.
FBtr0339503; FBpp0308587; FBgn0003514.
FBtr0339504; FBpp0308588; FBgn0003514.
FBtr0345294; FBpp0311461; FBgn0003514.
GeneIDi31554.
KEGGidme:Dmel_CG3595.

Similar proteinsi

Entry informationi

Entry nameiSQH_DROME
AccessioniPrimary (citable) accession number: P40423
Secondary accession number(s): Q540V2, Q9W428
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 27, 2017
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase