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P40422

- RPAB4_YEAST

UniProt

P40422 - RPAB4_YEAST

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Protein
DNA-directed RNA polymerases I, II, and III subunit RPABC4
Gene
RPC10, RPB12, YHR143W-A, YHR143BW
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. RNA polymerases are composed of mobile elements that move relative to each other. In Pol II, the core element with the central large cleft comprises RPB3, RBP10, RPB11, RPB12 and regions of RPB1 and RPB2 forming the active center.3 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi31 – 311Zinc
Metal bindingi34 – 341Zinc
Metal bindingi48 – 481Zinc
Metal bindingi51 – 511Zinc

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri31 – 5121C4-type
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. RNA polymerase I activity Source: UniProtKB
  3. zinc ion binding Source: SGD

GO - Biological processi

  1. ribosome biogenesis Source: UniProtKB-KW
  2. tRNA transcription from RNA polymerase III promoter Source: SGD
  3. transcription from RNA polymerase I promoter Source: UniProtKB
  4. transcription from RNA polymerase II promoter Source: SGD
  5. transcription from RNA polymerase III promoter Source: SGD
  6. transcription, RNA-templated Source: GOC
Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis, Transcription

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-31179-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerases I, II, and III subunit RPABC4
Short name:
RNA polymerases I, II, and III subunit ABC4
Alternative name(s):
ABC10-alpha
Gene namesi
Name:RPC10
Synonyms:RPB12
Ordered Locus Names:YHR143W-A
ORF Names:YHR143BW
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VIII

Organism-specific databases

CYGDiYHR143w-a.
SGDiS000001185. RPC10.

Subcellular locationi

Nucleusnucleolus 1 Publication

GO - Cellular componenti

  1. DNA-directed RNA polymerase I complex Source: UniProtKB
  2. DNA-directed RNA polymerase II, core complex Source: SGD
  3. DNA-directed RNA polymerase III complex Source: SGD
  4. nucleoplasm Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7070DNA-directed RNA polymerases I, II, and III subunit RPABC4
PRO_0000159753Add
BLAST

Post-translational modificationi

The N-terminus is blocked.

Proteomic databases

MaxQBiP40422.
PaxDbiP40422.
PeptideAtlasiP40422.

Expressioni

Gene expression databases

GenevestigatoriP40422.

Interactioni

Subunit structurei

Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes. Component of the RNA polymerase I (Pol I) complex consisting of 14 subunits: RPA135, RPA190, RPC40, RPA14, RPB5, RPO26, RPA43, RPB8, RPA12, RPB10, RPC19, RPC10, RPA49 and RPA34. The complex is composed of a horseshoe-shaped core containing ten subunits (RPA135, RPA190, RPB5, RPO26, RPB8, RPB10, RPC10, RPA12, RPC19 and RPC40) where RPA135 and RPA190 form the DNA-binding cleft. Outside of the core, RPA14 and RPA43 form the stalk that mediates interactions with transcription initiation factors and newly synthesized RNA. Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits: RPO21, RPB2, RPB3, RPB4, RPB5, RPO26, RPB7, RPB8, RPB9, RPB10 and RPC10. Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits. Interacts, via its C-terminus, with TFIIIC subunit TFC4.4 Publications

Protein-protein interaction databases

BioGridi36577. 64 interactions.
DIPiDIP-936N.
IntActiP40422. 7 interactions.
MINTiMINT-559375.
STRINGi4932.YHR143W-A.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi28 – 314
Beta strandi32 – 343
Beta strandi36 – 383
Beta strandi41 – 444
Beta strandi46 – 483
Beta strandi49 – 513
Beta strandi56 – 583
Beta strandi65 – 673

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1I3QX-ray3.10L1-70[»]
1I50X-ray2.80L1-70[»]
1I6HX-ray3.30L1-70[»]
1K83X-ray2.80L1-70[»]
1NIKX-ray4.10L1-70[»]
1NT9X-ray4.20L1-70[»]
1PQVX-ray3.80L1-70[»]
1R5UX-ray4.50L1-70[»]
1R9SX-ray4.25L1-70[»]
1R9TX-ray3.50L1-70[»]
1SFOX-ray3.61L1-70[»]
1TWAX-ray3.20L1-70[»]
1TWCX-ray3.00L1-70[»]
1TWFX-ray2.30L1-70[»]
1TWGX-ray3.30L1-70[»]
1TWHX-ray3.40L1-70[»]
1WCMX-ray3.80L1-70[»]
1Y1VX-ray3.80L1-70[»]
1Y1WX-ray4.00L1-70[»]
1Y1YX-ray4.00L1-70[»]
1Y77X-ray4.50L1-70[»]
2B63X-ray3.80L1-70[»]
2B8KX-ray4.15L1-70[»]
2E2HX-ray3.95L1-70[»]
2E2IX-ray3.41L1-70[»]
2E2JX-ray3.50L1-70[»]
2JA5X-ray3.80L1-70[»]
2JA6X-ray4.00L1-70[»]
2JA7X-ray3.80L/X1-70[»]
2JA8X-ray3.80L1-70[»]
2NVQX-ray2.90L1-70[»]
2NVTX-ray3.36L1-70[»]
2NVXX-ray3.60L1-70[»]
2NVYX-ray3.40L1-70[»]
2NVZX-ray4.30L1-70[»]
2R7ZX-ray3.80L1-70[»]
2R92X-ray3.80L1-70[»]
2R93X-ray4.00L1-70[»]
2VUMX-ray3.40L1-70[»]
2YU9X-ray3.40L1-70[»]
3CQZX-ray2.80L1-70[»]
3FKIX-ray3.88L1-70[»]
3GTGX-ray3.78L1-70[»]
3GTJX-ray3.42L1-70[»]
3GTKX-ray3.80L1-70[»]
3GTLX-ray3.38L1-70[»]
3GTMX-ray3.80L1-70[»]
3GTOX-ray4.00L1-70[»]
3GTPX-ray3.90L1-70[»]
3GTQX-ray3.80L1-70[»]
3H3VX-ray4.00M1-70[»]
3HOUX-ray3.20L/X1-70[»]
3HOVX-ray3.50L1-70[»]
3HOWX-ray3.60L1-70[»]
3HOXX-ray3.65L1-70[»]
3HOYX-ray3.40L1-70[»]
3HOZX-ray3.65L1-70[»]
3I4MX-ray3.70L1-70[»]
3I4NX-ray3.90L1-70[»]
3J1Nelectron microscopy16.00L1-70[»]
3K1FX-ray4.30L1-70[»]
3K7AX-ray3.80L1-70[»]
3M3YX-ray3.18L1-70[»]
3M4OX-ray3.57L1-70[»]
3PO2X-ray3.30L1-70[»]
3PO3X-ray3.30L1-70[»]
3QT1X-ray4.30L1-70[»]
3RZDX-ray3.30L1-70[»]
3RZOX-ray3.00L1-70[»]
3S14X-ray2.85L1-70[»]
3S15X-ray3.30L1-70[»]
3S16X-ray3.24L1-70[»]
3S17X-ray3.20L1-70[»]
3S1MX-ray3.13L1-70[»]
3S1NX-ray3.10L1-70[»]
3S1QX-ray3.30L1-70[»]
3S1RX-ray3.20L1-70[»]
3S2DX-ray3.20L1-70[»]
3S2HX-ray3.30L1-70[»]
4A3BX-ray3.50L1-70[»]
4A3CX-ray3.50L1-70[»]
4A3DX-ray3.40L1-70[»]
4A3EX-ray3.40L1-70[»]
4A3FX-ray3.50L1-70[»]
4A3GX-ray3.50L1-70[»]
4A3IX-ray3.80L1-70[»]
4A3JX-ray3.70L1-70[»]
4A3KX-ray3.50L1-70[»]
4A3LX-ray3.50L1-70[»]
4A3MX-ray3.90L1-70[»]
4A93X-ray3.40L1-70[»]
4BBRX-ray3.40L1-70[»]
4BBSX-ray3.60L1-70[»]
4BXXX-ray3.28L1-70[»]
4BXZX-ray4.80L1-70[»]
4BY1X-ray3.60L1-70[»]
4BY7X-ray3.15L1-70[»]
4C2MX-ray2.801/L1-70[»]
4C3HX-ray3.27L1-70[»]
4C3IX-ray3.0L1-70[»]
4C3JX-ray3.35L1-70[»]
ProteinModelPortaliP40422.
SMRiP40422. Positions 25-70.

Miscellaneous databases

EvolutionaryTraceiP40422.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG1996.
HOGENOMiHOG000191755.
KOiK03009.
OMAiKPRYSNT.
OrthoDBiEOG7K0ZRP.

Family and domain databases

Gene3Di2.20.28.30. 1 hit.
InterProiIPR006591. RNAP_P/RPABC4.
IPR029040. RPABC4/Spt4.
[Graphical view]
PfamiPF03604. DNA_RNApol_7kD. 1 hit.
[Graphical view]
SMARTiSM00659. RPOLCX. 1 hit.
[Graphical view]
SUPFAMiSSF63393. SSF63393. 1 hit.

Sequencei

Sequence statusi: Complete.

P40422-1 [UniParc]FASTAAdd to Basket

« Hide

MSREGFQIPT NLDAAAAGTS QARTATLKYI CAECSSKLSL SRTDAVRCKD   50
CGHRILLKAR TKRLVQFEAR 70
Length:70
Mass (Da):7,716
Last modified:February 1, 1995 - v1
Checksum:i066A3D982EC7361E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U23378 Genomic DNA. Translation: AAA64417.1.
U10397 Genomic DNA. Translation: AAB68994.1.
AY558549 Genomic DNA. Translation: AAS56875.1.
BK006934 Genomic DNA. Translation: DAA06837.1.
PIRiS58932.
RefSeqiNP_012013.1. NM_001179273.1.

Genome annotation databases

EnsemblFungiiYHR143W-A; YHR143W-A; YHR143W-A.
GeneIDi856547.
KEGGisce:YHR143W-A.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U23378 Genomic DNA. Translation: AAA64417.1 .
U10397 Genomic DNA. Translation: AAB68994.1 .
AY558549 Genomic DNA. Translation: AAS56875.1 .
BK006934 Genomic DNA. Translation: DAA06837.1 .
PIRi S58932.
RefSeqi NP_012013.1. NM_001179273.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1I3Q X-ray 3.10 L 1-70 [» ]
1I50 X-ray 2.80 L 1-70 [» ]
1I6H X-ray 3.30 L 1-70 [» ]
1K83 X-ray 2.80 L 1-70 [» ]
1NIK X-ray 4.10 L 1-70 [» ]
1NT9 X-ray 4.20 L 1-70 [» ]
1PQV X-ray 3.80 L 1-70 [» ]
1R5U X-ray 4.50 L 1-70 [» ]
1R9S X-ray 4.25 L 1-70 [» ]
1R9T X-ray 3.50 L 1-70 [» ]
1SFO X-ray 3.61 L 1-70 [» ]
1TWA X-ray 3.20 L 1-70 [» ]
1TWC X-ray 3.00 L 1-70 [» ]
1TWF X-ray 2.30 L 1-70 [» ]
1TWG X-ray 3.30 L 1-70 [» ]
1TWH X-ray 3.40 L 1-70 [» ]
1WCM X-ray 3.80 L 1-70 [» ]
1Y1V X-ray 3.80 L 1-70 [» ]
1Y1W X-ray 4.00 L 1-70 [» ]
1Y1Y X-ray 4.00 L 1-70 [» ]
1Y77 X-ray 4.50 L 1-70 [» ]
2B63 X-ray 3.80 L 1-70 [» ]
2B8K X-ray 4.15 L 1-70 [» ]
2E2H X-ray 3.95 L 1-70 [» ]
2E2I X-ray 3.41 L 1-70 [» ]
2E2J X-ray 3.50 L 1-70 [» ]
2JA5 X-ray 3.80 L 1-70 [» ]
2JA6 X-ray 4.00 L 1-70 [» ]
2JA7 X-ray 3.80 L/X 1-70 [» ]
2JA8 X-ray 3.80 L 1-70 [» ]
2NVQ X-ray 2.90 L 1-70 [» ]
2NVT X-ray 3.36 L 1-70 [» ]
2NVX X-ray 3.60 L 1-70 [» ]
2NVY X-ray 3.40 L 1-70 [» ]
2NVZ X-ray 4.30 L 1-70 [» ]
2R7Z X-ray 3.80 L 1-70 [» ]
2R92 X-ray 3.80 L 1-70 [» ]
2R93 X-ray 4.00 L 1-70 [» ]
2VUM X-ray 3.40 L 1-70 [» ]
2YU9 X-ray 3.40 L 1-70 [» ]
3CQZ X-ray 2.80 L 1-70 [» ]
3FKI X-ray 3.88 L 1-70 [» ]
3GTG X-ray 3.78 L 1-70 [» ]
3GTJ X-ray 3.42 L 1-70 [» ]
3GTK X-ray 3.80 L 1-70 [» ]
3GTL X-ray 3.38 L 1-70 [» ]
3GTM X-ray 3.80 L 1-70 [» ]
3GTO X-ray 4.00 L 1-70 [» ]
3GTP X-ray 3.90 L 1-70 [» ]
3GTQ X-ray 3.80 L 1-70 [» ]
3H3V X-ray 4.00 M 1-70 [» ]
3HOU X-ray 3.20 L/X 1-70 [» ]
3HOV X-ray 3.50 L 1-70 [» ]
3HOW X-ray 3.60 L 1-70 [» ]
3HOX X-ray 3.65 L 1-70 [» ]
3HOY X-ray 3.40 L 1-70 [» ]
3HOZ X-ray 3.65 L 1-70 [» ]
3I4M X-ray 3.70 L 1-70 [» ]
3I4N X-ray 3.90 L 1-70 [» ]
3J1N electron microscopy 16.00 L 1-70 [» ]
3K1F X-ray 4.30 L 1-70 [» ]
3K7A X-ray 3.80 L 1-70 [» ]
3M3Y X-ray 3.18 L 1-70 [» ]
3M4O X-ray 3.57 L 1-70 [» ]
3PO2 X-ray 3.30 L 1-70 [» ]
3PO3 X-ray 3.30 L 1-70 [» ]
3QT1 X-ray 4.30 L 1-70 [» ]
3RZD X-ray 3.30 L 1-70 [» ]
3RZO X-ray 3.00 L 1-70 [» ]
3S14 X-ray 2.85 L 1-70 [» ]
3S15 X-ray 3.30 L 1-70 [» ]
3S16 X-ray 3.24 L 1-70 [» ]
3S17 X-ray 3.20 L 1-70 [» ]
3S1M X-ray 3.13 L 1-70 [» ]
3S1N X-ray 3.10 L 1-70 [» ]
3S1Q X-ray 3.30 L 1-70 [» ]
3S1R X-ray 3.20 L 1-70 [» ]
3S2D X-ray 3.20 L 1-70 [» ]
3S2H X-ray 3.30 L 1-70 [» ]
4A3B X-ray 3.50 L 1-70 [» ]
4A3C X-ray 3.50 L 1-70 [» ]
4A3D X-ray 3.40 L 1-70 [» ]
4A3E X-ray 3.40 L 1-70 [» ]
4A3F X-ray 3.50 L 1-70 [» ]
4A3G X-ray 3.50 L 1-70 [» ]
4A3I X-ray 3.80 L 1-70 [» ]
4A3J X-ray 3.70 L 1-70 [» ]
4A3K X-ray 3.50 L 1-70 [» ]
4A3L X-ray 3.50 L 1-70 [» ]
4A3M X-ray 3.90 L 1-70 [» ]
4A93 X-ray 3.40 L 1-70 [» ]
4BBR X-ray 3.40 L 1-70 [» ]
4BBS X-ray 3.60 L 1-70 [» ]
4BXX X-ray 3.28 L 1-70 [» ]
4BXZ X-ray 4.80 L 1-70 [» ]
4BY1 X-ray 3.60 L 1-70 [» ]
4BY7 X-ray 3.15 L 1-70 [» ]
4C2M X-ray 2.80 1/L 1-70 [» ]
4C3H X-ray 3.27 L 1-70 [» ]
4C3I X-ray 3.0 L 1-70 [» ]
4C3J X-ray 3.35 L 1-70 [» ]
ProteinModelPortali P40422.
SMRi P40422. Positions 25-70.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36577. 64 interactions.
DIPi DIP-936N.
IntActi P40422. 7 interactions.
MINTi MINT-559375.
STRINGi 4932.YHR143W-A.

Proteomic databases

MaxQBi P40422.
PaxDbi P40422.
PeptideAtlasi P40422.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YHR143W-A ; YHR143W-A ; YHR143W-A .
GeneIDi 856547.
KEGGi sce:YHR143W-A.

Organism-specific databases

CYGDi YHR143w-a.
SGDi S000001185. RPC10.

Phylogenomic databases

eggNOGi COG1996.
HOGENOMi HOG000191755.
KOi K03009.
OMAi KPRYSNT.
OrthoDBi EOG7K0ZRP.

Enzyme and pathway databases

BioCyci YEAST:G3O-31179-MONOMER.

Miscellaneous databases

EvolutionaryTracei P40422.
NextBioi 982349.
PROi P40422.

Gene expression databases

Genevestigatori P40422.

Family and domain databases

Gene3Di 2.20.28.30. 1 hit.
InterProi IPR006591. RNAP_P/RPABC4.
IPR029040. RPABC4/Spt4.
[Graphical view ]
Pfami PF03604. DNA_RNApol_7kD. 1 hit.
[Graphical view ]
SMARTi SM00659. RPOLCX. 1 hit.
[Graphical view ]
SUPFAMi SSF63393. SSF63393. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "RPC10 encodes a new mini subunit shared by yeast nuclear RNA polymerases."
    Treich I., Carles C., Riva M., Sentenac A.
    Gene Expr. 2:31-37(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 4-23 AND 64-70.
    Strain: ATCC 204508 / S288c.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. "The yeast RNA polymerase III transcription machinery: a paradigm for eukaryotic gene activation."
    Chedin S., Ferri M.L., Peyroche G., Andrau J.-C., Jourdain S., Lefebvre O., Werner M., Carles C., Sentenac A.
    Cold Spring Harb. Symp. Quant. Biol. 63:381-389(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW ON THE RNA POL III COMPLEX.
  6. "Interaction between yeast RNA polymerase III and transcription factor TFIIIC via ABC10alpha and tau131 subunits."
    Dumay H., Rubbi L., Sentenac A., Marck C.
    J. Biol. Chem. 274:33462-33468(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TFC4.
  7. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  8. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  9. "Structural basis of transcription: RNA polymerase II at 2.8 A resolution."
    Cramer P., Bushnell D.A., Kornberg R.D.
    Science 292:1863-1876(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF THE RNA POL II CORE COMPLEX.
  10. "Structural basis of transcription: an RNA polymerase II elongation complex at 3.3 A resolution."
    Gnatt A.L., Cramer P., Fu J., Bushnell D.A., Kornberg R.D.
    Science 292:1876-1882(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF THE RNA POL II CORE COMPLEX.
  11. "Structural basis of transcription: alpha-amanitin-RNA polymerase II cocrystal at 2.8 A resolution."
    Bushnell D.A., Cramer P., Kornberg R.D.
    Proc. Natl. Acad. Sci. U.S.A. 99:1218-1222(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF THE RNA POL II CORE COMPLEX IN COMPLEX WITH ALPHA-AMANITIN.
  12. "Architecture of the RNA polymerase II-TFIIS complex and implications for mRNA cleavage."
    Kettenberger H., Armache K.J., Cramer P.
    Cell 114:347-357(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.8 ANGSTROMS) OF THE RNA POL II COMPLEX IN COMPLEX WITH DST1.
  13. "RNA polymerase II/TFIIF structure and conserved organization of the initiation complex."
    Chung W.H., Craighead J.L., Chang W.H., Ezeokonkwo C., Bareket-Samish A., Kornberg R.D., Asturias F.J.
    Mol. Cell 12:1003-1013(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: ELECTRON MICROSCOPY OF THE RNA POL II/TFIIF COMPLEX.
  14. "Architecture of initiation-competent 12-subunit RNA polymerase II."
    Armache K.J., Kettenberger H., Cramer P.
    Proc. Natl. Acad. Sci. U.S.A. 100:6964-6968(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.2 ANGSTROMS) OF THE RNA POL II COMPLEX.
  15. "Complete, 12-subunit RNA polymerase II at 4.1-A resolution: implications for the initiation of transcription."
    Bushnell D.A., Kornberg R.D.
    Proc. Natl. Acad. Sci. U.S.A. 100:6969-6973(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.1 ANGSTROMS) OF THE RNA POL II CORE COMPLEX.
  16. "Structural basis of transcription: nucleotide selection by rotation in the RNA polymerase II active center."
    Westover K.D., Bushnell D.A., Kornberg R.D.
    Cell 119:481-489(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF THE RNA POL II CORE COMPLEX.
  17. "Complete RNA polymerase II elongation complex structure and its interactions with NTP and TFIIS."
    Kettenberger H., Armache K.J., Cramer P.
    Mol. Cell 16:955-965(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.5 ANGSTROMS).
  18. "Structural basis of transcription: an RNA polymerase II-TFIIB cocrystal at 4.5 Angstroms."
    Bushnell D.A., Westover K.D., Davis R.E., Kornberg R.D.
    Science 303:983-988(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.5 ANGSTROMS) OF THE RNA POL II CORE COMPLEX.
  19. "Structures of complete RNA polymerase II and its subcomplex, Rpb4/7."
    Armache K.J., Mitterweger S., Meinhart A., Cramer P.
    J. Biol. Chem. 280:7131-7134(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.8 ANGSTROMS) OF THE RNA POL II COMPLEX.
  20. "Structural biology of RNA polymerase III: subcomplex C17/25 X-ray structure and 11 subunit enzyme model."
    Jasiak A.J., Armache K.J., Martens B., Jansen R.P., Cramer P.
    Mol. Cell 23:71-81(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING OF THE POL III CORE COMPLEX.
  21. "Structure of an RNA polymerase II-RNA inhibitor complex elucidates transcription regulation by noncoding RNAs."
    Kettenberger H., Eisenfuhr A., Brueckner F., Theis M., Famulok M., Cramer P.
    Nat. Struct. Mol. Biol. 13:44-48(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.8 ANGSTROMS) OF THE RNA POL II COMPLEX IN COMPLEX WITH INHIBITING NON-CODING RNA.
  22. "Phasing RNA polymerase II using intrinsically bound Zn atoms: an updated structural model."
    Meyer P.A., Ye P., Zhang M., Suh M.H., Fu J.
    Structure 14:973-982(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.15 ANGSTROMS) OF THE RNA POL II COMPLEX.
  23. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (12.00 ANGSTROMS) OF THE POL I COMPLEX, FUNCTION, SUBUNIT.
  24. Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE POL I COMPLEX, FUNCTION, SUBUNIT.
  25. "RNA polymerase I structure and transcription regulation."
    Engel C., Sainsbury S., Cheung A.C., Kostrewa D., Cramer P.
    Nature 502:650-655(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF THE POL I COMPLEX, FUNCTION, SUBUNIT.

Entry informationi

Entry nameiRPAB4_YEAST
AccessioniPrimary (citable) accession number: P40422
Secondary accession number(s): D3DL93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 11, 2014
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 907 molecules/cell in log phase SD medium.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

External Data

Dasty 3

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