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P40422

- RPAB4_YEAST

UniProt

P40422 - RPAB4_YEAST

Protein

DNA-directed RNA polymerases I, II, and III subunit RPABC4

Gene

RPC10

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. RNA polymerases are composed of mobile elements that move relative to each other. In Pol II, the core element with the central large cleft comprises RPB3, RBP10, RPB11, RPB12 and regions of RPB1 and RPB2 forming the active center.3 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi31 – 311Zinc
    Metal bindingi34 – 341Zinc
    Metal bindingi48 – 481Zinc
    Metal bindingi51 – 511Zinc

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri31 – 5121C4-typeAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: InterPro
    2. RNA polymerase I activity Source: UniProtKB
    3. zinc ion binding Source: SGD

    GO - Biological processi

    1. ribosome biogenesis Source: UniProtKB-KW
    2. transcription, RNA-templated Source: GOC
    3. transcription from RNA polymerase III promoter Source: SGD
    4. transcription from RNA polymerase II promoter Source: SGD
    5. transcription from RNA polymerase I promoter Source: UniProtKB
    6. tRNA transcription from RNA polymerase III promoter Source: SGD

    Keywords - Biological processi

    Ribosome biogenesis, Transcription

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31179-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA-directed RNA polymerases I, II, and III subunit RPABC4
    Short name:
    RNA polymerases I, II, and III subunit ABC4
    Alternative name(s):
    ABC10-alpha
    Gene namesi
    Name:RPC10
    Synonyms:RPB12
    Ordered Locus Names:YHR143W-A
    ORF Names:YHR143BW
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VIII

    Organism-specific databases

    CYGDiYHR143w-a.
    SGDiS000001185. RPC10.

    Subcellular locationi

    Nucleusnucleolus 1 Publication

    GO - Cellular componenti

    1. DNA-directed RNA polymerase I complex Source: UniProtKB
    2. DNA-directed RNA polymerase II, core complex Source: SGD
    3. DNA-directed RNA polymerase III complex Source: SGD
    4. nucleoplasm Source: Reactome

    Keywords - Cellular componenti

    DNA-directed RNA polymerase, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 7070DNA-directed RNA polymerases I, II, and III subunit RPABC4PRO_0000159753Add
    BLAST

    Post-translational modificationi

    The N-terminus is blocked.

    Proteomic databases

    MaxQBiP40422.
    PaxDbiP40422.
    PeptideAtlasiP40422.

    Expressioni

    Gene expression databases

    GenevestigatoriP40422.

    Interactioni

    Subunit structurei

    Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes. Component of the RNA polymerase I (Pol I) complex consisting of 14 subunits: RPA135, RPA190, RPC40, RPA14, RPB5, RPO26, RPA43, RPB8, RPA12, RPB10, RPC19, RPC10, RPA49 and RPA34. The complex is composed of a horseshoe-shaped core containing ten subunits (RPA135, RPA190, RPB5, RPO26, RPB8, RPB10, RPC10, RPA12, RPC19 and RPC40) where RPA135 and RPA190 form the DNA-binding cleft. Outside of the core, RPA14 and RPA43 form the stalk that mediates interactions with transcription initiation factors and newly synthesized RNA. Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits: RPO21, RPB2, RPB3, RPB4, RPB5, RPO26, RPB7, RPB8, RPB9, RPB10 and RPC10. Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits. Interacts, via its C-terminus, with TFIIIC subunit TFC4.7 Publications

    Protein-protein interaction databases

    BioGridi36577. 64 interactions.
    DIPiDIP-936N.
    IntActiP40422. 7 interactions.
    MINTiMINT-559375.
    STRINGi4932.YHR143W-A.

    Structurei

    Secondary structure

    1
    70
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi28 – 314
    Beta strandi32 – 343
    Beta strandi36 – 383
    Beta strandi41 – 444
    Beta strandi46 – 483
    Beta strandi49 – 513
    Beta strandi56 – 583
    Beta strandi65 – 673

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1I3QX-ray3.10L1-70[»]
    1I50X-ray2.80L1-70[»]
    1I6HX-ray3.30L1-70[»]
    1K83X-ray2.80L1-70[»]
    1NIKX-ray4.10L1-70[»]
    1NT9X-ray4.20L1-70[»]
    1PQVX-ray3.80L1-70[»]
    1R5UX-ray4.50L1-70[»]
    1R9SX-ray4.25L1-70[»]
    1R9TX-ray3.50L1-70[»]
    1SFOX-ray3.61L1-70[»]
    1TWAX-ray3.20L1-70[»]
    1TWCX-ray3.00L1-70[»]
    1TWFX-ray2.30L1-70[»]
    1TWGX-ray3.30L1-70[»]
    1TWHX-ray3.40L1-70[»]
    1WCMX-ray3.80L1-70[»]
    1Y1VX-ray3.80L1-70[»]
    1Y1WX-ray4.00L1-70[»]
    1Y1YX-ray4.00L1-70[»]
    1Y77X-ray4.50L1-70[»]
    2B63X-ray3.80L1-70[»]
    2B8KX-ray4.15L1-70[»]
    2E2HX-ray3.95L1-70[»]
    2E2IX-ray3.41L1-70[»]
    2E2JX-ray3.50L1-70[»]
    2JA5X-ray3.80L1-70[»]
    2JA6X-ray4.00L1-70[»]
    2JA7X-ray3.80L/X1-70[»]
    2JA8X-ray3.80L1-70[»]
    2NVQX-ray2.90L1-70[»]
    2NVTX-ray3.36L1-70[»]
    2NVXX-ray3.60L1-70[»]
    2NVYX-ray3.40L1-70[»]
    2NVZX-ray4.30L1-70[»]
    2R7ZX-ray3.80L1-70[»]
    2R92X-ray3.80L1-70[»]
    2R93X-ray4.00L1-70[»]
    2VUMX-ray3.40L1-70[»]
    2YU9X-ray3.40L1-70[»]
    3CQZX-ray2.80L1-70[»]
    3FKIX-ray3.88L1-70[»]
    3GTGX-ray3.78L1-70[»]
    3GTJX-ray3.42L1-70[»]
    3GTKX-ray3.80L1-70[»]
    3GTLX-ray3.38L1-70[»]
    3GTMX-ray3.80L1-70[»]
    3GTOX-ray4.00L1-70[»]
    3GTPX-ray3.90L1-70[»]
    3GTQX-ray3.80L1-70[»]
    3H3VX-ray4.00M1-70[»]
    3HOUX-ray3.20L/X1-70[»]
    3HOVX-ray3.50L1-70[»]
    3HOWX-ray3.60L1-70[»]
    3HOXX-ray3.65L1-70[»]
    3HOYX-ray3.40L1-70[»]
    3HOZX-ray3.65L1-70[»]
    3I4MX-ray3.70L1-70[»]
    3I4NX-ray3.90L1-70[»]
    3J1Nelectron microscopy16.00L1-70[»]
    3K1FX-ray4.30L1-70[»]
    3K7AX-ray3.80L1-70[»]
    3M3YX-ray3.18L1-70[»]
    3M4OX-ray3.57L1-70[»]
    3PO2X-ray3.30L1-70[»]
    3PO3X-ray3.30L1-70[»]
    3QT1X-ray4.30L1-70[»]
    3RZDX-ray3.30L1-70[»]
    3RZOX-ray3.00L1-70[»]
    3S14X-ray2.85L1-70[»]
    3S15X-ray3.30L1-70[»]
    3S16X-ray3.24L1-70[»]
    3S17X-ray3.20L1-70[»]
    3S1MX-ray3.13L1-70[»]
    3S1NX-ray3.10L1-70[»]
    3S1QX-ray3.30L1-70[»]
    3S1RX-ray3.20L1-70[»]
    3S2DX-ray3.20L1-70[»]
    3S2HX-ray3.30L1-70[»]
    4A3BX-ray3.50L1-70[»]
    4A3CX-ray3.50L1-70[»]
    4A3DX-ray3.40L1-70[»]
    4A3EX-ray3.40L1-70[»]
    4A3FX-ray3.50L1-70[»]
    4A3GX-ray3.50L1-70[»]
    4A3IX-ray3.80L1-70[»]
    4A3JX-ray3.70L1-70[»]
    4A3KX-ray3.50L1-70[»]
    4A3LX-ray3.50L1-70[»]
    4A3MX-ray3.90L1-70[»]
    4A93X-ray3.40L1-70[»]
    4BBRX-ray3.40L1-70[»]
    4BBSX-ray3.60L1-70[»]
    4BXXX-ray3.28L1-70[»]
    4BXZX-ray4.80L1-70[»]
    4BY1X-ray3.60L1-70[»]
    4BY7X-ray3.15L1-70[»]
    4C2MX-ray2.801/L1-70[»]
    4C3HX-ray3.27L1-70[»]
    4C3IX-ray3.0L1-70[»]
    4C3JX-ray3.35L1-70[»]
    ProteinModelPortaliP40422.
    SMRiP40422. Positions 25-70.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP40422.

    Family & Domainsi

    Sequence similaritiesi

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri31 – 5121C4-typeAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiCOG1996.
    HOGENOMiHOG000191755.
    KOiK03009.
    OMAiKPRYSNT.
    OrthoDBiEOG7K0ZRP.

    Family and domain databases

    Gene3Di2.20.28.30. 1 hit.
    InterProiIPR006591. RNAP_P/RPABC4.
    IPR029040. RPABC4/Spt4.
    [Graphical view]
    PfamiPF03604. DNA_RNApol_7kD. 1 hit.
    [Graphical view]
    SMARTiSM00659. RPOLCX. 1 hit.
    [Graphical view]
    SUPFAMiSSF63393. SSF63393. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P40422-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSREGFQIPT NLDAAAAGTS QARTATLKYI CAECSSKLSL SRTDAVRCKD   50
    CGHRILLKAR TKRLVQFEAR 70
    Length:70
    Mass (Da):7,716
    Last modified:February 1, 1995 - v1
    Checksum:i066A3D982EC7361E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U23378 Genomic DNA. Translation: AAA64417.1.
    U10397 Genomic DNA. Translation: AAB68994.1.
    AY558549 Genomic DNA. Translation: AAS56875.1.
    BK006934 Genomic DNA. Translation: DAA06837.1.
    PIRiS58932.
    RefSeqiNP_012013.1. NM_001179273.1.

    Genome annotation databases

    EnsemblFungiiYHR143W-A; YHR143W-A; YHR143W-A.
    GeneIDi856547.
    KEGGisce:YHR143W-A.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U23378 Genomic DNA. Translation: AAA64417.1 .
    U10397 Genomic DNA. Translation: AAB68994.1 .
    AY558549 Genomic DNA. Translation: AAS56875.1 .
    BK006934 Genomic DNA. Translation: DAA06837.1 .
    PIRi S58932.
    RefSeqi NP_012013.1. NM_001179273.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1I3Q X-ray 3.10 L 1-70 [» ]
    1I50 X-ray 2.80 L 1-70 [» ]
    1I6H X-ray 3.30 L 1-70 [» ]
    1K83 X-ray 2.80 L 1-70 [» ]
    1NIK X-ray 4.10 L 1-70 [» ]
    1NT9 X-ray 4.20 L 1-70 [» ]
    1PQV X-ray 3.80 L 1-70 [» ]
    1R5U X-ray 4.50 L 1-70 [» ]
    1R9S X-ray 4.25 L 1-70 [» ]
    1R9T X-ray 3.50 L 1-70 [» ]
    1SFO X-ray 3.61 L 1-70 [» ]
    1TWA X-ray 3.20 L 1-70 [» ]
    1TWC X-ray 3.00 L 1-70 [» ]
    1TWF X-ray 2.30 L 1-70 [» ]
    1TWG X-ray 3.30 L 1-70 [» ]
    1TWH X-ray 3.40 L 1-70 [» ]
    1WCM X-ray 3.80 L 1-70 [» ]
    1Y1V X-ray 3.80 L 1-70 [» ]
    1Y1W X-ray 4.00 L 1-70 [» ]
    1Y1Y X-ray 4.00 L 1-70 [» ]
    1Y77 X-ray 4.50 L 1-70 [» ]
    2B63 X-ray 3.80 L 1-70 [» ]
    2B8K X-ray 4.15 L 1-70 [» ]
    2E2H X-ray 3.95 L 1-70 [» ]
    2E2I X-ray 3.41 L 1-70 [» ]
    2E2J X-ray 3.50 L 1-70 [» ]
    2JA5 X-ray 3.80 L 1-70 [» ]
    2JA6 X-ray 4.00 L 1-70 [» ]
    2JA7 X-ray 3.80 L/X 1-70 [» ]
    2JA8 X-ray 3.80 L 1-70 [» ]
    2NVQ X-ray 2.90 L 1-70 [» ]
    2NVT X-ray 3.36 L 1-70 [» ]
    2NVX X-ray 3.60 L 1-70 [» ]
    2NVY X-ray 3.40 L 1-70 [» ]
    2NVZ X-ray 4.30 L 1-70 [» ]
    2R7Z X-ray 3.80 L 1-70 [» ]
    2R92 X-ray 3.80 L 1-70 [» ]
    2R93 X-ray 4.00 L 1-70 [» ]
    2VUM X-ray 3.40 L 1-70 [» ]
    2YU9 X-ray 3.40 L 1-70 [» ]
    3CQZ X-ray 2.80 L 1-70 [» ]
    3FKI X-ray 3.88 L 1-70 [» ]
    3GTG X-ray 3.78 L 1-70 [» ]
    3GTJ X-ray 3.42 L 1-70 [» ]
    3GTK X-ray 3.80 L 1-70 [» ]
    3GTL X-ray 3.38 L 1-70 [» ]
    3GTM X-ray 3.80 L 1-70 [» ]
    3GTO X-ray 4.00 L 1-70 [» ]
    3GTP X-ray 3.90 L 1-70 [» ]
    3GTQ X-ray 3.80 L 1-70 [» ]
    3H3V X-ray 4.00 M 1-70 [» ]
    3HOU X-ray 3.20 L/X 1-70 [» ]
    3HOV X-ray 3.50 L 1-70 [» ]
    3HOW X-ray 3.60 L 1-70 [» ]
    3HOX X-ray 3.65 L 1-70 [» ]
    3HOY X-ray 3.40 L 1-70 [» ]
    3HOZ X-ray 3.65 L 1-70 [» ]
    3I4M X-ray 3.70 L 1-70 [» ]
    3I4N X-ray 3.90 L 1-70 [» ]
    3J1N electron microscopy 16.00 L 1-70 [» ]
    3K1F X-ray 4.30 L 1-70 [» ]
    3K7A X-ray 3.80 L 1-70 [» ]
    3M3Y X-ray 3.18 L 1-70 [» ]
    3M4O X-ray 3.57 L 1-70 [» ]
    3PO2 X-ray 3.30 L 1-70 [» ]
    3PO3 X-ray 3.30 L 1-70 [» ]
    3QT1 X-ray 4.30 L 1-70 [» ]
    3RZD X-ray 3.30 L 1-70 [» ]
    3RZO X-ray 3.00 L 1-70 [» ]
    3S14 X-ray 2.85 L 1-70 [» ]
    3S15 X-ray 3.30 L 1-70 [» ]
    3S16 X-ray 3.24 L 1-70 [» ]
    3S17 X-ray 3.20 L 1-70 [» ]
    3S1M X-ray 3.13 L 1-70 [» ]
    3S1N X-ray 3.10 L 1-70 [» ]
    3S1Q X-ray 3.30 L 1-70 [» ]
    3S1R X-ray 3.20 L 1-70 [» ]
    3S2D X-ray 3.20 L 1-70 [» ]
    3S2H X-ray 3.30 L 1-70 [» ]
    4A3B X-ray 3.50 L 1-70 [» ]
    4A3C X-ray 3.50 L 1-70 [» ]
    4A3D X-ray 3.40 L 1-70 [» ]
    4A3E X-ray 3.40 L 1-70 [» ]
    4A3F X-ray 3.50 L 1-70 [» ]
    4A3G X-ray 3.50 L 1-70 [» ]
    4A3I X-ray 3.80 L 1-70 [» ]
    4A3J X-ray 3.70 L 1-70 [» ]
    4A3K X-ray 3.50 L 1-70 [» ]
    4A3L X-ray 3.50 L 1-70 [» ]
    4A3M X-ray 3.90 L 1-70 [» ]
    4A93 X-ray 3.40 L 1-70 [» ]
    4BBR X-ray 3.40 L 1-70 [» ]
    4BBS X-ray 3.60 L 1-70 [» ]
    4BXX X-ray 3.28 L 1-70 [» ]
    4BXZ X-ray 4.80 L 1-70 [» ]
    4BY1 X-ray 3.60 L 1-70 [» ]
    4BY7 X-ray 3.15 L 1-70 [» ]
    4C2M X-ray 2.80 1/L 1-70 [» ]
    4C3H X-ray 3.27 L 1-70 [» ]
    4C3I X-ray 3.0 L 1-70 [» ]
    4C3J X-ray 3.35 L 1-70 [» ]
    ProteinModelPortali P40422.
    SMRi P40422. Positions 25-70.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36577. 64 interactions.
    DIPi DIP-936N.
    IntActi P40422. 7 interactions.
    MINTi MINT-559375.
    STRINGi 4932.YHR143W-A.

    Proteomic databases

    MaxQBi P40422.
    PaxDbi P40422.
    PeptideAtlasi P40422.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YHR143W-A ; YHR143W-A ; YHR143W-A .
    GeneIDi 856547.
    KEGGi sce:YHR143W-A.

    Organism-specific databases

    CYGDi YHR143w-a.
    SGDi S000001185. RPC10.

    Phylogenomic databases

    eggNOGi COG1996.
    HOGENOMi HOG000191755.
    KOi K03009.
    OMAi KPRYSNT.
    OrthoDBi EOG7K0ZRP.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31179-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei P40422.
    NextBioi 982349.
    PROi P40422.

    Gene expression databases

    Genevestigatori P40422.

    Family and domain databases

    Gene3Di 2.20.28.30. 1 hit.
    InterProi IPR006591. RNAP_P/RPABC4.
    IPR029040. RPABC4/Spt4.
    [Graphical view ]
    Pfami PF03604. DNA_RNApol_7kD. 1 hit.
    [Graphical view ]
    SMARTi SM00659. RPOLCX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF63393. SSF63393. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "RPC10 encodes a new mini subunit shared by yeast nuclear RNA polymerases."
      Treich I., Carles C., Riva M., Sentenac A.
      Gene Expr. 2:31-37(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 4-23 AND 64-70.
      Strain: ATCC 204508 / S288c.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    5. "The yeast RNA polymerase III transcription machinery: a paradigm for eukaryotic gene activation."
      Chedin S., Ferri M.L., Peyroche G., Andrau J.-C., Jourdain S., Lefebvre O., Werner M., Carles C., Sentenac A.
      Cold Spring Harb. Symp. Quant. Biol. 63:381-389(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW ON THE RNA POL III COMPLEX.
    6. "Interaction between yeast RNA polymerase III and transcription factor TFIIIC via ABC10alpha and tau131 subunits."
      Dumay H., Rubbi L., Sentenac A., Marck C.
      J. Biol. Chem. 274:33462-33468(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TFC4.
    7. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    8. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    9. "Structural basis of transcription: RNA polymerase II at 2.8 A resolution."
      Cramer P., Bushnell D.A., Kornberg R.D.
      Science 292:1863-1876(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF THE RNA POL II CORE COMPLEX.
    10. "Structural basis of transcription: an RNA polymerase II elongation complex at 3.3 A resolution."
      Gnatt A.L., Cramer P., Fu J., Bushnell D.A., Kornberg R.D.
      Science 292:1876-1882(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF THE RNA POL II CORE COMPLEX.
    11. "Structural basis of transcription: alpha-amanitin-RNA polymerase II cocrystal at 2.8 A resolution."
      Bushnell D.A., Cramer P., Kornberg R.D.
      Proc. Natl. Acad. Sci. U.S.A. 99:1218-1222(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF THE RNA POL II CORE COMPLEX IN COMPLEX WITH ALPHA-AMANITIN.
    12. "Architecture of the RNA polymerase II-TFIIS complex and implications for mRNA cleavage."
      Kettenberger H., Armache K.J., Cramer P.
      Cell 114:347-357(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.8 ANGSTROMS) OF THE RNA POL II COMPLEX IN COMPLEX WITH DST1.
    13. "RNA polymerase II/TFIIF structure and conserved organization of the initiation complex."
      Chung W.H., Craighead J.L., Chang W.H., Ezeokonkwo C., Bareket-Samish A., Kornberg R.D., Asturias F.J.
      Mol. Cell 12:1003-1013(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: ELECTRON MICROSCOPY OF THE RNA POL II/TFIIF COMPLEX.
    14. "Architecture of initiation-competent 12-subunit RNA polymerase II."
      Armache K.J., Kettenberger H., Cramer P.
      Proc. Natl. Acad. Sci. U.S.A. 100:6964-6968(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (4.2 ANGSTROMS) OF THE RNA POL II COMPLEX.
    15. "Complete, 12-subunit RNA polymerase II at 4.1-A resolution: implications for the initiation of transcription."
      Bushnell D.A., Kornberg R.D.
      Proc. Natl. Acad. Sci. U.S.A. 100:6969-6973(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (4.1 ANGSTROMS) OF THE RNA POL II CORE COMPLEX.
    16. "Structural basis of transcription: nucleotide selection by rotation in the RNA polymerase II active center."
      Westover K.D., Bushnell D.A., Kornberg R.D.
      Cell 119:481-489(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF THE RNA POL II CORE COMPLEX.
    17. "Complete RNA polymerase II elongation complex structure and its interactions with NTP and TFIIS."
      Kettenberger H., Armache K.J., Cramer P.
      Mol. Cell 16:955-965(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (4.5 ANGSTROMS).
    18. "Structural basis of transcription: an RNA polymerase II-TFIIB cocrystal at 4.5 Angstroms."
      Bushnell D.A., Westover K.D., Davis R.E., Kornberg R.D.
      Science 303:983-988(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (4.5 ANGSTROMS) OF THE RNA POL II CORE COMPLEX.
    19. "Structures of complete RNA polymerase II and its subcomplex, Rpb4/7."
      Armache K.J., Mitterweger S., Meinhart A., Cramer P.
      J. Biol. Chem. 280:7131-7134(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.8 ANGSTROMS) OF THE RNA POL II COMPLEX.
    20. "Structural biology of RNA polymerase III: subcomplex C17/25 X-ray structure and 11 subunit enzyme model."
      Jasiak A.J., Armache K.J., Martens B., Jansen R.P., Cramer P.
      Mol. Cell 23:71-81(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: 3D-STRUCTURE MODELING OF THE POL III CORE COMPLEX.
    21. "Structure of an RNA polymerase II-RNA inhibitor complex elucidates transcription regulation by noncoding RNAs."
      Kettenberger H., Eisenfuhr A., Brueckner F., Theis M., Famulok M., Cramer P.
      Nat. Struct. Mol. Biol. 13:44-48(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.8 ANGSTROMS) OF THE RNA POL II COMPLEX IN COMPLEX WITH INHIBITING NON-CODING RNA.
    22. "Phasing RNA polymerase II using intrinsically bound Zn atoms: an updated structural model."
      Meyer P.A., Ye P., Zhang M., Suh M.H., Fu J.
      Structure 14:973-982(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (4.15 ANGSTROMS) OF THE RNA POL II COMPLEX.
    23. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (12.00 ANGSTROMS) OF THE POL I COMPLEX, FUNCTION, SUBUNIT.
    24. Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE POL I COMPLEX, FUNCTION, SUBUNIT.
    25. "RNA polymerase I structure and transcription regulation."
      Engel C., Sainsbury S., Cheung A.C., Kostrewa D., Cramer P.
      Nature 502:650-655(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF THE POL I COMPLEX, FUNCTION, SUBUNIT.

    Entry informationi

    Entry nameiRPAB4_YEAST
    AccessioniPrimary (citable) accession number: P40422
    Secondary accession number(s): D3DL93
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 142 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 907 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome VIII
      Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

    External Data

    Dasty 3