Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P40421

- RDGC_DROME

UniProt

P40421 - RDGC_DROME

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Serine/threonine-protein phosphatase rdgC

Gene

rdgC

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Phosphatase required to prevent light-induced retinal degeneration.1 Publication

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi158 – 1581Manganese 1By similarity
Metal bindingi160 – 1601Manganese 1By similarity
Metal bindingi187 – 1871Manganese 1By similarity
Metal bindingi187 – 1871Manganese 2By similarity
Metal bindingi219 – 2191Manganese 2By similarity
Active sitei220 – 2201Proton donorBy similarity
Metal bindingi271 – 2711Manganese 2By similarity
Metal bindingi360 – 3601Manganese 2By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi539 – 550121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi579 – 590122PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. calcium-dependent protein serine/threonine phosphatase activity Source: FlyBase
  2. calcium ion binding Source: InterPro
  3. calmodulin binding Source: FlyBase
  4. iron ion binding Source: InterPro
  5. manganese ion binding Source: InterPro
  6. protein serine/threonine phosphatase activity Source: FlyBase

GO - Biological processi

  1. calcium-mediated signaling Source: FlyBase
  2. deactivation of rhodopsin mediated signaling Source: FlyBase
  3. detection of stimulus involved in sensory perception Source: InterPro
  4. phototransduction Source: FlyBase
  5. protein dephosphorylation Source: FlyBase
  6. thermotaxis Source: FlyBase
  7. visual perception Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Sensory transduction, Vision

Keywords - Ligandi

Calcium, Magnesium, Manganese, Metal-binding

Enzyme and pathway databases

SignaLinkiP40421.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase rdgC (EC:3.1.3.16)
Alternative name(s):
Retinal degeneration C protein
Gene namesi
Name:rdgC
ORF Names:CG44746
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0265959. rdgC.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 661661Serine/threonine-protein phosphatase rdgCPRO_0000058903Add
BLAST

Proteomic databases

PaxDbiP40421.
PRIDEiP40421.

Expressioni

Tissue specificityi

Expressed in the visual system of the fly, as well as in the mushroom bodies of the central brain.1 Publication

Gene expression databases

BgeeiP40421.

Interactioni

Protein-protein interaction databases

BioGridi65488. 5 interactions.
IntActiP40421. 1 interaction.
MINTiMINT-6825050.

Structurei

3D structure databases

ProteinModelPortaliP40421.
SMRiP40421. Positions 115-410, 444-598.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 3226IQPROSITE-ProRule annotationAdd
BLAST
Domaini441 – 47636EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini526 – 56136EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini566 – 60136EF-hand 3PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni105 – 413309CatalyticAdd
BLAST

Sequence similaritiesi

Belongs to the PPP phosphatase family.Curated
Contains 3 EF-hand domains.PROSITE-ProRule annotation
Contains 1 IQ domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0639.
GeneTreeiENSGT00530000063173.
InParanoidiP40421.
KOiK13807.
OMAiNMLEYKS.
PhylomeDBiP40421.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR029052. Metallo-depent_PP-like.
IPR012008. Ser/Thr-Pase_EF-hand_contain.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
PF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFiPIRSF000912. PPEF. 1 hit.
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00054. EFh. 3 hits.
SM00015. IQ. 1 hit.
SM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 3 hits.
PS50096. IQ. 1 hit.
PS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40421-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDENAIRAAI FIQKWYRRHQ ARREMQRRCN WQIFQNLEYA SEQDQAELYK
60 70 80 90 100
FFNDLIKHMP QAAGRKNQYQ GSAHVSVLDD KDDLVEEFGD IVNAKIELPI
110 120 130 140 150
RKNHIDLLID VFRKKRGNRL HPKYVALILR EAAKSLKQLP NISPVSTAVS
160 170 180 190 200
QQVTVCGDLH GKLDDLLVVL HKNGLPSSSN PYVFNGDFVD RGKRGLEVLL
210 220 230 240 250
LLLSLYLAFP NAVFLNRGNH EDSVMNARYG FIREVESKYP RNHKRILAFI
260 270 280 290 300
DEVYRWLPLG SVLNSRVLIV HGGFSDSTSL DLIKSIDRGK YVSILRPPLT
310 320 330 340 350
DGEPLDKTEW QQIFDIMWSD PQATMGCVPN TLRGAGVWFG PDVTDNFLQR
360 370 380 390 400
HRLSYVIRSH ECKPNGHEFM HDNKIITIFS ASNYYAIGSN KGAYIRLNNQ
410 420 430 440 450
LMPHFVQYIS AASQTKRLSF KQRMGIVESS ALKELAVRMR DHRDELEDEF
460 470 480 490 500
RKYDPKDSGY ISISHWCKVM ENVTKLGLPW RLLRDKLAPG TDSQKVNYNR
510 520 530 540 550
TLDLLDTDVI LEAEADGMSV MDALYANKAS LVAIFNIIDA DNSGEITLDE
560 570 580 590 600
FETAIDLLVA HMPGAYSKAE MLEKCRMMDL NGDGKVDLNE FLEAFRLSDL
610 620 630 640 650
HRKEQQDENI RRRSTGRPSV AKTATDPVTL LADKISKNTL VVEHDIDPTD
660
CESKVIDPKK S
Length:661
Mass (Da):75,511
Last modified:February 1, 1995 - v1
Checksum:iA3DC42933E4CCA33
GO

Sequence cautioni

The sequence AAF49044.2 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence AAO41218.2 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence AAV36844.1 differs from that shown. Reason: Intron retention.Curated
The sequence AAV36844.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti522 – 5221D → G in AAV36844. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M89628 Genomic DNA. Translation: AAB00734.1.
AE014296 Genomic DNA. Translation: AAF49044.2. Sequence problems.
AE014296 Genomic DNA. Translation: AAO41217.1.
AE014296 Genomic DNA. Translation: AAO41218.2. Sequence problems.
BT015959 mRNA. Translation: AAV36844.1. Sequence problems.
PIRiA42287.
RefSeqiNP_536738.3. NM_080490.4.
NP_788544.2. NM_176366.2.
NP_788545.3. NM_176367.3.
NP_788546.1. NM_176368.2.

Genome annotation databases

EnsemblMetazoaiFBtr0074833; FBpp0074602; FBgn0004366.
GeneIDi40224.
KEGGidme:Dmel_CG6571.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M89628 Genomic DNA. Translation: AAB00734.1 .
AE014296 Genomic DNA. Translation: AAF49044.2 . Sequence problems.
AE014296 Genomic DNA. Translation: AAO41217.1 .
AE014296 Genomic DNA. Translation: AAO41218.2 . Sequence problems.
BT015959 mRNA. Translation: AAV36844.1 . Sequence problems.
PIRi A42287.
RefSeqi NP_536738.3. NM_080490.4.
NP_788544.2. NM_176366.2.
NP_788545.3. NM_176367.3.
NP_788546.1. NM_176368.2.

3D structure databases

ProteinModelPortali P40421.
SMRi P40421. Positions 115-410, 444-598.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 65488. 5 interactions.
IntActi P40421. 1 interaction.
MINTi MINT-6825050.

Proteomic databases

PaxDbi P40421.
PRIDEi P40421.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0074833 ; FBpp0074602 ; FBgn0004366 .
GeneIDi 40224.
KEGGi dme:Dmel_CG6571.

Organism-specific databases

CTDi 40224.
FlyBasei FBgn0265959. rdgC.

Phylogenomic databases

eggNOGi COG0639.
GeneTreei ENSGT00530000063173.
InParanoidi P40421.
KOi K13807.
OMAi NMLEYKS.
PhylomeDBi P40421.

Enzyme and pathway databases

SignaLinki P40421.

Miscellaneous databases

ChiTaRSi rdgC. fly.
GenomeRNAii 40224.
NextBioi 817660.
PROi P40421.

Gene expression databases

Bgeei P40421.

Family and domain databases

Gene3Di 1.10.238.10. 2 hits.
3.60.21.10. 1 hit.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR029052. Metallo-depent_PP-like.
IPR012008. Ser/Thr-Pase_EF-hand_contain.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view ]
Pfami PF13499. EF-hand_7. 1 hit.
PF00149. Metallophos. 1 hit.
[Graphical view ]
PIRSFi PIRSF000912. PPEF. 1 hit.
PRINTSi PR00114. STPHPHTASE.
SMARTi SM00054. EFh. 3 hits.
SM00015. IQ. 1 hit.
SM00156. PP2Ac. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
PROSITEi PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 3 hits.
PS50096. IQ. 1 hit.
PS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Drosophila retinal degeneration C (rdgC) encodes a novel serine/threonine protein phosphatase."
    Steele F.R., Washburn T., Rieger R., O'Tousa J.E.
    Cell 69:669-676(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, TISSUE SPECIFICITY.
    Strain: Oregon-R.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  4. Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M., Park S., Wan K.H., Yu C., Rubin G.M., Celniker S.E.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 48-661.
    Strain: Berkeley.
    Tissue: Head.

Entry informationi

Entry nameiRDGC_DROME
AccessioniPrimary (citable) accession number: P40421
Secondary accession number(s): A4V255, Q5U1D3, Q9VWA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 26, 2014
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3