Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P40421

- RDGC_DROME

UniProt

P40421 - RDGC_DROME

Protein

Serine/threonine-protein phosphatase rdgC

Gene

rdgC

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 141 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Phosphatase required to prevent light-induced retinal degeneration.1 Publication

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi158 – 1581Manganese 1By similarity
    Metal bindingi160 – 1601Manganese 1By similarity
    Metal bindingi187 – 1871Manganese 1By similarity
    Metal bindingi187 – 1871Manganese 2By similarity
    Metal bindingi219 – 2191Manganese 2By similarity
    Active sitei220 – 2201Proton donorBy similarity
    Metal bindingi271 – 2711Manganese 2By similarity
    Metal bindingi360 – 3601Manganese 2By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi539 – 550121PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi579 – 590122PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium-dependent protein serine/threonine phosphatase activity Source: FlyBase
    2. calcium ion binding Source: InterPro
    3. calmodulin binding Source: FlyBase
    4. iron ion binding Source: InterPro
    5. manganese ion binding Source: InterPro
    6. protein serine/threonine phosphatase activity Source: FlyBase

    GO - Biological processi

    1. calcium-mediated signaling Source: FlyBase
    2. deactivation of rhodopsin mediated signaling Source: FlyBase
    3. detection of stimulus involved in sensory perception Source: InterPro
    4. phototransduction Source: FlyBase
    5. protein dephosphorylation Source: FlyBase
    6. thermotaxis Source: FlyBase
    7. visual perception Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Biological processi

    Sensory transduction, Vision

    Keywords - Ligandi

    Calcium, Magnesium, Manganese, Metal-binding

    Enzyme and pathway databases

    SignaLinkiP40421.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase rdgC (EC:3.1.3.16)
    Alternative name(s):
    Retinal degeneration C protein
    Gene namesi
    Name:rdgC
    ORF Names:CG44746
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 3L

    Organism-specific databases

    FlyBaseiFBgn0265959. rdgC.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 661661Serine/threonine-protein phosphatase rdgCPRO_0000058903Add
    BLAST

    Proteomic databases

    PaxDbiP40421.
    PRIDEiP40421.

    Expressioni

    Tissue specificityi

    Expressed in the visual system of the fly, as well as in the mushroom bodies of the central brain.1 Publication

    Gene expression databases

    BgeeiP40421.

    Interactioni

    Protein-protein interaction databases

    BioGridi65488. 5 interactions.
    IntActiP40421. 1 interaction.
    MINTiMINT-6825050.

    Structurei

    3D structure databases

    ProteinModelPortaliP40421.
    SMRiP40421. Positions 115-410, 444-598.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini7 – 3226IQPROSITE-ProRule annotationAdd
    BLAST
    Domaini441 – 47636EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini526 – 56136EF-hand 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini566 – 60136EF-hand 3PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni105 – 413309CatalyticAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PPP phosphatase family.Curated
    Contains 3 EF-hand domains.PROSITE-ProRule annotation
    Contains 1 IQ domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG0639.
    GeneTreeiENSGT00530000063173.
    InParanoidiP40421.
    KOiK13807.
    OMAiNMLEYKS.
    PhylomeDBiP40421.

    Family and domain databases

    Gene3Di1.10.238.10. 2 hits.
    3.60.21.10. 1 hit.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR000048. IQ_motif_EF-hand-BS.
    IPR029052. Metallo-depent_PP-like.
    IPR012008. Ser/Thr-Pase_EF-hand_contain.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view]
    PfamiPF13499. EF-hand_7. 1 hit.
    PF00149. Metallophos. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000912. PPEF. 1 hit.
    PRINTSiPR00114. STPHPHTASE.
    SMARTiSM00054. EFh. 3 hits.
    SM00015. IQ. 1 hit.
    SM00156. PP2Ac. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.
    PROSITEiPS00018. EF_HAND_1. 2 hits.
    PS50222. EF_HAND_2. 3 hits.
    PS50096. IQ. 1 hit.
    PS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P40421-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDENAIRAAI FIQKWYRRHQ ARREMQRRCN WQIFQNLEYA SEQDQAELYK    50
    FFNDLIKHMP QAAGRKNQYQ GSAHVSVLDD KDDLVEEFGD IVNAKIELPI 100
    RKNHIDLLID VFRKKRGNRL HPKYVALILR EAAKSLKQLP NISPVSTAVS 150
    QQVTVCGDLH GKLDDLLVVL HKNGLPSSSN PYVFNGDFVD RGKRGLEVLL 200
    LLLSLYLAFP NAVFLNRGNH EDSVMNARYG FIREVESKYP RNHKRILAFI 250
    DEVYRWLPLG SVLNSRVLIV HGGFSDSTSL DLIKSIDRGK YVSILRPPLT 300
    DGEPLDKTEW QQIFDIMWSD PQATMGCVPN TLRGAGVWFG PDVTDNFLQR 350
    HRLSYVIRSH ECKPNGHEFM HDNKIITIFS ASNYYAIGSN KGAYIRLNNQ 400
    LMPHFVQYIS AASQTKRLSF KQRMGIVESS ALKELAVRMR DHRDELEDEF 450
    RKYDPKDSGY ISISHWCKVM ENVTKLGLPW RLLRDKLAPG TDSQKVNYNR 500
    TLDLLDTDVI LEAEADGMSV MDALYANKAS LVAIFNIIDA DNSGEITLDE 550
    FETAIDLLVA HMPGAYSKAE MLEKCRMMDL NGDGKVDLNE FLEAFRLSDL 600
    HRKEQQDENI RRRSTGRPSV AKTATDPVTL LADKISKNTL VVEHDIDPTD 650
    CESKVIDPKK S 661
    Length:661
    Mass (Da):75,511
    Last modified:February 1, 1995 - v1
    Checksum:iA3DC42933E4CCA33
    GO

    Sequence cautioni

    The sequence AAV36844.1 differs from that shown. Reason: Intron retention.
    The sequence AAV36844.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAF49044.2 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence AAO41218.2 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti522 – 5221D → G in AAV36844. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M89628 Genomic DNA. Translation: AAB00734.1.
    AE014296 Genomic DNA. Translation: AAF49044.2. Sequence problems.
    AE014296 Genomic DNA. Translation: AAO41217.1.
    AE014296 Genomic DNA. Translation: AAO41218.2. Sequence problems.
    BT015959 mRNA. Translation: AAV36844.1. Sequence problems.
    PIRiA42287.
    RefSeqiNP_788544.1. NM_176366.1.
    UniGeneiDm.5730.

    Genome annotation databases

    EnsemblMetazoaiFBtr0074833; FBpp0074602; FBgn0004366.
    GeneIDi40224.
    KEGGidme:Dmel_CG6571.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M89628 Genomic DNA. Translation: AAB00734.1 .
    AE014296 Genomic DNA. Translation: AAF49044.2 . Sequence problems.
    AE014296 Genomic DNA. Translation: AAO41217.1 .
    AE014296 Genomic DNA. Translation: AAO41218.2 . Sequence problems.
    BT015959 mRNA. Translation: AAV36844.1 . Sequence problems.
    PIRi A42287.
    RefSeqi NP_788544.1. NM_176366.1.
    UniGenei Dm.5730.

    3D structure databases

    ProteinModelPortali P40421.
    SMRi P40421. Positions 115-410, 444-598.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 65488. 5 interactions.
    IntActi P40421. 1 interaction.
    MINTi MINT-6825050.

    Proteomic databases

    PaxDbi P40421.
    PRIDEi P40421.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0074833 ; FBpp0074602 ; FBgn0004366 .
    GeneIDi 40224.
    KEGGi dme:Dmel_CG6571.

    Organism-specific databases

    CTDi 40224.
    FlyBasei FBgn0265959. rdgC.

    Phylogenomic databases

    eggNOGi COG0639.
    GeneTreei ENSGT00530000063173.
    InParanoidi P40421.
    KOi K13807.
    OMAi NMLEYKS.
    PhylomeDBi P40421.

    Enzyme and pathway databases

    SignaLinki P40421.

    Miscellaneous databases

    GenomeRNAii 40224.
    NextBioi 817660.
    PROi P40421.

    Gene expression databases

    Bgeei P40421.

    Family and domain databases

    Gene3Di 1.10.238.10. 2 hits.
    3.60.21.10. 1 hit.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR000048. IQ_motif_EF-hand-BS.
    IPR029052. Metallo-depent_PP-like.
    IPR012008. Ser/Thr-Pase_EF-hand_contain.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view ]
    Pfami PF13499. EF-hand_7. 1 hit.
    PF00149. Metallophos. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000912. PPEF. 1 hit.
    PRINTSi PR00114. STPHPHTASE.
    SMARTi SM00054. EFh. 3 hits.
    SM00015. IQ. 1 hit.
    SM00156. PP2Ac. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    PROSITEi PS00018. EF_HAND_1. 2 hits.
    PS50222. EF_HAND_2. 3 hits.
    PS50096. IQ. 1 hit.
    PS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Drosophila retinal degeneration C (rdgC) encodes a novel serine/threonine protein phosphatase."
      Steele F.R., Washburn T., Rieger R., O'Tousa J.E.
      Cell 69:669-676(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, TISSUE SPECIFICITY.
      Strain: Oregon-R.
    2. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    3. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    4. Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M., Park S., Wan K.H., Yu C., Rubin G.M., Celniker S.E.
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 48-661.
      Strain: Berkeley.
      Tissue: Head.

    Entry informationi

    Entry nameiRDGC_DROME
    AccessioniPrimary (citable) accession number: P40421
    Secondary accession number(s): A4V255, Q5U1D3, Q9VWA4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 141 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3