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Protein

Serine/threonine-protein phosphatase rdgC

Gene

rdgC

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Phosphatase required to prevent light-induced retinal degeneration.1 Publication

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi158Manganese 1By similarity1
Metal bindingi160Manganese 1By similarity1
Metal bindingi187Manganese 1By similarity1
Metal bindingi187Manganese 2By similarity1
Metal bindingi219Manganese 2By similarity1
Active sitei220Proton donorBy similarity1
Metal bindingi271Manganese 2By similarity1
Metal bindingi360Manganese 2By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi539 – 5501PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi579 – 5902PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • calcium-dependent protein serine/threonine phosphatase activity Source: FlyBase
  • calcium ion binding Source: InterPro
  • calmodulin binding Source: FlyBase
  • protein serine/threonine phosphatase activity Source: FlyBase

GO - Biological processi

  • calcium-mediated signaling Source: FlyBase
  • deactivation of rhodopsin mediated signaling Source: FlyBase
  • detection of temperature stimulus involved in sensory perception of pain Source: FlyBase
  • phototransduction Source: FlyBase
  • protein dephosphorylation Source: FlyBase
  • sensory perception of pain Source: FlyBase
  • thermotaxis Source: FlyBase
  • visual perception Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Sensory transduction, Vision

Keywords - Ligandi

Calcium, Magnesium, Manganese, Metal-binding

Enzyme and pathway databases

ReactomeiR-DME-2514859. Inactivation, recovery and regulation of the phototransduction cascade.
SignaLinkiP40421.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase rdgC (EC:3.1.3.16)
Alternative name(s):
Retinal degeneration C protein
Gene namesi
Name:rdgC
ORF Names:CG44746
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0265959. rdgC.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000589031 – 661Serine/threonine-protein phosphatase rdgCAdd BLAST661

Proteomic databases

PaxDbiP40421.
PRIDEiP40421.

Expressioni

Tissue specificityi

Expressed in the visual system of the fly, as well as in the mushroom bodies of the central brain.1 Publication

Gene expression databases

BgeeiFBgn0004366.
GenevisibleiP40421. DM.

Interactioni

GO - Molecular functioni

  • calmodulin binding Source: FlyBase

Protein-protein interaction databases

BioGridi65488. 5 interactors.
IntActiP40421. 1 interactor.
MINTiMINT-6825050.
STRINGi7227.FBpp0074602.

Structurei

3D structure databases

ProteinModelPortaliP40421.
SMRiP40421.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 32IQPROSITE-ProRule annotationAdd BLAST26
Domaini441 – 476EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini526 – 561EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini566 – 601EF-hand 3PROSITE-ProRule annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni105 – 413CatalyticAdd BLAST309

Sequence similaritiesi

Belongs to the PPP phosphatase family.Curated
Contains 3 EF-hand domains.PROSITE-ProRule annotation
Contains 1 IQ domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0377. Eukaryota.
COG0639. LUCA.
GeneTreeiENSGT00530000063173.
InParanoidiP40421.
KOiK13807.
OrthoDBiEOG091G02M5.
PhylomeDBiP40421.

Family and domain databases

CDDicd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 2 hits.
3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF13202. EF-hand_5. 2 hits.
PF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00054. EFh. 3 hits.
SM00015. IQ. 1 hit.
SM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
SSF56300. SSF56300. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 3 hits.
PS50096. IQ. 1 hit.
PS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40421-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDENAIRAAI FIQKWYRRHQ ARREMQRRCN WQIFQNLEYA SEQDQAELYK
60 70 80 90 100
FFNDLIKHMP QAAGRKNQYQ GSAHVSVLDD KDDLVEEFGD IVNAKIELPI
110 120 130 140 150
RKNHIDLLID VFRKKRGNRL HPKYVALILR EAAKSLKQLP NISPVSTAVS
160 170 180 190 200
QQVTVCGDLH GKLDDLLVVL HKNGLPSSSN PYVFNGDFVD RGKRGLEVLL
210 220 230 240 250
LLLSLYLAFP NAVFLNRGNH EDSVMNARYG FIREVESKYP RNHKRILAFI
260 270 280 290 300
DEVYRWLPLG SVLNSRVLIV HGGFSDSTSL DLIKSIDRGK YVSILRPPLT
310 320 330 340 350
DGEPLDKTEW QQIFDIMWSD PQATMGCVPN TLRGAGVWFG PDVTDNFLQR
360 370 380 390 400
HRLSYVIRSH ECKPNGHEFM HDNKIITIFS ASNYYAIGSN KGAYIRLNNQ
410 420 430 440 450
LMPHFVQYIS AASQTKRLSF KQRMGIVESS ALKELAVRMR DHRDELEDEF
460 470 480 490 500
RKYDPKDSGY ISISHWCKVM ENVTKLGLPW RLLRDKLAPG TDSQKVNYNR
510 520 530 540 550
TLDLLDTDVI LEAEADGMSV MDALYANKAS LVAIFNIIDA DNSGEITLDE
560 570 580 590 600
FETAIDLLVA HMPGAYSKAE MLEKCRMMDL NGDGKVDLNE FLEAFRLSDL
610 620 630 640 650
HRKEQQDENI RRRSTGRPSV AKTATDPVTL LADKISKNTL VVEHDIDPTD
660
CESKVIDPKK S
Length:661
Mass (Da):75,511
Last modified:February 1, 1995 - v1
Checksum:iA3DC42933E4CCA33
GO

Sequence cautioni

The sequence AAF49044 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAO41217 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAO41218 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAV36844 differs from that shown. Intron retention.Curated
The sequence AAV36844 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti522D → G in AAV36844 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M89628 Genomic DNA. Translation: AAB00734.1.
AE014296 Genomic DNA. Translation: AAF49044.3. Sequence problems.
AE014296 Genomic DNA. Translation: AAO41217.2. Sequence problems.
AE014296 Genomic DNA. Translation: AAO41218.3. Sequence problems.
BT015959 mRNA. Translation: AAV36844.1. Sequence problems.
PIRiA42287.
RefSeqiNP_536738.3. NM_080490.4.
NP_788544.2. NM_176366.2.
NP_788545.3. NM_176367.3.
NP_788546.1. NM_176368.2.

Genome annotation databases

EnsemblMetazoaiFBtr0342946; FBpp0309720; FBgn0265959.
GeneIDi40224.
KEGGidme:Dmel_CG44746.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M89628 Genomic DNA. Translation: AAB00734.1.
AE014296 Genomic DNA. Translation: AAF49044.3. Sequence problems.
AE014296 Genomic DNA. Translation: AAO41217.2. Sequence problems.
AE014296 Genomic DNA. Translation: AAO41218.3. Sequence problems.
BT015959 mRNA. Translation: AAV36844.1. Sequence problems.
PIRiA42287.
RefSeqiNP_536738.3. NM_080490.4.
NP_788544.2. NM_176366.2.
NP_788545.3. NM_176367.3.
NP_788546.1. NM_176368.2.

3D structure databases

ProteinModelPortaliP40421.
SMRiP40421.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi65488. 5 interactors.
IntActiP40421. 1 interactor.
MINTiMINT-6825050.
STRINGi7227.FBpp0074602.

Proteomic databases

PaxDbiP40421.
PRIDEiP40421.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0342946; FBpp0309720; FBgn0265959.
GeneIDi40224.
KEGGidme:Dmel_CG44746.

Organism-specific databases

CTDi40224.
FlyBaseiFBgn0265959. rdgC.

Phylogenomic databases

eggNOGiKOG0377. Eukaryota.
COG0639. LUCA.
GeneTreeiENSGT00530000063173.
InParanoidiP40421.
KOiK13807.
OrthoDBiEOG091G02M5.
PhylomeDBiP40421.

Enzyme and pathway databases

ReactomeiR-DME-2514859. Inactivation, recovery and regulation of the phototransduction cascade.
SignaLinkiP40421.

Miscellaneous databases

ChiTaRSirdgC. fly.
GenomeRNAii40224.
PROiP40421.

Gene expression databases

BgeeiFBgn0004366.
GenevisibleiP40421. DM.

Family and domain databases

CDDicd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 2 hits.
3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF13202. EF-hand_5. 2 hits.
PF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00054. EFh. 3 hits.
SM00015. IQ. 1 hit.
SM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
SSF56300. SSF56300. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 3 hits.
PS50096. IQ. 1 hit.
PS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRDGC_DROME
AccessioniPrimary (citable) accession number: P40421
Secondary accession number(s): A4V255, Q5U1D3, Q9VWA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 30, 2016
This is version 161 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.