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P40417

- ERKA_DROME

UniProt

P40417 - ERKA_DROME

Protein

Mitogen-activated protein kinase ERK-A

Gene

rl

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 145 (01 Oct 2014)
      Sequence version 3 (18 Sep 2013)
      Previous versions | rss
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    Functioni

    Required downstream of Raf in the sevenless (sev), torso (tor), and Drosophila EGF receptor homolog (DER) signal transduction pathways. Required for embryonic epithelial tissue repair.2 Publications

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Cofactori

    Magnesium.By similarity

    Enzyme regulationi

    Activated by tyrosine and threonine phosphorylation.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei67 – 671ATPPROSITE-ProRule annotation
    Active sitei162 – 1621Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi44 – 529ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. JUN kinase activity Source: FlyBase
    3. MAP kinase activity Source: FlyBase
    4. protein binding Source: IntAct
    5. protein kinase binding Source: FlyBase
    6. protein serine/threonine kinase activity Source: FlyBase
    7. transcription factor binding Source: FlyBase

    GO - Biological processi

    1. adherens junction maintenance Source: FlyBase
    2. anterior/posterior axis specification, embryo Source: FlyBase
    3. behavioral response to ethanol Source: FlyBase
    4. cellular response to arsenic-containing substance Source: FlyBase
    5. cellular response to cadmium ion Source: FlyBase
    6. cellular response to DNA damage stimulus Source: FlyBase
    7. cellular response to reactive oxygen species Source: FlyBase
    8. cellular response to starvation Source: FlyBase
    9. gastrulation Source: FlyBase
    10. heart development Source: FlyBase
    11. imaginal disc-derived wing morphogenesis Source: FlyBase
    12. imaginal disc-derived wing vein morphogenesis Source: FlyBase
    13. imaginal disc-derived wing vein specification Source: FlyBase
    14. JUN phosphorylation Source: GOC
    15. MAPK cascade Source: FlyBase
    16. metamorphosis Source: FlyBase
    17. mitotic nuclear division Source: FlyBase
    18. negative regulation of apoptotic process Source: FlyBase
    19. negative regulation of macroautophagy Source: FlyBase
    20. positive regulation of cell proliferation Source: FlyBase
    21. positive regulation of photoreceptor cell differentiation Source: FlyBase
    22. positive regulation of wound healing Source: FlyBase
    23. protein phosphorylation Source: FlyBase
    24. R7 cell development Source: FlyBase
    25. regulation of response to drug Source: FlyBase
    26. regulation of synapse structure and activity Source: FlyBase
    27. regulation of synaptic transmission Source: FlyBase
    28. regulation of transcription, DNA-templated Source: FlyBase
    29. torso signaling pathway Source: FlyBase
    30. transmembrane receptor protein tyrosine kinase signaling pathway Source: FlyBase

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Cell cycle

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.11.24. 1994.
    ReactomeiREACT_180240. Negative regulation of FGFR signaling.
    REACT_181315. Regulation of actin dynamics for phagocytic cup formation.
    REACT_181531. CREB phosphorylation through the activation of Ras.
    REACT_181532. RSK activation.
    REACT_181712. Oxidative Stress Induced Senescence.
    REACT_182058. Senescence-Associated Secretory Phenotype (SASP).
    REACT_184317. Oncogene Induced Senescence.
    REACT_202759. FCERI mediated MAPK activation.
    REACT_202836. Signaling by FGFR.
    REACT_202927. Signal transduction by L1.
    REACT_210254. Regulation of HSF1-mediated heat shock response.
    REACT_214284. NCAM signaling for neurite out-growth.
    REACT_215256. Signal attenuation.
    REACT_217884. Gastrin-CREB signalling pathway via PKC and MAPK.
    REACT_220914. ERK1 activation.
    REACT_226922. ERK2 activation.
    SignaLinkiP40417.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitogen-activated protein kinase ERK-A (EC:2.7.11.24)
    Alternative name(s):
    Extracellular-regulated kinase A
    Protein rolled
    Gene namesi
    Name:rl
    Synonyms:ERKa
    ORF Names:CG12559
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 2R Heterochromatin

    Organism-specific databases

    FlyBaseiFBgn0003256. rl.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication

    GO - Cellular componenti

    1. cell junction Source: FlyBase
    2. cytoplasm Source: FlyBase
    3. nucleus Source: FlyBase

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    Embryonic wound healing defects.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 376376Mitogen-activated protein kinase ERK-APRO_0000186309Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei198 – 1981Phosphothreonine2 Publications
    Modified residuei200 – 2001Phosphotyrosine2 Publications

    Post-translational modificationi

    Dually phosphorylated on Thr-198 and Tyr-200, which activates the enzyme By similarity. Phosphorylated on tyrosine residue(s) in response to insulin.By similarity2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP40417.

    Expressioni

    Tissue specificityi

    In third instar larvae, expressed in eye imaginal disks. In adults, expressed in head and body.1 Publication

    Developmental stagei

    Embryos, larvae and adults.1 Publication

    Gene expression databases

    BgeeiP40417.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ARRB2P321214EBI-867790,EBI-714559From a different organism.
    cicQ9U1H03EBI-867790,EBI-98330
    Dsor1Q243242EBI-867790,EBI-671282
    krzQ9V39312EBI-867790,EBI-100228
    S6kIIQ244962EBI-867790,EBI-870498

    Protein-protein interaction databases

    BioGridi78013. 47 interactions.
    DIPiDIP-17266N.
    IntActiP40417. 11 interactions.
    MINTiMINT-312120.

    Structurei

    3D structure databases

    ProteinModelPortaliP40417.
    SMRiP40417. Positions 25-368.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini38 – 326289Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi198 – 2003TXY

    Domaini

    The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00550000074298.
    InParanoidiP40417.
    KOiK04371.
    OMAiVCSAYDR.
    OrthoDBiEOG7M3J0K.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR003527. MAP_kinase_CS.
    IPR008349. MAPK_ERK1/2.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    PRINTSiPR01770. ERK1ERK2MAPK.
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS01351. MAPK. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform C (identifier: P40417-3) [UniParc]FASTAAdd to Basket

    Also known as: D, E

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEEFNSSGSV VNGTGSTEVP QSNAEVIRGQ IFEVGPRYIK LAYIGEGAYG    50
    MVVSADDTLT NQRVAIKKIS PFEHQTYCQR TLREITILTR FKHENIIDIR 100
    DILRVDSIDQ MRDVYIVQCL METDLYKLLK TQRLSNDHIC YFLYQILRGL 150
    KYIHSANVLH RDLKPSNLLL NKTCDLKICD FGLARIADPE HDHTGFLTEY 200
    VATRWYRAPE IMLNSKGYTK SIDIWSVGCI LAEMLSNRPI FPGKHYLDQL 250
    NHILGVLGSP SRDDLECIIN EKARNYLESL PFKPNVPWAK LFPNADALAL 300
    DLLGKMLTFN PHKRIPVEEA LAHPYLEQYY DPGDEPVAEV PFRINMENDD 350
    ISRDALKSLI FEETLKFKER QPDNAP 376
    Length:376
    Mass (Da):43,151
    Last modified:September 18, 2013 - v3
    Checksum:i2642B3CBB0F234D2
    GO
    Isoform H (identifier: P40417-1) [UniParc]FASTAAdd to Basket

    Also known as: F

    The sequence of this isoform differs from the canonical sequence as follows:
         1-110: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:266
    Mass (Da):30,778
    Checksum:iFF3E31EA7A9EDC24
    GO
    Isoform G (identifier: P40417-2) [UniParc]FASTAAdd to Basket

    Also known as: B

    The sequence of this isoform differs from the canonical sequence as follows:
         1-45: Missing.
         46-53: EGAYGMVV → MESALVIR

    Note: No experimental confirmation available.

    Show »
    Length:331
    Mass (Da):38,430
    Checksum:iB4BC3B8FE279331A
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 110110Missing in isoform H. CuratedVSP_047792Add
    BLAST
    Alternative sequencei1 – 4545Missing in isoform G. CuratedVSP_047793Add
    BLAST
    Alternative sequencei46 – 538EGAYGMVV → MESALVIR in isoform G. CuratedVSP_047794

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M95124 mRNA. Translation: AAA28677.1.
    CM000457 Genomic DNA. Translation: EAA46310.2.
    CM000457 Genomic DNA. Translation: EAA46311.2.
    CM000457 Genomic DNA. Translation: EAA46312.4.
    CM000457 Genomic DNA. Translation: EDP28106.2.
    CM000457 Genomic DNA. Translation: EDP28107.1.
    CM000457 Genomic DNA. Translation: EYR77323.1.
    AY070996 mRNA. Translation: AAL48618.1.
    PIRiA46036.
    B46036.
    RefSeqiNP_001015121.3. NM_001015121.3. [P40417-2]
    NP_001015122.1. NM_001015122.3. [P40417-3]
    NP_001015123.1. NM_001015123.3. [P40417-3]
    NP_001104348.2. NM_001110878.2. [P40417-1]
    NP_001104349.1. NM_001110879.2. [P40417-3]
    UniGeneiDm.20303.

    Genome annotation databases

    EnsemblMetazoaiFBtr0113700; FBpp0112423; FBgn0003256. [P40417-3]
    FBtr0113702; FBpp0112425; FBgn0003256. [P40417-3]
    FBtr0113703; FBpp0112426; FBgn0003256. [P40417-3]
    GeneIDi3354888.
    KEGGidme:Dmel_CG12559.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M95124 mRNA. Translation: AAA28677.1 .
    CM000457 Genomic DNA. Translation: EAA46310.2 .
    CM000457 Genomic DNA. Translation: EAA46311.2 .
    CM000457 Genomic DNA. Translation: EAA46312.4 .
    CM000457 Genomic DNA. Translation: EDP28106.2 .
    CM000457 Genomic DNA. Translation: EDP28107.1 .
    CM000457 Genomic DNA. Translation: EYR77323.1 .
    AY070996 mRNA. Translation: AAL48618.1 .
    PIRi A46036.
    B46036.
    RefSeqi NP_001015121.3. NM_001015121.3. [P40417-2 ]
    NP_001015122.1. NM_001015122.3. [P40417-3 ]
    NP_001015123.1. NM_001015123.3. [P40417-3 ]
    NP_001104348.2. NM_001110878.2. [P40417-1 ]
    NP_001104349.1. NM_001110879.2. [P40417-3 ]
    UniGenei Dm.20303.

    3D structure databases

    ProteinModelPortali P40417.
    SMRi P40417. Positions 25-368.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 78013. 47 interactions.
    DIPi DIP-17266N.
    IntActi P40417. 11 interactions.
    MINTi MINT-312120.

    Proteomic databases

    PaxDbi P40417.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0113700 ; FBpp0112423 ; FBgn0003256 . [P40417-3 ]
    FBtr0113702 ; FBpp0112425 ; FBgn0003256 . [P40417-3 ]
    FBtr0113703 ; FBpp0112426 ; FBgn0003256 . [P40417-3 ]
    GeneIDi 3354888.
    KEGGi dme:Dmel_CG12559.

    Organism-specific databases

    CTDi 3354888.
    FlyBasei FBgn0003256. rl.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00550000074298.
    InParanoidi P40417.
    KOi K04371.
    OMAi VCSAYDR.
    OrthoDBi EOG7M3J0K.

    Enzyme and pathway databases

    BRENDAi 2.7.11.24. 1994.
    Reactomei REACT_180240. Negative regulation of FGFR signaling.
    REACT_181315. Regulation of actin dynamics for phagocytic cup formation.
    REACT_181531. CREB phosphorylation through the activation of Ras.
    REACT_181532. RSK activation.
    REACT_181712. Oxidative Stress Induced Senescence.
    REACT_182058. Senescence-Associated Secretory Phenotype (SASP).
    REACT_184317. Oncogene Induced Senescence.
    REACT_202759. FCERI mediated MAPK activation.
    REACT_202836. Signaling by FGFR.
    REACT_202927. Signal transduction by L1.
    REACT_210254. Regulation of HSF1-mediated heat shock response.
    REACT_214284. NCAM signaling for neurite out-growth.
    REACT_215256. Signal attenuation.
    REACT_217884. Gastrin-CREB signalling pathway via PKC and MAPK.
    REACT_220914. ERK1 activation.
    REACT_226922. ERK2 activation.
    SignaLinki P40417.

    Miscellaneous databases

    ChiTaRSi rl. drosophila.
    GenomeRNAii 3354888.
    NextBioi 849506.

    Gene expression databases

    Bgeei P40417.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR003527. MAP_kinase_CS.
    IPR008349. MAPK_ERK1/2.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    PRINTSi PR01770. ERK1ERK2MAPK.
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS01351. MAPK. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Primary structure, expression, and signal-dependent tyrosine phosphorylation of a Drosophila homolog of extracellular signal-regulated kinase."
      Biggs W.H. III, Zipursky S.L.
      Proc. Natl. Acad. Sci. U.S.A. 89:6295-6299(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM C), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, PHOSPHORYLATION.
      Strain: Oregon-R.
      Tissue: Embryo and Imaginal disk.
    2. Erratum
      Biggs W.H. III, Zipursky S.L.
      Proc. Natl. Acad. Sci. U.S.A. 90:6377-6377(1993)
    3. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    4. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM C).
      Strain: Berkeley.
      Tissue: Embryo.
    6. "The Drosophila rolled locus encodes a MAP kinase required in the sevenless signal transduction pathway."
      Biggs W.H. III, Zavitz K.H., Dickson B., van der Straten A., Brunner D., Hafen E., Zipursky S.L.
      EMBO J. 13:1628-1635(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
      Strain: Oregon-R.
    7. "Phosphoproteome analysis of Drosophila melanogaster embryos."
      Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
      J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-198 AND TYR-200, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Embryo.
    8. "Hole-in-one mutant phenotypes link EGFR/ERK signaling to epithelial tissue repair in Drosophila."
      Geiger J.A., Carvalho L., Campos I., Santos A.C., Jacinto A.
      PLoS ONE 6:E28349-E28349(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiERKA_DROME
    AccessioniPrimary (citable) accession number: P40417
    Secondary accession number(s): A0A021WW06
    , A8Y4W1, A8Y4W2, Q7PL59, Q9W5M2, Q9W5M3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: September 18, 2013
    Last modified: October 1, 2014
    This is version 145 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3