Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

T-complex protein 1 subunit epsilon

Gene

CCT5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. In yeast may play a role in mitotic spindle formation.

GO - Molecular functioni

GO - Biological processi

  • 'de novo' protein folding Source: GO_Central
  • chaperone-mediated protein folding Source: GO_Central
  • protein folding Source: SGD

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31697-MONOMER.
ReactomeiR-SCE-390471. Association of TriC/CCT with target proteins during biosynthesis.
R-SCE-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit epsilon
Short name:
TCP-1-epsilon
Alternative name(s):
CCT-epsilon
Gene namesi
Name:CCT5
Synonyms:TCP5
Ordered Locus Names:YJR064W
ORF Names:J1752
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJR064W.
SGDiS000003825. CCT5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001283541 – 562T-complex protein 1 subunit epsilonAdd BLAST562

Proteomic databases

MaxQBiP40413.
PRIDEiP40413.

Interactioni

Subunit structurei

Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.

GO - Molecular functioni

  • protein binding involved in protein folding Source: GO_Central
  • unfolded protein binding Source: SGD

Protein-protein interaction databases

BioGridi33821. 204 interactors.
DIPiDIP-2205N.
IntActiP40413. 28 interactors.
MINTiMINT-636377.
STRINGi4932.YJR064W.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V81X-ray3.80E/M/e/m1-562[»]
4V8RX-ray3.80AE/Ae/BE/Be1-562[»]
4V94X-ray3.80E/M/e/m1-562[»]
5GW4electron microscopy4.70E/e1-562[»]
5GW5electron microscopy4.60E/e1-562[»]
ProteinModelPortaliP40413.
SMRiP40413.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

GeneTreeiENSGT00550000074988.
HOGENOMiHOG000226735.
InParanoidiP40413.
KOiK09497.
OMAiLKVNNVI.
OrthoDBiEOG092C1WYZ.

Family and domain databases

CDDicd03339. TCP1_epsilon. 1 hit.
Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
InterProiView protein in InterPro
IPR012718. Chap_CCT_epsi.
IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR037290. Cpn60/TCP-1_sf.
IPR027409. GroEL-like_apical_dom_sf.
IPR027413. GROEL-like_equatorial_sf.
PANTHERiPTHR11353. PTHR11353. 1 hit.
PTHR11353:SF178. PTHR11353:SF178. 1 hit.
PfamiView protein in Pfam
PF00118. Cpn60_TCP1. 1 hit.
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF48592. SSF48592. 2 hits.
SSF52029. SSF52029. 1 hit.
SSF54849. SSF54849. 2 hits.
TIGRFAMsiTIGR02343. chap_CCT_epsi. 1 hit.
PROSITEiView protein in PROSITE
PS00750. TCP1_1. 1 hit.
PS00995. TCP1_3. 1 hit.

Sequencei

Sequence statusi: Complete.

P40413-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARPQQPPM EMPDLSNAIV AQDEMGRPFI IVKDQGNKKR QHGLEAKKSH
60 70 80 90 100
ILAARSVASI IKTSLGPRGL DKILISPDGE ITITNDGATI LSQMELDNEI
110 120 130 140 150
AKLLVQLSKS QDDEIGDGTT GVVVLASALL DQALELIQKG IHPIKIANGF
160 170 180 190 200
DEAAKLAISK LEETCDDISA SNDELFRDFL LRAAKTSLGS KIVSKDHDRF
210 220 230 240 250
AEMAVEAVIN VMDKDRKDVD FDLIKMQGRV GGSISDSKLI NGVILDKDFS
260 270 280 290 300
HPQMPKCVLP KEGSDGVKLA ILTCPFEPPK PKTKHKLDIS SVEEYQKLQT
310 320 330 340 350
YEQDKFKEMI DDVKKAGADV VICQWGFDDE ANHLLLQNDL PAVRWVGGQE
360 370 380 390 400
LEHIAISTNG RIVPRFQDLS KDKLGTCSRI YEQEFGTTKD RMLIIEQSKE
410 420 430 440 450
TKTVTCFVRG SNKMIVDEAE RALHDSLCVV RNLVKDSRVV YGGGAAEVTM
460 470 480 490 500
SLAVSEEADK QRGIDQYAFR GFAQALDTIP MTLAENSGLD PIGTLSTLKS
510 520 530 540 550
KQLKEKISNI GVDCLGYGSN DMKELFVVDP FIGKKQQILL ATQLCRMILK
560
IDNVIISGKD EY
Length:562
Mass (Da):61,914
Last modified:December 12, 2006 - v3
Checksum:i8CDAF88C6403655F
GO

Sequence cautioni

The sequence AAA53132 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3A → T in AAA53132 (Ref. 1) Curated1
Sequence conflicti27R → T in AAA53132 (Ref. 1) Curated1
Sequence conflicti58A → D in AAA53132 (Ref. 1) Curated1
Sequence conflicti92S → T in AAA53132 (Ref. 1) Curated1
Sequence conflicti274 – 279CPFEPP → VHLNLL in AAA53132 (Ref. 1) Curated6
Sequence conflicti336L → I in AAA53132 (Ref. 1) Curated1
Sequence conflicti488G → N in AAA53132 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L37350 Genomic DNA. Translation: AAA53132.1. Different initiation.
L47993 Genomic DNA. Translation: AAB39290.1.
Z49564 Genomic DNA. Translation: CAA89592.1.
BK006943 Genomic DNA. Translation: DAA08851.1.
PIRiS57083.
RefSeqiNP_012598.1. NM_001181722.1.

Genome annotation databases

EnsemblFungiiYJR064W; YJR064W; YJR064W.
GeneIDi853527.
KEGGisce:YJR064W.

Similar proteinsi

Entry informationi

Entry nameiTCPE_YEAST
AccessioniPrimary (citable) accession number: P40413
Secondary accession number(s): D6VWN5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: December 12, 2006
Last modified: November 22, 2017
This is version 150 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names