Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P40413

- TCPE_YEAST

UniProt

P40413 - TCPE_YEAST

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

T-complex protein 1 subunit epsilon

Gene

CCT5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. In yeast may play a role in mitotic spindle formation.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. unfolded protein binding Source: SGD

GO - Biological processi

  1. protein folding Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31697-MONOMER.
ReactomeiREACT_244572. Formation of tubulin folding intermediates by CCT/TriC.
REACT_251852. Prefoldin mediated transfer of substrate to CCT/TriC.
REACT_260285. Folding of actin by CCT/TriC.

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit epsilon
Short name:
TCP-1-epsilon
Alternative name(s):
CCT-epsilon
Gene namesi
Name:CCT5
Synonyms:TCP5
Ordered Locus Names:YJR064W
ORF Names:J1752
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome X

Organism-specific databases

CYGDiYJR064w.
SGDiS000003825. CCT5.

Subcellular locationi

GO - Cellular componenti

  1. chaperonin-containing T-complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 562562T-complex protein 1 subunit epsilonPRO_0000128354Add
BLAST

Proteomic databases

MaxQBiP40413.
PaxDbiP40413.
PeptideAtlasiP40413.
PRIDEiP40413.

Expressioni

Gene expression databases

GenevestigatoriP40413.

Interactioni

Subunit structurei

Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.

Protein-protein interaction databases

BioGridi33821. 39 interactions.
DIPiDIP-2205N.
IntActiP40413. 18 interactions.
MINTiMINT-636377.
STRINGi4932.YJR064W.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3P9DX-ray3.80E/M1-562[»]
3P9EX-ray3.80e/m1-562[»]
4AOLX-ray3.80E/e1-562[»]
4APKX-ray3.80E/e1-562[»]
4D8QX-ray3.80E/M1-562[»]
4D8RX-ray3.80e/m1-562[»]
ProteinModelPortaliP40413.
SMRiP40413. Positions 25-559.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGiCOG0459.
GeneTreeiENSGT00550000074988.
HOGENOMiHOG000226735.
InParanoidiP40413.
KOiK09497.
OMAiYATDEYG.
OrthoDBiEOG773XR5.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR012718. Chap_CCT_epsi.
IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
[Graphical view]
PANTHERiPTHR11353. PTHR11353. 1 hit.
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF48592. SSF48592. 2 hits.
SSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02343. chap_CCT_epsi. 1 hit.
PROSITEiPS00750. TCP1_1. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40413-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAARPQQPPM EMPDLSNAIV AQDEMGRPFI IVKDQGNKKR QHGLEAKKSH
60 70 80 90 100
ILAARSVASI IKTSLGPRGL DKILISPDGE ITITNDGATI LSQMELDNEI
110 120 130 140 150
AKLLVQLSKS QDDEIGDGTT GVVVLASALL DQALELIQKG IHPIKIANGF
160 170 180 190 200
DEAAKLAISK LEETCDDISA SNDELFRDFL LRAAKTSLGS KIVSKDHDRF
210 220 230 240 250
AEMAVEAVIN VMDKDRKDVD FDLIKMQGRV GGSISDSKLI NGVILDKDFS
260 270 280 290 300
HPQMPKCVLP KEGSDGVKLA ILTCPFEPPK PKTKHKLDIS SVEEYQKLQT
310 320 330 340 350
YEQDKFKEMI DDVKKAGADV VICQWGFDDE ANHLLLQNDL PAVRWVGGQE
360 370 380 390 400
LEHIAISTNG RIVPRFQDLS KDKLGTCSRI YEQEFGTTKD RMLIIEQSKE
410 420 430 440 450
TKTVTCFVRG SNKMIVDEAE RALHDSLCVV RNLVKDSRVV YGGGAAEVTM
460 470 480 490 500
SLAVSEEADK QRGIDQYAFR GFAQALDTIP MTLAENSGLD PIGTLSTLKS
510 520 530 540 550
KQLKEKISNI GVDCLGYGSN DMKELFVVDP FIGKKQQILL ATQLCRMILK
560
IDNVIISGKD EY
Length:562
Mass (Da):61,914
Last modified:December 12, 2006 - v3
Checksum:i8CDAF88C6403655F
GO

Sequence cautioni

The sequence AAA53132.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31A → T in AAA53132. 1 PublicationCurated
Sequence conflicti27 – 271R → T in AAA53132. 1 PublicationCurated
Sequence conflicti58 – 581A → D in AAA53132. 1 PublicationCurated
Sequence conflicti92 – 921S → T in AAA53132. 1 PublicationCurated
Sequence conflicti274 – 2796CPFEPP → VHLNLL in AAA53132. 1 PublicationCurated
Sequence conflicti336 – 3361L → I in AAA53132. 1 PublicationCurated
Sequence conflicti488 – 4881G → N in AAA53132. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L37350 Genomic DNA. Translation: AAA53132.1. Different initiation.
L47993 Genomic DNA. Translation: AAB39290.1.
Z49564 Genomic DNA. Translation: CAA89592.1.
BK006943 Genomic DNA. Translation: DAA08851.1.
PIRiS57083.
RefSeqiNP_012598.1. NM_001181722.1.

Genome annotation databases

EnsemblFungiiYJR064W; YJR064W; YJR064W.
GeneIDi853527.
KEGGisce:YJR064W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L37350 Genomic DNA. Translation: AAA53132.1 . Different initiation.
L47993 Genomic DNA. Translation: AAB39290.1 .
Z49564 Genomic DNA. Translation: CAA89592.1 .
BK006943 Genomic DNA. Translation: DAA08851.1 .
PIRi S57083.
RefSeqi NP_012598.1. NM_001181722.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3P9D X-ray 3.80 E/M 1-562 [» ]
3P9E X-ray 3.80 e/m 1-562 [» ]
4AOL X-ray 3.80 E/e 1-562 [» ]
4APK X-ray 3.80 E/e 1-562 [» ]
4D8Q X-ray 3.80 E/M 1-562 [» ]
4D8R X-ray 3.80 e/m 1-562 [» ]
ProteinModelPortali P40413.
SMRi P40413. Positions 25-559.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33821. 39 interactions.
DIPi DIP-2205N.
IntActi P40413. 18 interactions.
MINTi MINT-636377.
STRINGi 4932.YJR064W.

Proteomic databases

MaxQBi P40413.
PaxDbi P40413.
PeptideAtlasi P40413.
PRIDEi P40413.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YJR064W ; YJR064W ; YJR064W .
GeneIDi 853527.
KEGGi sce:YJR064W.

Organism-specific databases

CYGDi YJR064w.
SGDi S000003825. CCT5.

Phylogenomic databases

eggNOGi COG0459.
GeneTreei ENSGT00550000074988.
HOGENOMi HOG000226735.
InParanoidi P40413.
KOi K09497.
OMAi YATDEYG.
OrthoDBi EOG773XR5.

Enzyme and pathway databases

BioCyci YEAST:G3O-31697-MONOMER.
Reactomei REACT_244572. Formation of tubulin folding intermediates by CCT/TriC.
REACT_251852. Prefoldin mediated transfer of substrate to CCT/TriC.
REACT_260285. Folding of actin by CCT/TriC.

Miscellaneous databases

NextBioi 974218.
PROi P40413.

Gene expression databases

Genevestigatori P40413.

Family and domain databases

Gene3Di 1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProi IPR012718. Chap_CCT_epsi.
IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
[Graphical view ]
PANTHERi PTHR11353. PTHR11353. 1 hit.
Pfami PF00118. Cpn60_TCP1. 1 hit.
[Graphical view ]
PRINTSi PR00304. TCOMPLEXTCP1.
SUPFAMi SSF48592. SSF48592. 2 hits.
SSF52029. SSF52029. 1 hit.
TIGRFAMsi TIGR02343. chap_CCT_epsi. 1 hit.
PROSITEi PS00750. TCP1_1. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cytosolic chaperonin(CCT) subunits have a conserved ATPase domain but diverged polypeptide-binding domains."
    Kim S.
    Submitted (NOV-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: YPH501.
  2. "Analysis of a 62 kb DNA sequence of chromosome X reveals 36 open reading frames and a gene cluster with a counterpart on chromosome XI."
    Huang M.-E., Manus V., Chuat J.-C., Galibert F.
    Yeast 12:869-875(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
    Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
    , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
    EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.

Entry informationi

Entry nameiTCPE_YEAST
AccessioniPrimary (citable) accession number: P40413
Secondary accession number(s): D6VWN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: December 12, 2006
Last modified: November 26, 2014
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

External Data

Dasty 3