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P40413

- TCPE_YEAST

UniProt

P40413 - TCPE_YEAST

Protein

T-complex protein 1 subunit epsilon

Gene

CCT5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 3 (12 Dec 2006)
      Previous versions | rss
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    Functioni

    Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. In yeast may play a role in mitotic spindle formation.

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. unfolded protein binding Source: SGD

    GO - Biological processi

    1. protein folding Source: SGD

    Keywords - Molecular functioni

    Chaperone

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31697-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    T-complex protein 1 subunit epsilon
    Short name:
    TCP-1-epsilon
    Alternative name(s):
    CCT-epsilon
    Gene namesi
    Name:CCT5
    Synonyms:TCP5
    Ordered Locus Names:YJR064W
    ORF Names:J1752
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome X

    Organism-specific databases

    CYGDiYJR064w.
    SGDiS000003825. CCT5.

    Subcellular locationi

    GO - Cellular componenti

    1. chaperonin-containing T-complex Source: SGD

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 562562T-complex protein 1 subunit epsilonPRO_0000128354Add
    BLAST

    Proteomic databases

    MaxQBiP40413.
    PaxDbiP40413.
    PeptideAtlasiP40413.
    PRIDEiP40413.

    Expressioni

    Gene expression databases

    GenevestigatoriP40413.

    Interactioni

    Subunit structurei

    Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.

    Protein-protein interaction databases

    BioGridi33821. 38 interactions.
    DIPiDIP-2205N.
    IntActiP40413. 18 interactions.
    MINTiMINT-636377.
    STRINGi4932.YJR064W.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3P9DX-ray3.80E/M1-562[»]
    3P9EX-ray3.80e/m1-562[»]
    4AOLX-ray3.80E/e1-562[»]
    4APKX-ray3.80E/e1-562[»]
    4D8QX-ray3.80E/M1-562[»]
    4D8RX-ray3.80e/m1-562[»]
    ProteinModelPortaliP40413.
    SMRiP40413. Positions 25-559.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TCP-1 chaperonin family.Curated

    Phylogenomic databases

    eggNOGiCOG0459.
    GeneTreeiENSGT00550000074988.
    HOGENOMiHOG000226735.
    KOiK09497.
    OMAiYATDEYG.
    OrthoDBiEOG773XR5.

    Family and domain databases

    Gene3Di1.10.560.10. 2 hits.
    3.30.260.10. 2 hits.
    3.50.7.10. 1 hit.
    InterProiIPR012718. Chap_CCT_epsi.
    IPR017998. Chaperone_TCP-1.
    IPR002194. Chaperonin_TCP-1_CS.
    IPR002423. Cpn60/TCP-1.
    IPR027409. GroEL-like_apical_dom.
    IPR027413. GROEL-like_equatorial.
    IPR027410. TCP-1-like_intermed.
    [Graphical view]
    PANTHERiPTHR11353. PTHR11353. 1 hit.
    PfamiPF00118. Cpn60_TCP1. 1 hit.
    [Graphical view]
    PRINTSiPR00304. TCOMPLEXTCP1.
    SUPFAMiSSF48592. SSF48592. 2 hits.
    SSF52029. SSF52029. 1 hit.
    TIGRFAMsiTIGR02343. chap_CCT_epsi. 1 hit.
    PROSITEiPS00750. TCP1_1. 1 hit.
    PS00995. TCP1_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P40413-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAARPQQPPM EMPDLSNAIV AQDEMGRPFI IVKDQGNKKR QHGLEAKKSH    50
    ILAARSVASI IKTSLGPRGL DKILISPDGE ITITNDGATI LSQMELDNEI 100
    AKLLVQLSKS QDDEIGDGTT GVVVLASALL DQALELIQKG IHPIKIANGF 150
    DEAAKLAISK LEETCDDISA SNDELFRDFL LRAAKTSLGS KIVSKDHDRF 200
    AEMAVEAVIN VMDKDRKDVD FDLIKMQGRV GGSISDSKLI NGVILDKDFS 250
    HPQMPKCVLP KEGSDGVKLA ILTCPFEPPK PKTKHKLDIS SVEEYQKLQT 300
    YEQDKFKEMI DDVKKAGADV VICQWGFDDE ANHLLLQNDL PAVRWVGGQE 350
    LEHIAISTNG RIVPRFQDLS KDKLGTCSRI YEQEFGTTKD RMLIIEQSKE 400
    TKTVTCFVRG SNKMIVDEAE RALHDSLCVV RNLVKDSRVV YGGGAAEVTM 450
    SLAVSEEADK QRGIDQYAFR GFAQALDTIP MTLAENSGLD PIGTLSTLKS 500
    KQLKEKISNI GVDCLGYGSN DMKELFVVDP FIGKKQQILL ATQLCRMILK 550
    IDNVIISGKD EY 562
    Length:562
    Mass (Da):61,914
    Last modified:December 12, 2006 - v3
    Checksum:i8CDAF88C6403655F
    GO

    Sequence cautioni

    The sequence AAA53132.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti3 – 31A → T in AAA53132. 1 PublicationCurated
    Sequence conflicti27 – 271R → T in AAA53132. 1 PublicationCurated
    Sequence conflicti58 – 581A → D in AAA53132. 1 PublicationCurated
    Sequence conflicti92 – 921S → T in AAA53132. 1 PublicationCurated
    Sequence conflicti274 – 2796CPFEPP → VHLNLL in AAA53132. 1 PublicationCurated
    Sequence conflicti336 – 3361L → I in AAA53132. 1 PublicationCurated
    Sequence conflicti488 – 4881G → N in AAA53132. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L37350 Genomic DNA. Translation: AAA53132.1. Different initiation.
    L47993 Genomic DNA. Translation: AAB39290.1.
    Z49564 Genomic DNA. Translation: CAA89592.1.
    BK006943 Genomic DNA. Translation: DAA08851.1.
    PIRiS57083.
    RefSeqiNP_012598.1. NM_001181722.1.

    Genome annotation databases

    EnsemblFungiiYJR064W; YJR064W; YJR064W.
    GeneIDi853527.
    KEGGisce:YJR064W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L37350 Genomic DNA. Translation: AAA53132.1 . Different initiation.
    L47993 Genomic DNA. Translation: AAB39290.1 .
    Z49564 Genomic DNA. Translation: CAA89592.1 .
    BK006943 Genomic DNA. Translation: DAA08851.1 .
    PIRi S57083.
    RefSeqi NP_012598.1. NM_001181722.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3P9D X-ray 3.80 E/M 1-562 [» ]
    3P9E X-ray 3.80 e/m 1-562 [» ]
    4AOL X-ray 3.80 E/e 1-562 [» ]
    4APK X-ray 3.80 E/e 1-562 [» ]
    4D8Q X-ray 3.80 E/M 1-562 [» ]
    4D8R X-ray 3.80 e/m 1-562 [» ]
    ProteinModelPortali P40413.
    SMRi P40413. Positions 25-559.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33821. 38 interactions.
    DIPi DIP-2205N.
    IntActi P40413. 18 interactions.
    MINTi MINT-636377.
    STRINGi 4932.YJR064W.

    Proteomic databases

    MaxQBi P40413.
    PaxDbi P40413.
    PeptideAtlasi P40413.
    PRIDEi P40413.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YJR064W ; YJR064W ; YJR064W .
    GeneIDi 853527.
    KEGGi sce:YJR064W.

    Organism-specific databases

    CYGDi YJR064w.
    SGDi S000003825. CCT5.

    Phylogenomic databases

    eggNOGi COG0459.
    GeneTreei ENSGT00550000074988.
    HOGENOMi HOG000226735.
    KOi K09497.
    OMAi YATDEYG.
    OrthoDBi EOG773XR5.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31697-MONOMER.

    Miscellaneous databases

    NextBioi 974218.
    PROi P40413.

    Gene expression databases

    Genevestigatori P40413.

    Family and domain databases

    Gene3Di 1.10.560.10. 2 hits.
    3.30.260.10. 2 hits.
    3.50.7.10. 1 hit.
    InterProi IPR012718. Chap_CCT_epsi.
    IPR017998. Chaperone_TCP-1.
    IPR002194. Chaperonin_TCP-1_CS.
    IPR002423. Cpn60/TCP-1.
    IPR027409. GroEL-like_apical_dom.
    IPR027413. GROEL-like_equatorial.
    IPR027410. TCP-1-like_intermed.
    [Graphical view ]
    PANTHERi PTHR11353. PTHR11353. 1 hit.
    Pfami PF00118. Cpn60_TCP1. 1 hit.
    [Graphical view ]
    PRINTSi PR00304. TCOMPLEXTCP1.
    SUPFAMi SSF48592. SSF48592. 2 hits.
    SSF52029. SSF52029. 1 hit.
    TIGRFAMsi TIGR02343. chap_CCT_epsi. 1 hit.
    PROSITEi PS00750. TCP1_1. 1 hit.
    PS00995. TCP1_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cytosolic chaperonin(CCT) subunits have a conserved ATPase domain but diverged polypeptide-binding domains."
      Kim S.
      Submitted (NOV-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: YPH501.
    2. "Analysis of a 62 kb DNA sequence of chromosome X reveals 36 open reading frames and a gene cluster with a counterpart on chromosome XI."
      Huang M.-E., Manus V., Chuat J.-C., Galibert F.
      Yeast 12:869-875(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
      Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
      , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
      EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.

    Entry informationi

    Entry nameiTCPE_YEAST
    AccessioniPrimary (citable) accession number: P40413
    Secondary accession number(s): D6VWN5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 120 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome X
      Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

    External Data

    Dasty 3