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Protein

Iron-uptake system-binding protein

Gene

feuA

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the uptake of iron.1 Publication
Part of the ABC transporter complex FeuABC/YusV involved in import of the catecholate siderophores bacillibactin and enterobactin.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron

Enzyme and pathway databases

BioCyciBSUB:BSU01630-MONOMER.

Protein family/group databases

TCDBi3.A.1.14.15. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Iron-uptake system-binding protein
Gene namesi
Name:feuA
Ordered Locus Names:BSU01630
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Disruption phenotypei

Strains lacking this gene show a reduction in growth stimulation by the catecholate siderophores enterobactin and bacillibactin.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19CuratedAdd BLAST19
ChainiPRO_000003182220 – 317Iron-uptake system-binding proteinAdd BLAST298

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi20N-palmitoyl cysteineCurated1
Lipidationi20S-diacylglycerol cysteineCurated1

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiP40409.

Expressioni

Inductioni

Repressed by fur. Induced by Btr in iron-limited conditions.2 Publications

Interactioni

Subunit structurei

The complex is composed of one ATP-binding protein (YusV), two transmembrane proteins (FeuB and FeuC) and a solute-binding protein (FeuA).Curated

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100000928.

Structurei

Secondary structure

1317
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi37 – 43Combined sources7
Beta strandi46 – 53Combined sources8
Beta strandi57 – 59Combined sources3
Helixi63 – 72Combined sources10
Beta strandi77 – 82Combined sources6
Helixi88 – 90Combined sources3
Turni91 – 93Combined sources3
Beta strandi98 – 102Combined sources5
Helixi108 – 114Combined sources7
Beta strandi117 – 122Combined sources6
Helixi127 – 134Combined sources8
Beta strandi139 – 142Combined sources4
Helixi146 – 148Combined sources3
Helixi149 – 160Combined sources12
Helixi163 – 183Combined sources21
Helixi186 – 189Combined sources4
Beta strandi193 – 199Combined sources7
Beta strandi202 – 205Combined sources4
Helixi213 – 216Combined sources4
Turni217 – 220Combined sources4
Helixi226 – 230Combined sources5
Beta strandi232 – 236Combined sources5
Helixi239 – 245Combined sources7
Beta strandi248 – 254Combined sources7
Helixi256 – 258Combined sources3
Helixi265 – 271Combined sources7
Helixi273 – 276Combined sources4
Helixi279 – 282Combined sources4
Beta strandi286 – 288Combined sources3
Beta strandi297 – 299Combined sources3
Helixi300 – 314Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PHZX-ray2.15A21-317[»]
2WHYX-ray1.70A21-317[»]
2WI8X-ray1.55A21-317[»]
2XUZX-ray1.90A21-317[»]
2XV1X-ray2.15A21-317[»]
ProteinModelPortaliP40409.
SMRiP40409.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP40409.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 317Fe/B12 periplasmic-bindingPROSITE-ProRule annotationAdd BLAST261

Sequence similaritiesi

Contains 1 Fe/B12 periplasmic-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0614. LUCA.
HOGENOMiHOG000095659.
InParanoidiP40409.
KOiK02016.
OMAiKAVKEDH.
PhylomeDBiP40409.

Family and domain databases

InterProiIPR002491. ABC_transptr_periplasmic_BD.
[Graphical view]
PfamiPF01497. Peripla_BP_2. 1 hit.
[Graphical view]
PROSITEiPS50983. FE_B12_PBP. 1 hit.
PS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P40409-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKISLTLLI LLLALTAAAC GSKNESTASK ASGTASEKKK IEYLDKTYEV
60 70 80 90 100
TVPTDKIAIT GSVESMEDAK LLDVHPQGAI SFSGKFPDMF KDITDKAEPT
110 120 130 140 150
GEKMEPNIEK ILEMKPDVIL ASTKFPEKTL QKISTAGTTI PVSHISSNWK
160 170 180 190 200
ENMMLLAQLT GKEKKAKKII ADYEQDLKEI KTKINDKAKD SKALVIRIRQ
210 220 230 240 250
GNIYIYPEQV YFNSTLYGDL GLKAPNEVKA AKAQELSSLE KLSEMNPDHI
260 270 280 290 300
FVQFSDDENA DKPDALKDLE KNPIWKSLKA VKEDHVYVNS VDPLAQGGTA
310
WSKVRFLKAA AEKLTQN
Length:317
Mass (Da):35,108
Last modified:February 1, 1995 - v1
Checksum:i57193CB61E835D25
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19954 Genomic DNA. Translation: AAA64354.1.
AB002150 Genomic DNA. Translation: BAA19496.1.
AL009126 Genomic DNA. Translation: CAB11939.1.
PIRiI39842.
RefSeqiNP_388044.1. NC_000964.3.
WP_003234978.1. NZ_JNCM01000030.1.

Genome annotation databases

EnsemblBacteriaiCAB11939; CAB11939; BSU01630.
GeneIDi938891.
KEGGibsu:BSU01630.
PATRICi18971869. VBIBacSub10457_0168.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19954 Genomic DNA. Translation: AAA64354.1.
AB002150 Genomic DNA. Translation: BAA19496.1.
AL009126 Genomic DNA. Translation: CAB11939.1.
PIRiI39842.
RefSeqiNP_388044.1. NC_000964.3.
WP_003234978.1. NZ_JNCM01000030.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PHZX-ray2.15A21-317[»]
2WHYX-ray1.70A21-317[»]
2WI8X-ray1.55A21-317[»]
2XUZX-ray1.90A21-317[»]
2XV1X-ray2.15A21-317[»]
ProteinModelPortaliP40409.
SMRiP40409.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100000928.

Protein family/group databases

TCDBi3.A.1.14.15. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiP40409.

Protocols and materials databases

DNASUi938891.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB11939; CAB11939; BSU01630.
GeneIDi938891.
KEGGibsu:BSU01630.
PATRICi18971869. VBIBacSub10457_0168.

Phylogenomic databases

eggNOGiCOG0614. LUCA.
HOGENOMiHOG000095659.
InParanoidiP40409.
KOiK02016.
OMAiKAVKEDH.
PhylomeDBiP40409.

Enzyme and pathway databases

BioCyciBSUB:BSU01630-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP40409.

Family and domain databases

InterProiIPR002491. ABC_transptr_periplasmic_BD.
[Graphical view]
PfamiPF01497. Peripla_BP_2. 1 hit.
[Graphical view]
PROSITEiPS50983. FE_B12_PBP. 1 hit.
PS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFEUA_BACSU
AccessioniPrimary (citable) accession number: P40409
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.