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Protein

Iron-uptake system-binding protein

Gene

feuA

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the uptake of iron.1 Publication
Part of the ABC transporter complex FeuABC/YusV involved in import of the catecholate siderophores bacillibactin and enterobactin.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron

Enzyme and pathway databases

BioCyciBSUB:BSU01630-MONOMER.

Protein family/group databases

TCDBi3.A.1.14.15. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Iron-uptake system-binding protein
Gene namesi
Name:feuA
Ordered Locus Names:BSU01630
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Disruption phenotypei

Strains lacking this gene show a reduction in growth stimulation by the catecholate siderophores enterobactin and bacillibactin.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919CuratedAdd
BLAST
Chaini20 – 317298Iron-uptake system-binding proteinPRO_0000031822Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi20 – 201N-palmitoyl cysteineCurated
Lipidationi20 – 201S-diacylglycerol cysteineCurated

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiP40409.

Expressioni

Inductioni

Repressed by fur. Induced by Btr in iron-limited conditions.2 Publications

Interactioni

Subunit structurei

The complex is composed of one ATP-binding protein (YusV), two transmembrane proteins (FeuB and FeuC) and a solute-binding protein (FeuA).Curated

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100000928.

Structurei

Secondary structure

1
317
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi37 – 437Combined sources
Beta strandi46 – 538Combined sources
Beta strandi57 – 593Combined sources
Helixi63 – 7210Combined sources
Beta strandi77 – 826Combined sources
Helixi88 – 903Combined sources
Turni91 – 933Combined sources
Beta strandi98 – 1025Combined sources
Helixi108 – 1147Combined sources
Beta strandi117 – 1226Combined sources
Helixi127 – 1348Combined sources
Beta strandi139 – 1424Combined sources
Helixi146 – 1483Combined sources
Helixi149 – 16012Combined sources
Helixi163 – 18321Combined sources
Helixi186 – 1894Combined sources
Beta strandi193 – 1997Combined sources
Beta strandi202 – 2054Combined sources
Helixi213 – 2164Combined sources
Turni217 – 2204Combined sources
Helixi226 – 2305Combined sources
Beta strandi232 – 2365Combined sources
Helixi239 – 2457Combined sources
Beta strandi248 – 2547Combined sources
Helixi256 – 2583Combined sources
Helixi265 – 2717Combined sources
Helixi273 – 2764Combined sources
Helixi279 – 2824Combined sources
Beta strandi286 – 2883Combined sources
Beta strandi297 – 2993Combined sources
Helixi300 – 31415Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2PHZX-ray2.15A21-317[»]
2WHYX-ray1.70A21-317[»]
2WI8X-ray1.55A21-317[»]
2XUZX-ray1.90A21-317[»]
2XV1X-ray2.15A21-317[»]
ProteinModelPortaliP40409.
SMRiP40409. Positions 39-315.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP40409.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini57 – 317261Fe/B12 periplasmic-bindingPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Fe/B12 periplasmic-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0614. LUCA.
HOGENOMiHOG000095659.
InParanoidiP40409.
KOiK02016.
OMAiKAVKEDH.
PhylomeDBiP40409.

Family and domain databases

InterProiIPR002491. ABC_transptr_periplasmic_BD.
[Graphical view]
PfamiPF01497. Peripla_BP_2. 1 hit.
[Graphical view]
PROSITEiPS50983. FE_B12_PBP. 1 hit.
PS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P40409-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKISLTLLI LLLALTAAAC GSKNESTASK ASGTASEKKK IEYLDKTYEV
60 70 80 90 100
TVPTDKIAIT GSVESMEDAK LLDVHPQGAI SFSGKFPDMF KDITDKAEPT
110 120 130 140 150
GEKMEPNIEK ILEMKPDVIL ASTKFPEKTL QKISTAGTTI PVSHISSNWK
160 170 180 190 200
ENMMLLAQLT GKEKKAKKII ADYEQDLKEI KTKINDKAKD SKALVIRIRQ
210 220 230 240 250
GNIYIYPEQV YFNSTLYGDL GLKAPNEVKA AKAQELSSLE KLSEMNPDHI
260 270 280 290 300
FVQFSDDENA DKPDALKDLE KNPIWKSLKA VKEDHVYVNS VDPLAQGGTA
310
WSKVRFLKAA AEKLTQN
Length:317
Mass (Da):35,108
Last modified:February 1, 1995 - v1
Checksum:i57193CB61E835D25
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19954 Genomic DNA. Translation: AAA64354.1.
AB002150 Genomic DNA. Translation: BAA19496.1.
AL009126 Genomic DNA. Translation: CAB11939.1.
PIRiI39842.
RefSeqiNP_388044.1. NC_000964.3.
WP_003234978.1. NZ_JNCM01000030.1.

Genome annotation databases

EnsemblBacteriaiCAB11939; CAB11939; BSU01630.
GeneIDi938891.
KEGGibsu:BSU01630.
PATRICi18971869. VBIBacSub10457_0168.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19954 Genomic DNA. Translation: AAA64354.1.
AB002150 Genomic DNA. Translation: BAA19496.1.
AL009126 Genomic DNA. Translation: CAB11939.1.
PIRiI39842.
RefSeqiNP_388044.1. NC_000964.3.
WP_003234978.1. NZ_JNCM01000030.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2PHZX-ray2.15A21-317[»]
2WHYX-ray1.70A21-317[»]
2WI8X-ray1.55A21-317[»]
2XUZX-ray1.90A21-317[»]
2XV1X-ray2.15A21-317[»]
ProteinModelPortaliP40409.
SMRiP40409. Positions 39-315.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100000928.

Protein family/group databases

TCDBi3.A.1.14.15. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiP40409.

Protocols and materials databases

DNASUi938891.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB11939; CAB11939; BSU01630.
GeneIDi938891.
KEGGibsu:BSU01630.
PATRICi18971869. VBIBacSub10457_0168.

Phylogenomic databases

eggNOGiCOG0614. LUCA.
HOGENOMiHOG000095659.
InParanoidiP40409.
KOiK02016.
OMAiKAVKEDH.
PhylomeDBiP40409.

Enzyme and pathway databases

BioCyciBSUB:BSU01630-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP40409.

Family and domain databases

InterProiIPR002491. ABC_transptr_periplasmic_BD.
[Graphical view]
PfamiPF01497. Peripla_BP_2. 1 hit.
[Graphical view]
PROSITEiPS50983. FE_B12_PBP. 1 hit.
PS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFEUA_BACSU
AccessioniPrimary (citable) accession number: P40409
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 7, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.