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Protein

Chemoreceptor glutamine deamidase CheD

Gene

cheD

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Deamidates 'Gln-593' and 'Gln-594' of the chemoreceptor McpA. In addition, deamidates other chemoreceptors, including McpB and McpC. CheD-mediated MCP (methyl-accepting chemotaxis proteins) deamidation is required for productive communication of the conformational signals of the chemoreceptors to the CheA kinase. CheD is absolutely required for a behavioral response mediated by McpC but is not required for the response to asparagine mediated by McpB. CheD is necessary for the generation of wild-type prestimulus CheA autophosphorylation levels. Also required for methylation of MCPs by CheR. In addition, enhances the activity of CheC 5-fold in vitro.3 Publications

Catalytic activityi

Protein L-glutamine + H2O = protein L-glutamate + NH3.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processChemotaxis

Enzyme and pathway databases

BioCyciBSUB:BSU16460-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Chemoreceptor glutamine deamidase CheD (EC:3.5.1.44)
Gene namesi
Name:cheD
Synonyms:ylxK
Ordered Locus Names:BSU16460
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Pathology & Biotechi

Disruption phenotypei

Cells exhibit poorly methylated receptors, are tumbly and have a decreased sensitivity to attractants.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000896391 – 166Chemoreceptor glutamine deamidase CheDAdd BLAST166

Proteomic databases

PaxDbiP40404
PRIDEiP40404

Interactioni

Subunit structurei

Forms a complex with CheC.

Protein-protein interaction databases

IntActiP40404, 3 interactors
STRINGi224308.Bsubs1_010100009076

Structurei

3D structure databases

ProteinModelPortaliP40404
SMRiP40404
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CheD family.Curated

Phylogenomic databases

eggNOGiCOG1871 LUCA
HOGENOMiHOG000273195
InParanoidiP40404
KOiK03411
OMAiVGMADLN
PhylomeDBiP40404

Family and domain databases

CDDicd16352 CheD, 1 hit
Gene3Di3.30.1330.200, 1 hit
HAMAPiMF_01440 CheD, 1 hit
InterProiView protein in InterPro
IPR038592 CheD-like_sf
IPR005659 Chemorcpt_Glu_NH3ase_CheD
IPR011324 Cytotoxic_necrot_fac-like_cat
PANTHERiPTHR35147 PTHR35147, 1 hit
PfamiView protein in Pfam
PF03975 CheD, 1 hit
SUPFAMiSSF64438 SSF64438, 1 hit

Sequencei

Sequence statusi: Complete.

P40404-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTTEAVVIK VGIADVKIAR FPDTIRTSGL GSCVGLVLYD KEKQTAGLVH
60 70 80 90 100
VMLPDSTLSK TAELNRAKYA DTAVQTTIDM LIEAGCRKFA LKAKLAGGSE
110 120 130 140 150
MFKFKSTNDL MKIGPRNVLA IKEQLSLFNI PIISEDTGGS SGRTIEFEPK
160
SCMLHIRTVK QGEKTI
Length:166
Mass (Da):18,008
Last modified:February 1, 1995 - v1
Checksum:i3932F57E08C29ED8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20144 Genomic DNA Translation: AAA61469.1
AL009126 Genomic DNA Translation: CAB13519.1
PIRiB55216
RefSeqiNP_389528.1, NC_000964.3
WP_003244852.1, NZ_JNCM01000035.1

Genome annotation databases

EnsemblBacteriaiCAB13519; CAB13519; BSU16460
GeneIDi939959
KEGGibsu:BSU16460
PATRICifig|224308.179.peg.1787

Similar proteinsi

Entry informationi

Entry nameiCHED_BACSU
AccessioniPrimary (citable) accession number: P40404
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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