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Protein

Guanine nucleotide exchange factor subunit RIC1

Gene

RIC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates YPT6 by exchanging bound GDP for free GTP. It is thereby required for efficient fusion of endosome-derived vesicles with the Golgi. The RIC1-RGP1 participates in the recycling of SNC1, presumably by mediating fusion of endosomal vesicles with the Golgi compartment. May also be indirectly involved in the transcription of both ribosomal protein genes and ribosomal RNA.3 Publications

GO - Molecular functioni

GO - Biological processi

  • intracellular protein transport Source: SGD
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • retrograde transport, endosome to Golgi Source: SGD
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-32197-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide exchange factor subunit RIC1Curated
Alternative name(s):
Protein RIC1
Ribosome control protein 1
Short name:
Ric1p1 Publication
Gene namesi
Name:RIC1Imported
Ordered Locus Names:YLR039C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR039C.
SGDiS000004029. RIC1.

Subcellular locationi

GO - Cellular componenti

  • cis-Golgi network Source: SGD
  • cytosol Source: GOC
  • Golgi membrane Source: SGD
  • guanyl-nucleotide exchange factor complex Source: SGD
  • nucleus Source: SGD
  • RIC1-RGP1 guanyl-nucleotide exchange factor complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000973321 – 1056Guanine nucleotide exchange factor subunit RIC1Add BLAST1056

Proteomic databases

MaxQBiP40395.
PRIDEiP40395.

Interactioni

Subunit structurei

Forms a complex with RGP1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
RGP1P166644EBI-15183,EBI-15080

GO - Molecular functioni

Protein-protein interaction databases

BioGridi31315. 721 interactors.
DIPiDIP-2564N.
IntActiP40395. 11 interactors.
MINTiMINT-424650.

Structurei

3D structure databases

ProteinModelPortaliP40395.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RIC1 family. Highly divergent.Curated

Phylogenomic databases

HOGENOMiHOG000141738.
InParanoidiP40395.
KOiK20476.
OMAiKIETKHW.
OrthoDBiEOG092C0A93.

Family and domain databases

InterProiIPR009771. Ribosome_control_1.
[Graphical view]
PfamiPF07064. RIC1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40395-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFIKQSEKNT PKCLYKKKGK VRVLLTGSCK KLNTWKMHLW PVSPPQLLRI
60 70 80 90 100
PPRNAELGEG TKIDDCNILQ SMTLPQANVL IMLTPTRVLI YNFKPMALVA
110 120 130 140 150
SHERTMASLK EFGDNRSMKR SAPYNDIIEG LISKKDSQYL LWHQGKLIFY
160 170 180 190 200
VMTDKNFLLT YQILKNCTNE IIFKEYGIPV IEPLLMSEEE ANSAEYDYNN
210 220 230 240 250
DDDTLTVFDK NSSSRIIQNG FGITKEKGFL HFLSNQENID ELPVKKLELR
260 270 280 290 300
LKVVLKFDYE IIDMIGIKTF SKVGDGRYEE VLIVLFPHGL QILTISDFKV
310 320 330 340 350
SKSSLVEVKK GSKTIVCNKQ LMVLSHDSVE KQTIVSIIDI EKQAVEAIPL
360 370 380 390 400
TDTPDELLTC LEVNGYLVVV YKEKIICFDT RIKKVSHSWK PPFVIKLCDK
410 420 430 440 450
INDKILLLVS EDSVNIHFYT EFGNLLFATY FDEDDYNGDN NNDNSKDKNE
460 470 480 490 500
KKAAEYKISD FVCLDKSLIT VSHSGKYQVW KLWEEIKQTQ FDFRNPKCYV
510 520 530 540 550
LTNTNNDVII YSPVTSSSIN NDNLQVIKLP TKTFNNHIAF VKINSSLRLF
560 570 580 590 600
ATYVSNKNIL LIHNLETNMW SSFADQNVLD LHWLGDNYLV CHMKNDDGST
610 620 630 640 650
NLKCLQIPLQ EANPDVELSD YVMWEYNVPE NTIVFSLHVN TLSRYKLLKM
660 670 680 690 700
KSKNHNASEK QPDALLKTAE IILVTDTQTI VFDVISTVHP CGLNIIKKFY
710 720 730 740 750
QYLKINIPID VLPNKIEWII NMKEGLLFFA DRKFIKLGKV DGGGWQTLTL
760 770 780 790 800
LDNIEKIIDV IRDEIFVVQG HNYVVYSLED LWDDKKPLVS IPIEEDLYPI
810 820 830 840 850
STTPETATTH TLHCIFNARF SKLVVKHQIY LDQLILAKLE DNTDLEDISH
860 870 880 890 900
NYRFLKPYKF ALEKILSTKI LRSDSLDDIL KLIKMYDNTD PEHNISPPTH
910 920 930 940 950
SGMLEIISNC LRKIETKYWN HLFTNLKMTP RDLLALCIEE NEAKMLGVLL
960 970 980 990 1000
LVFLNYDEKD LGDDLHFKKS DLGTEESKAL NDNSTKKSEK SVTNLLKDEE
1010 1020 1030 1040 1050
LMLKVLELLV TSAANATDPI KATDSWDMCF QLIRLLKELD RENNTQLVQK

ALERFK
Length:1,056
Mass (Da):121,650
Last modified:February 1, 1995 - v1
Checksum:i2368616B67AEAD31
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D43895 Genomic DNA. Translation: BAA07866.1.
Z73211 Genomic DNA. Translation: CAA97567.1.
BK006945 Genomic DNA. Translation: DAA09358.1.
PIRiS56039.
RefSeqiNP_013140.1. NM_001181926.1.

Genome annotation databases

EnsemblFungiiYLR039C; YLR039C; YLR039C.
GeneIDi850728.
KEGGisce:YLR039C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D43895 Genomic DNA. Translation: BAA07866.1.
Z73211 Genomic DNA. Translation: CAA97567.1.
BK006945 Genomic DNA. Translation: DAA09358.1.
PIRiS56039.
RefSeqiNP_013140.1. NM_001181926.1.

3D structure databases

ProteinModelPortaliP40395.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31315. 721 interactors.
DIPiDIP-2564N.
IntActiP40395. 11 interactors.
MINTiMINT-424650.

Proteomic databases

MaxQBiP40395.
PRIDEiP40395.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLR039C; YLR039C; YLR039C.
GeneIDi850728.
KEGGisce:YLR039C.

Organism-specific databases

EuPathDBiFungiDB:YLR039C.
SGDiS000004029. RIC1.

Phylogenomic databases

HOGENOMiHOG000141738.
InParanoidiP40395.
KOiK20476.
OMAiKIETKHW.
OrthoDBiEOG092C0A93.

Enzyme and pathway databases

BioCyciYEAST:G3O-32197-MONOMER.

Miscellaneous databases

PROiP40395.

Family and domain databases

InterProiIPR009771. Ribosome_control_1.
[Graphical view]
PfamiPF07064. RIC1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRIC1_YEAST
AccessioniPrimary (citable) accession number: P40395
Secondary accession number(s): D6VY42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 30, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 78 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.