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P40387 (TPS1_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alpha,alpha-trehalose-phosphate synthase [UDP-forming]

EC=2.4.1.15
Alternative name(s):
Trehalose-6-phosphate synthase
UDP-glucose-glucosephosphate glucosyltransferase
Gene names
Name:tps1
ORF Names:SPAC328.03
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length513 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Appears to have a role in spore germination. In S.pombe it appears to have no role in the control of the initial steps of glycolysis.

Catalytic activity

UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate.

Induction

By heat shock.

Sequence similarities

Belongs to the glycosyltransferase 20 family.

Sequence caution

The sequence CAA82861.1 differs from that shown. Reason: Frameshift at position 475.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 513513Alpha,alpha-trehalose-phosphate synthase [UDP-forming]
PRO_0000122500

Amino acid modifications

Modified residue401Phosphotyrosine Ref.3
Modified residue5031Phosphoserine Ref.3

Experimental info

Sequence conflict2771A → R in CAA82861. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P40387 [UniParc].

Last modified August 14, 2001. Version 2.
Checksum: 9FC247B626CE2B00

FASTA51358,493
        10         20         30         40         50         60 
MSDAHDTIKS LTGDASNSRR LIVVSNRLPI TIKRKDNGTY DFSMSSGGLV SALSGLKKLM 

        70         80         90        100        110        120 
TFQWLGWCGQ EIPEDEKPMI IQRLQDECSA IPVFLDDETA DRHYNGFSNS ILWPLFHYHP 

       130        140        150        160        170        180 
GEINFDEENW EAYRAANYAF AEAIVKNLQD GDLIWVQDYH LMVLPQMLRE LIGDKFKDIK 

       190        200        210        220        230        240 
IGFFLHTPFP SSEIYRVLPV RNEILEGVLN CDLVGFHTYD YARHFLSACS RILNLSTLPN 

       250        260        270        280        290        300 
GVEYNGQMVS VGTFPIGIDP EKFSDALKSD VVKDRIASIE RRLQGVKVIV GVDRLDYIKG 

       310        320        330        340        350        360 
VPQKFHAFEV FLEQYPEWVG KVVLVQVAVP SRQDVEEYQN LRAVVNELVG RINGRFGTVE 

       370        380        390        400        410        420 
YTPIHFLHKS VRFEELVALY NVSDVCLITS TRDGMNLVSY EYICTQQERH GALILSEFAG 

       430        440        450        460        470        480 
AAQSLNGSIV INPWNTEELA NSIHDALTMP EKQREANENK LFRYVNKYTS QFWGQSFVGE 

       490        500        510 
LQRIQHYSHP HPRRTNPILR TKSAQVLSMN SSS 

« Hide

References

« Hide 'large scale' references
[1]"Trehalose-6-P synthase is dispensable for growth on glucose but not for spore germination in Schizosaccharomyces pombe."
Blazquez M.A., Stucka R., Feldmann H., Gancedo C.
J. Bacteriol. 176:3895-3902(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[3]"Phosphoproteome analysis of fission yeast."
Wilson-Grady J.T., Villen J., Gygi S.P.
J. Proteome Res. 7:1088-1097(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-40 AND SER-503, IDENTIFICATION BY MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z29971 Genomic DNA. Translation: CAA82861.1. Frameshift.
CU329670 Genomic DNA. Translation: CAB95998.1.
PIRT46564.
RefSeqNP_594205.1. NM_001019628.2.

3D structure databases

ProteinModelPortalP40387.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid279113. 92 interactions.
MINTMINT-4689743.
STRING4896.SPAC328.03-1.

Protein family/group databases

CAZyGT20. Glycosyltransferase Family 20.

Proteomic databases

PaxDbP40387.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPAC328.03.1; SPAC328.03.1:pep; SPAC328.03.
GeneID2542660.
KEGGspo:SPAC328.03.

Organism-specific databases

PomBaseSPAC328.03.

Phylogenomic databases

eggNOGCOG0380.
HOGENOMHOG000191477.
KOK00697.
OMAIEFMPIH.
OrthoDBEOG76QFS6.
PhylomeDBP40387.

Family and domain databases

InterProIPR001830. Glyco_trans_20.
IPR012766. Trehalose_OtsA.
[Graphical view]
PfamPF00982. Glyco_transf_20. 1 hit.
[Graphical view]
TIGRFAMsTIGR02400. trehalose_OtsA. 1 hit.
ProtoNetSearch...

Other

NextBio20803708.
PROP40387.

Entry information

Entry nameTPS1_SCHPO
AccessionPrimary (citable) accession number: P40387
Secondary accession number(s): Q9P3U3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: August 14, 2001
Last modified: April 16, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names