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Protein

Alpha,alpha-trehalose-phosphate synthase [UDP-forming]

Gene

tps1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Appears to have a role in spore germination. In S.pombe it appears to have no role in the control of the initial steps of glycolysis.

Catalytic activityi

UDP-alpha-D-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate.

GO - Molecular functioni

  • alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity Source: PomBase
  • phosphatase activity Source: GO_Central

GO - Biological processi

  • ascospore formation Source: PomBase
  • trehalose biosynthesis in response to heat stress Source: PomBase
  • trehalose metabolism in response to stress Source: PomBase

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processStress response

Protein family/group databases

CAZyiGT20 Glycosyltransferase Family 20

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] (EC:2.4.1.15)
Alternative name(s):
Trehalose-6-phosphate synthase
UDP-glucose-glucosephosphate glucosyltransferase
Gene namesi
Name:tps1
ORF Names:SPAC328.03
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC328.03
PomBaseiSPAC328.03 tps1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001225001 – 513Alpha,alpha-trehalose-phosphate synthase [UDP-forming]Add BLAST513

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei40Phosphotyrosine1 Publication1
Modified residuei503Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP40387
PaxDbiP40387
PRIDEiP40387

PTM databases

iPTMnetiP40387

Expressioni

Inductioni

By heat shock.

Interactioni

Protein-protein interaction databases

BioGridi279113, 93 interactors
STRINGi4896.SPAC328.03.1

Structurei

3D structure databases

ProteinModelPortaliP40387
SMRiP40387
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 20 family.Curated

Phylogenomic databases

HOGENOMiHOG000191477
InParanoidiP40387
KOiK00697
OMAiIEFMPIH
OrthoDBiEOG092C0LDC
PhylomeDBiP40387

Family and domain databases

CDDicd03788 GT1_TPS, 1 hit
InterProiView protein in InterPro
IPR001830 Glyco_trans_20
IPR012766 Trehalose_OtsA
PfamiView protein in Pfam
PF00982 Glyco_transf_20, 1 hit
TIGRFAMsiTIGR02400 trehalose_OtsA, 1 hit

Sequencei

Sequence statusi: Complete.

P40387-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDAHDTIKS LTGDASNSRR LIVVSNRLPI TIKRKDNGTY DFSMSSGGLV
60 70 80 90 100
SALSGLKKLM TFQWLGWCGQ EIPEDEKPMI IQRLQDECSA IPVFLDDETA
110 120 130 140 150
DRHYNGFSNS ILWPLFHYHP GEINFDEENW EAYRAANYAF AEAIVKNLQD
160 170 180 190 200
GDLIWVQDYH LMVLPQMLRE LIGDKFKDIK IGFFLHTPFP SSEIYRVLPV
210 220 230 240 250
RNEILEGVLN CDLVGFHTYD YARHFLSACS RILNLSTLPN GVEYNGQMVS
260 270 280 290 300
VGTFPIGIDP EKFSDALKSD VVKDRIASIE RRLQGVKVIV GVDRLDYIKG
310 320 330 340 350
VPQKFHAFEV FLEQYPEWVG KVVLVQVAVP SRQDVEEYQN LRAVVNELVG
360 370 380 390 400
RINGRFGTVE YTPIHFLHKS VRFEELVALY NVSDVCLITS TRDGMNLVSY
410 420 430 440 450
EYICTQQERH GALILSEFAG AAQSLNGSIV INPWNTEELA NSIHDALTMP
460 470 480 490 500
EKQREANENK LFRYVNKYTS QFWGQSFVGE LQRIQHYSHP HPRRTNPILR
510
TKSAQVLSMN SSS
Length:513
Mass (Da):58,493
Last modified:August 14, 2001 - v2
Checksum:i9FC247B626CE2B00
GO

Sequence cautioni

The sequence CAA82861 differs from that shown. Reason: Frameshift at position 475.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti277A → R in CAA82861 (PubMed:8021171).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z29971 Genomic DNA Translation: CAA82861.1 Frameshift.
CU329670 Genomic DNA Translation: CAB95998.1
PIRiT46564
RefSeqiNP_594205.1, NM_001019628.2

Genome annotation databases

EnsemblFungiiSPAC328.03.1; SPAC328.03.1:pep; SPAC328.03
GeneIDi2542660
KEGGispo:SPAC328.03

Similar proteinsi

Entry informationi

Entry nameiTPS1_SCHPO
AccessioniPrimary (citable) accession number: P40387
Secondary accession number(s): Q9P3U3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: August 14, 2001
Last modified: March 28, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health