ID MAOX_SCHPO Reviewed; 565 AA. AC P40375; A1EGU1; DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-1995, sequence version 1. DT 16-JUN-2009, entry version 66. DE RecName: Full=NAD-dependent malic enzyme; DE Short=NAD-ME; DE EC=1.1.1.38; GN Name=mae2; ORFNames=SPCC794.12c; OS Schizosaccharomyces pombe (Fission yeast). OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; OC Schizosaccharomycetes; Schizosaccharomycetales; OC Schizosaccharomycetaceae; Schizosaccharomyces. OX NCBI_TaxID=4896; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=ATCC 38366 / 972; RX MEDLINE=95028159; PubMed=7941746; DOI=10.1002/yea.320100506; RA Viljoen M., Subden R.E., Krizus A., van Vuuren H.J.J.; RT "Molecular analysis of the malic enzyme gene (mae2) of RT Schizosaccharomyces pombe."; RL Yeast 10:613-624(1994). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RA Li A., Su X., Zhang W.; RT "Sequencing and analysis of malate degradation related enzyme gene RT from Schizosaccharomyces pombe."; RL Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 38366 / 972; RX MEDLINE=21848401; PubMed=11859360; DOI=10.1038/nature724; RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., RA Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A., RA Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., RA Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., RA James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., RA Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., RA Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., RA Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., RA Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., RA Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., RA Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., RA Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., RA Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., RA Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., RA Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., RA Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., RA Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., RA Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., RA Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., RA Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., RA Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., RA Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.; RT "The genome sequence of Schizosaccharomyces pombe."; RL Nature 415:871-880(2002). RN [4] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-445, AND MASS RP SPECTROMETRY. RX PubMed=18257517; DOI=10.1021/pr7006335; RA Wilson-Grady J.T., Villen J., Gygi S.P.; RT "Phosphoproteome analysis of fission yeast."; RL J. Proteome Res. 7:1088-1097(2008). CC -!- CATALYTIC ACTIVITY: (S)-malate + NAD(+) = pyruvate + CO(2) + NADH. CC -!- COFACTOR: Divalent metal cations. Prefers magnesium or manganese CC (By similarity). CC -!- SIMILARITY: Belongs to the malic enzymes family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; U00621; AAA18985.1; -; Genomic_DNA. DR EMBL; EF125016; ABL67725.1; -; Genomic_DNA. DR EMBL; CU329672; CAA19139.1; -; Genomic_DNA. DR PIR; S44330; S44330. DR RefSeq; NP_587760.1; -. DR HSSP; P23368; 1GZ3. DR GeneID; 2539592; -. DR KEGG; spo:SPCC794.12c; -. DR NMPDR; fig|4896.1.peg.98; -. DR GeneDB_Spombe; SPCC794.12c; -. DR OMA; P40375; ESERTAF. DR BioCyc; SPOM-XXX-01:SPOM-XXX-01-002119-MON; -. DR BRENDA; 1.1.1.38; 653. DR ArrayExpress; P40375; -. DR GO; GO:0005829; C:cytosol; IDA:GeneDB_SPombe. DR GO; GO:0016619; F:malate dehydrogenase (oxaloacetate-decarbox...; IMP:GeneDB_SPombe. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0051287; F:NAD or NADH binding; IEA:InterPro. DR GO; GO:0006108; P:malate metabolic process; IMP:GeneDB_SPombe. DR GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW. DR GO; GO:0006090; P:pyruvate metabolic process; IMP:GeneDB_SPombe. DR InterPro; IPR015884; Malic_enzyme_CS. DR InterPro; IPR012301; Malic_N. DR InterPro; IPR012302; Malic_NAD_bd. DR InterPro; IPR001891; Malic_OxRdtase. DR InterPro; IPR016040; NAD(P)-bd_dom. DR Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1. DR Pfam; PF00390; malic; 1. DR Pfam; PF03949; Malic_M; 1. DR PRINTS; PR00072; MALOXRDTASE. DR PROSITE; PS00331; MALIC_ENZYMES; 1. PE 1: Evidence at protein level; KW Complete proteome; Metal-binding; NAD; Oxidoreductase; Phosphoprotein. FT CHAIN 1 565 NAD-dependent malic enzyme. FT /FTId=PRO_0000160205. FT ACT_SITE 103 103 Proton donor (By similarity). FT ACT_SITE 177 177 Proton acceptor (By similarity). FT METAL 248 248 Divalent metal cation (By similarity). FT METAL 249 249 Divalent metal cation (By similarity). FT METAL 272 272 Divalent metal cation (By similarity). FT BINDING 272 272 NAD (By similarity). FT BINDING 419 419 NAD (By similarity). FT SITE 272 272 Important for activity (By similarity). FT MOD_RES 445 445 Phosphoserine. SQ SEQUENCE 565 AA; 62535 MW; AF22D98E1BB72CA8 CRC64; MPAGTKEQIE CPLKGVTLLN SPRYNKDTAF TPEERQKFEI SSRLPPIVET LQQQVDRCYD QYKAIGDEPL QKNLYLSQLS VTNQTLFYAL ISQHLIEMIP IIYTPTEGDA IKQFSDIYRY PEGCYLDIDH NDLSYIKQQL SEFGKSDSVE YIIITDSEGI LGIGDQGVGG VLISVAKGHL MTLCAGLDPN RFLPIVLDVG TNNETHRKNH QYMGLRKDRV RGEQYDSFLD NVIKAIREVF PEAFIHFEDF GLANAKRILD HYRPDIACFN DDIQGTGAVA LAAIIGALHV TKSPLTEQRI MIFGAGTAGV GIANQIVAGM VTDGLSLDKA RGNLFMIDRC GLLLERHAKI ATDGQKPFLK KDSDFKEVPS GDINLESAIA LVKPTILLGC SGQPGKFTEK AIREMSKHVE RPIIFPISNP TTLMEAKPDQ IDKWSDGKAL IATGSPLPPL NRNGKKYVIS QCNNALLYPA LGVACVLSRC KLLSDGMLKA ASDALATVPR SLFAADEALL PDLNNAREIS RHIVFAVLKQ AVSEGMSTVD LPKDDAKLKE WIIEREWNPE YKPFV //