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Protein

ATP phosphoribosyltransferase

Gene

his1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity).By similarity

Catalytic activityi

1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate.

Pathwayi: L-histidine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (his1)
  2. Histidine biosynthesis bifunctional protein his7 (his7)
  3. Histidine biosynthesis bifunctional protein his7 (his7)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (SPAC3F10.09)
  5. Imidazole glycerol phosphate synthase hisHF (his4)
  6. Imidazoleglycerol-phosphate dehydratase (his5)
  7. Histidinol-phosphate aminotransferase (his3)
  8. Probable histidinol-phosphatase (SPCC1672.01)
  9. Histidinol dehydrogenase (his2)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00031; UER00006.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP phosphoribosyltransferase (EC:2.4.2.17)
Short name:
ATP-PRT
Short name:
ATP-PRTase
Gene namesi
Name:his1
ORF Names:SPAC25G10.05c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC25G10.05c.
PomBaseiSPAC25G10.05c. his1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001519561 – 310ATP phosphoribosyltransferaseAdd BLAST310

Proteomic databases

MaxQBiP40373.
PRIDEiP40373.

Interactioni

Protein-protein interaction databases

BioGridi279171. 19 interactors.
MINTiMINT-4689582.

Structurei

3D structure databases

ProteinModelPortaliP40373.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000223250.
InParanoidiP40373.
KOiK00765.
OMAiAIQKNGR.
OrthoDBiEOG092C3OBM.
PhylomeDBiP40373.

Family and domain databases

Gene3Di3.30.70.120. 1 hit.
HAMAPiMF_00079. HisG_Long. 1 hit.
InterProiIPR013820. ATP_PRibTrfase_cat.
IPR018198. ATP_PRibTrfase_CS.
IPR001348. ATP_PRibTrfase_HisG.
IPR020621. ATP_PRibTrfase_HisG_long.
IPR013115. HisG_C.
IPR011322. N-reg_PII-like_a/b.
IPR015867. N-reg_PII/ATP_PRibTrfase_C.
[Graphical view]
PANTHERiPTHR21403. PTHR21403. 1 hit.
PfamiPF01634. HisG. 1 hit.
PF08029. HisG_C. 1 hit.
[Graphical view]
SUPFAMiSSF54913. SSF54913. 1 hit.
TIGRFAMsiTIGR00070. hisG. 1 hit.
TIGR03455. HisG_C-term. 1 hit.
PROSITEiPS01316. ATP_P_PHORIBOSYLTR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40373-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLVNHLEDR LLFAVPKKGR LYESCVNVLK GSDIKFRRNP RLDIALVQNL
60 70 80 90 100
PIALVFLPAA DIPRFVGTGR VHLGITGQDQ IAEARLRIGD KLKIEELVDL
110 120 130 140 150
QFGGCKLQVQ VPESGDITSV DQLVGRRIVT SFEYLVAEYF DKVEKKAKSE
160 170 180 190 200
GKVDSGIKTE ISFVSGSVEA SCALGIADAV VDLVESGETM RASGLKPIET
210 220 230 240 250
VMSTSAVLVR SSNCSSELEP LLQTIITRIR GYIIAQQYVL VNYNVNREHL
260 270 280 290 300
PVVLKITPGK RAPTITTLDE PGWVAVSSMV VKKEVAQVMD KLSQNHAHDI
310
LVLSIDNSRP
Length:310
Mass (Da):34,029
Last modified:February 1, 1995 - v1
Checksum:i39AB325FF0D3E2EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07830 mRNA. Translation: AAA92790.1.
CU329670 Genomic DNA. Translation: CAA94634.1.
PIRiS55076.
RefSeqiNP_594525.1. NM_001019954.2.

Genome annotation databases

EnsemblFungiiSPAC25G10.05c.1; SPAC25G10.05c.1:pep; SPAC25G10.05c.
GeneIDi2542720.
KEGGispo:SPAC25G10.05c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07830 mRNA. Translation: AAA92790.1.
CU329670 Genomic DNA. Translation: CAA94634.1.
PIRiS55076.
RefSeqiNP_594525.1. NM_001019954.2.

3D structure databases

ProteinModelPortaliP40373.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279171. 19 interactors.
MINTiMINT-4689582.

Proteomic databases

MaxQBiP40373.
PRIDEiP40373.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC25G10.05c.1; SPAC25G10.05c.1:pep; SPAC25G10.05c.
GeneIDi2542720.
KEGGispo:SPAC25G10.05c.

Organism-specific databases

EuPathDBiFungiDB:SPAC25G10.05c.
PomBaseiSPAC25G10.05c. his1.

Phylogenomic databases

HOGENOMiHOG000223250.
InParanoidiP40373.
KOiK00765.
OMAiAIQKNGR.
OrthoDBiEOG092C3OBM.
PhylomeDBiP40373.

Enzyme and pathway databases

UniPathwayiUPA00031; UER00006.

Miscellaneous databases

PROiP40373.

Family and domain databases

Gene3Di3.30.70.120. 1 hit.
HAMAPiMF_00079. HisG_Long. 1 hit.
InterProiIPR013820. ATP_PRibTrfase_cat.
IPR018198. ATP_PRibTrfase_CS.
IPR001348. ATP_PRibTrfase_HisG.
IPR020621. ATP_PRibTrfase_HisG_long.
IPR013115. HisG_C.
IPR011322. N-reg_PII-like_a/b.
IPR015867. N-reg_PII/ATP_PRibTrfase_C.
[Graphical view]
PANTHERiPTHR21403. PTHR21403. 1 hit.
PfamiPF01634. HisG. 1 hit.
PF08029. HisG_C. 1 hit.
[Graphical view]
SUPFAMiSSF54913. SSF54913. 1 hit.
TIGRFAMsiTIGR00070. hisG. 1 hit.
TIGR03455. HisG_C-term. 1 hit.
PROSITEiPS01316. ATP_P_PHORIBOSYLTR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHIS1_SCHPO
AccessioniPrimary (citable) accession number: P40373
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 30, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.