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Protein

Protein phosphatase 2C homolog 1

Gene

ptc1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

It has a serine and threonine phosphatase activity. Has a specialized role in the heat shock response. May be responsible for the dephosphorylation of hsp90. Also has a role in maintaining osmotic stability.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi109Manganese 1By similarity1
Metal bindingi109Manganese 2By similarity1
Metal bindingi110Manganese 1; via carbonyl oxygenBy similarity1
Metal bindingi275Manganese 2By similarity1
Metal bindingi314Manganese 2By similarity1

GO - Molecular functioni

  • magnesium-dependent protein serine/threonine phosphatase activity Source: PomBase
  • MAP kinase serine/threonine phosphatase activity Source: PomBase
  • metal ion binding Source: UniProtKB-KW
  • protein serine/threonine phosphatase activity Source: PomBase

GO - Biological processi

  • cellular response to osmotic stress Source: PomBase
  • negative regulation of stress-activated MAPK cascade Source: PomBase
  • peptidyl-serine dephosphorylation Source: PomBase
  • peptidyl-threonine dephosphorylation Source: PomBase
  • regulation of cellular response to heat Source: PomBase

Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processStress response
LigandMagnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 2C homolog 1 (EC:3.1.3.16)
Short name:
PP2C-1
Gene namesi
Name:ptc1
ORF Names:SPCC4F11.02
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC4F11.02.
PomBaseiSPCC4F11.02. ptc1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000577701 – 347Protein phosphatase 2C homolog 1Add BLAST347

Proteomic databases

MaxQBiP40371.
PRIDEiP40371.

PTM databases

iPTMnetiP40371.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

BioGridi276058. 320 interactors.
MINTiMINT-4689555.
STRINGi4896.SPCC4F11.02.1.

Structurei

3D structure databases

ProteinModelPortaliP40371.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini71 – 323PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST253

Sequence similaritiesi

Belongs to the PP2C family.Curated

Phylogenomic databases

HOGENOMiHOG000233896.
InParanoidiP40371.
KOiK19704.
OMAiVMSGRVN.
OrthoDBiEOG092C52JO.
PhylomeDBiP40371.

Family and domain databases

CDDicd00143. PP2Cc. 1 hit.
Gene3Di3.60.40.10. 1 hit.
InterProiView protein in InterPro
IPR015655. PP2C.
IPR000222. PP2C_BS.
IPR036457. PPM-type_dom_sf.
IPR001932. PPM-type_phosphatase_dom.
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiView protein in Pfam
PF00481. PP2C. 1 hit.
SMARTiView protein in SMART
SM00332. PP2Cc. 1 hit.
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiView protein in PROSITE
PS01032. PPM_1. 1 hit.
PS51746. PPM_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P40371-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGSHPNAGS LLEPLHKLNP FSENSTSGHR KNASDHSADG ETRPIAIEMK
60 70 80 90 100
DSKGNTVPVG NSRPSKASNW LAGLMEDKNQ RWRRSMEDTH ICLYDFGGNQ
110 120 130 140 150
DDGFVAVYDG HAGIQASDYC QKNLHKVLLE KVRNEPDRLV TDLMDETFVE
160 170 180 190 200
VNSKIAKATH NDICGCTAAV AFFRYEKNRT RRVLYTANAG DARIVLCRDG
210 220 230 240 250
KAIRLSYDHK GSDANESRRV TQLGGLMVQN RINGVLAVTR ALGDTYLKEL
260 270 280 290 300
VSAHPFTTET RIWNGHDEFF IIACDGLWDV VSDQEAVDFV RNFVSPREAA
310 320 330 340
VRLVEFALKR LSTDNITCIV VNLTRNPGDL DDSGLTADND SYSNDYY
Length:347
Mass (Da):38,676
Last modified:February 1, 1995 - v1
Checksum:i50675A545502403B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26970 mRNA. Translation: AAA35327.1.
CU329672 Genomic DNA. Translation: CAB55768.1.
PIRiA56058.
RefSeqiNP_588401.1. NM_001023392.2.

Genome annotation databases

EnsemblFungiiSPCC4F11.02.1; SPCC4F11.02.1:pep; SPCC4F11.02.
GeneIDi2539495.
KEGGispo:SPCC4F11.02.

Similar proteinsi

Entry informationi

Entry nameiPP2C1_SCHPO
AccessioniPrimary (citable) accession number: P40371
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 25, 2017
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families