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P40371

- PP2C1_SCHPO

UniProt

P40371 - PP2C1_SCHPO

Protein

Protein phosphatase 2C homolog 1

Gene

ptc1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    It has a serine and threonine phosphatase activity. Has a specialized role in the heat shock response. May be responsible for the dephosphorylation of hsp90. Also has a role in maintaining osmotic stability.

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi109 – 1091Manganese 1By similarity
    Metal bindingi109 – 1091Manganese 2By similarity
    Metal bindingi110 – 1101Manganese 1; via carbonyl oxygenBy similarity
    Metal bindingi275 – 2751Manganese 2By similarity
    Metal bindingi314 – 3141Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein serine/threonine phosphatase activity Source: PomBase

    GO - Biological processi

    1. cellular response to heat Source: PomBase
    2. inactivation of MAPK activity involved in osmosensory signaling pathway Source: PomBase
    3. protein dephosphorylation Source: PomBase

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Biological processi

    Stress response

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein phosphatase 2C homolog 1 (EC:3.1.3.16)
    Short name:
    PP2C-1
    Gene namesi
    Name:ptc1
    ORF Names:SPCC4F11.02
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome III

    Organism-specific databases

    PomBaseiSPCC4F11.02.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: PomBase
    2. nucleus Source: PomBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 347347Protein phosphatase 2C homolog 1PRO_0000057770Add
    BLAST

    Proteomic databases

    MaxQBiP40371.

    Interactioni

    Subunit structurei

    Monomer.

    Protein-protein interaction databases

    BioGridi276058. 319 interactions.
    MINTiMINT-4689555.
    STRINGi4896.SPCC4F11.02-1.

    Structurei

    3D structure databases

    ProteinModelPortaliP40371.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PP2C family.Curated

    Phylogenomic databases

    eggNOGiCOG0631.
    HOGENOMiHOG000233896.
    KOiK01090.
    OMAiATHNDIC.
    OrthoDBiEOG7D2FR2.
    PhylomeDBiP40371.

    Family and domain databases

    Gene3Di3.60.40.10. 1 hit.
    InterProiIPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view]
    PANTHERiPTHR13832. PTHR13832. 1 hit.
    PfamiPF00481. PP2C. 1 hit.
    [Graphical view]
    SMARTiSM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 1 hit.
    PROSITEiPS01032. PP2C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P40371-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKGSHPNAGS LLEPLHKLNP FSENSTSGHR KNASDHSADG ETRPIAIEMK    50
    DSKGNTVPVG NSRPSKASNW LAGLMEDKNQ RWRRSMEDTH ICLYDFGGNQ 100
    DDGFVAVYDG HAGIQASDYC QKNLHKVLLE KVRNEPDRLV TDLMDETFVE 150
    VNSKIAKATH NDICGCTAAV AFFRYEKNRT RRVLYTANAG DARIVLCRDG 200
    KAIRLSYDHK GSDANESRRV TQLGGLMVQN RINGVLAVTR ALGDTYLKEL 250
    VSAHPFTTET RIWNGHDEFF IIACDGLWDV VSDQEAVDFV RNFVSPREAA 300
    VRLVEFALKR LSTDNITCIV VNLTRNPGDL DDSGLTADND SYSNDYY 347
    Length:347
    Mass (Da):38,676
    Last modified:February 1, 1995 - v1
    Checksum:i50675A545502403B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L26970 mRNA. Translation: AAA35327.1.
    CU329672 Genomic DNA. Translation: CAB55768.1.
    PIRiA56058.
    RefSeqiNP_588401.1. NM_001023392.2.

    Genome annotation databases

    EnsemblFungiiSPCC4F11.02.1; SPCC4F11.02.1:pep; SPCC4F11.02.
    GeneIDi2539495.
    KEGGispo:SPCC4F11.02.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L26970 mRNA. Translation: AAA35327.1 .
    CU329672 Genomic DNA. Translation: CAB55768.1 .
    PIRi A56058.
    RefSeqi NP_588401.1. NM_001023392.2.

    3D structure databases

    ProteinModelPortali P40371.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 276058. 319 interactions.
    MINTi MINT-4689555.
    STRINGi 4896.SPCC4F11.02-1.

    Proteomic databases

    MaxQBi P40371.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPCC4F11.02.1 ; SPCC4F11.02.1:pep ; SPCC4F11.02 .
    GeneIDi 2539495.
    KEGGi spo:SPCC4F11.02.

    Organism-specific databases

    PomBasei SPCC4F11.02.

    Phylogenomic databases

    eggNOGi COG0631.
    HOGENOMi HOG000233896.
    KOi K01090.
    OMAi ATHNDIC.
    OrthoDBi EOG7D2FR2.
    PhylomeDBi P40371.

    Miscellaneous databases

    NextBioi 20800657.
    PROi P40371.

    Family and domain databases

    Gene3Di 3.60.40.10. 1 hit.
    InterProi IPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view ]
    PANTHERi PTHR13832. PTHR13832. 1 hit.
    Pfami PF00481. PP2C. 1 hit.
    [Graphical view ]
    SMARTi SM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 1 hit.
    PROSITEi PS01032. PP2C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Protein phosphatase 2C, encoded by ptc1+, is important in the heat shock response of Schizosaccharomyces pombe."
      Shiozaki K., Akhavan-Niaki H., McGowan C.H., Russell P.
      Mol. Cell. Biol. 14:3742-3751(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: 972 / ATCC 24843.
    2. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.

    Entry informationi

    Entry nameiPP2C1_SCHPO
    AccessioniPrimary (citable) accession number: P40371
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3