Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein phosphatase 2C homolog 1

Gene

ptc1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

It has a serine and threonine phosphatase activity. Has a specialized role in the heat shock response. May be responsible for the dephosphorylation of hsp90. Also has a role in maintaining osmotic stability.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi109Manganese 1By similarity1
Metal bindingi109Manganese 2By similarity1
Metal bindingi110Manganese 1; via carbonyl oxygenBy similarity1
Metal bindingi275Manganese 2By similarity1
Metal bindingi314Manganese 2By similarity1

GO - Molecular functioni

  • magnesium-dependent protein serine/threonine phosphatase activity Source: PomBase
  • MAP kinase threonine phosphatase activity Source: PomBase
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • inactivation of MAPK activity involved in osmosensory signaling pathway Source: PomBase
  • negative regulation of stress-activated MAPK cascade Source: PomBase
  • peptidyl-serine dephosphorylation Source: PomBase
  • peptidyl-threonine dephosphorylation Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Stress response

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 2C homolog 1 (EC:3.1.3.16)
Short name:
PP2C-1
Gene namesi
Name:ptc1
ORF Names:SPCC4F11.02
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC4F11.02.
PomBaseiSPCC4F11.02. ptc1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000577701 – 347Protein phosphatase 2C homolog 1Add BLAST347

Proteomic databases

MaxQBiP40371.
PRIDEiP40371.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

BioGridi276058. 320 interactors.
MINTiMINT-4689555.

Structurei

3D structure databases

ProteinModelPortaliP40371.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini71 – 323PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST253

Sequence similaritiesi

Belongs to the PP2C family.Curated
Contains 1 PPM-type phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000233896.
InParanoidiP40371.
KOiK19704.
OMAiATHNDIC.
OrthoDBiEOG092C52JO.
PhylomeDBiP40371.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR015655. PP2C.
IPR000222. PP2C_BS.
IPR001932. PPM-type_phosphatase_dom.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PPM_1. 1 hit.
PS51746. PPM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40371-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGSHPNAGS LLEPLHKLNP FSENSTSGHR KNASDHSADG ETRPIAIEMK
60 70 80 90 100
DSKGNTVPVG NSRPSKASNW LAGLMEDKNQ RWRRSMEDTH ICLYDFGGNQ
110 120 130 140 150
DDGFVAVYDG HAGIQASDYC QKNLHKVLLE KVRNEPDRLV TDLMDETFVE
160 170 180 190 200
VNSKIAKATH NDICGCTAAV AFFRYEKNRT RRVLYTANAG DARIVLCRDG
210 220 230 240 250
KAIRLSYDHK GSDANESRRV TQLGGLMVQN RINGVLAVTR ALGDTYLKEL
260 270 280 290 300
VSAHPFTTET RIWNGHDEFF IIACDGLWDV VSDQEAVDFV RNFVSPREAA
310 320 330 340
VRLVEFALKR LSTDNITCIV VNLTRNPGDL DDSGLTADND SYSNDYY
Length:347
Mass (Da):38,676
Last modified:February 1, 1995 - v1
Checksum:i50675A545502403B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26970 mRNA. Translation: AAA35327.1.
CU329672 Genomic DNA. Translation: CAB55768.1.
PIRiA56058.
RefSeqiNP_588401.1. NM_001023392.2.

Genome annotation databases

EnsemblFungiiSPCC4F11.02.1; SPCC4F11.02.1:pep; SPCC4F11.02.
GeneIDi2539495.
KEGGispo:SPCC4F11.02.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26970 mRNA. Translation: AAA35327.1.
CU329672 Genomic DNA. Translation: CAB55768.1.
PIRiA56058.
RefSeqiNP_588401.1. NM_001023392.2.

3D structure databases

ProteinModelPortaliP40371.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276058. 320 interactors.
MINTiMINT-4689555.

Proteomic databases

MaxQBiP40371.
PRIDEiP40371.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC4F11.02.1; SPCC4F11.02.1:pep; SPCC4F11.02.
GeneIDi2539495.
KEGGispo:SPCC4F11.02.

Organism-specific databases

EuPathDBiFungiDB:SPCC4F11.02.
PomBaseiSPCC4F11.02. ptc1.

Phylogenomic databases

HOGENOMiHOG000233896.
InParanoidiP40371.
KOiK19704.
OMAiATHNDIC.
OrthoDBiEOG092C52JO.
PhylomeDBiP40371.

Miscellaneous databases

PROiP40371.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR015655. PP2C.
IPR000222. PP2C_BS.
IPR001932. PPM-type_phosphatase_dom.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PPM_1. 1 hit.
PS51746. PPM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPP2C1_SCHPO
AccessioniPrimary (citable) accession number: P40371
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.