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P40371

- PP2C1_SCHPO

UniProt

P40371 - PP2C1_SCHPO

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Protein

Protein phosphatase 2C homolog 1

Gene

ptc1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

It has a serine and threonine phosphatase activity. Has a specialized role in the heat shock response. May be responsible for the dephosphorylation of hsp90. Also has a role in maintaining osmotic stability.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi109 – 1091Manganese 1By similarity
Metal bindingi109 – 1091Manganese 2By similarity
Metal bindingi110 – 1101Manganese 1; via carbonyl oxygenBy similarity
Metal bindingi275 – 2751Manganese 2By similarity
Metal bindingi314 – 3141Manganese 2By similarity

GO - Molecular functioni

  1. magnesium-dependent protein serine/threonine phosphatase activity Source: PomBase
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. inactivation of MAPK activity involved in osmosensory signaling pathway Source: PomBase
  2. peptidyl-serine dephosphorylation Source: PomBase
  3. peptidyl-threonine dephosphorylation Source: PomBase
  4. response to stress Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Stress response

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 2C homolog 1 (EC:3.1.3.16)
Short name:
PP2C-1
Gene namesi
Name:ptc1
ORF Names:SPCC4F11.02
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome III

Organism-specific databases

PomBaseiSPCC4F11.02.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: PomBase
  2. nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 347347Protein phosphatase 2C homolog 1PRO_0000057770Add
BLAST

Proteomic databases

MaxQBiP40371.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

BioGridi276058. 319 interactions.
MINTiMINT-4689555.
STRINGi4896.SPCC4F11.02-1.

Structurei

3D structure databases

ProteinModelPortaliP40371.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PP2C family.Curated

Phylogenomic databases

eggNOGiCOG0631.
HOGENOMiHOG000233896.
InParanoidiP40371.
KOiK01090.
OMAiATHNDIC.
OrthoDBiEOG7D2FR2.
PhylomeDBiP40371.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PP2C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40371-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKGSHPNAGS LLEPLHKLNP FSENSTSGHR KNASDHSADG ETRPIAIEMK
60 70 80 90 100
DSKGNTVPVG NSRPSKASNW LAGLMEDKNQ RWRRSMEDTH ICLYDFGGNQ
110 120 130 140 150
DDGFVAVYDG HAGIQASDYC QKNLHKVLLE KVRNEPDRLV TDLMDETFVE
160 170 180 190 200
VNSKIAKATH NDICGCTAAV AFFRYEKNRT RRVLYTANAG DARIVLCRDG
210 220 230 240 250
KAIRLSYDHK GSDANESRRV TQLGGLMVQN RINGVLAVTR ALGDTYLKEL
260 270 280 290 300
VSAHPFTTET RIWNGHDEFF IIACDGLWDV VSDQEAVDFV RNFVSPREAA
310 320 330 340
VRLVEFALKR LSTDNITCIV VNLTRNPGDL DDSGLTADND SYSNDYY
Length:347
Mass (Da):38,676
Last modified:February 1, 1995 - v1
Checksum:i50675A545502403B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L26970 mRNA. Translation: AAA35327.1.
CU329672 Genomic DNA. Translation: CAB55768.1.
PIRiA56058.
RefSeqiNP_588401.1. NM_001023392.2.

Genome annotation databases

EnsemblFungiiSPCC4F11.02.1; SPCC4F11.02.1:pep; SPCC4F11.02.
GeneIDi2539495.
KEGGispo:SPCC4F11.02.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L26970 mRNA. Translation: AAA35327.1 .
CU329672 Genomic DNA. Translation: CAB55768.1 .
PIRi A56058.
RefSeqi NP_588401.1. NM_001023392.2.

3D structure databases

ProteinModelPortali P40371.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 276058. 319 interactions.
MINTi MINT-4689555.
STRINGi 4896.SPCC4F11.02-1.

Proteomic databases

MaxQBi P40371.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPCC4F11.02.1 ; SPCC4F11.02.1:pep ; SPCC4F11.02 .
GeneIDi 2539495.
KEGGi spo:SPCC4F11.02.

Organism-specific databases

PomBasei SPCC4F11.02.

Phylogenomic databases

eggNOGi COG0631.
HOGENOMi HOG000233896.
InParanoidi P40371.
KOi K01090.
OMAi ATHNDIC.
OrthoDBi EOG7D2FR2.
PhylomeDBi P40371.

Miscellaneous databases

NextBioi 20800657.
PROi P40371.

Family and domain databases

Gene3Di 3.60.40.10. 1 hit.
InterProi IPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view ]
PANTHERi PTHR13832. PTHR13832. 1 hit.
Pfami PF00481. PP2C. 1 hit.
[Graphical view ]
SMARTi SM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81606. SSF81606. 1 hit.
PROSITEi PS01032. PP2C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Protein phosphatase 2C, encoded by ptc1+, is important in the heat shock response of Schizosaccharomyces pombe."
    Shiozaki K., Akhavan-Niaki H., McGowan C.H., Russell P.
    Mol. Cell. Biol. 14:3742-3751(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 972 / ATCC 24843.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiPP2C1_SCHPO
AccessioniPrimary (citable) accession number: P40371
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 29, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3