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P40371 (PP2C1_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein phosphatase 2C homolog 1

Short name=PP2C-1
EC=3.1.3.16
Gene names
Name:ptc1
ORF Names:SPCC4F11.02
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length347 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

It has a serine and threonine phosphatase activity. Has a specialized role in the heat shock response. May be responsible for the dephosphorylation of hsp90. Also has a role in maintaining osmotic stability.

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Subunit structure

Monomer.

Sequence similarities

Belongs to the PP2C family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 347347Protein phosphatase 2C homolog 1
PRO_0000057770

Sites

Metal binding1091Manganese 1 By similarity
Metal binding1091Manganese 2 By similarity
Metal binding1101Manganese 1; via carbonyl oxygen By similarity
Metal binding2751Manganese 2 By similarity
Metal binding3141Manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
P40371 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 50675A545502403B

FASTA34738,676
        10         20         30         40         50         60 
MKGSHPNAGS LLEPLHKLNP FSENSTSGHR KNASDHSADG ETRPIAIEMK DSKGNTVPVG 

        70         80         90        100        110        120 
NSRPSKASNW LAGLMEDKNQ RWRRSMEDTH ICLYDFGGNQ DDGFVAVYDG HAGIQASDYC 

       130        140        150        160        170        180 
QKNLHKVLLE KVRNEPDRLV TDLMDETFVE VNSKIAKATH NDICGCTAAV AFFRYEKNRT 

       190        200        210        220        230        240 
RRVLYTANAG DARIVLCRDG KAIRLSYDHK GSDANESRRV TQLGGLMVQN RINGVLAVTR 

       250        260        270        280        290        300 
ALGDTYLKEL VSAHPFTTET RIWNGHDEFF IIACDGLWDV VSDQEAVDFV RNFVSPREAA 

       310        320        330        340 
VRLVEFALKR LSTDNITCIV VNLTRNPGDL DDSGLTADND SYSNDYY 

« Hide

References

« Hide 'large scale' references
[1]"Protein phosphatase 2C, encoded by ptc1+, is important in the heat shock response of Schizosaccharomyces pombe."
Shiozaki K., Akhavan-Niaki H., McGowan C.H., Russell P.
Mol. Cell. Biol. 14:3742-3751(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: 972 / ATCC 24843.
[2]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L26970 mRNA. Translation: AAA35327.1.
CU329672 Genomic DNA. Translation: CAB55768.1.
PIRA56058.
RefSeqNP_588401.1. NM_001023392.2.

3D structure databases

ProteinModelPortalP40371.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid276058. 319 interactions.
MINTMINT-4689555.
STRING4896.SPCC4F11.02-1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPCC4F11.02.1; SPCC4F11.02.1:pep; SPCC4F11.02.
GeneID2539495.
KEGGspo:SPCC4F11.02.

Organism-specific databases

PomBaseSPCC4F11.02.

Phylogenomic databases

eggNOGCOG0631.
HOGENOMHOG000233896.
KOK01090.
OMAATHNDIC.
OrthoDBEOG7D2FR2.
PhylomeDBP40371.

Family and domain databases

Gene3D3.60.40.10. 1 hit.
InterProIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERPTHR13832. PTHR13832. 1 hit.
PfamPF00481. PP2C. 1 hit.
[Graphical view]
SMARTSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMSSF81606. SSF81606. 1 hit.
PROSITEPS01032. PP2C. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20800657.
PROP40371.

Entry information

Entry namePP2C1_SCHPO
AccessionPrimary (citable) accession number: P40371
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 16, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names