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Protein

Amino-acid acetyltransferase, mitochondrial

Gene

ARG2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

N-acetylglutamate synthase involved in arginine biosynthesis.2 Publications

Miscellaneous

Present with 112 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

Acetyl-CoA + L-glutamate = CoA + N-acetyl-L-glutamate.

Enzyme regulationi

Feedback inhibition by L-arginine.1 Publication

Pathwayi: L-arginine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Amino-acid acetyltransferase, mitochondrial (ARG2), Arginine biosynthesis bifunctional protein ArgJ, mitochondrial (ARG7)
  2. Protein ARG5,6, mitochondrial (ARG5,6)
  3. Protein ARG5,6, mitochondrial (ARG5,6)
  4. Acetylornithine aminotransferase, mitochondrial (ARG8)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

  • arginine biosynthetic process Source: SGD
  • ornithine biosynthetic process Source: SGD

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processAmino-acid biosynthesis

Enzyme and pathway databases

BioCyciYEAST:YJL071W-MONOMER
UniPathwayiUPA00068; UER00106

Names & Taxonomyi

Protein namesi
Recommended name:
Amino-acid acetyltransferase, mitochondrial (EC:2.3.1.1)
Alternative name(s):
Arginine-requiring protein 2
Glutamate N-acetyltransferase
N-acetylglutamate synthase
Short name:
AGS
Short name:
NAGS
Gene namesi
Name:ARG2
Ordered Locus Names:YJL071W
ORF Names:HRB574, J1091
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJL071W
SGDiS000003607 ARG2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 13MitochondrionAdd BLAST13
ChainiPRO_000020305414 – 574Amino-acid acetyltransferase, mitochondrialAdd BLAST561

Proteomic databases

MaxQBiP40360
PaxDbiP40360
PRIDEiP40360

PTM databases

CarbonylDBiP40360
iPTMnetiP40360

Interactioni

Subunit structurei

Interacts with the acetylglutamate kinase chain of AGR5,6.1 Publication

Protein-protein interaction databases

BioGridi33684, 21 interactors
DIPiDIP-5679N
IntActiP40360, 1 interactor
STRINGi4932.YJL071W

Structurei

3D structure databases

ProteinModelPortaliP40360
SMRiP40360
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini392 – 560N-acetyltransferasePROSITE-ProRule annotationAdd BLAST169

Sequence similaritiesi

Belongs to the acetyltransferase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000113727
InParanoidiP40360
KOiK00618
OMAiKWYFQRS
OrthoDBiEOG092C3BDM

Family and domain databases

InterProiView protein in InterPro
IPR011190 GlcNAc_Synth_fun
IPR006855 Vertebrate-like_GNAT_dom
PfamiView protein in Pfam
PF04768 NAT, 1 hit
PIRSFiPIRSF007892 NAGS_fungal, 1 hit
PROSITEiView protein in PROSITE
PS51731 GNAT_NAGS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P40360-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWRRIFAHEL KYDQPNASSK NLILSVLNTT ATKREAKDYL SKYTNDSGQH
60 70 80 90 100
NHCLFFIRDL HKVAPAILSQ FSSVIKRLGM LGLRPMFVIP PSPTHVNIQA
110 120 130 140 150
ELLDSIVTEA DLKPLHLKEG LTKSRTGLYH SVFSQESRFF DIGNSNFIPI
160 170 180 190 200
VKPYVYNEET ASEFMTKDVV KFMDCLCQGN IPHIDKFFIL NNAGGIPSGE
210 220 230 240 250
RNDNAHVFIN LSQELEHLSS SLSHNISTLT KREPRSQNLL HRMEVYVKKD
260 270 280 290 300
EISSLECEYH DHLENLLLMD KVLSNLAATA TGLITTVKAA ALSSDRKNPL
310 320 330 340 350
VYNLLTDRSL ISSSLPRFKK KDGEIDSPAN MFDDHAWYEL PSQQVNAAPS
360 370 380 390 400
NSDAVLVTTV LKKGVHIKTY DYKTLTQFNS IGLPKKFHVP EKGAKPSSNS
410 420 430 440 450
PKLDINKFKS IIDQSFKRSL DLHDYIKRIN GKIATIIVIG DYEGIAILTY
460 470 480 490 500
EGSEENSFVY LDKFAVLPHL KGSLGISDII FNLMFKKFPN EILWRSRKDN
510 520 530 540 550
VVNKWYFQRS VAVLDLSIDL DPEHCDEKQS QFKLFYYGNP QYAKRALRDK
560 570
KRLREFMRSV RDIKPSWENE KNIS
Length:574
Mass (Da):65,610
Last modified:February 1, 1995 - v1
Checksum:i167456A4900B7D59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X88851 Genomic DNA Translation: CAA61310.1
Z34288 Genomic DNA Translation: CAA84051.1
Z49346 Genomic DNA Translation: CAA89363.1
BK006943 Genomic DNA Translation: DAA08728.1
PIRiS50800
RefSeqiNP_012464.1, NM_001181504.1

Genome annotation databases

EnsemblFungiiYJL071W; YJL071W; YJL071W
GeneIDi853374
KEGGisce:YJL071W

Similar proteinsi

Entry informationi

Entry nameiNAGS_YEAST
AccessioniPrimary (citable) accession number: P40360
Secondary accession number(s): D6VWB2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: March 28, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health