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P40359

- PSF2_YEAST

UniProt

P40359 - PSF2_YEAST

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Protein

DNA replication complex GINS protein PSF2

Gene

PSF2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Functions as part of the GINS complex which plays an essential role in the initiation of DNA replication by binding to DNA replication origins and facilitating the assembly of the DNA replication machinery.1 Publication

GO - Biological processi

  1. DNA-dependent DNA replication Source: SGD
  2. double-strand break repair via break-induced replication Source: SGD
Complete GO annotation...

Keywords - Biological processi

DNA replication

Enzyme and pathway databases

BioCyciYEAST:G3O-31530-MONOMER.
ReactomeiREACT_255883. Unwinding of DNA.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA replication complex GINS protein PSF2
Alternative name(s):
Partner of Sld five 2
Gene namesi
Name:PSF2
Ordered Locus Names:YJL072C
ORF Names:HRF213, J1086
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome X

Organism-specific databases

CYGDiYJL072c.
SGDiS000003608. PSF2.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. DNA replication preinitiation complex Source: SGD
  2. GINS complex Source: SGD
  3. nuclear replication fork Source: SGD
  4. nucleus Source: SGD
  5. replication fork protection complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 213213DNA replication complex GINS protein PSF2PRO_0000194822Add
BLAST

Proteomic databases

MaxQBiP40359.
PaxDbiP40359.

Expressioni

Gene expression databases

GenevestigatoriP40359.

Interactioni

Subunit structurei

Component of the GINS complex which is a heterotetramer of SLD5, PSF1, PSF2 and PSF3.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PSF1Q124883EBI-25936,EBI-22066
PSF3Q121465EBI-25936,EBI-30392
SLD5Q034068EBI-25936,EBI-37437

Protein-protein interaction databases

BioGridi33683. 21 interactions.
DIPiDIP-3858N.
IntActiP40359. 6 interactions.
MINTiMINT-550028.
STRINGi4932.YJL072C.

Structurei

3D structure databases

ProteinModelPortaliP40359.
SMRiP40359. Positions 15-197.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GINS2/PSF2 family.Curated

Phylogenomic databases

eggNOGiCOG5093.
GeneTreeiENSGT00390000007838.
HOGENOMiHOG000246603.
InParanoidiP40359.
KOiK10733.
OMAiDLPWNWL.
OrthoDBiEOG7XH72F.

Family and domain databases

InterProiIPR021151. GINS_complex.
IPR007257. GINS_Psf2.
IPR016906. GINS_Psf2_subgr.
[Graphical view]
PANTHERiPTHR12772. PTHR12772. 1 hit.
PfamiPF05916. Sld5. 1 hit.
[Graphical view]
PIRSFiPIRSF028998. GINS_Psf2_subgr. 1 hit.

Sequencei

Sequence statusi: Complete.

P40359-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLPAHLQQT FSPEEIQFIV ENEPIKIFPR ITTRQKIRGD DRGTGNHTRW
60 70 80 90 100
QLITTDDKAL NNMVAMRSTE VVLWIALLLK QQSKCSIVAP QWLTTKELDR
110 120 130 140 150
KIQYEKTHPD RFSELPWNWL VLARILFNKA KDDFHDPIHE LRGKIQDLRE
160 170 180 190 200
IRQIKVLKGL KYLNESHLQL DNLSLLEINE LRPFITEIMD KLREIHTASL
210
TAGTENDEEE FNI
Length:213
Mass (Da):25,061
Last modified:February 1, 1995 - v1
Checksum:iC8B52C0462A37A3A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X88851 Genomic DNA. Translation: CAA61311.1.
Z34288 Genomic DNA. Translation: CAA84050.1.
Z49347 Genomic DNA. Translation: CAA89364.1.
AY558248 Genomic DNA. Translation: AAS56574.1.
BK006943 Genomic DNA. Translation: DAA08727.1.
PIRiS50799.
RefSeqiNP_012463.1. NM_001181505.1.

Genome annotation databases

EnsemblFungiiYJL072C; YJL072C; YJL072C.
GeneIDi853373.
KEGGisce:YJL072C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X88851 Genomic DNA. Translation: CAA61311.1 .
Z34288 Genomic DNA. Translation: CAA84050.1 .
Z49347 Genomic DNA. Translation: CAA89364.1 .
AY558248 Genomic DNA. Translation: AAS56574.1 .
BK006943 Genomic DNA. Translation: DAA08727.1 .
PIRi S50799.
RefSeqi NP_012463.1. NM_001181505.1.

3D structure databases

ProteinModelPortali P40359.
SMRi P40359. Positions 15-197.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33683. 21 interactions.
DIPi DIP-3858N.
IntActi P40359. 6 interactions.
MINTi MINT-550028.
STRINGi 4932.YJL072C.

Proteomic databases

MaxQBi P40359.
PaxDbi P40359.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YJL072C ; YJL072C ; YJL072C .
GeneIDi 853373.
KEGGi sce:YJL072C.

Organism-specific databases

CYGDi YJL072c.
SGDi S000003608. PSF2.

Phylogenomic databases

eggNOGi COG5093.
GeneTreei ENSGT00390000007838.
HOGENOMi HOG000246603.
InParanoidi P40359.
KOi K10733.
OMAi DLPWNWL.
OrthoDBi EOG7XH72F.

Enzyme and pathway databases

BioCyci YEAST:G3O-31530-MONOMER.
Reactomei REACT_255883. Unwinding of DNA.

Miscellaneous databases

NextBioi 973816.
PROi P40359.

Gene expression databases

Genevestigatori P40359.

Family and domain databases

InterProi IPR021151. GINS_complex.
IPR007257. GINS_Psf2.
IPR016906. GINS_Psf2_subgr.
[Graphical view ]
PANTHERi PTHR12772. PTHR12772. 1 hit.
Pfami PF05916. Sld5. 1 hit.
[Graphical view ]
PIRSFi PIRSF028998. GINS_Psf2_subgr. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "GINS, a novel multiprotein complex required for chromosomal DNA replication in budding yeast."
    Takayama Y., Kamimura Y., Okawa M., Muramatsu S., Sugino A., Araki H.
    Genes Dev. 17:1153-1165(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, IDENTIFICATION IN THE GINS COMPLEX, SUBCELLULAR LOCATION.
  2. Sor F.J.
    Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. "Sequence of a 17.1 kb DNA fragment from chromosome X of Saccharomyces cerevisiae includes the mitochondrial ribosomal protein L8."
    Vandenbol M., Durand P., Dion C., Portetelle D., Hilger F.
    Yeast 11:57-60(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
    Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
    , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
    EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  6. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.

Entry informationi

Entry nameiPSF2_YEAST
AccessioniPrimary (citable) accession number: P40359
Secondary accession number(s): D6VWB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 26, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

External Data

Dasty 3