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P40359 (PSF2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA replication complex GINS protein PSF2
Alternative name(s):
Partner of Sld five 2
Gene names
Name:PSF2
Ordered Locus Names:YJL072C
ORF Names:HRF213, J1086
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length213 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Functions as part of the GINS complex which plays an essential role in the initiation of DNA replication by binding to DNA replication origins and facilitating the assembly of the DNA replication machinery. Ref.1

Subunit structure

Component of the GINS complex which is a heterotetramer of SLD5, PSF1, PSF2 and PSF3. Ref.1

Subcellular location

Nucleus Ref.1.

Sequence similarities

Belongs to the GINS2/PSF2 family.

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 213213DNA replication complex GINS protein PSF2
PRO_0000194822

Sequences

Sequence LengthMass (Da)Tools
P40359 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: C8B52C0462A37A3A

FASTA21325,061
        10         20         30         40         50         60 
MSLPAHLQQT FSPEEIQFIV ENEPIKIFPR ITTRQKIRGD DRGTGNHTRW QLITTDDKAL 

        70         80         90        100        110        120 
NNMVAMRSTE VVLWIALLLK QQSKCSIVAP QWLTTKELDR KIQYEKTHPD RFSELPWNWL 

       130        140        150        160        170        180 
VLARILFNKA KDDFHDPIHE LRGKIQDLRE IRQIKVLKGL KYLNESHLQL DNLSLLEINE 

       190        200        210 
LRPFITEIMD KLREIHTASL TAGTENDEEE FNI 

« Hide

References

« Hide 'large scale' references
[1]"GINS, a novel multiprotein complex required for chromosomal DNA replication in budding yeast."
Takayama Y., Kamimura Y., Okawa M., Muramatsu S., Sugino A., Araki H.
Genes Dev. 17:1153-1165(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, IDENTIFICATION IN THE GINS COMPLEX, SUBCELLULAR LOCATION.
[2]Sor F.J.
Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"Sequence of a 17.1 kb DNA fragment from chromosome X of Saccharomyces cerevisiae includes the mitochondrial ribosomal protein L8."
Vandenbol M., Durand P., Dion C., Portetelle D., Hilger F.
Yeast 11:57-60(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K. expand/collapse author list , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[5]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[6]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X88851 Genomic DNA. Translation: CAA61311.1.
Z34288 Genomic DNA. Translation: CAA84050.1.
Z49347 Genomic DNA. Translation: CAA89364.1.
AY558248 Genomic DNA. Translation: AAS56574.1.
BK006943 Genomic DNA. Translation: DAA08727.1.
PIRS50799.
RefSeqNP_012463.1. NM_001181505.1.

3D structure databases

ProteinModelPortalP40359.
SMRP40359. Positions 15-197.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid33683. 22 interactions.
DIPDIP-3858N.
IntActP40359. 6 interactions.
MINTMINT-550028.
STRING4932.YJL072C.

Proteomic databases

PaxDbP40359.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYJL072C; YJL072C; YJL072C.
GeneID853373.
KEGGsce:YJL072C.

Organism-specific databases

CYGDYJL072c.
SGDS000003608. PSF2.

Phylogenomic databases

eggNOGCOG5093.
GeneTreeENSGT00390000007838.
HOGENOMHOG000246603.
KOK10733.
OMALPWNWLV.
OrthoDBEOG7XH72F.

Enzyme and pathway databases

BioCycYEAST:G3O-31530-MONOMER.

Gene expression databases

GenevestigatorP40359.

Family and domain databases

InterProIPR021151. GINS_complex.
IPR007257. GINS_Psf2.
IPR016906. GINS_Psf2_subgr.
[Graphical view]
PANTHERPTHR12772. PTHR12772. 1 hit.
PfamPF05916. Sld5. 1 hit.
[Graphical view]
PIRSFPIRSF028998. GINS_Psf2_subgr. 1 hit.
ProtoNetSearch...

Other

NextBio973816.
PROP40359.

Entry information

Entry namePSF2_YEAST
AccessionPrimary (citable) accession number: P40359
Secondary accession number(s): D6VWB1
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 16, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome X

Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families