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P40359

- PSF2_YEAST

UniProt

P40359 - PSF2_YEAST

Protein

DNA replication complex GINS protein PSF2

Gene

PSF2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Functions as part of the GINS complex which plays an essential role in the initiation of DNA replication by binding to DNA replication origins and facilitating the assembly of the DNA replication machinery.1 Publication

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. DNA-dependent DNA replication Source: SGD
    2. double-strand break repair via break-induced replication Source: SGD

    Keywords - Biological processi

    DNA replication

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31530-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA replication complex GINS protein PSF2
    Alternative name(s):
    Partner of Sld five 2
    Gene namesi
    Name:PSF2
    Ordered Locus Names:YJL072C
    ORF Names:HRF213, J1086
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome X

    Organism-specific databases

    CYGDiYJL072c.
    SGDiS000003608. PSF2.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. DNA replication preinitiation complex Source: SGD
    2. GINS complex Source: SGD
    3. nuclear replication fork Source: SGD
    4. nucleus Source: SGD
    5. replication fork protection complex Source: SGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 213213DNA replication complex GINS protein PSF2PRO_0000194822Add
    BLAST

    Proteomic databases

    MaxQBiP40359.
    PaxDbiP40359.

    Expressioni

    Gene expression databases

    GenevestigatoriP40359.

    Interactioni

    Subunit structurei

    Component of the GINS complex which is a heterotetramer of SLD5, PSF1, PSF2 and PSF3.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PSF1Q124883EBI-25936,EBI-22066
    PSF3Q121465EBI-25936,EBI-30392
    SLD5Q034068EBI-25936,EBI-37437

    Protein-protein interaction databases

    BioGridi33683. 22 interactions.
    DIPiDIP-3858N.
    IntActiP40359. 6 interactions.
    MINTiMINT-550028.
    STRINGi4932.YJL072C.

    Structurei

    3D structure databases

    ProteinModelPortaliP40359.
    SMRiP40359. Positions 15-197.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GINS2/PSF2 family.Curated

    Phylogenomic databases

    eggNOGiCOG5093.
    GeneTreeiENSGT00390000007838.
    HOGENOMiHOG000246603.
    KOiK10733.
    OMAiDLPWNWL.
    OrthoDBiEOG7XH72F.

    Family and domain databases

    InterProiIPR021151. GINS_complex.
    IPR007257. GINS_Psf2.
    IPR016906. GINS_Psf2_subgr.
    [Graphical view]
    PANTHERiPTHR12772. PTHR12772. 1 hit.
    PfamiPF05916. Sld5. 1 hit.
    [Graphical view]
    PIRSFiPIRSF028998. GINS_Psf2_subgr. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P40359-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLPAHLQQT FSPEEIQFIV ENEPIKIFPR ITTRQKIRGD DRGTGNHTRW    50
    QLITTDDKAL NNMVAMRSTE VVLWIALLLK QQSKCSIVAP QWLTTKELDR 100
    KIQYEKTHPD RFSELPWNWL VLARILFNKA KDDFHDPIHE LRGKIQDLRE 150
    IRQIKVLKGL KYLNESHLQL DNLSLLEINE LRPFITEIMD KLREIHTASL 200
    TAGTENDEEE FNI 213
    Length:213
    Mass (Da):25,061
    Last modified:February 1, 1995 - v1
    Checksum:iC8B52C0462A37A3A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X88851 Genomic DNA. Translation: CAA61311.1.
    Z34288 Genomic DNA. Translation: CAA84050.1.
    Z49347 Genomic DNA. Translation: CAA89364.1.
    AY558248 Genomic DNA. Translation: AAS56574.1.
    BK006943 Genomic DNA. Translation: DAA08727.1.
    PIRiS50799.
    RefSeqiNP_012463.1. NM_001181505.1.

    Genome annotation databases

    EnsemblFungiiYJL072C; YJL072C; YJL072C.
    GeneIDi853373.
    KEGGisce:YJL072C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X88851 Genomic DNA. Translation: CAA61311.1 .
    Z34288 Genomic DNA. Translation: CAA84050.1 .
    Z49347 Genomic DNA. Translation: CAA89364.1 .
    AY558248 Genomic DNA. Translation: AAS56574.1 .
    BK006943 Genomic DNA. Translation: DAA08727.1 .
    PIRi S50799.
    RefSeqi NP_012463.1. NM_001181505.1.

    3D structure databases

    ProteinModelPortali P40359.
    SMRi P40359. Positions 15-197.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33683. 22 interactions.
    DIPi DIP-3858N.
    IntActi P40359. 6 interactions.
    MINTi MINT-550028.
    STRINGi 4932.YJL072C.

    Proteomic databases

    MaxQBi P40359.
    PaxDbi P40359.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YJL072C ; YJL072C ; YJL072C .
    GeneIDi 853373.
    KEGGi sce:YJL072C.

    Organism-specific databases

    CYGDi YJL072c.
    SGDi S000003608. PSF2.

    Phylogenomic databases

    eggNOGi COG5093.
    GeneTreei ENSGT00390000007838.
    HOGENOMi HOG000246603.
    KOi K10733.
    OMAi DLPWNWL.
    OrthoDBi EOG7XH72F.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31530-MONOMER.

    Miscellaneous databases

    NextBioi 973816.
    PROi P40359.

    Gene expression databases

    Genevestigatori P40359.

    Family and domain databases

    InterProi IPR021151. GINS_complex.
    IPR007257. GINS_Psf2.
    IPR016906. GINS_Psf2_subgr.
    [Graphical view ]
    PANTHERi PTHR12772. PTHR12772. 1 hit.
    Pfami PF05916. Sld5. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF028998. GINS_Psf2_subgr. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "GINS, a novel multiprotein complex required for chromosomal DNA replication in budding yeast."
      Takayama Y., Kamimura Y., Okawa M., Muramatsu S., Sugino A., Araki H.
      Genes Dev. 17:1153-1165(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, IDENTIFICATION IN THE GINS COMPLEX, SUBCELLULAR LOCATION.
    2. Sor F.J.
      Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. "Sequence of a 17.1 kb DNA fragment from chromosome X of Saccharomyces cerevisiae includes the mitochondrial ribosomal protein L8."
      Vandenbol M., Durand P., Dion C., Portetelle D., Hilger F.
      Yeast 11:57-60(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
      Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
      , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
      EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    5. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    6. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.

    Entry informationi

    Entry nameiPSF2_YEAST
    AccessioniPrimary (citable) accession number: P40359
    Secondary accession number(s): D6VWB1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome X
      Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

    External Data

    Dasty 3