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Protein

DNA replication complex GINS protein PSF2

Gene

PSF2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as part of the GINS complex which plays an essential role in the initiation of DNA replication by binding to DNA replication origins and facilitating the assembly of the DNA replication machinery.1 Publication

GO - Biological processi

  • DNA-dependent DNA replication Source: SGD
  • DNA duplex unwinding Source: GOC
  • double-strand break repair via break-induced replication Source: SGD
  • mitotic DNA replication initiation Source: GO_Central

Keywordsi

Biological processDNA replication

Enzyme and pathway databases

BioCyciYEAST:G3O-31530-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA replication complex GINS protein PSF2
Alternative name(s):
Partner of Sld five 2
Gene namesi
Name:PSF2
Ordered Locus Names:YJL072C
ORF Names:HRF213, J1086
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJL072C
SGDiS000003608 PSF2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001948221 – 213DNA replication complex GINS protein PSF2Add BLAST213

Proteomic databases

MaxQBiP40359
PaxDbiP40359
PRIDEiP40359

Interactioni

Subunit structurei

Component of the GINS complex which is a heterotetramer of SLD5, PSF1, PSF2 and PSF3. Interacts with PSF1 and SLD5.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi33683, 196 interactors
DIPiDIP-3858N
IntActiP40359, 7 interactors
MINTiP40359
STRINGi4932.YJL072C

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3JC5electron microscopy4.70B1-213[»]
3JC6electron microscopy3.70B1-213[»]
3JC7electron microscopy4.80B1-213[»]
5U8Selectron microscopy6.10B1-213[»]
5U8Telectron microscopy4.90B1-213[»]
ProteinModelPortaliP40359
SMRiP40359
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GINS2/PSF2 family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000007838
HOGENOMiHOG000246603
InParanoidiP40359
KOiK10733
OMAiEVAFLCE
OrthoDBiEOG092C52QV

Family and domain databases

InterProiView protein in InterPro
IPR021151 GINS_A
IPR036224 GINS_bundle-like_dom_sf
IPR007257 GINS_Psf2
PANTHERiPTHR12772 PTHR12772, 1 hit
PfamiView protein in Pfam
PF05916 Sld5, 1 hit
PIRSFiPIRSF028998 GINS_Psf2_subgr, 1 hit
SUPFAMiSSF158573 SSF158573, 1 hit

Sequencei

Sequence statusi: Complete.

P40359-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLPAHLQQT FSPEEIQFIV ENEPIKIFPR ITTRQKIRGD DRGTGNHTRW
60 70 80 90 100
QLITTDDKAL NNMVAMRSTE VVLWIALLLK QQSKCSIVAP QWLTTKELDR
110 120 130 140 150
KIQYEKTHPD RFSELPWNWL VLARILFNKA KDDFHDPIHE LRGKIQDLRE
160 170 180 190 200
IRQIKVLKGL KYLNESHLQL DNLSLLEINE LRPFITEIMD KLREIHTASL
210
TAGTENDEEE FNI
Length:213
Mass (Da):25,061
Last modified:February 1, 1995 - v1
Checksum:iC8B52C0462A37A3A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X88851 Genomic DNA Translation: CAA61311.1
Z34288 Genomic DNA Translation: CAA84050.1
Z49347 Genomic DNA Translation: CAA89364.1
AY558248 Genomic DNA Translation: AAS56574.1
BK006943 Genomic DNA Translation: DAA08727.1
PIRiS50799
RefSeqiNP_012463.1, NM_001181505.1

Genome annotation databases

EnsemblFungiiYJL072C; YJL072C; YJL072C
GeneIDi853373
KEGGisce:YJL072C

Similar proteinsi

Entry informationi

Entry nameiPSF2_YEAST
AccessioniPrimary (citable) accession number: P40359
Secondary accession number(s): D6VWB1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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