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P40352

- RAD26_YEAST

UniProt

P40352 - RAD26_YEAST

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Protein

DNA repair and recombination protein RAD26

Gene
RAD26, GTA1085, YJR035W, J1606
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in the preferential repair of active genes.

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi322 – 3298ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: UniProtKB-KW
  3. DNA-dependent ATPase activity Source: SGD
  4. helicase activity Source: UniProtKB-KW

GO - Biological processi

  1. ATP catabolic process Source: GOC
  2. histone H2A-H2B dimer displacement Source: SGD
  3. nucleotide-excision repair Source: SGD
  4. transcription-coupled nucleotide-excision repair Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31672-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA repair and recombination protein RAD26 (EC:3.6.4.12)
Alternative name(s):
ATP-dependent helicase RAD26
Gene namesi
Name:RAD26
Synonyms:GTA1085
Ordered Locus Names:YJR035W
ORF Names:J1606
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome X

Organism-specific databases

CYGDiYJR035w.
SGDiS000003796. RAD26.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10851085DNA repair and recombination protein RAD26PRO_0000074336Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei30 – 301Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP40352.
PaxDbiP40352.
PeptideAtlasiP40352.

Expressioni

Gene expression databases

GenevestigatoriP40352.

Interactioni

Protein-protein interaction databases

BioGridi33788. 110 interactions.
DIPiDIP-3008N.
IntActiP40352. 2 interactions.
MINTiMINT-439055.
STRINGi4932.YJR035W.

Structurei

3D structure databases

ProteinModelPortaliP40352.
SMRiP40352. Positions 300-825.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini309 – 518210Helicase ATP-bindingAdd
BLAST
Domaini655 – 818164Helicase C-terminalAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi469 – 4724DEGH box

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi173 – 22856Asp/Glu-rich (acidic)Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0553.
GeneTreeiENSGT00590000083118.
HOGENOMiHOG000170952.
KOiK10841.
OMAiQLLLLWH.
OrthoDBiEOG7SXWC3.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
[Graphical view]
PfamiPF00271. Helicase_C. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40352-1 [UniParc]FASTAAdd to Basket

« Hide

MEDKEQQDNA KLENNESLKD LGVNVLSQSS LEEKIANDVT NFSNLQSLQQ     50
EETRLERSKT ALQRYVNKKN HLTRKLNNTT RISVKQNLRD QIKNLQSDDI 100
ERVLKDIDDI QSRIKELKEQ VDQGAENKGS KEGLQRPGET EKEFLIRTGK 150
ITAFGHKAGF SLDTANREYA KNDEQKDEDF EMATEQMVEN LTDEDDNLSD 200
QDYQMSGKES EDDEEEENDD KILKELEDLR FRGQPGEAKD DGDELYYQER 250
LKKWVKQRSC GSQRSSDLPE WRRPHPNIPD AKLNSQFKIP GEIYSLLFNY 300
QKTCVQWLYE LYQQNCGGII GDEMGLGKTI QVIAFIAALH HSGLLTGPVL 350
IVCPATVMKQ WCNEFQHWWP PLRTVILHSM GSGMASDQKF KMDENDLENL 400
IMNSKPSDFS YEDWKNSTRT KKALESSYHL DKLIDKVVTD GHILITTYVG 450
LRIHSDKLLK VKWQYAVLDE GHKIRNPDSE ISLTCKKLKT HNRIILSGTP 500
IQNNLTELWS LFDFIFPGKL GTLPVFQQQF VIPINIGGYA NATNIQVQTG 550
YKCAVALRDL ISPYLLRRVK ADVAKDLPQK KEMVLFCKLT KYQRSKYLEF 600
LHSSDLNQIQ NGKRNVLFGI DILRKICNHP DLLDRDTKRH NPDYGDPKRS 650
GKMQVVKQLL LLWHKQGYKA LLFTQSRQML DILEEFISTK DPDLSHLNYL 700
RMDGTTNIKG RQSLVDRFNN ESFDVFLLTT RVGGLGVNLT GANRIIIFDP 750
DWNPSTDMQA RERAWRIGQK REVSIYRLMV GGSIEEKIYH RQIFKQFLTN 800
RILTDPKQKR FFKIHELHDL FSLGGENGYS TEELNEEVQK HTENLKNSKS 850
EESDDFEQLV NLSGVSKLES FYNGKEKKEN SKTEDDRLIE GLLGGESNLE 900
TVMSHDSVVN SHAGSSSSNI ITKEASRVAI EAVNALRKSR KKITKQYEIG 950
TPTWTGRFGK AGKIRKRDPL KNKLTGSAAI LGNITKSQKE ASKEARQENY 1000
DDGITFARSK EINSNTKTLE NIRAYLQKQN NFFSSSVSIL NSIGVSLSDK 1050
EDVIKVRALL KTIAQFDKER KGWVLDEEFR NNNAS 1085
Length:1,085
Mass (Da):124,528
Last modified:February 1, 1995 - v1
Checksum:i2A8C34A7300148E3
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti366 – 3661Q → H in CAA57290. 1 Publication
Sequence conflicti963 – 9631K → E in CAA57290. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L26910 Genomic DNA. Translation: AAA34655.1.
X81635 Genomic DNA. Translation: CAA57290.1.
Z49535 Genomic DNA. Translation: CAA89562.1.
BK006943 Genomic DNA. Translation: DAA08824.1.
PIRiJC2227.
RefSeqiNP_012569.1. NM_001181693.1.

Genome annotation databases

EnsemblFungiiYJR035W; YJR035W; YJR035W.
GeneIDi853492.
KEGGisce:YJR035W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L26910 Genomic DNA. Translation: AAA34655.1 .
X81635 Genomic DNA. Translation: CAA57290.1 .
Z49535 Genomic DNA. Translation: CAA89562.1 .
BK006943 Genomic DNA. Translation: DAA08824.1 .
PIRi JC2227.
RefSeqi NP_012569.1. NM_001181693.1.

3D structure databases

ProteinModelPortali P40352.
SMRi P40352. Positions 300-825.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33788. 110 interactions.
DIPi DIP-3008N.
IntActi P40352. 2 interactions.
MINTi MINT-439055.
STRINGi 4932.YJR035W.

Proteomic databases

MaxQBi P40352.
PaxDbi P40352.
PeptideAtlasi P40352.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YJR035W ; YJR035W ; YJR035W .
GeneIDi 853492.
KEGGi sce:YJR035W.

Organism-specific databases

CYGDi YJR035w.
SGDi S000003796. RAD26.

Phylogenomic databases

eggNOGi COG0553.
GeneTreei ENSGT00590000083118.
HOGENOMi HOG000170952.
KOi K10841.
OMAi QLLLLWH.
OrthoDBi EOG7SXWC3.

Enzyme and pathway databases

BioCyci YEAST:G3O-31672-MONOMER.

Miscellaneous databases

NextBioi 974125.
PROi P40352.

Gene expression databases

Genevestigatori P40352.

Family and domain databases

Gene3Di 3.40.50.300. 3 hits.
InterProi IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
[Graphical view ]
Pfami PF00271. Helicase_C. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view ]
SMARTi SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 3 hits.
PROSITEi PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A possible yeast homolog of human active-gene-repairing helicase ERCC6+."
    Huang M.-E., Chuat J.-C., Galibert F.
    Biochem. Biophys. Res. Commun. 201:310-317(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "RAD26, the functional S. cerevisiae homolog of the Cockayne syndrome B gene ERCC6."
    van Gool A.J., Verhage R., Swagemakers S.M.A., van de Putte P., Brouwer J., Troelstra C., Bootsma D., Hoeijmakers J.H.J.
    EMBO J. 13:5361-5369(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
    Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
    , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
    EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-30, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRAD26_YEAST
AccessioniPrimary (citable) accession number: P40352
Secondary accession number(s): D6VWK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 3, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

External Data

Dasty 3

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