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Protein

DNA repair and recombination protein RAD26

Gene

RAD26

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the preferential repair of active genes.

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi322 – 329ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • DNA binding Source: UniProtKB-KW
  • DNA-dependent ATPase activity Source: SGD
  • helicase activity Source: UniProtKB-KW

GO - Biological processi

  • histone H2A-H2B dimer displacement Source: SGD
  • nucleotide-excision repair Source: SGD
  • transcription-coupled nucleotide-excision repair Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31672-MONOMER.
ReactomeiR-SCE-6781823. Formation of TC-NER Pre-Incision Complex.
R-SCE-6782135. Dual incision in TC-NER.
R-SCE-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA repair and recombination protein RAD26 (EC:3.6.4.12)
Alternative name(s):
ATP-dependent helicase RAD26
Gene namesi
Name:RAD26
Synonyms:GTA1085
Ordered Locus Names:YJR035W
ORF Names:J1606
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJR035W.
SGDiS000003796. RAD26.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000743361 – 1085DNA repair and recombination protein RAD26Add BLAST1085

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei30PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP40352.
PRIDEiP40352.

PTM databases

iPTMnetiP40352.

Interactioni

Protein-protein interaction databases

BioGridi33788. 109 interactors.
DIPiDIP-3008N.
IntActiP40352. 2 interactors.
MINTiMINT-439055.

Structurei

3D structure databases

ProteinModelPortaliP40352.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini309 – 518Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST210
Domaini655 – 818Helicase C-terminalPROSITE-ProRule annotationAdd BLAST164

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi469 – 472DEGH box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi173 – 228Asp/Glu-rich (acidic)Add BLAST56

Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family.Curated
Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00590000083118.
HOGENOMiHOG000170952.
InParanoidiP40352.
KOiK10841.
OMAiATNIQVQ.
OrthoDBiEOG092C10RV.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
[Graphical view]
PfamiPF00271. Helicase_C. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40352-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDKEQQDNA KLENNESLKD LGVNVLSQSS LEEKIANDVT NFSNLQSLQQ
60 70 80 90 100
EETRLERSKT ALQRYVNKKN HLTRKLNNTT RISVKQNLRD QIKNLQSDDI
110 120 130 140 150
ERVLKDIDDI QSRIKELKEQ VDQGAENKGS KEGLQRPGET EKEFLIRTGK
160 170 180 190 200
ITAFGHKAGF SLDTANREYA KNDEQKDEDF EMATEQMVEN LTDEDDNLSD
210 220 230 240 250
QDYQMSGKES EDDEEEENDD KILKELEDLR FRGQPGEAKD DGDELYYQER
260 270 280 290 300
LKKWVKQRSC GSQRSSDLPE WRRPHPNIPD AKLNSQFKIP GEIYSLLFNY
310 320 330 340 350
QKTCVQWLYE LYQQNCGGII GDEMGLGKTI QVIAFIAALH HSGLLTGPVL
360 370 380 390 400
IVCPATVMKQ WCNEFQHWWP PLRTVILHSM GSGMASDQKF KMDENDLENL
410 420 430 440 450
IMNSKPSDFS YEDWKNSTRT KKALESSYHL DKLIDKVVTD GHILITTYVG
460 470 480 490 500
LRIHSDKLLK VKWQYAVLDE GHKIRNPDSE ISLTCKKLKT HNRIILSGTP
510 520 530 540 550
IQNNLTELWS LFDFIFPGKL GTLPVFQQQF VIPINIGGYA NATNIQVQTG
560 570 580 590 600
YKCAVALRDL ISPYLLRRVK ADVAKDLPQK KEMVLFCKLT KYQRSKYLEF
610 620 630 640 650
LHSSDLNQIQ NGKRNVLFGI DILRKICNHP DLLDRDTKRH NPDYGDPKRS
660 670 680 690 700
GKMQVVKQLL LLWHKQGYKA LLFTQSRQML DILEEFISTK DPDLSHLNYL
710 720 730 740 750
RMDGTTNIKG RQSLVDRFNN ESFDVFLLTT RVGGLGVNLT GANRIIIFDP
760 770 780 790 800
DWNPSTDMQA RERAWRIGQK REVSIYRLMV GGSIEEKIYH RQIFKQFLTN
810 820 830 840 850
RILTDPKQKR FFKIHELHDL FSLGGENGYS TEELNEEVQK HTENLKNSKS
860 870 880 890 900
EESDDFEQLV NLSGVSKLES FYNGKEKKEN SKTEDDRLIE GLLGGESNLE
910 920 930 940 950
TVMSHDSVVN SHAGSSSSNI ITKEASRVAI EAVNALRKSR KKITKQYEIG
960 970 980 990 1000
TPTWTGRFGK AGKIRKRDPL KNKLTGSAAI LGNITKSQKE ASKEARQENY
1010 1020 1030 1040 1050
DDGITFARSK EINSNTKTLE NIRAYLQKQN NFFSSSVSIL NSIGVSLSDK
1060 1070 1080
EDVIKVRALL KTIAQFDKER KGWVLDEEFR NNNAS
Length:1,085
Mass (Da):124,528
Last modified:February 1, 1995 - v1
Checksum:i2A8C34A7300148E3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti366Q → H in CAA57290 (PubMed:7957102).Curated1
Sequence conflicti963K → E in CAA57290 (PubMed:7957102).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26910 Genomic DNA. Translation: AAA34655.1.
X81635 Genomic DNA. Translation: CAA57290.1.
Z49535 Genomic DNA. Translation: CAA89562.1.
BK006943 Genomic DNA. Translation: DAA08824.1.
PIRiJC2227.
RefSeqiNP_012569.1. NM_001181693.1.

Genome annotation databases

EnsemblFungiiYJR035W; YJR035W; YJR035W.
GeneIDi853492.
KEGGisce:YJR035W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26910 Genomic DNA. Translation: AAA34655.1.
X81635 Genomic DNA. Translation: CAA57290.1.
Z49535 Genomic DNA. Translation: CAA89562.1.
BK006943 Genomic DNA. Translation: DAA08824.1.
PIRiJC2227.
RefSeqiNP_012569.1. NM_001181693.1.

3D structure databases

ProteinModelPortaliP40352.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33788. 109 interactors.
DIPiDIP-3008N.
IntActiP40352. 2 interactors.
MINTiMINT-439055.

PTM databases

iPTMnetiP40352.

Proteomic databases

MaxQBiP40352.
PRIDEiP40352.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYJR035W; YJR035W; YJR035W.
GeneIDi853492.
KEGGisce:YJR035W.

Organism-specific databases

EuPathDBiFungiDB:YJR035W.
SGDiS000003796. RAD26.

Phylogenomic databases

GeneTreeiENSGT00590000083118.
HOGENOMiHOG000170952.
InParanoidiP40352.
KOiK10841.
OMAiATNIQVQ.
OrthoDBiEOG092C10RV.

Enzyme and pathway databases

BioCyciYEAST:G3O-31672-MONOMER.
ReactomeiR-SCE-6781823. Formation of TC-NER Pre-Incision Complex.
R-SCE-6782135. Dual incision in TC-NER.
R-SCE-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.

Miscellaneous databases

PROiP40352.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
[Graphical view]
PfamiPF00271. Helicase_C. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAD26_YEAST
AccessioniPrimary (citable) accession number: P40352
Secondary accession number(s): D6VWK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.